DD294178A5 - INJECTION DEVICE WITH AN ORIGINALITY SAFETY DEVICE HAVING AN OPENING ORGANIZATION DEVICE - Google Patents

Abstract

The invention relates to an injection device comprising a syringe barrel, a piston guided in the syringe barrel and a piston rod connected to it in particular via a coupling device, which preferably has a length which is greater than the length of the syringe barrel, which is one on the side remote from the piston rod having the syringe cylinder provided coupling arrangement, via which an injection needle with the syringe cylinder can be coupled. The piston and / or the piston rod is a Originalitaetssicherungungsvorrichtung associated with a connected to the piston and or or the piston rod or arranged therebetween OEffnungsorgan. FIG {injection device; Hypodermic needle; Clutch assembly; Syringe barrel; Piston; Coupling device; Piston rod; Originalitaetssicherungsvorrichtung; OEffnungsorgan}

Description

Injection device with an opening member having Ori gical security precaution

Field of application of the invention

The invention relates to an injection device comprising a syringe barrel, a piston guided in the syringe barrel and a piston rod connected thereto in particular via a coupling device, which preferably has a length which is greater than the length of the syringe barrel and with a side facing away from the piston rod the injection cylinder provided coupling arrangement, via which an injection needle with the syringe barrel can be coupled.

Characteristic of the known state of the art

There have already become known such various injection syringes with tamper-evident provisions which can be provided with different safety devices to ensure a one-time use of the injection device. So it is to avoid multiple use, already known - according to GB-OS 2 195 of the same applicant - to surround the injection needle with a tamper-evident closure, such as a protective cover. In a

Now use of a syringe must this tamper evident closure and the protective cap must be removed, whereby after use of the injection device, the destruction of the tamper evident at any time recognizable and thus determined whether the injection device has already been used or not. In addition, it is also known to provide in the syringes themselves, for example, between the syringe needles and the syringe barrels through membranes or the like, formed tamper evident, which are pierced only immediately before use of the injection device, so that the drug hermetically sealed to the actual use the syringe barrel is housed. A disadvantage of these injection devices that after spraying the drug from the syringe barrel by actuation of the syringe plunger, another drug can be sucked into the syringe barrel and thus the injection device can be used in an unauthorized manner a second time. This poses a great danger, especially in countries with low hygiene awareness, which often leads to an epidemic spread of most infectious diseases, especially AIDS.

Object of the invention

The aim of the invention is therefore to provide an injection device of the type mentioned, which allows the cost-effective production of the same at the justifiable additional expense and thus but excludes a possible reusability.

Explanation of the essence of the invention

The invention is based on the object, an injection device with a syringe barrel, a piston guided in the syringe barrel and connected thereto in particular via a coupling device piston rod, which preferably has a length which is greater than the length of the syringe barrel and with a on the of The piston rod averted side of the syringe barrel provided coupling arrangement via which a hypodermic needle with the syringe

Cylinder is coupled, to create, which can not be used to fill a new or new drug even after spraying a small amount of a drug.

According to the invention the object is achieved in that the piston and or or the piston rod is associated with a tamper-evident device having connected to the piston and or or the piston rod or disposed therebetween opening member or actuator. The advantage of this tamper-evident device is that due to the movement without any aids, for example memory elements such as prestressed rings or the like., The injection device is made unusable or destroyed, so that reuse is reliably prevented. By the use of an opening member which is connected to the piston or piston

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bar is connected or arranged between them, can be made unusable at any preselectable position between the piston rod and piston regardless of the height of the piston stroke in the syringe barrel, so that a multiple use is not possible if not the entire solution content from the interior of the Syringe cylinder is squeezed out.

According to another embodiment of the invention, it is provided that a drive connection between the piston rod and the piston is released by the cooperating with the piston rod opening member of the tamper-evident device. It is advantageous that an efficient tamper-evident assurance is achieved by the forced actuated release of the piston and piston rod, for example in a renewed return stroke to record a further solution in the interior of the syringe barrel, which also offers a great security against unwanted manipulation.

Furthermore, it is also possible that a closure element between the solution receiving cylinder chamber and an ambient air or a bypass line opened by the movement of the piston rod movement associated opening member of the tamper-evident device, in particular destroyed, thereby only by the procurement of components from the original production, however are not available in spare parts, such injection device could be restored. In addition, it would require complicated assembly aids to allow for destruction or removal of the closure element and its restoration assembly of the injection device.

According to another embodiment, it is provided that between the piston and the piston rod, a coupling device is arranged with a longitudinal play extending in the direction of the piston rod, whereby the opening member of the tamper-evident device is activated in a simple manner by utilizing this longitudinal clearance at different directions of movement of the piston rod relative to the piston ,

But it is also advantageous if the opening member is arranged in the region of the coupling device on the piston rod and or or the piston and this is associated with a weakening area in the closure element, which between the injection needle and the end face facing the piston facing the cylinder chamber in Syringe cylinder and the ambient air is arranged, as by the destruction of the piston in the interior of the injection device no sufficient negative pressure can be built to raise a solution in the interior of the syringe barrel, so that further use of the injection device after squeezing a first solution is reliably prevented ,

Another embodiment describes claim 6, whereby a secure and tight closure of the interior when mounting the first solution to be injected ensured and on the other hand, a simple destruction during the pressing of this first solution can be achieved from the interior.

An embodiment according to claim 7 is also advantageous. By using a further piston, that is to say a so-called double piston arrangement, a small amount of solution can be sucked in after the destruction of the closure element in an advantageous manner with appropriate formation and arrangement of the bypass line with the inner piston guided in the piston. as is necessary, for example, in so-called aspiration. Nevertheless, it is achieved, however, that the drawing of a larger amount of solution in the interior of the syringe barrel is possible only by an operation of the piston receiving the inner piston, which is no longer ready for use with prior destruction of the closure element.

But it is also an embodiment according to claim 8 possible, whereby the possibility is created by a relative displacement of the piston rod relative to the piston to destroy the closure element in a simple manner or to open.

Also advantageous is an embodiment according to claim 9, as can be pierced by the operation of the inner piston for advancing the piston when squeezing the solution from the interior of the injection device with the (jffnungsdorn the closure element, so that a line connection between the piston chamber of the inner piston and the interior of the Syringe cylinder which receives the solution is produced.

Another embodiment describes claim 10, since when using a cooperating with the closure member opening mandrel when retracting the inner piston, for example, for mounting another solution, forcibly a connection of the interior with the ambient air is made, so that no negative pressure for mounting a further solution prepared in the interior can be and therefore the injection device is rendered useless.

Furthermore, an embodiment according to claim 11 is also possible because with destroyed closure element and a position of the inner piston for mounting a further solution no negative pressure in the interior of the injection device can be applied more.

Also advantageous is an embodiment according to claim 12, since the locking member is lifted from the opening mandrel and thus the solution can reliably enter between the closure member and the inner surface of the piston and squeeze out the existing air there by the spreading.

A further embodiment describes claim 13, as a result, regardless of the force when squeezing the solution in any case, the closure element is destroyed before the user can determine the slightly higher resistance during spreading of the closure element by the spreading members so as to prevent the user of such Injection device always applied only so small amounts of solution that the closure element is not destroyed.

Another development is provided according to claim 14, whereby a secure puncture of the closure element is achieved even in the case of industrial production not completely avoidable tolerances and a safe operation of the injection device is ensured.

But it is also an embodiment according to claim 15 possible, whereby a tight seal of the interior is also possible over a long storage time and on the other hand, after the piercing of the closure element with the opening mandrel, a remaining opening is ensured.

Another embodiment describes claim 16, so that it is possible under certain circumstances instead of piercing the closure element, to eject the sealing washer only to avoid further use of the piston.

But it is also a development according to claim 17 possible, whereby the sealing disc is only at a greater force, as it is necessary, for example, to inject a solution into a human or animal body, is ejected.

By a further embodiment according to claim 18, a contraction of the piston and thus a difficult operation of the injection device is prevented.

Advantageous is the development according to claim 19, whereby a perfect function of the opening mandrel is ensured even when applying high compressive forces for piercing the closure element.

In the embodiment according to claim 20, the tilting of the piston and thus destruction of the injection device during initial use is prevented.

In the embodiment according to claim 21, a higher tightness and thus a higher pressure can be built.

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Furthermore, a configuration according to claim 22 is possible, whereby an undesired passage of the same in the direction of the piston rod and thus a loss of solution can be prevented during the extrusion of the solution during initial use.

An advantageous embodiment describes claim 23, since this ensures that when piercing the closure element or its removal this does not enter the interior and thus can prevent the escape of the solution through the injection needle.

According to a development according to claim 24 accidental destruction of the injection device is prevented before first use and certainly in any case a release of the piston rod is achieved by the piston after pressing a certain amount of solution. A further advantage is that in the event of accidental retraction of the piston rod and a concomitant decoupling between this and the piston, as might be the case, for example, in a too far retraction during aspiration, the piston rod reintroduced and at least one compressive force can be applied to squeeze the solution from the injection device. In a renewed attempt to retract the piston with the piston rod, the piston rod disengages automatically from the piston and the injection device is unusable for further use.

Another embodiment describes claim 25, as a safe uncoupling of the locking lugs of the locking arms is ensured even with manufacturing tolerances.

Due to the design according to claim 26, the insertion of the control is favored into the passage opening before the passage of the control strips through the latter and thus a reliable triggering function is achieved.

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A further advantageous embodiment describes claim 27, whereby the piston for pulling the drug and then for squeezing the drug can be moved in the direction of the injection needle, but after squeezing the drug retraction of the piston is prevented to a renewed filling of the injection device.

Furthermore, an embodiment according to claim 28 is advantageous. As a result, activation of the coupling device is made possible due to the relative movement between the piston and the piston rod.

However, it is also an embodiment according to claim 29 possible, whereby a zwangsbetätige decoupling is achieved in a forward movement of the piston rod in the direction of the piston.

Furthermore, an education according to claim 30 is possible. As a result, a very compact shape for the coupling device and a further guide arrangement on the piston can be achieved with very small dimensions of the components and thus of the injection device as a whole.

Similarly, a further development according to claim 31 is possible. The integrated arrangement of the coupling elements on the piston rod additional components can be saved, whereby the assembly cost is reduced and the cost of manufacturing such parts can be saved, while increasing the reliability.

But also advantageous is a development according to claim 32, whereby the coupling elements can automatically move from a use position to a rest position or uncoupling position.

Also advantageous is an embodiment according to claim 33, whereby the coupling elements forcibly persist in a position of use and is ensured without further means that they reach after cancellation of this forced state in a defined rest position.

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Furthermore, an arrangement according to claim 34 is possible, whereby unintentional entanglement of the coupling elements and an undesirable entrainment of the piston after uncoupling of the piston and piston rod can be prevented.

It is also possible, however, a further development according to claim 35. This makes it surprisingly easy to form the drive connection between the piston rod and piston by selectively molding of coupling elements on the piston or on the piston rod.

Also advantageous is a further development according to claim 36, which return to its original position after uncoupling or relaxation of the coupling elements and thereby the coupling elements disengage.

A further embodiment is described in claim 37, whereby a secure decoupling between piston and piston rod will be ensured because the actuator does not jam undesirable and thus may allow in an inadmissible manner further actuation of the injection device.

In the further embodiment described in claim 38 is advantageous that defined contact surfaces are created, which can be precisely produced, whereby an exact triggering of the function of the injection device is made possible.

Furthermore, an embodiment according to claim 39 is possible, whereby a tilting of the actuator and thereby effected ineffective the injection device is reliably prevented.

According to another advantageous embodiment according to claim 40 it is achieved that after the pressing out of the medicament the piston is destroyed by releasing the breakthrough, i. is made unusable and thus a reuse is possible at all.

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In the embodiment according to claim 41 is a flawless function of the injection device gewähr1 ei stet even with production-related tolerances.

The development according to claim 42 prevents after withdrawal of the closure pin, this can be used by a simple forward pushing the piston rod in the direction of the piston back into the opening to optionally make a pressure filling of the injection device via the injection needle.

In the embodiment according to claim 43 can be achieved without tilting the locking pin at the slightest tilt that this deviates laterally and can not be used in the breakthrough.

The embodiment according to claim 44 sufficient strength of the actuator for triggering the drive connection between the piston and piston rod is achieved.

In the embodiment according to claim 45 it is prevented that the coupling device between the piston and piston rod can be accidentally released when mounted and in the position suitable for mounting the drug piston.

Also advantageous is a development according to claim 46, since thereby withdrawal of the piston from the syringe barrel is reliably turned off when the drug is raised.

But it is also an embodiment according to claim 47 possible, with which the force required to move the piston force can be adjusted to prevent by appropriate dimensioning of the thrust resistance pressure filling of the injection device.

Furthermore, a configuration according to claim 48 is possible, whereby the guide surfaces of the piston rod in the syringe cylinder can be used to increase the frictional resistance to an undesired pressure filling of the injection device.

A development according to claim 49 is also advantageous. This provides a functionally reliable solution for a single-use injection device which also permits aspiration with such an injection device. In addition, the available for aspirating stroke of the injection device for the user of the same is visually displayed, so that false triggering possible avoided.

Furthermore, an embodiment according to claim 50 is possible, whereby a safe triggering of the drive connection between the piston and piston rod is achieved after aspiration.

Another development is described in claim 51, whereby a secure triggering of the drive connection between the piston and piston rod is achieved even with production-related tolerances of the items.

Also advantageous is an embodiment according to claim 52, which allows only a relative movement in the direction of actuation of the injection device triggering the tamper-evident device.

Another embodiment variant is described in claim 53, which enables a secure spreading of the support arms when mounting a solution in the interior of the injection device regardless of the springback properties of a plastic part. This can be found with cheaper base materials Auslangen and it is also possible after assembly of the injection device sterilization at high temperatures while maintaining proper function.

In a further development according to claim 54, it is advantageous that only on the central web an additional elastic material with high elastic properties must be applied and thus without additional item Auslangen can be found.

Another development describes claim 55. The arrangement of a hose which can be passed through the central web in the radial direction proves to be very simple, which is easy to assemble and, above all, can be produced very easily from an extruded profile by cutting it to length.

Another advantage is also a further development according to claim 56, as a result, with a smaller wall thickness for the middle web, the Auslangen can be found.

A further embodiment according to claim 57 is also advantageous. As a result, the injection device according to the invention also remains functionally reliable in the case of sterilization with very high temperatures and a high storage life with pretensioned support arms.

Also advantageous is a further embodiment according to claim 58, since with a single part sufficient bias of the support arms in the radial direction can be achieved to the outside.

According to another embodiment according to claim 59, it is achieved that an additional loose insert part is avoided and the corresponding spring force is ensured by a built-in piston rod component.

Another embodiment describes claim 60, which prevents the deflection of the support arms and thus a malfunction of the triggering or tamper-evident device on the action of the biasing force caused by the pressing device.

Finally, a variant according to claim 61 is possible, whereby the adjustment resistance of the support arms and the weight of the piston rod is reduced and a uniform flow of the plastic in the manufacture of the piston rod in the form can be achieved.

Ausführungsbei game

The invention will be explained in more detail below. In the accompanying drawings show:

1 shows an inventively designed injection device in side view, cut and highly simplified schematic representation,

2 shows the injection device according to Fig.l after the solution received in the injection device was partially pressed with another embodiment of an inner piston,

3 shows another embodiment of an injection device according to the invention in side view, cut, according to the lines IH-III in Figure 4,

4: the injection device in front view, cut, according to the lines IV-IV in Figure 3,

5 shows the injection device according to FIG. 3 during the drawing up of a solution into the interior of the injection device in side view, cut away, FIG.

6 shows the piston rod of the injection device according to FIGS. 3 to 5 in an end view, cut, according to the lines VI-VI in FIG.

7 shows the injection device according to FIGS. 3 to 6 in a position when the solution is pressed out of the interior of the injection device and when the opening element has been destroyed,

8 shows another variant of an embodiment of an injection device according to the invention in side view, cut in its position when drawing a solution into the interior,

9 shows the injection device according to Figure 8 in its position during aspiration or squeezing out of the solution from the interior,

10: the injection device according to FIGS. 8 and 9 during the aspirating process during the retraction of the piston rod,

11 shows another embodiment of an injection device according to the invention with a two-part inner piston in its position when drawing the solution into the interior of the injection device in side view, cut,

FIG. 12 shows the injection device according to FIG. 11 in its position when the solution is pressed out of the interior and when another attempt is made to wind up another solution in a side view, cut and in a greatly simplified schematic representation, FIG.

13 shows an injection device designed according to the invention with a tamper-evident device formed by an opening element and a coupling device, partly in section, in side view,

14 shows an injection device according to FIG. 13 with a different position of the piston and the piston rod, FIG.

15 shows another side view of another embodiment of the injection device according to FIGS. 13 and 14 with a tamper-evident tamper-evident device;

16 shows a piston of the injection device according to Fig.15 in section along the lines XVI-XVI in Fig.15,

17 shows a piston of the injection device of Figure 15 in section along the lines XVII-XVII in Figure 15,

18 shows another embodiment of a piston rod of an injection device according to the invention with an aspiration-permitting tamper-evident device in side view,

19 shows the piston rod according to Fig.18 cut in front view according to the lines XIX-XIX in Fig.18.

In Fig.l an injection device 1 is shown, which consists of a syringe barrel 2 and a via a coupling assembly 3 connected thereto injection needle 4. The clutch assembly 3 is disposed on a tubular outlet 5 of the syringe barrel 2. In the interior of the syringe barrel 2, a piston rod 6 is slidably disposed in the longitudinal direction thereof, which is connected by means of a coupling device 7 with a piston 8 for movement. The coupling device 7 is associated with a tamper-evident device 201. The piston 8 may consist of a rubber or plastic part or a corresponding plastic insert, on the circumference of sealing elements, such as O-rings or rubber sleeves or the like., Are arranged. With these rubber sleeves or O-rings of the piston 8 is located on an inner wall 10 of the syringe barrel 2 and subdivided into an associated with the outlet 5 in the cylinder chamber 11 and an opening 12 of the syringe cylinder 2 associated cylinder chamber 13th

For actuating the piston rod 6 and for displacing the same along a longitudinal axis 202 of the syringe barrel 2, it is provided with a handle 203, which, as seen from the illustrated embodiment, at a position in which an end face 204 of the piston 8 at the injection needle 4th facing front wall of the syringe barrel 2, the handle 203 still out of the syringe barrel 2 out-

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protrudes. The illustrated position also corresponds to the packaging state of an injection device 1 designed according to the invention, in which case the injection needle 4 has not yet been pushed onto the outlet 5.

In the piston 8, a bore 205 is arranged, in which an inner piston 206 is slidably mounted in the direction of the longitudinal axis 202. The inner piston 206 is movably connected to the piston rod 6, which has a diameter corresponding to a lifting height or a longitudinal play 207 of the coupling device 7, which diameter corresponds essentially to a diameter of an inlet opening 209. The bore 205 is limited by stops 210. This diameter 208 is smaller than a diameter of the cylinder chamber 13 or a wrapping circle which encloses the piston rod 6 formed of four cheeks oriented at 90 ° to each other.

The bore 205 is closed in its end region opposite the inlet opening 209 by a closure element 211 which has a weakened region 212. The closure element can be formed by the end face 204 of the piston 8 or an area with a smaller wall thickness. On both sides of the weakened region 212, stops 213, which may also be formed by a thickening of the wall thickness in the end face 204 of the piston 8, may be provided. On these stops 213, the inner piston 206, when it is pressed with the piston rod 6 in the direction of the piston 8, support. The inner piston 206 further has an opening mandrel 214, which forms an opening member 215. This opening member is associated with the closure element or its weakening region 212.

Furthermore, a vent opening 216 is arranged in the piston 8, via which an inner space 217 of the bore 205 with an ambient air 218, which is also located in the cylinder chamber 13, is connected.

To guide the piston 8 may further be provided with a guide lug 219, which in itself causes no seal to the inner wall 10 of the syringe barrel 2, on the other hand prevents, however, that during displacement of the piston 8, this can assume an inclined position relative to the longitudinal axis 202.

Furthermore, the syringe barrel 2, as indicated schematically, in the region of its opening 12 provided with protruding into the cylinder chamber 13 knobs or wart-shaped elevations 220, which may be distributed over the circumference of the syringe barrel. These elevations 220 are intended to prevent that when pulling up in the injection needle 4 by strokes symbolically indicated solution 221, for example, a drug or an injection liquid or blood, for example, the piston 8 can be pulled out only after overcoming a resistance from the syringe barrel 2, so a accidental withdrawal of the piston 8 is avoided as possible.

However, the elevations 220 must not be made too high, so that the elasticity of the piston seal or arranged on the piston 8 piston rings sufficient to push the piston 8 from the opening 12 ago in the syringe barrel 2 can.

In the position shown in Fig.l solution is sucked by pulling out the piston rod б in the direction of arrow 222 solution in the cylinder chamber 11, to which the piston 8 is moved in the direction of the opening 12. During this suction of the solution 221, a sufficient negative pressure in the cylinder chamber 11 can be produced, since the end face 204 of the piston 8 seals the syringe cylinder 2 against the opening 12.

Is now a sufficient amount of solution contained in the cylinder chamber 11 and this should be injected, for example, in an animal or human body, the piston rod 6 must be pressed against the handle 203 against an arrow 222 in the direction of the injection needle 4. Due to the resistance that the solution 221 of a movement

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tion of the piston 8 in the direction of the injection needle 4 opposes, therefore, for the time being, the inner piston 206 will move relative to the piston 8 within the bore 205.

2 shows a substantially corresponding to the representation in Fig.I corresponding injection device I, which differs from the embodiment shown in Fig.I only by the formation of the inner piston 223.

In this embodiment, the inner piston 223 relative to the piston 8 is sealed by the fact that instead of circumferential sealing rings in the manner of piston rings or O-rings on the front sides of the inner piston 223 circumferential sealing rings 224 are arranged. Otherwise, the effect and the operation is the same with the injection device shown in Fig.I. From this illustration in Figure 2 it can be seen that during forward pushing of the piston rod 6, the inner piston 206 or 223 is moved so far until it rests against the stops 213 formed, for example, by parts of the piston 8. Before it comes to the abutment of the piston 8 at these stops 213, but the tip of the mandrel 214 already severed the weakening region 212, so that it occupies the position shown in Figure 2 after the forward adjustment and conditioning of the inner piston 223 at the stops 213.

In this position, a correspondingly high force can now be applied via the piston rod 6 to advance the entire piston 8 in the direction of the injection needle or the outlet 5, so that the indicated by small dashes solution 221 can be discharged from the cylinder chamber 11.

If the injection device] is now to be used a second time, contrary to the usual regulations, it is necessary for the time being to retract the inner piston 223 from the position shown in FIG. 2 into the position shown in FIG. 1, so that the installation of the inner piston 206 or 223 at the stops 210, the entire piston 8 can be taken along by a movement in the direction of the arrow 222 at a

reaching negative pressure in the cylinder chamber II, so that a solution 221 can be recorded. However, this is no longer possible with the described injection device I, since even after the retraction of the opening member 215 in the drawn in Fig. 2 in dashed lines position, the closure element, which was pierced in the weakened area by the opening member 215, remains open and thus the ambient air 218, which has been indicated by thin corrugated arrows, enters the cylinder chamber 11 via the cylinder chamber 13 and the vent opening 216, and as a result, sufficient negative pressure can not be generated in it to absorb a solution 221 or a liquid.

Thus, it is reliably prevented that the injection device 1 according to the invention is used several times, as is reliably prevented by the arranged in the piston, formed by the closure member 211 with the weakened region 212 and the opening mandrel 214 tamper-evident device 201.

3 to 7 show a further embodiment of an injection device 1 according to the invention, which is constructed substantially similar to the injection device 1 according to Fig.l, which is why the same reference numerals are used for the same parts, but only in terms of the execution of Tamper-evident device 201 differs from the injection device 1 shown in Fig.l and 2. Also in this embodiment of the injection device 1, an inner piston 223 connected to the piston rod 6 is included in addition to the piston 8. The movement of the inner piston 223 is again limited by stops 210 and 213 in both directions. The interior 217 of the inner piston 223 receiving bore 205 is in turn connected via a vent opening 216 with the separated by the piston 8 of the cylinder chamber 11 cylinder chamber 13 in the syringe barrel 2. In the present case, the tamper-evident device 201 again consists of an opening mandrel 214, which acts as an opening member 215, and a length 225 via an end face 226 of the inner piston 223.

protrudes, as is the case also in Fig.I and 2. In the present case, however, this length 225 is greater, since 226 spreading members 227 are arranged between the opening mandrel 214 and the end face.

The length 225 of the mandrel 214 and the spreader 227 is in any case greater than a distance 228 between the inner piston 223 associated bearing surface 229 of the stop 213 and the closure member 211 for the bore 205 forming sealing foil 230. As shown in the illustration 4 to is seen, the spreading members 227 are formed by four at 90 ° to each other arranged, projecting lobes. Likewise, as can be seen better from FIG. 6, the piston rod 6 has a cross-shaped or plus-shaped cross section. As can be seen from this illustration, a diameter 208 of an enveloping circle enveloping the piston rod 6 is smaller than the diameter of the inlet opening 209, indicated by dashed lines in FIG. 6, in the region of a rear side 231 of the piston 8.

The inlet opening 209 may also be formed conically converging in the direction of the outlet 5, so that the insertion of the inner piston 223 is facilitated.

The function of the injection device according to the invention, which is shown in FIGS. 3 to 7, is as follows.

If the piston is entrained in the position shown in FIG. 3 by movement of the inner piston 223 in the direction of the arrow 222, then a liquid or a solution can be drawn up via the outlet 5. The position between inner piston 223 and piston 8 which is present during the drawing up of the liquid or solution is best seen in FIG. In this case, a sufficient negative pressure in the cylinder chamber 11 can be generated because the bore 205 is closed by the sealing film 230.

Now, if the recorded solution to be squeezed out through the outlet 5, so must the inner piston 223 are brought into the apparent from Fig.7 relative position to the piston 8. However, this displacement of the inner piston 223 causes the opening mandrel 214 pierces the sealing foil 230, which is then torn open by the following expansion elements 227 that a sufficiently direct connection of the cylinder chamber 11 with the located between the sealing film 230 and the end face 226 of the inner piston 223 Airspace is produced.

This prevents in a simple manner that when the liquid is pressed out of the cylinder chamber 11 after the venting of the injection device 1 still air bubbles can be entrained with the liquid or the solution.

As already described with reference to Fig.l and 2, a repeated use of the injection device 1 is made impossible in that upon retraction of the inner piston 223, so that the piston 8 can be moved away from the outlet 5, the inner piston 223 first relative to the piston 8 in the position shown in Figure 5, but generating a negative pressure in the cylinder chamber 11 is no longer possible because of the destroyed sealing foil 230 air can penetrate through the vent opening 216 in the cylinder chamber 11.

Also in this injection device 1, it is also possible, as in the injection devices in Fig.l and 2, by the choice of a longitudinal distance 232 predefine a volume to which the inner piston 223 can be adjusted relative to the piston 8 without ambient air 218 in the Cylinder chamber Π can enter. This longitudinal distance 232 or the stroke of the inner piston 223 can be used for so-called aspiration. This process is necessary to determine whether a vein has been hit during the insertion of the injection device 1 into the animal or human body, so that in solutions or drugs that must be injected directly into the bloodstream, this

can be checked immediately. On the other hand, it is possible for those drugs that are not allowed to be injected into the bloodstream to determine whether or not a vein has actually been hit.

In these described devices, however, it requires a sensitive handling of the injection device I, since otherwise when the vent opening 216 is exceeded by the inner piston 223 again ambient air 218 may enter the cylinder chamber Il. In this case, the injection process must be interrupted again to remove the air from the cylinder chamber 13 again.

FIGS. 8 to 10 show another embodiment of an injection device 1 with different positions of the piston 8 and of the inner piston 223, the same reference numerals being used again for the same parts. In this embodiment, the inner space 217 of the bore 205 in the piston 8 with respect to the cylinder chamber 11 by a sealing washer 233, which forms the closure element 211, sealed. This sealing washer 233 is inserted into a recess 234 and at least slightly pressed. Moreover, it can be provided with holding members 235, which project beyond the stops 213 by a distance 236, which is greater than a depth 237 of the sealing disc 233 receiving recess 234. These holding members 235 can, as will be explained later, prevent even with a release of the sealing disc 233 these fall into the cylinder chamber 11 and optionally block the outlet 5.

As can further be seen from the illustrations in FIGS. 8 to 10, the sealing between the piston 8 or inner piston 223 and between the piston 8 and the syringe cylinder 2 can be effected by piston rings 238 or by O-rings or other sealing elements. The arrangement of the sealing disc 233 is now to be created in the injection device 1 according to the invention a way to enable aspiration so that after the attachment of the injection device 1 or the insertion of the injection needle 4 in the animal or human body with high probability no air more in the cylinder

chamber Π can enter. While now, as already described with reference to the preceding embodiments, by moving back the piston 8 in the direction of arrow 222, a liquid or a solution can be sucked to squeeze this solution 221 from the cylinder chamber Il of the inner piston 223 in Fig. 9 to adjust the position shown. Since a power transmission from the piston rod 6 to the piston 8 can only take place when the inner piston 223 abuts against the stops 213, before a movement of the piston 8 in the direction of the outlet 5, the sealing disc 233 of the opening mandrel 214 as in Fig.9 and IO shown, pierced. Characterized in that the material is designed sufficiently stiff even in a weakening region 212 of the sealing disc 233 and the sealing disc 233 is sufficiently firmly inserted into the recess 234, the opening mandrel 214 penetrates the sealing disc 233 and spits it between the opening mandrel 214 and the spreading members 227. Thus, the sealing disc, as shown in Figure 9, pushed out of the recess 234 and lifted. This state is achieved when venting the syringe, in which a certain amount of solution 221 must be squeezed out of the cylinder chamber 11. At the same time, the venting of the cylinder chamber 11 can take place in this position. This is usually done so that the doctor or nurse administering the injection by tapping the syringe spills the air bubbles into the area of the outlet 5, whereupon so much solution 221 is ejected until the air bubbles have leaked out through the needle.

Now, if the injection device 1 is vented, the injection needle 4 is inserted into the body and then withdrawn so far with the piston rod 6 of the inner piston 223 relative to the piston 8 until the sealing disc 233 occupies the position shown in Fig.10. Now, if the strength of the locking connection between the opening mandrel 214 and the sealing washer 233 is sufficiently large, so that the piston 8 can be retracted over the piston rod 6 a small piece before, for example, the opening mandrel 214 detaches from the sealing disc 233. On the other hand, it is also possible, the distance between the mandrel 214 and this facing end face 226 of the inner piston 223 so

-24- 194

large interpreted that a sufficient amount of liquid can be sucked by the movement of the inner piston 223, so that in the transparent part of the injection device I, namely the syringe barrel 2 can be seen whether a vein has been hit or not. This can be seen by whether or not blood is sucked into the cylinder chamber II when retracting the piston rod 6. Thereupon, by moving the piston rod 6 counter to the arrow 222, in which the inner piston 223 assumes the relative position to the piston shown in FIG. 9, the required quantity of liquid or the solution 221 from the cylinder chamber 11 can be injected into the body. It should also be considered that the vent 216 is to be arranged such that at the held in the sealing disc 233 opening mandrel 214 and inserted into the recess 234 sealing washer 233 of the inner piston 223 is still between the vent 216 and the stops 213, otherwise turn the There would be a risk that air could penetrate into the cylinder chamber 11 through the vent opening 216. Thus, this solution creates a possibility that aspiration is possible in an injection device according to the invention in compliance with all medical regulations and still in the attempt to suck in a further solution after ejection of the solution 221, due to the force required by the inner piston 223 of the Gasket 233 emerges and assumes its position shown in Figure 8. Due to the destroyed sealing disk 233, however, no further vacuum is built up in the cylinder chamber 11 via the vent opening 216 upon further retraction of the piston rod 6, and no solution 221 can be sucked in any longer.

Of course, it is possible to modify the design of the sealing disc 233 or the closure element 211 or the opening mandrel 214 as desired. Thus, inter alia, a plurality of mandrels 214 can be arranged, for example, on the individual wings or spreading elements 227, or slender tips or blade-like organs or the like can likewise be used. It is essential that the severing of the weakened areas 212 can be done without too much effort, so that at that effort that is necessary to a solution 221 from

To squeeze the cylinder chamber 11, the closure element 211 is reliably destroyed and thus a reuse of the injection device 1 is turned off from the outset.

11 and 12, a solution is shown in which on the piston rod 6, locking arms 242 are formed with locking lugs 243, and in which the retraction of the solution 221 against the direction of the arrow 248 is withdrawn, and in which a in Piston arranged inner piston 257 consists of two parts 258 and 259. The part 258 is disc-shaped and is sealingly against the bore 205 in the piston 8. The part 259 consists of a cross-shaped plate having an opening 260 which is penetrated by locking arms 242, which are integrally formed on the piston rod 6 or with this motion. The latching arms 242 have radially outwardly directed locking lugs 243, which engage under the part 259 of the part 258 side facing. Furthermore, the part 258 is provided with control arms 261, which have approximately the length of the bore 205 corresponding length. The bar-shaped arms of the support plate serving as part 259 of the inner piston 257 are each arranged between two such control arms 261. On the latching arms 242, control strips 262 are arranged at a distance which is less than a length of the bore 205. The control strips 262 have an enveloping circle diameter which corresponds approximately to the diameter of the inlet opening 209 to the bore 205.

The part 258 is designed to be sealing in the area of an end face 226 and has on the side facing the part 259 a recess 263 with undercuts 264, which are designed to receive the locking lugs 243 of the latching arms 242. The injection device 1 prepared for use is now supplied in such a way that the part 259 loosely rests on the part 258 of the inner piston 257 and the locking arms engage with their locking lugs 243 only the part 259. If a corresponding amount of solution 221 is to be received with the injection device, then the piston rod 6 is withdrawn against the direction of the arrow 248, whereby the part 259 entrains the piston 8, and accordingly in the cylinder chamber 11 a vacuum is created

which the solution is sucked. If a corresponding amount of solution is contained in the injection device 1, a pressure can be exerted on the piston 8 by pushing the piston rod 6 forward in the direction of the arrow 248 via the part 258, which causes a squeezing out of solutions through the outlet 5. As a result of the pressure exerted, the latching arms 242 enter the recess 263 and their latching lugs 243 snap into the undercut 264. If, for example, the aspiration of the piston rod 6 is then withdrawn again in a direction opposite to the arrow 248, then the part with the control arms 261 likewise moves in the direction of the inlet opening 209. The control arms 261 are compressed in the inlet opening 209. Now running the control bars 262 in a further movement of the piston rod 6 against the arrow 248 on the control arms 261, so the latching arms 242 are pressed radially inward in the direction of the longitudinal axis 202 so that they emerge from the undercuts 264 and the locking tabs 243 a If, in addition, a force directed counter to the direction of the arrow 248 is exerted on the piston rod 6, the piston rod 6 is pulled out loosely without the piston 8 continuing to move , Thus, until the occurrence of a slightly higher resistance, namely, when the control bars 262 accumulate on the control arms 261, a retraction for aspiration done, the necessary for aspirating free space is created by the retraction of the inner piston 257 in the bore 205. But even in the event that the piston rod 6 is already pulled out of the piston 8 by too strong retraction of the piston rod 6 during the Aspiriervorganges, it is possible to make the reinsertion of the piston rod 6 in the piston 8 in the direction of the arrow 248, however a re-engagement is prevented. But even in the event that the piston rod 6 is accidentally inserted so that it re-engages with the parts 258 and 259 in a latching connection, the piston rod 6 with a renewed backward movement against the direction of the arrow 248 by the interaction of the control strips 262 with the control arms 261 reliably decoupled.

Accordingly, also with this embodiment, an injection device is provided, with which aspiration is possible, but a targeted two-time use of the injection device is turned off.

Of course, the parts described in the individual embodiments can also be used occasionally in the other embodiments, and it is also possible to form the piston 8 and the inner piston 206, 223 and 257 in any known from the prior art design. Above all, it should be noted that the individual parts, the inner piston 206, 223 and 257 and piston 8 during the shift require a corresponding actuation force and on the other hand require the adjustment of the latching arms 242 and the tearing of the closure element 211 a little effort, so not by the forces required to actuate the aforementioned elements sufficient to move the piston 8 relative to the syringe barrel 2.

FIGS. 13 and 14 show an injection device 301 that consists of a syringe barrel 302 and an injection needle 304 that is connected to it via a coupling arrangement 303. The clutch assembly 303 is disposed on a tubular outlet 305 of the syringe barrel 302. In the interior of the syringe barrel 302, a piston rod 306 is slidably disposed in the longitudinal direction thereof, which is connected by means of a coupling device 307 with a piston 308 for movement. The coupling device 307 is assigned a triggering device 309. The piston 308 may consist of a rubber or plastic part or a corresponding plastic insert, on whose circumference sealing elements, such as 0-rings or rubber sleeves or the like. Are arranged. With these rubber cuffs or 0-rings, the piston 308 abuts against an inner wall 310 of the syringe barrel 302 and divides this into a cylinder chamber 311 communicating with the outlet 305 and a cylinder chamber 313 associated with an opening 312 of the syringe barrel 302.

" 28- 1У ty ftf

The piston 308 is substantially a tubular member which forms a piston surface 314 at its end facing the outlet 305. At its front end opposite the piston surface 314 is a e.g. circumferential bead-shaped guide extension 315 arranged. In the recess 316 formed by the tubular component, the coupling device 307 of a tamper-evident device 317 is arranged. At the end of the piston rod 306 facing the piston 308, protruding, approximately finger-like coupling elements 319 are arranged in the direction of the piston 308 and approximately parallel to a longitudinal axis of the syringe cylinder 302. At their ends, protrusions 320 formed by a thickening are provided which project in the direction of the piston 308 and cooperate with a further coupling element 321 connected to the piston, namely an annular support surface 322 constricting the recess 316 of the piston 308 stand. The projections 320 of the coupling elements 319 further have contact surfaces 323 extending in the direction of the longitudinal axis 318 and approximately parallel thereto for an approximately cylindrical actuator 324. The coupling elements 319 are mounted with their projections 320 in the recess 316 of the piston 308 longitudinally movable in the direction of the longitudinal axis 318 slidably.

A range of motion in which the piston rod 306 can move relative to the piston 308 is limited by an end wall 325 of the piston 308 in one direction. In the opposite direction, ie to the opening 312 of the syringe barrel 302 through the support surface 322 of the coupling element 321 which cooperates with the projecting in the direction of the piston 308 by the coupling elements 326 protrusions 320 cooperates. Thus, the piston rod 306 can move by a distance 327 from the solid lines in the drawn in dashed lines position.

The common forward movement of the Kupplungslemente 321,326 with the arranged between the abutment surfaces 323 actuator 324 counteracts an actuator 328. This actuator 328 forms the unlocking or triggering device 309 of the tamper-evident

Device 317 and is disposed in the recess 316 and e.g. integrally connected to the piston 308. The actuator 328 is approximately frusto-conical in shape and concentric with the longitudinal axis 318 aligned and extends from the end wall 325 of the piston 308 in the direction of the actuator 324th

By the actuator 324 it is ensured that the coupling elements 319 in a use position in which the projections 320 as coupling element 326, the coupling element formed by the support surface 322 321 of the piston 308 overlap. As a result, when the piston 308 is retracted from the position shown in FIG. 13, the piston 308 is moved along with the piston rod 306 to the position shown in FIG. As a result, in the so-called mounting of the injection device 301, a medicament can be aspirated from a container via the injection needle 304.

If the piston rod 306 is moved in the direction of an arrow 329 after the medicament has been drawn up, this movement is counteracted by the pressure required to squeeze the medicament contained in the cylinder chamber 311 through the injection needle 304. This pressure is higher than the frictional resistance between the piston 308 and the piston rod 306 and the abutment surfaces 323, whereby the piston rod 306 moves forward relative to the piston 308. This results after a short displacement movement that the actuator 324 impinges on the actuator 328 and could not move further in the direction of the injection needle 304 and the end wall 325 of the piston 308, while the coupling elements 319 further forward into the in 13 shown dashed position move until they are supported on the end wall 325 of the piston 308, whereby a correspondingly high pressure force can be exerted, so against the resistance of the fluid or the drug when passing through the injection needle 304 from the cylinder chamber 311 can be forced out. During the forward movement of the coupling elements 319 over the distance 327, which corresponds approximately to a length of the actuating member 328, which this of the end wall 325 in the direction of the piston rod 306th

protrudes, the actuator 324 is moved from the area of the contact surface 323 of the coupling elements 319 in a downstream between the coupling elements of this contact surface 323 free space 330.

The recess 316 of the piston 308 has a length which is equal to or greater than the sum of a length of the contact surface 323 of the coupling elements 319 and the length of the actuator 328 all in the direction of the longitudinal axis 318. In addition, a width or diameter 331 of the actuator 328th smaller than a distance or diameter 332 between the coupling elements 319 located in their rest position. A diameter 333 of the free space 330 is greater than a diameter 334 of the actuator 324.

The tamper-evident device 317 further includes but also an opening member 335, which has a closure element 336, which in a longitudinal axis 318 aligned passage 337 which is inserted through the piston 308 inserted in the longitudinal direction and this against the outflow of the drug or in the Cylinder chamber 311 provided liquid seals. The opening member 335 is preferably integrally formed on the actuator 324. On the side opposite the closure element 336 side of the actuator 324 this is provided with a preferably also integrally connected thereto or integrally formed guide extension 338, which is guided in a longitudinal bore 338 arranged parallel to the longitudinal axis 338 longitudinal guide 339 in the piston rod 306. In the preassembled state of the injection device 301, as shown for example in FIG. 13, the longitudinal guide 339 has a length 341 extending beyond the length of the guide extension 338 or its end face 340, which length is greater than a cover length 342 between the contact surfaces 323 and the facing this surface of the actuator 324th

After pressing a drug, in which, as described above, by means of the actuator 328, the actuator 324 has been pushed back into the free space 330, is now against the indicated by an arrow 329 with a movement of the piston rod 306

Direction the actuator 324 via projections 343 of the coupling elements 319 - as shown in particular in Figure 14 - taken and thus the closure member 336 pulled out of the opening 337, so that the piston 308 is destroyed for the further recording of a drug. A entrainment of the piston 308 with the piston rod 306 is not possible, since by the expression of the actuator 324 a coupling elements 319 comprehensive enveloping circle diameter is smaller than a diameter 344 of the piston in the region of the support surface 322nd order now to prevent that by clever handling with the piston rod, the closure element 336 in turn can be inserted into the opening 337 to optionally refill the cylinder chamber 311 with a liquid or a drug via a pressure filling, the opening member 335 and the closure element 336 at an angle 345 to the longitudinal axis 318 , So be arranged obliquely. If the piston rod 306 with the closure element 336 is then moved again in the direction of the arrow 329, the closure element 336 is deflected laterally, as shown schematically in FIG. 14, which is additionally directed by a corresponding frustoconical or truncated pyramid-shaped design of the actuator 324 End of the actuator 328 can be supported.

In order to prevent a corresponding deformation of the closure element 336 in an attempted reintroduction of the closure element 336 in the opening 337, it is also possible to provide the closure element 336 with a weakening region 346, for example, a circumferential groove with different depths, so that the least resistance in the direction of movement Arrow 329, the closure element 336, as shown in Fig.14, laterally evades. However, the weakened areas can also be dimensioned so that in this case the closure element 336 breaks off at all.

However, this inclination of the closure element 336 or the arrangement of the weakened areas 346 is not mandatory for the present solution and it is also possible, the closure element 336 at all

eccentrically on the actuator 324 to arrange, so that a subsequent re-threading of the closure element 336 is made almost impossible.

Furthermore, the piston rod 306 is provided at its end having an actuating projection 347 with stops 348 which cooperate with Ausfahrsicherungen 349 in the syringe barrel 302.

As a result, it is possible to prevent the tamper-evident device 317 from being accidentally triggered, for example in the position shown in FIG. 1, prior to use of the injection device.

At the same time this Ausfahrsicherung 349 ensures that when mounting the drug with the piston 308, this can not be pulled out of the syringe barrel 302.

The piston 308 is provided in the present embodiment with a circumferential seal 350, for example, an O-ring. However, it can also be used pistons, which are provided with other sealing surfaces.

In order to prevent the interior of the cylinder chamber 311 from being filled by a pressure filling after use of the injection device, the piston 308 is formed in the region of the guide extensions 315, for example with a diameter which is slightly larger than an inner diameter 351 of the syringe cylinder 302. Likewise, the piston rod can be provided, for example, in a part surrounding the free space 330 with braking surfaces 352.

In order to fine tune a suspension force against a pressure filling, it is also possible that guide surfaces 353 of staggered webs of the piston rod 306 are arranged within an enveloping circle, which also has a slightly larger diameter than an inner diameter or a cross section 354 in the area the extension fuses 349.

By sensitive adjustment of the resistance values, a corresponding braking resistor, for example at the level of 3N, can be built up. On the other hand, according to the regulations in force in many countries, forces up to ION are allowed for the collection of medicaments by means of such injection devices 301. As a result, even before the closure element 336 is pulled from the opening 337, a pressure filling of the cylinder chamber 3Π can be reliably prevented.

FIGS. 15 to 17 show an embodiment variant of the injection device 301 which basically corresponds in its construction to that described in FIGS. 13 and 14, for which reason the same reference numerals are used for the same parts.

From this embodiment described above, the present embodiment differs in that an additional triggering device 355 is arranged. This triggering device 355 has support arms 356 connected to the piston rod 306, each of which forms parts of the piston rod 306 separated from a central web 358 by a slot 357.

In this middle web 358 is now again the longitudinal guide 339 and the free space 330 arranged.

On the support arms 356 protrusions 360 are arranged in one of the desired feed size 359 of the piston 308 for aspirating - starting from the maximum filling position of the syringe barrel 302. These projections 360 protrude in the radial direction over a guide surface 353 facing the syringe barrel 302.

If, after filling the cylinder chamber 311, the piston 308 is moved with the piston rod 306 by a smaller amount than the feed size 359 in the direction of the injection needle 304, as shown in dotted lines, then the position of the support arms 356 changes

34 ff

nothing to the piston 308. In this position, therefore, the piston 308 can be withdrawn from the syringe barrel 302 at any time by moving the piston rod 306 back.

If, on the other hand, the piston rod 306 is pushed into the syringe barrel 302 by an amount greater than the feed amount 359, as shown in solid lines, the support arms 356 are deformed in the direction of the longitudinal axis 318 after the protrusions 360 enter the syringe barrel 302. As a result, the support arms 356 no longer rest on an end face 361 of the piston 308 facing the piston rod 306, but enter into a recess 362 within the coupling elements 321. Thus, since the piston 308 is retained against rapid advancement by the medium contained in the cylinder chamber 311, coupling elements 319 are moved relative to the piston 308 in the direction of the piston surface 314 until they are supported with their end faces on the end wall 325 of the piston 308 , whereby a correspondingly high pressure force can be exerted. In this forward sliding of the coupling elements 319 but simultaneously via the actuator 328, the actuator 324, as already described with reference to the Fig.13 and 14, pushed out of the area of the contact surfaces 323, so that the release between piston 308 and piston rod 306 is completed.

All other sequences and functions of the injection device 301 shown then correspond to the Ausführungsvari described in Figs.13 and 14 anten.

Thus, the drive connection between the piston rod 306 and piston 308 is interrupted against the arrow 329. A re-aspiration of a drug via the injection needle 304 and the opening in the cylinder chamber 311 is therefore effectively prevented and this injection device 301 is only suitable for single use. Thereby, the dangers which may arise due to multiple use of an injection device, such as e.g. Infection with infectious diseases,

- ³⁵ - Z 941 tj

Aids, etc., just where cost reasons, such injection device has been used several times, can be effectively prevented.

As can be seen further from FIGS. 16 and 17, the piston rod 306 comprises two support arms 363 which are offset by 180.degree. In the circumferential direction. The coupling elements 319 are circular-segment-shaped and are separated from each other by slots 364. The arrangement of the distributed over the circumference support arms 363 and coupling elements 319, a compulsion of the various items in the syringe barrel 302 is prevented even with careless handling, whereby a speedy and safe operation of the injection device 301 is secured.

In addition, this injection device 301 has only a single additional part, namely the actuator 324, compared with the known injection devices currently in use. Thus, the manufacturing costs are very low, and the mass use of such injection device 301, especially in developing countries, with a high security against multiple use possible.

After the support arms 356 occupy the position shown in Fig.15 in the storage and transport position prior to use, it may in various types of plastics, especially inferior materials such as PVC and the like., Especially due to the sterilization on the individual parts acting high temperatures will happen that the support arms 356 after the emergence of the protrusions 360 from the cylinder chamber 313 and the syringe barrel 302 no longer aufspredern in the position shown in dashed lines position radially outward. In these embodiments, it is advantageous if a pressing device 365 between the central web 358 and the support arms 356 is arranged. These pressing devices 365 exert on the support arms 356 a biasing force 366 indicated by arrows. In the present exemplary embodiment, this pressing device is formed by elastic elements 367 fastened to the middle web 358. These elastic elements preferably consist of elastically deformable tubular

made of silicone or latex, since these materials even after heat treatment in the deformed state, as shown in Fig.15, retained their return assets and thus ensure that the support arms 356 even after prolonged storage in the position shown in Fig.15 a sufficient biasing force 366 can be exerted on the support arms 356. These pieces of tubing are, for example, attached to the central web 358 with an adhesive.

In FIGS. 18 and 19, only the piston rod 306 in its production state is shown by an injection device 301. The middle web 358 and the support arms 356 which are distanced via the slots 357 can clearly be seen. These support arms 356 are provided with reinforcing ribs 368 - better seen in FIG. 19 - and, as shown in FIG. 18, are made such that a radial distance 369 between the support arms 356 is considerably greater than an inner diameter 351 As a result, the highest possible resilience of the support arms 356 after being deformed into the installed position, as shown in FIG. 15, should be achieved in the radial outward direction in accordance with the pretensioning force 366 indicated by the arrows.

In the present embodiment, the pressing device 365 by a central web 358 in the vertical direction passing through elastic member 370, e.g. formed an elastically deformable hose or a full profile. This embodiment has the advantage that a clear centering of the elastic element over a long period is achieved by the guide in the central web 358 of the piston rod 306 and also the attachment is simplified. Moreover, only with a single item for the formation of the pressing device 365 Auslangen be found.

Furthermore, on the central web 358 parallel to the support arms 356 protruding guide elements 371 are arranged, which cause the support arms 356 during the deformation process of the elastic members 370 of the pressing device 365 can not dodge in the circumferential direction of the syringe barrel 302.

On the side facing away from the guide elements 371 side of the piston rod 306, an actuating projection 347 is attached, which should allow easy operation of the injection device 301.

Of course, as an elastic element, a spring clip 372 through the middle web 358 in a recess - as shown in Fig.18 dash-dotted lines - which is supported on abutments 373 on the central web 358. Upon compression of the support arms from the solid lines in the drawn in dashed lines position, a biasing force 366 is constructed by this spring clip 372.

Of course, it is also possible that the spring clip 372 is inserted into the mold before producing the piston rod 306 and molded with the plastic used for the production of the piston rod 306, so that the bracket is embedded as a whole in the plastic part.

Instead of the U-shaped spring clip shown, it is of course also possible to associate each of the two support arms own spring clip, which can then be supported on the respective opposite sides in openings on the central web. In order to prevent falling out of the spring clip during the transport of the injection device, it is possible to support the spring clips in recesses in the reinforcing ribs of the support arms.

For safe operation of the described injection device 301, a height 374 of the projections 360 is dimensioned so that the projections to a deformation of the support arms 356 by a pivot angle 375, the one

Inward adjustment of the support arms 356 causes, which is greater than a cover width 376 between the end faces of the support arms 356 and the facing end face of the piston 308th

Advantageously, in the case of the injection devices 301 according to the invention described above in the various exemplary embodiments, it is possible to produce all the individual parts from plastic. Only with very small injection devices, it will be advisable for better sealing of the piston 308 relative to the syringe barrel 302, in the region of the piston 308 to arrange an O-ring made of rubber or the like. For sealing.

Of course, it is also possible that individual parts, such as the actuator 324 and the piston 308 may be made of a silicone rubber or optionally a stainless steel or the like. Likewise, it is also possible that the syringe barrel 302 can be made of both plastic and glass.

Finally, it should be pointed out that various details of the injection devices described in the preceding embodiments can also be interchanged and the individual embodiments or combinations of individual solution variants of the trigger device 309 or tamper-evident device 317 or the piston 308 or piston rods 306 each independently independent represent solutions according to the invention.

As shown in Fig.15 further shown, the closure member 336 may be provided on its piston 308 associated end with a laterally projecting lip or flag-like extension 377, which after insertion of the closure element 336 in the opening 337 in a subsequent to the breakthrough 337 arranged free space protrudes 378, which has a larger diameter or a larger cross-sectional area than the opening 337th Regardless of a thermal treatment, this extension can therefore retain their position and springs after retraction of the closure element 336, as in Fig.14 in

Dashed lines shown, returned to its original position, so that a re-introduction of the closure member 336 in the opening 337 is reliably prevented in any case.

Claims (61)

claims Injection device comprising a syringe barrel, a piston guided in the syringe barrel and a piston rod connected thereto in particular via a coupling device, which preferably has a length which is greater than the length of the syringe barrel and with a side of the syringe barrel facing away from the piston rod provided coupling arrangement, via which an injection needle with the syringe cylinder can be coupled, characterized in that the piston (308) and or or the piston rod (306) is assigned a tamper-evident device (201,317) which is connected to the piston (308) and or or Having the piston rod (306) connected or arranged therebetween opening member (215) or actuator (324). 2. Injection device according to claim 1, characterized in that a drive connection between the piston rod (6) and piston (8) by means of the piston rod (6) cooperating opening member (215) of the tamper-evident device (201) is forcibly released. 3. Injection device according to claim 1 or 2, characterized in that a closure element (211) between the solution receiving cylinder chamber (11) and an ambient air (218) or a bypass line through the movement with the piston rod (6) opening member (215) the tamper-evident device (201) is opened, in particular destroyed. 4. Injection device according to one of claims I or 2, characterized in that between the piston (8) and the piston rod (6) a coupling device (7) with a in the direction of the piston rod (6) extending longitudinal clearance (207) is arranged. 5. Injection device according to one or more of claims I to 4, characterized in that the opening member (215) in the region of the coupling device (7) on the piston rod (6) and or or the piston (8) is arranged and this a weakening area (212) in the closure element (211) is assigned, which between the injection needle (4) and this facing end face (204) of the piston (8) bounded cylinder chamber (11) in the syringe barrel (2) and the ambient air (218) is arranged. 6. Injection device according to one or more of claims 1 to 5, characterized in that the closure element (211) by a sealing foil (230) or a weakening region (212) in an end face (204) of the piston (8) or in the end face (204) of the piston (8) inserted sealing disc ( 233) is formed. 7. Injection device according to one or more of claims 1 to 6, characterized in that the piston (8) has a parallel to the longitudinal axis of the syringe barrel (2) extending bore (205) in which a with the piston rod (6) motion-connected inner piston is mounted and the bore (205) both in the direction of Piston rod (6) and in the direction of the cylinder chamber (11) by coupling elements of the coupling device (7) forming stops is limited, which protrude into the cross section of the movement path of the inner piston (206,223). 8. Injection device according to one or more of claims 1 to 7, characterized in that the bore (205) on the cylinder chamber (11) facing the end face by the closure element (211) is closed. -44- Ζ34 9. Injection device according to one or more of claims I to 8, characterized in that the opening member (215) by an opening mandrel (214) is formed, via a the closure element (211) facing end face (226) of the inner piston (206,223) protrudes. 10. Injection device according to one or more of claims 1 to 9, characterized in that the bore (205) via a vent opening (216) with the ambient air (218) is connected. 11. Injection device according to one or more of claims 1 to 10, characterized in that at one of the piston rod (6) facing stops (213) adjacent position of the inner piston (206,223), the vent opening (216) between the inner piston (206,223) and the closure element (211) is arranged. 12. Injection device according to one or more of claims 1 to 11, characterized in that the opening mandrel (214) in the radial direction adjacent spreader members (227) are assigned, which also project beyond the end face (226) of the inner piston (206,223). 13. Injection device according to one or more of claims 1 to 12, characterized in that the opening mandrel (214) projects beyond the spreading members (227) in the direction of the closure element (211). 14. Injection device according to one or more of claims 1 to 13, characterized in that a length (225) of the end member (226) projecting opening member (215) is greater than a distance (228) between the end face (226) of the inner piston (206,223) associated AnIageflachen (229) of the attacks ( 213) and the closure element (211), in particular the weakening region (212) parallel to the longitudinal axis (202) of the syringe barrel (2). 15. Injection device according to one or more of claims 1 to 14, characterized in that the closure element (211) is formed by a particular plastic-coated aluminum foil. 16. Injection device according to one or more of claims 1 to 15, characterized in that the closure element (211) by a sealing disc (233) is formed. 17. Injection device according to one or more of claims 1 to 16, characterized in that the sealing disc (233) is inserted into a recess (234) in the end face (204) of the piston (8). 18. Injection device according to one or more of claims 1 to 17, characterized in that the weakening region (212) is arranged centrally, in particular in the region of the longitudinal axis (202) of the syringe barrel (2) in the closure element (211). 19. Injection device according to one or more of claims 1 to 18, characterized in that the opening mandrel (214) concentric to the longitudinal axis (202) of the syringe barrel (2) or the inner piston (206,223) or the piston rod (6) is arranged. 20. Injection device according to one or more of claims 1 to 19, characterized in that on the piston rod (6) facing side of the piston (8) and or or of the inner piston (206,223) a guide lug (219) is provided. 21. Injection device according to one or more of claims 1 to 20, characterized in that the piston (8) is provided with piston rings (238). 22. Injection device according to one or more of claims 1 to 21, characterized in that between the inner piston (206,223) and the bore (205) piston rings (238) are arranged. 23. Injection device according to one or more of claims 1 to 22, characterized in that the closure element (211) holding members (235) which engage behind the closure element (211) closest stops (213), wherein in the recess (234) inserted closure element (211) has a distance (236) between the holding members (235) and the stops (213) is greater than a depth (237) of the recess (234). 24. Injection device according to one or more of claims 1 to 23, characterized in that the inner piston (257) is in two parts and the piston rod (6) comprises latching arms (242) which pass through a support plate of the inner piston (257) and whose locking lugs (243) in the piston part is associated with a recess and in that the latching arms (242) have Steuer1 first project radially outward by a distance that a comprehensive enveloping this circle has approximately a diameter corresponding to a diameter of the through hole of the piston and in that the piston part in the direction of the piston rod (6) extending control arms ( 261) are arranged, which have at least a length which is greater than a distance between the locking lugs (243) and the control strips (262). 25. Injection device according to one or more of claims 1 to 24, characterized in that in the radial direction, a thickness of the control strips (262) is greater than a latching depth of the locking lugs (243). 26. Injection device according to one or more of claims 1 to 25, characterized in that the passage opening widens conically in the direction of the inner piston (257). 27. Injection device one or more of claims 1 to 26, characterized in that the actuator (324) of the tamper-evident device (317) together with the piston (308) and the piston rod (306) movement-connected coupling elements (319,321), the coupling device (307) form and the coupling elements (319.321) are held by the actuator in a use position in engagement. 28. Injection device according to one or more of claims 1 to 27, characterized in that the piston rod (306) relative within a in the direction of the injection needle (304) by an end wall (325) of the piston (308) and in the opposite direction by the piston (308) movement-connected coupling elements (321) limited movement range to the piston (308) is adjustable and that the tamper-evident device (317) has a disconnecting device with an actuating member (328) which projects into the movement region. 29. Injection device according to one or more of claims 1 to 28, characterized in that the actuating member (328) for permanent decoupling of the coupling elements (319.321) forms a stop for the actuator (324). 30. Injection device according to one or more of claims 1 to 29, characterized in that the coupling device (37) and the tamper-evident device (317) in the region, preferably within, an approximately cylindrical recess (316) of the piston (308) are arranged. 31. Injection device according to one or more of claims 1 to 30, characterized in that the coupling device (307) and the tamper-evident device (317) in the region of a front end of the piston rod (306) in the direction of the piston (308) superior, approximately finger-like coupling elements (319) is arranged. 32. Injection device according to one or more of claims I to 31, characterized in that connected to the piston rod (306) and or or the piston (308) coupling elements (319.321) has an end face of the piston rod (306) and or or Projecting piston (308) in the direction of the longitudinal axis (318) and in a plane perpendicular to the longitudinal axis (318) arranged plane are formed elastically deformable. 33. Injection device according to one or more of claims 1 to 8, characterized in that the with the piston (308) and or or the piston rod (306) connected coupling elements (319.321) are formed by annularly arranged, elastically deformable in the radial direction latching fingers. 34. Injection device according to one or more of claims 1 to 9, characterized in that a distance between the coupling elements (319), in particular the latching fingers, in the end portion facing the actuating member (328) is smaller than a distance between the lugs (320) of the coupling elements (319) or a surrounding circular diameter connected to the pistons (308) for movement-connected coupling elements (321). 35. Injection device according to one or more of claims 1 to 10, characterized in that the coupling elements (319, 311) connected to the piston (308) and / or the piston rod (306) are adjusted in the radial direction by the actuator (324), in particular are deformed and extend into the longitudinal axis (318). overlap or intermesh parallel direction. 36. Injection device according to one or more of claims 1 to 11, characterized in that a distance (327) between the lugs (320) or a surrounding HülIkreisdurchmesser located in the use position coupling elements (319) is greater as the opening width between the by the stops or support surfaces (322) of the piston (308) and or or the piston rod (306) formed coupling elements (321). 37. Injection device according to one or more of claims 1 to 12, characterized in that the actuating member (328) of the unlocking device is in movement communication with the piston (308) and / or the piston rod (306) and extends in the direction of the coupling elements (319.321). 38. Injection device according to one or more of claims 1 to 13, characterized in that in the end region of the coupling elements (319) between the mutually facing lugs (320) opposite inner side surfaces a clearance for the actuator (324) is arranged and a distance between the inner side surfaces of the coupling elements (319) is greater than a diameter or a distance between at least two spreading surfaces of the actuator (324) associated with the side surfaces. 39. Injection device according to one or more of claims 1 to 38, characterized in that the actuator has a extending in the direction of the piston rod guide extension, which is slidably supported in a longitudinal guide of the piston rod. 40. Injection device according to one or more of claims 1 to 39, characterized in that the tamper-evident device comprises a closure member connected to the actuator, e.g. a closure pin which extends in the direction of the piston and is sealingly supported at between the coupling surfaces of the latching arms befindlichem actuator in a piston parallel to the longitudinal axis (318) penetrating breakthrough. 41. Injection device according to one or more of claims 1 to 40, characterized in that a length of the longitudinal guide between a piston rod facing the end face of the guide extension and the opposite end of the longitudinal guide is greater than an overlap length between the actuator and the coupling surfaces parallel to the longitudinal axis (318). 42. Injection device according to one or more of claims I to 41, characterized in that a central axis of the closure pin is inclined at an angle to the longitudinal axis (318) of the actuator or the injection device. 43. Injection device according to one or more of claims 1 to 42, characterized in that the closure pin is provided over its length with at least one weakened region, which is preferably different in size over the circumference of the closure pin. 44. Injection device according to one or more of claims 1 to 43, characterized in that the longitudinal guide and / or the guide extension and / or the closure pin has a smaller diameter than a diameter of the actuator. 45. Injection device according to one or more of claims 1 to 44, characterized in that on the piston rod in a length of an interior of the syringe cylinder corresponding distance from an end face of the piston over the guide surfaces of the piston rod projecting stops are provided. 46. Injection device according to one or more of claims 1 to 45, characterized in that an envelope of the guide surfaces of the same size or slightly larger than a minimum cross-section between an educated by a federal government or in the interior of the syringe barrel formed Ausfahrsicherung. 47. Injection device according to one or more of claims 1 to 46, characterized in that the piston rod is provided with a particular circumferential friction surface having an outer diameter which is equal to or slightly larger than an inner diameter of the syringe barrel. 48. Injection device according to one or more of claims 1 to 47, characterized in that the pistons are provided with circumferential guide surfaces which have a diameter or enveloping circle diameter which is equal to or slightly larger than the inner diameter of the syringe barrel. 49. Injection device according to one or more of claims 1 to 48, characterized in that the piston rod (306) is provided with guide surfaces, of which two in the piston end region facing are formed as support arms, and via slots in the radial direction relative to the central web of the piston rod are adjustable. 50. Injection device according to one or more of claims 1 to 49, characterized in that in a feed size corresponding distance from the piston (308) facing the end of the support arms, a projection is arranged and a height of the projection is greater than an overlap width between the end face of the piston (308) and the facing end faces the support arms. 51. Injection device according to one or more of claims 1 to 50, characterized in that a length of a guide surface of the support arms is equal to or greater a length of the lugs (320) on the side facing the actuator (324) plus a possible distance in the direction of the longitudinal axis (318) between the actuator (328) and the actuator (324). 52. Injection device according to one or more of claims 1 to 51, characterized in that a distance between an end face of the actuating member (328) facing the actuator and the end position of the coupling elements (319) closest to the end face of the piston (308) is greater than a length of the projections (320) on which the actuator ( 324) facing side. 53. Injection device according to one or more of claims 1 to 52, characterized in that the support arms is associated with a pressing device with a radially outwardly directed in the direction of the projections biasing force. 54. Injection device according to one or more of claims 1 to 53, characterized in that the pressing device is formed by an inserted in the center web of the piston rod on this projecting in the direction of the support arms elastic element, in particular a hose made of silicone or latex. 55. Injection device according to one or more of claims 1 to 54, characterized in that the hose passes through the center web in the radial direction. 56. Injection device according to one or more of claims 1 to 55, characterized in that a pressing device, in particular an elastically deformable hose is arranged on both sides of the central web. 57. Injection device according to one or more of claims 1 to 56, characterized in that the pressing device is formed by a web between the middle and the support arms arranged spring element, in particular a metal spring clip. 58. Injection device according to one or more of claims I to 57, characterized in that the mutually opposite support arms are connected in movement with a particular U-shaped spring clip. 59. Injection device according to one or more of claims 1 to 58, characterized in that the pressing device is embedded in the piston rod, in particular the support arms, in particular injected. 60. Injection device according to one or more of claims 1 to 59, characterized in that the support arms between arranged in one of the thickness of the support arms corresponding distance from each other arranged on the central web-mounted guide surfaces provided with guide plates is adjustably arranged. 61. Injection device according to one or more of claims 1 to 60, characterized in that the guide plate are provided with openings. For this 7 pages drawings