DE2243320C2 - Arzneimittel auf der Basis von jodhaltigen Verbindungen und entzündungshemmenden Corticosteroiden - Google Patents

Arzneimittel auf der Basis von jodhaltigen Verbindungen und entzündungshemmenden Corticosteroiden

Info

Publication number: DE2243320C2
Authority: DE; Germany
Prior art keywords: iodine; weight; inflammatory; parts; polyvinylpyrrolidone
Prior art date: 1972-05-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

DE2243320A

Other languages

German (de)

English (en)

Other versions

DE2243320A1 (de

Inventor

Alfred Great Neck N.Y. Halpern

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Synergistics Inc

Original Assignee

Synergistics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-05-30

Filing date

1972-09-02

Publication date

1985-03-07

1972-09-02 Application filed by Synergistics Inc filed Critical Synergistics Inc

1973-12-13 Publication of DE2243320A1 publication Critical patent/DE2243320A1/de

1985-03-07 Application granted granted Critical

1985-03-07 Publication of DE2243320C2 publication Critical patent/DE2243320C2/de

Status Expired legal-status Critical Current

Links

229910052740 iodine Inorganic materials 0.000 title claims description 38
239000011630 iodine Substances 0.000 title claims description 38
230000003110 anti-inflammatory effect Effects 0.000 title claims description 29
239000003814 drug Substances 0.000 title claims description 7
239000003246 corticosteroid Substances 0.000 title claims description 5
229960001334 corticosteroids Drugs 0.000 title claims description 5
229940079593 drug Drugs 0.000 title claims description 3
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 title description 25
150000001875 compounds Chemical class 0.000 title description 5
150000003431 steroids Chemical class 0.000 claims description 19
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 10
208000017520 skin disease Diseases 0.000 claims description 9
ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 claims description 7
229960001067 hydrocortisone acetate Drugs 0.000 claims description 7
239000003937 drug carrier Substances 0.000 claims description 6
229960000890 hydrocortisone Drugs 0.000 claims description 5
229960004618 prednisone Drugs 0.000 claims description 4
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 4
230000000699 topical effect Effects 0.000 claims description 4
229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 3
LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 claims description 3
229940057838 polyethylene glycol 4000 Drugs 0.000 claims description 3
229960002800 prednisolone acetate Drugs 0.000 claims description 3
229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 2
239000008367 deionised water Substances 0.000 claims description 2
229910021641 deionized water Inorganic materials 0.000 claims description 2
229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Polymers OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 claims 1
150000002497 iodine compounds Chemical class 0.000 claims 1
238000002360 preparation method Methods 0.000 description 18
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
239000000203 mixture Substances 0.000 description 9
229920001223 polyethylene glycol Polymers 0.000 description 7
239000002260 anti-inflammatory agent Substances 0.000 description 6
230000000694 effects Effects 0.000 description 6
208000015181 infectious disease Diseases 0.000 description 6
239000002202 Polyethylene glycol Substances 0.000 description 5
235000011187 glycerol Nutrition 0.000 description 5
210000002966 serum Anatomy 0.000 description 5
239000000126 substance Substances 0.000 description 5
230000002110 toxicologic effect Effects 0.000 description 5
201000004624 Dermatitis Diseases 0.000 description 4
102000003886 Glycoproteins Human genes 0.000 description 4
108090000288 Glycoproteins Proteins 0.000 description 4
230000002070 germicidal effect Effects 0.000 description 4
208000014674 injury Diseases 0.000 description 4
239000000047 product Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
241001465754 Metazoa Species 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000000969 carrier Substances 0.000 description 3
210000004185 liver Anatomy 0.000 description 3
230000002195 synergetic effect Effects 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
208000027418 Wounds and injury Diseases 0.000 description 2
229940022663 acetate Drugs 0.000 description 2
229960001138 acetylsalicylic acid Drugs 0.000 description 2
230000006378 damage Effects 0.000 description 2
231100000673 dose–response relationship Toxicity 0.000 description 2
239000003862 glucocorticoid Substances 0.000 description 2
230000002458 infectious effect Effects 0.000 description 2
230000002757 inflammatory effect Effects 0.000 description 2
238000000034 method Methods 0.000 description 2
238000010525 oxidative degradation reaction Methods 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
239000000902 placebo Substances 0.000 description 2
229940068196 placebo Drugs 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000007787 solid Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
231100000723 toxicological property Toxicity 0.000 description 2
231100000027 toxicology Toxicity 0.000 description 2
230000008733 trauma Effects 0.000 description 2
CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
SRETXDDCKMOQNE-UHFFFAOYSA-N 2,3-bis(4-methoxyphenyl)-1h-indole Chemical compound C1=CC(OC)=CC=C1C1=C(C=2C=CC(OC)=CC=2)C2=CC=CC=C2N1 SRETXDDCKMOQNE-UHFFFAOYSA-N 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
206010012438 Dermatitis atopic Diseases 0.000 description 1
206010017533 Fungal infection Diseases 0.000 description 1
206010018691 Granuloma Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
208000031888 Mycoses Diseases 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
208000002193 Pain Diseases 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
229920000153 Povidone-iodine Polymers 0.000 description 1
208000003251 Pruritus Diseases 0.000 description 1
206010040047 Sepsis Diseases 0.000 description 1
206010048038 Wound infection Diseases 0.000 description 1
208000038016 acute inflammation Diseases 0.000 description 1
230000006022 acute inflammation Effects 0.000 description 1
230000001195 anabolic effect Effects 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
230000001139 anti-pruritic effect Effects 0.000 description 1
230000003260 anti-sepsis Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
201000008937 atopic dermatitis Diseases 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
230000000721 bacterilogical effect Effects 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
210000002808 connective tissue Anatomy 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
230000000249 desinfective effect Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000033687 granuloma formation Effects 0.000 description 1
238000000227 grinding Methods 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000003999 initiator Substances 0.000 description 1
208000005005 intertrigo Diseases 0.000 description 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
230000007794 irritation Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000003641 microbiacidal effect Effects 0.000 description 1
229940124561 microbicide Drugs 0.000 description 1
239000002855 microbicide agent Substances 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229960002895 phenylbutazone Drugs 0.000 description 1
VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
-1 polyethylene Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
229960001621 povidone-iodine Drugs 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
150000003873 salicylate salts Chemical class 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000013589 supplement Substances 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000759 toxicological effect Toxicity 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DE2243320A 1972-05-30 1972-09-02 Arzneimittel auf der Basis von jodhaltigen Verbindungen und entzündungshemmenden Corticosteroiden Expired DE2243320C2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25750572A	1972-05-30	1972-05-30

Publications (2)

Publication Number	Publication Date
DE2243320A1 DE2243320A1 (de)	1973-12-13
DE2243320C2 true DE2243320C2 (de)	1985-03-07

Family

ID=22976573

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE2243320A Expired DE2243320C2 (de)	1972-05-30	1972-09-02	Arzneimittel auf der Basis von jodhaltigen Verbindungen und entzündungshemmenden Corticosteroiden

Country Status (8)

Country	Link
JP (1)	JPS4926415A (fr)
AU (1)	AU471794B2 (fr)
BE (1)	BE788113A (fr)
CA (1)	CA986412A (fr)
DE (1)	DE2243320C2 (fr)
FR (1)	FR2186252A1 (fr)
NL (1)	NL176228C (fr)
ZA (1)	ZA725898B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3234350A1 (de) *	1982-09-16	1984-03-22	Roland 3400 Göttingen Hemmann	Verfahren zur herstellung eines keimtoetenden und oberflaechenanaesthesierenden heilmittels

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1543907A (en) *	1975-02-19	1979-04-11	Dermal Labor Ltd	Steroid compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT200256B (de) *	1953-12-29	1958-10-25	Gen Aniline & Film Corp	Verfahren zur Herstellung von Heil- und Desinfektionsmitteln, die freie Halogene oder Halogen abspaltende Verbindungen enthalten
CA775085A (en) *	1963-07-18	1968-01-02	E. Underwood Gerald	Anti-inflammatory compositions comprising topical anti-inflammatory glucocorticoids and topical antiviral nucleosides

1972
- 1972-08-28 ZA ZA725898A patent/ZA725898B/xx unknown
- 1972-08-29 BE BE788113A patent/BE788113A/fr not_active IP Right Cessation
- 1972-08-29 CA CA150,483A patent/CA986412A/en not_active Expired
- 1972-08-31 AU AU46157/72A patent/AU471794B2/en not_active Expired
- 1972-09-02 DE DE2243320A patent/DE2243320C2/de not_active Expired
- 1972-10-06 NL NLAANVRAGE7213545,A patent/NL176228C/xx not_active IP Right Cessation
- 1972-11-08 FR FR7239563A patent/FR2186252A1/fr active Granted
- 1972-11-28 JP JP47118607A patent/JPS4926415A/ja active Pending

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3234350A1 (de) *	1982-09-16	1984-03-22	Roland 3400 Göttingen Hemmann	Verfahren zur herstellung eines keimtoetenden und oberflaechenanaesthesierenden heilmittels

Also Published As

Publication number	Publication date
BE788113A (fr)	1972-12-18
FR2186252B1 (fr)	1976-05-21
NL176228C (nl)	1985-03-18
AU471794B2 (en)	1976-05-06
AU4615772A (en)	1974-03-07
NL176228B (nl)	1984-10-16
DE2243320A1 (de)	1973-12-13
JPS4926415A (fr)	1974-03-08
CA986412A (en)	1976-03-30
NL7213545A (fr)	1973-12-04
FR2186252A1 (en)	1974-01-11
ZA725898B (en)	1973-05-30

Legal Events

Date	Code	Title	Description
1979-08-16	OD	Request for examination
1982-01-28	8128	New person/name/address of the agent	Representative=s name: EISENFUEHR, G., DIPL.-ING. SPEISER, D., DIPL.-ING.
1985-03-07	D2	Grant after examination
1985-09-05	8364	No opposition during term of opposition
1988-09-15	8339	Ceased/non-payment of the annual fee

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DE2243320C2 (de)	1985-03-07	Arzneimittel auf der Basis von jodhaltigen Verbindungen und entzündungshemmenden Corticosteroiden
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DE2323744C3 (de)	1978-11-23	4,4'-Bismethylen-(3-methoxy-2-naphthoesäure-triamcinolon-acetonidester) und Verfahren zu dessen Herstellung
CH684520A5 (de)	1994-10-14	Zusammensetzung zur Beschleunigung der Heilung von Wunden.
DE69922471T2 (de)	2005-12-22	Topische Borneol und Wismutgallat enthaltende pharmazeutische Zubereitungen zur Wundheilung
EP1131101B1 (fr)	2004-01-07	Preparation de khelline et son utilisation pour des traitements a action locale
DE60012183T2 (de)	2004-11-18	Verwendung einer makrolid-verbindung zur herstellung eines medikaments zur behandlung von gehirnschäden aufgrund von ischämie oder blutungen
DE102012000416A1 (de)	2013-05-29	Zusammensetzung für die topische Applikation II
WO2004014396A1 (fr)	2004-02-19	Medicament contenant de la fluocinolone et de la dexamethasone et/ou de l'hydrocortisone et de la gentamicine et/ou de la neomycine

DE2243320C2 - Arzneimittel auf der Basis von jodhaltigen Verbindungen und entzündungshemmenden Corticosteroiden - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (1)

Publications (2)

Family

ID=22976573

Family Applications (1)

Country Status (8)

Cited By (1)

Families Citing this family (1)

Family Cites Families (2)

Cited By (1)

Also Published As

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