DE3267355D1 - Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids - Google Patents

Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids

Info

Publication number
DE3267355D1
DE3267355D1 DE8282730023T DE3267355T DE3267355D1 DE 3267355 D1 DE3267355 D1 DE 3267355D1 DE 8282730023 T DE8282730023 T DE 8282730023T DE 3267355 T DE3267355 T DE 3267355T DE 3267355 D1 DE3267355 D1 DE 3267355D1
Authority
DE
Germany
Prior art keywords
delta
homopregnane
pregnane
intermediates
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8282730023T
Other languages
English (en)
Inventor
Klaus Dr Annen
Henry Dr Laurent
Helmut Dr Hofmeister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE8282730023T priority Critical patent/DE3267355D1/de
Application granted granted Critical
Publication of DE3267355D1 publication Critical patent/DE3267355D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE8282730023T 1981-03-09 1982-03-05 Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids Expired DE3267355D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8282730023T DE3267355D1 (en) 1981-03-09 1982-03-05 Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813109459 DE3109459A1 (de) 1981-03-09 1981-03-09 (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden
DE8282730023T DE3267355D1 (en) 1981-03-09 1982-03-05 Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids

Publications (1)

Publication Number Publication Date
DE3267355D1 true DE3267355D1 (en) 1985-12-19

Family

ID=6127032

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19813109459 Withdrawn DE3109459A1 (de) 1981-03-09 1981-03-09 (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden
DE8282730023T Expired DE3267355D1 (en) 1981-03-09 1982-03-05 Process for the preparation of delta 9(11)- and delta 16-21-chloro-20-keto steroids of the pregnane and d-homopregnane series and their use as intermediates for the synthesis of highly effective corticoids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19813109459 Withdrawn DE3109459A1 (de) 1981-03-09 1981-03-09 (delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch)1(pfeil hoch)(pfeil hoch))(pfeil hoch)- und (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)6(pfeil hoch)-21-chlor-20-keto-steroide der pregnan- und d-homo-pregnan-reihe, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte fuer die synthese von hochwirksamen corticoiden

Country Status (4)

Country Link
US (1) US4404141A (de)
EP (1) EP0061416B1 (de)
JP (1) JPS57159799A (de)
DE (2) DE3109459A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123735A1 (de) * 1983-04-29 1984-11-07 Gist-Brocades N.V. Verfahren zur Herstellung von 20-keto-delta-16-Steroiden und in diesem Verfahren erhaltene Zwischenprodukte
FR2677029B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one.
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
HUE027463T2 (en) 2008-05-28 2016-09-28 Reveragen Biopharma Inc Non-hormonal steroid modulators of nf-kb for treatment of disease
WO2010079594A1 (ja) 2009-01-07 2010-07-15 三菱化学株式会社 ステロール側鎖切断酵素蛋白質およびその利用
US9198921B2 (en) 2010-04-05 2015-12-01 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
CN101875681B (zh) * 2010-06-22 2012-08-08 浙江工业大学 一种16α-羟基泼尼松龙的合成方法
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions
CN113493486B (zh) * 2020-04-02 2024-05-24 河南利华制药有限公司 一种哈西奈德及其中间体的制备方法
CN117229344A (zh) * 2022-06-08 2023-12-15 湖南中南制药有限责任公司 一种哈西奈德的制备方法
CN116574149B (zh) * 2023-05-08 2025-08-26 南京安一合医药科技有限公司 一种哈西奈德中间体的制备方法
CN118420696A (zh) * 2024-04-25 2024-08-02 湖南玉新药业有限公司 一种哈西奈德中间体异构体杂质的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2000229C3 (de) * 1970-01-03 1973-09-20 Syntex Corp., Panama Verfahren zur Herstellung von 9alpha, 1 lbeta Dichlorsteroiden
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
US3892857A (en) * 1972-11-24 1975-07-01 Squibb & Sons Inc Steroid formulation
US4021459A (en) * 1975-08-14 1977-05-03 Schering Corporation Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy 20-keto-pregnenes
US4277409A (en) * 1977-03-18 1981-07-07 Roussel Uclaf Preparation of 9α-fluoro-16α-methyl-21-acetoxy-Δ1,4 -pregnadiene-11β-ol-3,20-dione
US4113722A (en) * 1977-11-11 1978-09-12 E. R. Squibb & Sons, Inc. Steroidal[16α,17-b]benzodioxins
US4116978A (en) * 1977-07-20 1978-09-26 E. R. Squibb & Sons, Inc. D-homo oxasteroids
US4265815A (en) * 1980-03-31 1981-05-05 E. R. Squibb & Sons, Inc. 17-(Substituted thio)androst-4-ene[16,17,-b]-[1,4]benzodioxin-3-ones

Also Published As

Publication number Publication date
JPS57159799A (en) 1982-10-01
EP0061416B1 (de) 1985-11-13
US4404141A (en) 1983-09-13
DE3109459A1 (de) 1982-09-23
EP0061416A1 (de) 1982-09-29
JPH033680B2 (de) 1991-01-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8339 Ceased/non-payment of the annual fee