DE3684366D1 - Verfahren zur enzymatischen herstellung von l-alpha-aminosaeuren aus alpha-ketosaeuren. - Google Patents
Verfahren zur enzymatischen herstellung von l-alpha-aminosaeuren aus alpha-ketosaeuren.Info
- Publication number
- DE3684366D1 DE3684366D1 DE8686401267T DE3684366T DE3684366D1 DE 3684366 D1 DE3684366 D1 DE 3684366D1 DE 8686401267 T DE8686401267 T DE 8686401267T DE 3684366 T DE3684366 T DE 3684366T DE 3684366 D1 DE3684366 D1 DE 3684366D1
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- acids
- amino acids
- enzymatic production
- keto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000007649 L alpha amino acids Chemical class 0.000 title 1
- 150000004716 alpha keto acids Chemical class 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 241000194107 Bacillus megaterium Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 abstract 1
- -1 ammonium ions Chemical class 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 229950006238 nadide Drugs 0.000 abstract 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8509121A FR2583432B1 (fr) | 1985-06-13 | 1985-06-13 | Procede de production enzymatique de l-a-aminoacides a partir d'a-cetoacides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3684366D1 true DE3684366D1 (de) | 1992-04-23 |
Family
ID=9320292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686401267T Expired - Lifetime DE3684366D1 (de) | 1985-06-13 | 1986-06-11 | Verfahren zur enzymatischen herstellung von l-alpha-aminosaeuren aus alpha-ketosaeuren. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0206904B1 (de) |
| JP (1) | JPS62289A (de) |
| AT (1) | ATE73851T1 (de) |
| DE (1) | DE3684366D1 (de) |
| FR (1) | FR2583432B1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4970157A (en) * | 1986-08-12 | 1990-11-13 | Sagami Chemical Research Center | Isolated phenylalanine dehydrogenase gene and process for production of phenylalanine dehydrogenase |
| FR2628751B1 (fr) * | 1988-03-15 | 1990-09-14 | Inst Francais Du Petrole | Procede de production continue de l-(alpha)-amino acides a partir d'(alpha)-cetoacides a l'aide de cellules de bacillus |
| CA2008702A1 (en) * | 1989-02-27 | 1990-08-27 | Ronald L. Hanson | Process for transformation of hydroxyketo acids to hydroxyamino acids |
| CA2153561A1 (en) * | 1994-07-11 | 1996-01-12 | Ryoichi Katsumata | Process for producing an optically active .gamma.-hydroxy-l-glutamic acid |
| JP4590981B2 (ja) * | 2003-08-26 | 2010-12-01 | 三菱化学株式会社 | 光学活性環状アミノ酸の製造方法 |
| DE102004014280A1 (de) * | 2004-03-22 | 2005-10-27 | Degussa Ag | Verfahren zur Herstellung von optisch aktiven Aminosäuren mittels eines Ganzzellkatalysators |
| TWI640541B (zh) | 2011-12-28 | 2018-11-11 | 中外製藥股份有限公司 | Peptide compound having an annular portion and pharmaceutical composition thereof |
| US10815489B2 (en) | 2015-03-13 | 2020-10-27 | Chugai Seiyaku Kabushiki Kaisha | Modified aminoacyl-tRNA synthetase and use thereof |
| US12391971B2 (en) | 2017-01-31 | 2025-08-19 | Chugai Seiyaku Kabushiki Kaisha | Method for synthesizing peptides in cell-free translation system |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| CN111479819B (zh) | 2017-12-15 | 2024-06-14 | 中外制药株式会社 | 制备肽的方法和处理碱的方法 |
| EP3878836B1 (de) | 2018-11-07 | 2025-07-23 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur herstellung von o-substituierten serinderivaten |
| WO2020111238A1 (ja) | 2018-11-30 | 2020-06-04 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
| CN113692401A (zh) | 2019-03-15 | 2021-11-23 | 中外制药株式会社 | 芳香族氨基酸衍生物的制备方法 |
| JP6880352B1 (ja) | 2019-11-07 | 2021-06-02 | 中外製薬株式会社 | Kras阻害作用を有する環状ペプチド化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3036958A (en) * | 1959-03-17 | 1962-05-29 | Ajinomoto Kk | Process for producing l-tryptophan from 3-indolepyruvic acid |
| FR2217296A1 (en) * | 1972-10-10 | 1974-09-06 | Inst Francais Du Petrole | Organic cpds. prepn. by co-enzymatic reduction - with continuous regeneration of the oxidised coenzyme with a reducing agent |
| DE2930070A1 (de) * | 1979-07-25 | 1981-02-19 | Biotechnolog Forschung Gmbh | Verfahren zur kontinuierlichen enzymatischen umwandlung von wasserloeslichen alpha -ketocarbonsaeuren in die entsprechenden aminosaeuren |
| FR2526442B1 (fr) * | 1982-05-06 | 1985-09-27 | Inst Francais Du Petrole | Production de glucose deshydrogenase et utilisation de l'enzyme obtenu dans la synthese enzymatique de la l-carnitine |
| US4600692A (en) * | 1983-02-10 | 1986-07-15 | Purification Engineering, Inc. | Immobilized cells for preparing phenylalanine |
| DE3423936A1 (de) * | 1984-06-29 | 1986-01-02 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von l-phenylalanin |
| US4849345A (en) * | 1985-04-17 | 1989-07-18 | Sagami Chemical Research Center | L-phenylalanine dehydrogenase and use thereof |
-
1985
- 1985-06-13 FR FR8509121A patent/FR2583432B1/fr not_active Expired
-
1986
- 1986-06-11 DE DE8686401267T patent/DE3684366D1/de not_active Expired - Lifetime
- 1986-06-11 AT AT86401267T patent/ATE73851T1/de not_active IP Right Cessation
- 1986-06-11 EP EP86401267A patent/EP0206904B1/de not_active Expired - Lifetime
- 1986-06-13 JP JP61139107A patent/JPS62289A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0206904B1 (de) | 1992-03-18 |
| JPS62289A (ja) | 1987-01-06 |
| ATE73851T1 (de) | 1992-04-15 |
| FR2583432B1 (fr) | 1988-11-04 |
| FR2583432A1 (fr) | 1986-12-19 |
| EP0206904A2 (de) | 1986-12-30 |
| EP0206904A3 (en) | 1989-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |