DE3781420T2 - Hybrides plasminogenaktivatoraehnliches polypeptid. - Google Patents

Hybrides plasminogenaktivatoraehnliches polypeptid.

Info

Publication number
DE3781420T2
DE3781420T2 DE8787101209T DE3781420T DE3781420T2 DE 3781420 T2 DE3781420 T2 DE 3781420T2 DE 8787101209 T DE8787101209 T DE 8787101209T DE 3781420 T DE3781420 T DE 3781420T DE 3781420 T2 DE3781420 T2 DE 3781420T2
Authority
DE
Germany
Prior art keywords
polypeptide
amino acid
plasminogen activator
terminal
plasmid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787101209T
Other languages
German (de)
English (en)
Other versions
DE3781420D1 (de
Inventor
Naganori Numao
Michito Tagawa
Masakatsu Wada
Masayuki Yamada
Midori Yokoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Central Glass Co Ltd
Hodogaya Chemical Co Ltd
Nippon Soda Co Ltd
Nissan Chemical Corp
Sagami Chemical Research Institute
Tosoh Corp
Original Assignee
Central Glass Co Ltd
Hodogaya Chemical Co Ltd
Nippon Soda Co Ltd
Nissan Chemical Corp
Sagami Chemical Research Institute
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Central Glass Co Ltd, Hodogaya Chemical Co Ltd, Nippon Soda Co Ltd, Nissan Chemical Corp, Sagami Chemical Research Institute, Tosoh Corp filed Critical Central Glass Co Ltd
Application granted granted Critical
Publication of DE3781420D1 publication Critical patent/DE3781420D1/de
Publication of DE3781420T2 publication Critical patent/DE3781420T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8787101209T 1986-01-31 1987-01-29 Hybrides plasminogenaktivatoraehnliches polypeptid. Expired - Lifetime DE3781420T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1773486 1986-01-31

Publications (2)

Publication Number Publication Date
DE3781420D1 DE3781420D1 (de) 1992-10-08
DE3781420T2 true DE3781420T2 (de) 1993-02-25

Family

ID=11951975

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787101209T Expired - Lifetime DE3781420T2 (de) 1986-01-31 1987-01-29 Hybrides plasminogenaktivatoraehnliches polypeptid.

Country Status (7)

Country Link
EP (1) EP0231883B1 (es)
JP (1) JP2589687B2 (es)
DE (1) DE3781420T2 (es)
DK (1) DK175604B1 (es)
ES (1) ES2043610T3 (es)
SU (1) SU1732814A3 (es)
WO (1) WO1987004720A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916071A (en) * 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
ZA879286B (en) * 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
NL8700013A (nl) * 1987-01-06 1988-08-01 Leuven Res & Dev Vzw Hybride plasminogeenactivatoren met verbeterde trombolytische eigenschappen en geneesmiddelen die deze plasminogeenactivatoren bevatten.
NL8701021A (nl) * 1987-04-29 1988-11-16 Stichting Centraal Lab Humane t-pa(u-pa) substitutie-mutant eiwitten, daarvoor coderend recombinant dna, getransfecteerde gastheercellen, bereiding van de mutant eiwitten, en farmaceutische preparaten.
JP2561122B2 (ja) * 1988-04-13 1996-12-04 寳酒造株式会社 機能性ポリペプチド
JPH07143877A (ja) * 1993-10-01 1995-06-06 Sumitomo Pharmaceut Co Ltd 新規なｔ−ＰＡ類似体
CA3178856A1 (en) * 2020-03-31 2021-10-07 National Cancer Center Fusion protein suitable for dissolving fibrin clot, and pharmaceutical composition containing said fusion protein
EP4506458A1 (en) * 2022-04-08 2025-02-12 RIN Institute Inc. Antibody binding to fibrin, fibrinolytic protein containing antibody, and pharmaceutical formulation containing protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79202B (es) * 1982-05-05 1984-10-22 Genentech Inc
GB8314362D0 (en) * 1983-05-24 1983-06-29 Celltech Ltd Polypeptide and protein products
JPS60136520A (ja) * 1983-12-23 1985-07-20 Otsuka Pharmaceut Co Ltd フイブリン吸着性ウロキナ−ゼ複合体
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
DK50987D0 (da) 1987-01-30
JP2589687B2 (ja) 1997-03-12
DK50987A (da) 1987-08-01
WO1987004720A1 (en) 1987-08-13
DK175604B1 (da) 2004-12-20
JPS62272975A (ja) 1987-11-27
EP0231883A1 (en) 1987-08-12
ES2043610T3 (es) 1994-01-01
SU1732814A3 (ru) 1992-05-07
EP0231883B1 (en) 1992-09-02
DE3781420D1 (de) 1992-10-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition