DE60226334T2 - Neue antiphlogistische androstan derivate - 17-carboxy-lactone substituiert mit einer aryl-carboxylic estergruppe in der 17.alpha.-stelle - Google Patents

Neue antiphlogistische androstan derivate - 17-carboxy-lactone substituiert mit einer aryl-carboxylic estergruppe in der 17.alpha.-stelle Download PDF

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Publication number: DE60226334T2
Authority: DE; Germany
Prior art keywords: compound; formula; oxo; methyl; hydroxy
Prior art date: 2001-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60226334T

Other languages

German (de)

English (en)

Other versions

DE60226334D1 (de

Inventor

Keith Stevenage BIGGADIKE

Paul Stevenage JONES

Jeremy John Stevenage PAYNE

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-20

Filing date

2002-10-17

Publication date

2009-06-04

2002-10-17 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2008-06-12 Application granted granted Critical

2008-06-12 Publication of DE60226334D1 publication Critical patent/DE60226334D1/de

2009-06-04 Publication of DE60226334T2 publication Critical patent/DE60226334T2/de

2022-10-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000002260 anti-inflammatory agent Substances 0.000 title description 3
QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical class C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 title 1
229940092458 androstan derivative Drugs 0.000 title 1
230000001741 anti-phlogistic effect Effects 0.000 title 1
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239000012453 solvate Substances 0.000 claims abstract description 35
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229910052739 hydrogen Inorganic materials 0.000 claims abstract description 27
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 16
229910052717 sulfur Inorganic materials 0.000 claims abstract description 15
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 12
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238000004519 manufacturing process Methods 0.000 claims abstract description 8
229910052736 halogen Inorganic materials 0.000 claims abstract description 6
150000002367 halogens Chemical class 0.000 claims abstract description 6
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims abstract description 3
238000000034 method Methods 0.000 claims description 67
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IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

DE60226334T 2001-10-20 2002-10-17 Neue antiphlogistische androstan derivate - 17-carboxy-lactone substituiert mit einer aryl-carboxylic estergruppe in der 17.alpha.-stelle Expired - Lifetime DE60226334T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0125259		2001-10-20
GBGB0125259.2A GB0125259D0 (en)	2001-10-20	2001-10-20	Novel compounds
PCT/EP2002/011634 WO2003035668A2 (en)	2001-10-20	2002-10-17	Novel anti-inflammatory androstane derivatives -17-carboxy-lactone substituted steroids with an aryl-carboxylic ester in position 17.alpha

Publications (2)

Publication Number	Publication Date
DE60226334D1 DE60226334D1 (de)	2008-06-12
DE60226334T2 true DE60226334T2 (de)	2009-06-04

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Application Number	Title	Priority Date	Filing Date
DE60226334T Expired - Lifetime DE60226334T2 (de)	2001-10-20	2002-10-17	Neue antiphlogistische androstan derivate - 17-carboxy-lactone substituiert mit einer aryl-carboxylic estergruppe in der 17.alpha.-stelle

Country Status (9)

Country	Link
US (1)	US7405206B2 (2)
EP (1)	EP1444248B1 (2)
JP (1)	JP4495456B2 (2)
AT (1)	ATE393771T1 (2)
AU (1)	AU2002350561A1 (2)
DE (1)	DE60226334T2 (2)
ES (1)	ES2304457T3 (2)
GB (1)	GB0125259D0 (2)
WO (1)	WO2003035668A2 (2)

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JP6130391B2 (ja)	2011-11-23	2017-05-17	インテリカイン，エルエルシー	Ｍｔｏｒ阻害剤を使用する強化された治療レジメン
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2001
- 2001-10-20 GB GBGB0125259.2A patent/GB0125259D0/en not_active Ceased
2002
- 2002-10-17 EP EP02785235A patent/EP1444248B1/en not_active Expired - Lifetime
- 2002-10-17 US US10/492,813 patent/US7405206B2/en not_active Expired - Lifetime
- 2002-10-17 ES ES02785235T patent/ES2304457T3/es not_active Expired - Lifetime
- 2002-10-17 AU AU2002350561A patent/AU2002350561A1/en not_active Abandoned
- 2002-10-17 AT AT02785235T patent/ATE393771T1/de not_active IP Right Cessation
- 2002-10-17 DE DE60226334T patent/DE60226334T2/de not_active Expired - Lifetime
- 2002-10-17 JP JP2003538181A patent/JP4495456B2/ja not_active Expired - Lifetime
- 2002-10-17 WO PCT/EP2002/011634 patent/WO2003035668A2/en not_active Ceased

Also Published As

Publication number	Publication date
JP2005509642A (ja)	2005-04-14
US7405206B2 (en)	2008-07-29
WO2003035668A2 (en)	2003-05-01
JP4495456B2 (ja)	2010-07-07
GB0125259D0 (en)	2001-12-12
AU2002350561A1 (en)	2003-05-06
DE60226334D1 (de)	2008-06-12
WO2003035668A3 (en)	2003-07-31
ATE393771T1 (de)	2008-05-15
EP1444248A2 (en)	2004-08-11
US20050054622A1 (en)	2005-03-10
EP1444248B1 (en)	2008-04-30
ES2304457T3 (es)	2008-10-16

Legal Events

Date	Code	Title	Description
2009-05-20	8364	No opposition during term of opposition

Publication	Publication Date	Title
DE60226334T2 (de)	2009-06-04	Neue antiphlogistische androstan derivate - 17-carboxy-lactone substituiert mit einer aryl-carboxylic estergruppe in der 17.alpha.-stelle
DE60131750T2 (de)	2008-11-06	6.alpha.,9.alpha.-difluoro-17.alpha.-(2-furanylcarboxyl)oxy-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4-diene-17-carbothioic acid s-fluoromethyl ester als entzündungshemmendes arzneimittel
EP1395604B1 (en)	2008-06-25	Novel anti inflammatory 17.alpha.-heterocyclic-esters of 17.beta.-carbothioate androstane derivatives
KR100831534B1 (ko)	2008-05-22	17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체
US6537983B1 (en)	2003-03-25	Anti-inflammatory androstane derivatives
DE69822164T2 (de)	2005-04-14	Verfahren zur identifizierung von verbindungen mit verminderter systemischer aktivität
WO2003064445A1 (en)	2003-08-07	17-alpha-heterocyclic esters of androstane derivatives having anti-inflammatory activity
AU2001276497A1 (en)	2002-05-16	17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
DE60311831T2 (de)	2007-11-22	Entzündungshemmende bzw. antiallergische androstankomplexe
EP1218401B1 (de)	2004-06-16	4-benzylaminochinoline konjugate mit gallensaeure und ihre heteroanalogen, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und deren anwendung
DE69609201T2 (de)	2001-03-01	21-[2-oxo-tetrahydrofuran]-thio pregnan derivative, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon
DE69609870T2 (de)	2001-01-25	17beta-(2-oxo-tetrahydrofuran-4-yl)-thio-androstane derivate (17beta-(gamma-buttersäure-lacton)-thio derivate) zur behandlung von entzündungen, pharmazeutische präparate davon und ein verfahren zu ihrer herstellung
ZA200308192B (en)	2005-01-21	Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha.