DE69006555T2 - Reinigungs- und Trennverfahren für eine Carbonsäure. - Google Patents
Reinigungs- und Trennverfahren für eine Carbonsäure.Info
- Publication number
- DE69006555T2 DE69006555T2 DE69006555T DE69006555T DE69006555T2 DE 69006555 T2 DE69006555 T2 DE 69006555T2 DE 69006555 T DE69006555 T DE 69006555T DE 69006555 T DE69006555 T DE 69006555T DE 69006555 T2 DE69006555 T2 DE 69006555T2
- Authority
- DE
- Germany
- Prior art keywords
- succinic acid
- solution
- acid
- succinate
- crystallization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title abstract description 12
- 238000000926 separation method Methods 0.000 title description 2
- 238000004140 cleaning Methods 0.000 title 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 92
- 239000001384 succinic acid Substances 0.000 claims abstract description 39
- 238000000909 electrodialysis Methods 0.000 claims abstract description 31
- 238000000855 fermentation Methods 0.000 claims abstract description 20
- 230000004151 fermentation Effects 0.000 claims abstract description 17
- 229940074404 sodium succinate Drugs 0.000 claims abstract description 14
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims abstract description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 69
- 238000002425 crystallisation Methods 0.000 claims description 30
- 230000008025 crystallization Effects 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 29
- 239000013078 crystal Substances 0.000 claims description 15
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 9
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 7
- 238000000746 purification Methods 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- 244000005700 microbiome Species 0.000 claims description 2
- 239000000243 solution Substances 0.000 abstract description 35
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract description 17
- 239000001632 sodium acetate Substances 0.000 abstract description 17
- 235000017281 sodium acetate Nutrition 0.000 abstract description 17
- 150000003839 salts Chemical class 0.000 abstract description 15
- 238000004519 manufacturing process Methods 0.000 abstract description 10
- 239000012266 salt solution Substances 0.000 abstract description 3
- 239000012528 membrane Substances 0.000 description 38
- 235000011044 succinic acid Nutrition 0.000 description 33
- 235000011054 acetic acid Nutrition 0.000 description 21
- 239000002253 acid Substances 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 235000010633 broth Nutrition 0.000 description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 150000001450 anions Chemical class 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 150000001768 cations Chemical class 0.000 description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 150000003890 succinate salts Chemical class 0.000 description 4
- 150000001735 carboxylic acids Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 description 2
- 241000722954 Anaerobiospirillum succiniciproducens Species 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 150000001734 carboxylic acid salts Chemical class 0.000 description 2
- 239000002178 crystalline material Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- 229920000557 Nafion® Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 150000001243 acetic acids Chemical class 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 238000005341 cation exchange Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003444 succinic acids Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (7)
1. Verfahren zur Herstellung und Reinigung von
Bernsteinsäure, dadurch gekennzeichnet, daß
(a) ein ein Succinat erzeugender Mikroorganismus
anaerobisch auf einem Kohlehydrat-Substrat
gezüchtet wird, um eine Fermentierungsbrühe zu
erzeugen, die Acetat und Succinat enthält,
(b) die Fermentierungsbrühe einer wasserspaltenden
Elektrodialyse unterworfen wird, um das Acetat
in Essigsäure umzuwandeln und eine übersättigte
Bernsteinsäurelösung zu erzeugen und daß
(c) die Bernsteinsäure aus der übersättigten
Bernsteinsäurelösung, die auch Essigsäure
enthält, auskristallisiert wird.
2. Verfahren nach Anspruch 1, dadurch gekennzeichnet,
daß die Brühe, aus der die Bernsteinsäure
auskristallisiert worden ist, konzentriert und wieder
in die erste Stufe (a) eingeführt wird.
3. Verfahren nach den Ansprüchen 1 und 2, dadurch
gekennzeichnet, daß das Auskristallisieren der
Bernsteinsäure in der Weise erfolgt, daß die
übersättigte Lösung mit Bernsteinsäurekristallen
geimpft wird.
4. Verfahren nach einem der vorhergehenden Ansprüche,
dadurch gekennzeichnet, daß das Succinat
Natriumsuccinat ist.
5. Verfahren nach einem der vorhergehenden Ansprüche,
dadurch gekennzeichnet, daß die Fermentierungsbrühe,
die das Succinat und das Acetat enthält, bevor sie der
wasserspaltenden Elektrodialyse unterworfen wird, durch
eine übliche Elektrodialyse konzentriert wird.
6. Verfahren nach Anspruch 5, dadurch gekennzeichnet,
daß die Fermentierungsbrühe so konzentriert wird, daß
sie etwa 10 bis 25 Gew.-% Natriumsuccinat enthält.
7. Verfahren zum Auskristallisieren von Bernsteinsäure
aus einer übersättigten Lösung von Bernsteinsäure,
dadurch gekennzeichnet, daß die Kristallisation in
Anwesenheit einer wirksamen Menge von Essigsäure
durchgeführt wird, um das Auskristallisieren der
Bernsteinsäure zu steigern.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/385,638 US5034105A (en) | 1989-07-27 | 1989-07-27 | Carboxylic acid purification and crystallization process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69006555D1 DE69006555D1 (de) | 1994-03-24 |
| DE69006555T2 true DE69006555T2 (de) | 1994-08-25 |
Family
ID=23522255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69006555T Expired - Fee Related DE69006555T2 (de) | 1989-07-27 | 1990-07-25 | Reinigungs- und Trennverfahren für eine Carbonsäure. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5034105A (de) |
| EP (1) | EP0410728B1 (de) |
| JP (1) | JP2944157B2 (de) |
| AT (1) | ATE101388T1 (de) |
| AU (1) | AU5989390A (de) |
| DE (1) | DE69006555T2 (de) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011160760A1 (de) | 2010-06-25 | 2011-12-29 | Uhde Gmbh | Verfahren zur abtrennung, gewinnung und reinigung von dicarbonsäuren |
| DE102011120632A1 (de) | 2011-12-09 | 2013-06-13 | Thyssenkrupp Uhde Gmbh | Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen |
| WO2014095080A2 (en) | 2012-12-21 | 2014-06-26 | Thyssenkrupp Industrial Solutions Ag | Process for the purification of carboxylic acids |
| DE102013000027A1 (de) | 2013-01-03 | 2014-07-03 | Thyssenkrupp Industrial Solutions Ag | Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen |
| WO2014108163A2 (de) | 2013-01-11 | 2014-07-17 | Thyssenkrupp Uhde Gmbh | Verfahren zur herstellung von dicarbonsäuren |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5198086A (en) * | 1990-12-21 | 1993-03-30 | Allied-Signal | Electrodialysis of salts of weak acids and/or weak bases |
| US5780704A (en) * | 1992-06-04 | 1998-07-14 | Mitsui Chemicals, Inc. | Process for treating plastic product |
| US6140428A (en) * | 1992-06-17 | 2000-10-31 | Basf Aktiengesellschaft | Simultaneous production of dicarboxylic acids and diamines by splitting polyamides into their monomeric constituents |
| US5296639A (en) * | 1992-12-18 | 1994-03-22 | E. I. Du Pont De Nemours And Company | Adipic acid purification |
| CA2126365C (en) * | 1993-07-06 | 1999-08-24 | Steven W. Felman | Recovery of citric acid from impure process streams by addition of strong acids and salts thereof |
| CA2126368A1 (en) * | 1993-07-06 | 1995-01-07 | Steven W. Felman | Recovery of organic acid salts from impure process streams by addition of bases |
| US5352825A (en) * | 1993-07-06 | 1994-10-04 | Hoarmann & Reimer Corp. | Recovery of organic acid salts from impure process streams by addition of bases |
| DE4342668A1 (de) * | 1993-12-15 | 1995-06-22 | Basf Ag | Verfahren zur Gewinnung von Carbonsäuren aus ihren Salzen |
| US5525365A (en) * | 1994-12-22 | 1996-06-11 | Gray & Company | Method for processing food |
| US5536385A (en) * | 1995-03-03 | 1996-07-16 | Envirocorp Services & Technology, Inc. | Production and purification of contaminated effluent streams containing ammonium sulfate and ammonia |
| US5681728A (en) * | 1995-06-07 | 1997-10-28 | Chronopol, Inc. | Method and apparatus for the recovery and purification of organic acids |
| US5766439A (en) * | 1996-10-10 | 1998-06-16 | A. E. Staley Manufacturing Co. | Production and recovery of organic acids |
| JPH10179183A (ja) * | 1996-12-20 | 1998-07-07 | Daicel Chem Ind Ltd | カルボン酸の製造方法 |
| DE19705329A1 (de) * | 1997-02-12 | 1998-08-13 | Basf Ag | Dicarbonsäurekristallisate |
| WO1999000178A1 (en) * | 1997-06-30 | 1999-01-07 | Electrosynthesis Company, Inc. | Electrochemical methods for recovery of ascorbic acid |
| US5958744A (en) * | 1997-08-18 | 1999-09-28 | Applied Carbochemicals | Succinic acid production and purification |
| US6902917B1 (en) | 1999-08-03 | 2005-06-07 | Archer-Daniels-Midland Company | Process for recovery of organic acids from fermentration broths |
| US6509179B1 (en) | 2000-10-12 | 2003-01-21 | Barbara I. Veldhuis-Stribos | Continuous process for preparing lactic acid |
| JP4469568B2 (ja) * | 2003-07-09 | 2010-05-26 | 三菱化学株式会社 | 有機酸の製造方法 |
| US7211682B2 (en) | 2003-07-21 | 2007-05-01 | Akzo Nobel N.V. | Aqueous solution of a sodium salt of HEDTA |
| EP1672077B1 (de) * | 2003-08-28 | 2015-01-21 | Mitsubishi Chemical Corporation | Verfahren zur herstellung von bernsteinsäure |
| JP4619291B2 (ja) * | 2003-09-17 | 2011-01-26 | 三菱化学株式会社 | 非アミノ有機酸の製造方法 |
| CN100534972C (zh) * | 2003-09-30 | 2009-09-02 | 味之素株式会社 | 从发酵液中纯化琥珀酸的方法 |
| JP5572279B2 (ja) * | 2004-05-20 | 2014-08-13 | 味の素株式会社 | コハク酸生産菌及びコハク酸の製造方法 |
| JP5023701B2 (ja) * | 2004-05-20 | 2012-09-12 | 味の素株式会社 | コハク酸生産菌及びコハク酸の製造方法 |
| JP4554277B2 (ja) * | 2004-05-27 | 2010-09-29 | 昭和電工株式会社 | 微生物によるコハク酸の製造方法 |
| US20060096525A1 (en) * | 2004-11-08 | 2006-05-11 | Sirkar Kamalesh K | Solid hollow fiber cooling crystallization systems and methods |
| JP4995196B2 (ja) * | 2004-12-21 | 2012-08-08 | ビーエーエスエフ ソシエタス・ヨーロピア | 発酵培養液より得られるスクシネートからのピロリドンの製造方法 |
| JP2009077719A (ja) | 2005-04-22 | 2009-04-16 | Mitsubishi Chemicals Corp | ポリエステル及びその製造方法 |
| JP4380704B2 (ja) | 2005-04-22 | 2009-12-09 | 三菱化学株式会社 | バイオマス資源由来ポリエステル及びその製造方法 |
| JP4906720B2 (ja) * | 2005-06-29 | 2012-03-28 | 兵治 榎本 | 乳酸の製造方法および乳酸製造装置 |
| CN101297043B (zh) * | 2005-10-18 | 2013-01-16 | 味之素株式会社 | 用于产生琥珀酸的方法 |
| JP5180060B2 (ja) * | 2006-02-24 | 2013-04-10 | 三菱化学株式会社 | 有機酸生産菌及び有機酸の製造法 |
| WO2008010373A1 (en) * | 2006-07-19 | 2008-01-24 | Showa Denko K.K. | A process for producing succinic acid |
| JP5052234B2 (ja) * | 2006-07-19 | 2012-10-17 | 昭和電工株式会社 | コハク酸の製造方法 |
| FR2925068B1 (fr) * | 2007-12-13 | 2010-01-08 | Roquette Freres | Procedes de production d'acide succinique |
| BRPI0722315A2 (pt) * | 2007-12-28 | 2014-06-10 | Roquette Freres | Método de cultura microbiana em larga escala |
| WO2011064151A1 (en) | 2009-11-24 | 2011-06-03 | Dsm Ip Assets B.V. | Process for the crystallization of succinic acid |
| WO2011069008A1 (en) | 2009-12-02 | 2011-06-09 | Board Of Trustees Michigan State University | Carboxylic acid recovery and methods related thereto |
| EP2519491A4 (de) | 2009-12-31 | 2014-10-08 | Groupe Novasep Sas | Reinigung von bernsteinsäure aus der fermentierung von sprossen mit ammoniumsuccinat |
| PL2360137T3 (pl) * | 2010-02-12 | 2014-01-31 | Purac Biochem Bv | Proces produkcji kwasu bursztynowego |
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| US8580096B2 (en) | 2011-09-29 | 2013-11-12 | Uchicago Argonne, Llc | Bioprocess utilizing carbon dioxide and electrodeionization |
| CN102603511A (zh) * | 2012-01-25 | 2012-07-25 | 保定味群食品科技股份有限公司 | 一种无水琥珀酸二钠的制作方法 |
| WO2014055650A1 (en) | 2012-10-02 | 2014-04-10 | The Michigan Biotechnology Institute | Integrated systems and methods for organic acid production |
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| JP2015080744A (ja) * | 2013-10-22 | 2015-04-27 | 三菱化学株式会社 | 脂肪族ジカルボン酸含有液の製造方法 |
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| JP6944746B2 (ja) * | 2016-09-09 | 2021-10-06 | 花王株式会社 | ジカルボン酸結晶及びその製造方法 |
| WO2018047443A1 (ja) * | 2016-09-09 | 2018-03-15 | 花王株式会社 | ジカルボン酸結晶及びその製造方法 |
| DE102018000672A1 (de) | 2018-01-29 | 2019-08-14 | Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen | Verfahren zur Übertragung eines Zielstoffs zwischen zwei flüssigen Phasen |
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| IT202000017368A1 (it) | 2020-07-16 | 2022-01-16 | Radici Chimica S P A | Purificazione di acidi dicarbossilici alifatici prodotti mediante processi biotecnologici |
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|---|---|---|---|---|
| US4100188A (en) * | 1972-04-27 | 1978-07-11 | Ethyl Corporation | Chemical process |
| US4146730A (en) * | 1975-12-25 | 1979-03-27 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for obtaining glutaric acid, succinic acid, and adipic acid from an acid mixture comprising them |
| US4110175A (en) * | 1976-06-30 | 1978-08-29 | Aqua-Chem, Inc. | Electrodialysis method |
| US4137260A (en) * | 1977-02-03 | 1979-01-30 | Ethyl Corporation | Process for precipitation of carboxyalkoxy succinate tetrahydrate salt |
| FR2555200B1 (fr) * | 1983-11-23 | 1986-07-25 | Centre Nat Rech Scient | Procede de preparation d'acide lactique par fermentation de lactoserum et installation pour la mise en oeuvre en continu de ce procede |
| DE3434918A1 (de) * | 1984-09-22 | 1986-04-03 | Hüls AG, 4370 Marl | Verfahren zur gewinnung von l-aepfelsaeure |
| DE3542861A1 (de) * | 1985-12-04 | 1987-06-11 | Huels Chemische Werke Ag | Verfahren zur gewinnung von l-aepfelsaeure |
| US4766161A (en) * | 1986-06-05 | 1988-08-23 | Allied Corporation | Bipolar membranes and methods of making same |
| US4678553A (en) * | 1986-07-11 | 1987-07-07 | Ionics, Incorporated | Renaturing reversibly denatured polypeptides and proteins by electrodialysis of solutions thereof in denaturants |
| US4781809A (en) * | 1986-07-21 | 1988-11-01 | Ionics, Incorporated | Recovering free organic acids from solutions in which they occur with other organic matter |
| GB8630104D0 (en) * | 1986-12-17 | 1987-01-28 | Bp Chem Int Ltd | Chemical process |
-
1989
- 1989-07-27 US US07/385,638 patent/US5034105A/en not_active Expired - Lifetime
-
1990
- 1990-07-25 EP EP90308162A patent/EP0410728B1/de not_active Expired - Lifetime
- 1990-07-25 DE DE69006555T patent/DE69006555T2/de not_active Expired - Fee Related
- 1990-07-25 AT AT90308162T patent/ATE101388T1/de active
- 1990-07-26 AU AU59893/90A patent/AU5989390A/en not_active Abandoned
- 1990-07-27 JP JP2201033A patent/JP2944157B2/ja not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011160760A1 (de) | 2010-06-25 | 2011-12-29 | Uhde Gmbh | Verfahren zur abtrennung, gewinnung und reinigung von dicarbonsäuren |
| DE102010025167A1 (de) | 2010-06-25 | 2011-12-29 | Uhde Gmbh | Verfahren zur Abtrennung, Gewinnung und Reinigung von Bernsteinsäure |
| US8957249B2 (en) | 2010-06-25 | 2015-02-17 | Thyssenkrupp Uhde Gmbh | Process for removing, isolating and purifying dicarboxylic acids |
| DE102011120632A1 (de) | 2011-12-09 | 2013-06-13 | Thyssenkrupp Uhde Gmbh | Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen |
| WO2013083229A1 (de) | 2011-12-09 | 2013-06-13 | Thyssenkrupp Uhde Gmbh | Verfahren zur aufreinigung von carbonsäuren aus fermentationsbrühen |
| US9272976B2 (en) | 2011-12-09 | 2016-03-01 | Thyssenkrupp Industrial Solutions Ag | Method for purifying carboxylic acids from fermentation broths |
| WO2014095080A2 (en) | 2012-12-21 | 2014-06-26 | Thyssenkrupp Industrial Solutions Ag | Process for the purification of carboxylic acids |
| DE102013000027A1 (de) | 2013-01-03 | 2014-07-03 | Thyssenkrupp Industrial Solutions Ag | Verfahren zur Aufreinigung von Carbonsäuren aus Fermentationsbrühen |
| WO2014106532A2 (de) | 2013-01-03 | 2014-07-10 | Thyssenkrupp Industrial Solutions Ag | Verfahren zur aufreinigung von carbonsäuren aus fermentationsbrühen |
| WO2014108163A2 (de) | 2013-01-11 | 2014-07-17 | Thyssenkrupp Uhde Gmbh | Verfahren zur herstellung von dicarbonsäuren |
| WO2014108163A3 (de) * | 2013-01-11 | 2014-10-23 | Thyssenkrupp Uhde Gmbh | Verfahren zur herstellung von dicarbonsäuren |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03151884A (ja) | 1991-06-28 |
| EP0410728B1 (de) | 1994-02-09 |
| US5034105A (en) | 1991-07-23 |
| AU5989390A (en) | 1991-01-31 |
| EP0410728A1 (de) | 1991-01-30 |
| ATE101388T1 (de) | 1994-02-15 |
| DE69006555D1 (de) | 1994-03-24 |
| JP2944157B2 (ja) | 1999-08-30 |
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