DE69713109T2 - Verbindungen mit wachstumshormon freisetzenden eigenschaften - Google Patents

Verbindungen mit wachstumshormon freisetzenden eigenschaften

Info

Publication number: DE69713109T2
Authority: DE; Germany
Prior art keywords: ethyl; methyl; naphthyl; mmol; solution
Prior art date: 1996-07-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69713109T

Other languages

German (de)

English (en)

Other versions

DE69713109D1 (de

Inventor

Michael Ankersen

Kruse Hansen

Bernd Peschke

Henning Thoegersen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Helsinn Therapeutics US Inc

Original Assignee

Novo Nordisk AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-22

Filing date

1997-07-17

Publication date

2003-01-02

1997-07-17 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

2002-07-11 Publication of DE69713109D1 publication Critical patent/DE69713109D1/de

2003-01-02 Application granted granted Critical

2003-01-02 Publication of DE69713109T2 publication Critical patent/DE69713109T2/de

2017-07-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

102000018997 Growth Hormone Human genes 0.000 title claims abstract description 39
108010051696 Growth Hormone Proteins 0.000 title claims abstract description 39
239000000122 growth hormone Substances 0.000 title claims abstract description 39
230000003578 releasing effect Effects 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims abstract description 114
241001465754 Metazoa Species 0.000 claims abstract description 14
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239000003814 drug Substances 0.000 claims abstract description 9
210000002268 wool Anatomy 0.000 claims abstract description 5
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239000008267 milk Substances 0.000 claims abstract description 4
210000004080 milk Anatomy 0.000 claims abstract description 4
239000000203 mixture Substances 0.000 claims description 37
229910052739 hydrogen Inorganic materials 0.000 claims description 28
239000001257 hydrogen Substances 0.000 claims description 28
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 27
-1 amino, hydroxyl Chemical group 0.000 claims description 27
150000003839 salts Chemical class 0.000 claims description 19
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
125000003118 aryl group Chemical group 0.000 claims description 14
159000000021 acetate salts Chemical class 0.000 claims description 13
229910052736 halogen Inorganic materials 0.000 claims description 13
150000002367 halogens Chemical group 0.000 claims description 13
206010062767 Hypophysitis Diseases 0.000 claims description 12
210000003635 pituitary gland Anatomy 0.000 claims description 12
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
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239000004480 active ingredient Substances 0.000 claims description 8
239000003937 drug carrier Substances 0.000 claims description 8
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125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 7
230000015556 catabolic process Effects 0.000 claims description 7
239000003085 diluting agent Substances 0.000 claims description 7
230000000694 effects Effects 0.000 claims description 7
150000002431 hydrogen Chemical class 0.000 claims description 7
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XXAPNPUABGNKAW-GDLZYMKVSA-N 3-(aminomethyl)-n-[(2r)-1-[2-[2-(2-hydroxyethoxy)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]benzamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(=O)C=1C=C(CN)C=CC=1)N(C)CCC1=CC=CC=C1OCCO XXAPNPUABGNKAW-GDLZYMKVSA-N 0.000 claims description 4
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PKVGEUCCBFDWEF-YBLZLUOVSA-N (e)-5-[[(2r)-2-hydroxypropyl]amino]-n,5-dimethyl-n-[(2r)-1-[methyl(2-phenylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)/C=C/CC(C)(C)NC[C@H](O)C)N(C)CCC1=CC=CC=C1 PKVGEUCCBFDWEF-YBLZLUOVSA-N 0.000 claims description 3
IEEUKABHJLYTDI-UDKPXMKSSA-N (e)-5-amino-n,5-dimethyl-n-[(2r)-1-[methyl(2-phenylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1 IEEUKABHJLYTDI-UDKPXMKSSA-N 0.000 claims description 3
NKTMLMJWHNDQDF-VISBSAOHSA-N (e)-5-amino-n,5-dimethyl-n-[(2r)-1-[methyl(2-thiophen-2-ylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CS1 NKTMLMJWHNDQDF-VISBSAOHSA-N 0.000 claims description 3
WAMMBZKCAXKZKW-LZZUIANGSA-N (e)-5-amino-n-[(2r)-1-[2-[2-(2-hydroxyethoxy)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1OCCO WAMMBZKCAXKZKW-LZZUIANGSA-N 0.000 claims description 3
QUDVOSPQRDYTCI-BYFPVTHSSA-N (e)-5-amino-n-[(2r)-1-[2-[2-(benzenesulfonamido)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1NS(=O)(=O)C1=CC=CC=C1 QUDVOSPQRDYTCI-BYFPVTHSSA-N 0.000 claims description 3
BOSXPQNYNMINOQ-MGUPHCMFSA-N (e)-5-amino-n-[(2r)-1-[2-[2-(methanesulfonamido)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1NS(C)(=O)=O BOSXPQNYNMINOQ-MGUPHCMFSA-N 0.000 claims description 3
ITQNUYSUYRVNQP-LZZUIANGSA-N (e)-5-amino-n-[(2r)-1-[2-[2-[(2-aminoacetyl)amino]phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethylhex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CC=C1NC(=O)CN ITQNUYSUYRVNQP-LZZUIANGSA-N 0.000 claims description 3
COPOOZYPAUETCC-FEBJRPPSSA-N (e)-n,5-dimethyl-5-(methylamino)-n-[(2r)-1-[methyl(2-phenylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)/C=C/CC(C)(C)NC)N(C)CCC1=CC=CC=C1 COPOOZYPAUETCC-FEBJRPPSSA-N 0.000 claims description 3
GYIPHGRIGGSXCL-BVEXFFHSSA-N (e)-n-[(2r)-1-[2-[2-(2-hydroxyethoxy)phenyl]ethyl-methylamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-n,5-dimethyl-5-(methylamino)hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)/C=C/CC(C)(C)NC)N(C)CCC1=CC=CC=C1OCCO GYIPHGRIGGSXCL-BVEXFFHSSA-N 0.000 claims description 3
YEJLGCGPEJEPLW-ZSTWXAJCSA-N 3-(1-aminoethyl)-n-methyl-n-[(2r)-1-[methyl(2-thiophen-2-ylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]benzamide Chemical compound CC(N)C1=CC=CC(C(=O)N(C)[C@H](CC=2C=C3C=CC=CC3=CC=2)C(=O)N(C)CCC=2SC=CC=2)=C1 YEJLGCGPEJEPLW-ZSTWXAJCSA-N 0.000 claims description 3
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XYTIFQRQPIRQKL-LNFHGXOESA-N (e)-5-amino-n,5-dimethyl-n-[(2r)-1-[methyl(2-thiophen-2-ylethyl)amino]-1-oxo-3-(4-phenylphenyl)propan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=CC(=CC=1)C=1C=CC=CC=1)N(C)C(=O)\C=C\CC(C)(C)N)N(C)CCC1=CC=CS1 XYTIFQRQPIRQKL-LNFHGXOESA-N 0.000 claims description 2
LRHAXAVCVRWWKU-PVBLUSGHSA-N (e)-n,5-dimethyl-5-(methylamino)-n-[(2r)-1-[methyl(2-thiophen-2-ylethyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]hex-2-enamide Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)N(C)C(=O)/C=C/CC(C)(C)NC)N(C)CCC1=CC=CS1 LRHAXAVCVRWWKU-PVBLUSGHSA-N 0.000 claims description 2
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KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
VFRSADQPWYCXDG-LEUCUCNGSA-N ethyl (2s,5s)-5-methylpyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCOC(=O)[C@@H]1CC[C@H](C)N1 VFRSADQPWYCXDG-LEUCUCNGSA-N 0.000 claims 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69713109T 1996-07-22 1997-07-17 Verbindungen mit wachstumshormon freisetzenden eigenschaften Expired - Lifetime DE69713109T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK80396		1996-07-22
PCT/DK1997/000314 WO1998003473A1 (en)	1996-07-22	1997-07-17	Compounds with growth hormone releasing properties

Publications (2)

Publication Number	Publication Date
DE69713109D1 DE69713109D1 (de)	2002-07-11
DE69713109T2 true DE69713109T2 (de)	2003-01-02

Family

ID=8097747

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69734215T Expired - Lifetime DE69734215T2 (de)	1996-07-22	1997-07-17	Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften
DE69713109T Expired - Lifetime DE69713109T2 (de)	1996-07-22	1997-07-17	Verbindungen mit wachstumshormon freisetzenden eigenschaften

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE69734215T Expired - Lifetime DE69734215T2 (de)	1996-07-22	1997-07-17	Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften

Country Status (8)

Country	Link
US (3)	US5922770A (2)
EP (2)	EP0923539B1 (2)
JP (1)	JP4425992B2 (2)
AT (2)	ATE218537T1 (2)
AU (1)	AU3434697A (2)
DE (2)	DE69734215T2 (2)
WO (1)	WO1998003473A1 (2)
ZA (1)	ZA976371B (2)

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1997
- 1997-07-17 US US08/896,550 patent/US5922770A/en not_active Expired - Lifetime
- 1997-07-17 WO PCT/DK1997/000314 patent/WO1998003473A1/en not_active Ceased
- 1997-07-17 AU AU34346/97A patent/AU3434697A/en not_active Abandoned
- 1997-07-17 DE DE69734215T patent/DE69734215T2/de not_active Expired - Lifetime
- 1997-07-17 EP EP97930368A patent/EP0923539B1/en not_active Expired - Lifetime
- 1997-07-17 AT AT97930368T patent/ATE218537T1/de not_active IP Right Cessation
- 1997-07-17 DE DE69713109T patent/DE69713109T2/de not_active Expired - Lifetime
- 1997-07-17 JP JP50646598A patent/JP4425992B2/ja not_active Expired - Lifetime
- 1997-07-17 AT AT01123155T patent/ATE304528T1/de not_active IP Right Cessation
- 1997-07-17 EP EP01123155A patent/EP1184370B1/en not_active Expired - Lifetime
- 1997-07-18 ZA ZA9706371A patent/ZA976371B/xx unknown
1999
- 1999-03-17 US US09/270,862 patent/US6127354A/en not_active Expired - Lifetime
2000
- 2000-07-19 US US09/619,227 patent/US6274584B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE218537T1 (de)	2002-06-15
DE69713109D1 (de)	2002-07-11
US5922770A (en)	1999-07-13
DE69734215T2 (de)	2006-06-29
EP0923539A1 (en)	1999-06-23
EP1184370A2 (en)	2002-03-06
EP1184370B1 (en)	2005-09-14
ZA976371B (en)	1998-01-22
US6127354A (en)	2000-10-03
DE69734215D1 (de)	2005-10-20
WO1998003473A1 (en)	1998-01-29
ATE304528T1 (de)	2005-09-15
JP4425992B2 (ja)	2010-03-03
US6274584B1 (en)	2001-08-14
EP0923539B1 (en)	2002-06-05
AU3434697A (en)	1998-02-10
JP2000515517A (ja)	2000-11-21
EP1184370A3 (en)	2002-03-27

Legal Events

Date	Code	Title	Description
2006-12-14	8364	No opposition during term of opposition
2009-12-31	8327	Change in the person/name/address of the patent owner	Owner name: SAPPHIRE THERAPEUTICS, INC., BRIDGEWATER, N.J., US

Publication	Publication Date	Title
DE69713109T2 (de)	2003-01-02	Verbindungen mit wachstumshormon freisetzenden eigenschaften
DE69633003T2 (de)	2005-08-18	Verbindungen mit wachstumshormon-freisetzenden eigenschaften
JP4130519B2 (ja)	2008-08-06	成長ホルモン放出特性を有する化合物
DE60015173T2 (de)	2005-12-08	Verbindung mit wachstumshormon-freisetzenden eigenschaften
ES2331102T3 (es)	2009-12-21	Compuestos con propiedades de liberacion de la hormona del crecimiento.
DE69718469T2 (de)	2003-10-30	Verbindungen mit wachtumshormon freisetzenden eigenschaften
JP4116097B2 (ja)	2008-07-09	成長ホルモン放出特性をもつ化合物
EP1117642B1 (de)	2004-05-26	Substituierte 1,3-diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)-propanolderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO1996024580A1 (en)	1996-08-15	Compounds with growth hormone releasing properties
DE69921611T2 (de)	2005-11-03	Verbindungen mit wachstumshormon-freisetzenden eigenschaften
WO1996024587A1 (en)	1996-08-15	Compounds with growth hormone releasing properties
RU2298547C2 (ru)	2007-05-10	Соединения и фармацевтическая композиция, обладающие свойствами высвобождения гормона роста, способ стимуляции выделения гормона роста из гипофиза млекопитающего
DE69908756T2 (de)	2004-04-29	Matrix-metalloproteinase-inhibitoren
US6566337B1 (en)	2003-05-20	Compounds with growth hormone releasing properties
DE69919195T2 (de)	2005-08-04	Verbindungen mit wachstumshormon-freisetzender eigenschaft
JP3007613B2 (ja)	2000-02-07	成長ホルモン放出特性を有する化合物
MXPA00006692A (en)	2001-07-31	Compounds with growthhormone releasing properties