CU23558A1 - Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento - Google Patents

Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento

Info

Publication number
CU23558A1
CU23558A1 CU20060050A CU20060050A CU23558A1 CU 23558 A1 CU23558 A1 CU 23558A1 CU 20060050 A CU20060050 A CU 20060050A CU 20060050 A CU20060050 A CU 20060050A CU 23558 A1 CU23558 A1 CU 23558A1
Authority
CU
Cuba
Prior art keywords
growth hormone
secretagogs
peptidic
compounds
compounds analog
Prior art date
Application number
CU20060050A
Other languages
English (en)
Inventor
Masso Julio Raul Fernandez
Lasa Alexis Musacchio
La Nuez Veulens Ania De
Fernandez Rolando Eduardo Rodriguez
Acosta Jorge Amador Berlanga
Garcia Mario Pablo Estrada
Santiago Glay Chinea
Acosta Osvaldo Reyes
Del Barco Herrera Diana Garcia
Rodriguez Rebeca Martinez
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40130780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23558(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20060050A priority Critical patent/CU23558A1/es
Priority to ARP070100806A priority patent/AR059646A1/es
Priority to CL2007000528A priority patent/CL2007000528A1/es
Priority to MX2008011142A priority patent/MX2008011142A/es
Priority to PCT/CU2007/000007 priority patent/WO2007098716A1/es
Priority to BRPI0708366-1A priority patent/BRPI0708366A2/pt
Priority to CA2637593A priority patent/CA2637593C/en
Priority to KR1020087023543A priority patent/KR101409277B1/ko
Priority to MYPI20083178A priority patent/MY184130A/en
Priority to US12/281,085 priority patent/US8367620B2/en
Priority to AU2007219569A priority patent/AU2007219569B2/en
Priority to ES07711101.1T priority patent/ES2441441T3/es
Priority to RU2008138569/10A priority patent/RU2416618C2/ru
Priority to CN2007800153594A priority patent/CN101432294B/zh
Priority to JP2008556643A priority patent/JP5183496B2/ja
Priority to EP07711101.1A priority patent/EP1997827B1/en
Priority to ZA200807162A priority patent/ZA200807162B/xx
Priority to NO20084118A priority patent/NO20084118L/no
Publication of CU23558A1 publication Critical patent/CU23558A1/es
Priority to CL2016001648A priority patent/CL2016001648A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compuestos químicos peptídicos obtenidos por modelación molecular in silico, y cuya estructura les permite efectuar las mismas funciones que los secretagogos peptídicos de la hormona de crecimiento. La invención comprende además las compocisiones que contienen dichos compuestos y su uso en la preparación de medicamentos, suplementos nutricionales, u otras formulaciones de uso humano o animal.
CU20060050A 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento CU23558A1 (es)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
ARP070100806A AR059646A1 (es) 2006-02-28 2007-02-27 Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen
CL2007000528A CL2007000528A1 (es) 2006-02-28 2007-02-27 Compuestos analogos a los secretagogos peptidicos de la hormona del crecimiento; composicion farmaceutica y veterinaria que los comprende; metodo para inducir cardioproteccion, neuroproteccion, control del apetito, y metodo para estimular el crecimiento y resistencia a enfermedades en organismos acuaticos.
EP07711101.1A EP1997827B1 (en) 2006-02-28 2007-02-28 Compounds analogous to growth hormone peptide secretagogues and preparations containing them
MYPI20083178A MY184130A (en) 2006-02-28 2007-02-28 Peptidic growth hormone secretagogues analog compounds and preparations thereof
RU2008138569/10A RU2416618C2 (ru) 2006-02-28 2007-02-28 Соединения, представляющие собой пептидные аналоги стимуляторов секреции гормона роста, и содержащие их препараты
BRPI0708366-1A BRPI0708366A2 (pt) 2006-02-28 2007-02-28 compostos quìmicos de natureza peptìdica, composição farmacêutica, composição veterinária e uso de compostos quìmicos
CA2637593A CA2637593C (en) 2006-02-28 2007-02-28 Compounds analogous to growth hormone peptide secretagogues and preparations containing them
KR1020087023543A KR101409277B1 (ko) 2006-02-28 2007-02-28 펩티드 성장 호르몬 분비촉진제와 유사한 화합물 및 이를 포함하는 제형
MX2008011142A MX2008011142A (es) 2006-02-28 2007-02-28 Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen.
US12/281,085 US8367620B2 (en) 2006-02-28 2007-02-28 Peptidic growth hormone secretagogues analog compounds and preparations thereof
AU2007219569A AU2007219569B2 (en) 2006-02-28 2007-02-28 Compounds analogous to growth hormone peptide secretagogues and preparations containing them
ES07711101.1T ES2441441T3 (es) 2006-02-28 2007-02-28 Compuestos análogos a secretagogos peptídicos de la hormona del crecimiento y preparaciones que los contienen
PCT/CU2007/000007 WO2007098716A1 (es) 2006-02-28 2007-02-28 Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen
CN2007800153594A CN101432294B (zh) 2006-02-28 2007-02-28 类似于生长激素的肽性促分泌素的化合物以及包含其的制剂及用途
JP2008556643A JP5183496B2 (ja) 2006-02-28 2007-02-28 成長ホルモンのペプチド性分泌促進物質に類似した化合物及びそれを含有する製剤
ZA200807162A ZA200807162B (en) 2006-02-28 2008-08-19 Compounds analogous to growth hormone peptide secret-agogues and preparations containing them
NO20084118A NO20084118L (no) 2006-02-28 2008-09-29 Peptidisk veksthormonsekretutskillbare analoge forbindelser og fremstillinger derav
CL2016001648A CL2016001648A1 (es) 2006-02-28 2016-06-24 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento; composición farmacéutica y veterinaria que los comprende; método para inducir cardioprotección, neuroprotección, control del apetito, y método para estimular el crecimiento y resistencia a enfermedades en organismos acuáticos. (divisional de solicitud 2007-00528).

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento

Publications (1)

Publication Number Publication Date
CU23558A1 true CU23558A1 (es) 2010-07-20

Family

ID=40130780

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento

Country Status (18)

Country Link
US (1) US8367620B2 (es)
EP (1) EP1997827B1 (es)
JP (1) JP5183496B2 (es)
KR (1) KR101409277B1 (es)
CN (1) CN101432294B (es)
AR (1) AR059646A1 (es)
AU (1) AU2007219569B2 (es)
BR (1) BRPI0708366A2 (es)
CA (1) CA2637593C (es)
CL (2) CL2007000528A1 (es)
CU (1) CU23558A1 (es)
ES (1) ES2441441T3 (es)
MX (1) MX2008011142A (es)
MY (1) MY184130A (es)
NO (1) NO20084118L (es)
RU (1) RU2416618C2 (es)
WO (1) WO2007098716A1 (es)
ZA (1) ZA200807162B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010052828A1 (ja) * 2008-11-06 2010-05-14 国立大学法人名古屋大学 非虚血性心筋障害に対する医薬
CU24473B1 (es) * 2016-11-01 2020-02-04 Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma Composición vacunal que comprende un péptido secretagogo de la hormona de crecimiento como adyuvante vacunal
RU2734835C1 (ru) * 2020-02-11 2020-10-23 Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделение Российской академии наук (ЛИН СО РАН) Способ повышения жизнестойкости эмбрионов рыб в аквакультуре

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239345A (en) 1965-02-15 1966-03-08 Estrogenic compounds and animal growth promoters
US4411890A (en) 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4036979A (en) 1974-01-25 1977-07-19 American Cyanamid Company Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate
EP0398961B1 (en) 1988-01-28 1994-11-02 Polygen Holding Corporation Polypeptide compounds having growth hormone releasing activity
DE68922602T2 (de) 1988-01-28 1995-12-07 Polygen Holding Corp Polypeptide mit hormonwachstumsbefreiender wirkung.
JP2670680B2 (ja) 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
ES2084190T3 (es) 1990-10-25 1996-05-01 Genentech Inc Utilizacion de agentes protectores contra especies de oxigeno reactivas.
US5663146A (en) 1991-08-22 1997-09-02 Administrators Of The Tulane Educational Fund Polypeptide analogues having growth hormone releasing activity
CA2147503A1 (en) 1992-11-06 1994-05-26 Judith M. Pisano Substituted dipeptide analogs promote release of growth hormone
US5726319A (en) 1992-11-06 1998-03-10 Merck & Co., Inc. Biphenyl substituted dipeptide analogs promote release of growth hormone
US5536716A (en) 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
NZ258412A (en) 1992-12-11 1997-01-29 Merck & Co Inc Spiro-fused piperidine derivatives and pharmaceutical compositions
FI961681L (fi) 1993-10-19 1996-06-12 Merck & Co Inc Bisfosfonaattien ja kasvuhormoonin eritystä lisäävien aineiden yhdistelmä
WO1995013069A1 (en) 1993-11-09 1995-05-18 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US5494919A (en) 1993-11-09 1996-02-27 Merck & Co., Inc. 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US5492916A (en) 1993-12-23 1996-02-20 Merck & Co., Inc. Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
AU684878B2 (en) 1993-11-24 1998-01-08 Merck & Co., Inc. Compounds and the use thereof to promote the release of growth hormone(s)
US5721251A (en) 1993-12-10 1998-02-24 Merck & Co., Inc. Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
US5721250A (en) 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
ATE197158T1 (de) 1993-12-23 2000-11-15 Novo Nordisk As Verbindungen mit wachstumshormonfreisetzenden eigenschaften
EP0736038B1 (en) 1993-12-23 2001-07-04 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1995034311A1 (en) 1994-06-13 1995-12-21 Merck & Co., Inc. Piperazine compounds promote release of growth hormone
US5783582A (en) 1994-07-20 1998-07-21 Merck & Co., Inc. Piperidines and hexahydro-1H-azepines spiro substituted at the 4-position promote release of growth hormone
US5798337A (en) 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
WO1996022996A1 (en) 1995-01-25 1996-08-01 Nippon Chemiphar Co., Ltd. Dihydrophenazine derivatives
AU705744B2 (en) 1995-01-27 1999-06-03 Sapphire Therapeutics, Inc. Compounds with growth hormone releasing properties
WO1996024580A1 (en) 1995-02-09 1996-08-15 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU4534696A (en) 1995-02-09 1996-08-27 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5559128A (en) 1995-04-18 1996-09-24 Merck & Co., Inc. 3-substituted piperidines promote release of growth hormone
EP0823904A4 (en) 1995-04-19 1998-09-09 Merck & Co Inc Process for the preparation of spiroindolines
WO1996035713A1 (en) 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
DE69533991T2 (de) 1995-05-29 2006-04-13 Pfizer Inc. Dipeptide, die die ausschüttung von wachstumshormonen stimulieren
EP0833845A1 (en) 1995-06-22 1998-04-08 Novo Nordisk A/S Compounds with growth hormone releasing properties
EP0761220A1 (en) 1995-08-21 1997-03-12 Eli Lilly And Company 2-Acylaminopropanamides as growth hormone secretagogues
AU6724496A (en) 1995-08-21 1997-03-12 Eli Lilly And Company 2-acylaminopropanamines as growth hormone secretagogues
EP0766966A3 (en) 1995-09-08 2001-02-28 Eli Lilly And Company Method of treating insulin resistance
WO1997011697A1 (en) 1995-09-26 1997-04-03 Merck & Co., Inc. 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone
US5723616A (en) 1995-10-27 1998-03-03 Merck & Co., Inc. Process for the preparation of a growth hormone secretagogue
AU7468596A (en) 1995-10-27 1997-05-15 Merck & Co., Inc. Process for the preparation of a growth hormone secretagogue
US5767124A (en) 1995-10-27 1998-06-16 Merck & Co., Inc. Polymorphic forms of a growth hormone secretagogue
EP0857020A4 (en) 1995-10-27 1999-01-07 Merck & Co Inc FORMULATION OF SECRETAGOGUE STIMULATING THE SECRETION OF THE GROWTH HORMONE, INTENDED TO BE GRANULATED BY WET
WO1997021730A1 (en) 1995-12-13 1997-06-19 Merck & Co., Inc. Growth hormone secretagogue receptor family
WO1997022004A1 (en) 1995-12-13 1997-06-19 Merck & Co., Inc. Assays for growth hormone secretagogue receptors
IT1277113B1 (it) 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
WO1997022367A1 (en) 1995-12-20 1997-06-26 Merck & Co., Inc. Radiolabeled growth hormone secretagogue
HUP9802580A3 (en) 1995-12-22 1999-03-29 Novo Nordisk As Compounds with growth hormone releasing properties
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
WO1997034604A1 (en) 1996-03-21 1997-09-25 Merck & Co., Inc. 4-spiroindoline piperidines promote release of growth hormone
AU2722297A (en) 1996-04-03 1997-10-22 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
SE9601397D0 (sv) 1996-04-12 1996-04-12 Pharmacia Ab Use of growth hormone
EP0910579A1 (en) 1996-04-19 1999-04-28 Novo Nordisk A/S Compounds with growth hormone releasing properties
US5919777A (en) 1996-04-24 1999-07-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU722421B2 (en) 1996-04-24 2000-08-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1997041878A1 (en) 1996-05-07 1997-11-13 Merck & Co., Inc. Treatment of mood disorders with a growth hormone secretagogue
JP2000511885A (ja) 1996-05-07 2000-09-12 メルク エンド カンパニー インコーポレーテッド 成長ホルモン分泌促進薬による睡眠の強化
AU2764797A (en) 1996-05-14 1997-12-05 Novo Nordisk A/S Somatostatin agonists and antagonists
AU3220097A (en) 1996-05-22 1997-12-09 Arch Development Corporation Sleep quality improvement using a growth hormone secretagogue
BR9709499A (pt) 1996-05-31 1999-08-10 Novo Nordisk As Processo para prevenção ou tratamento de osteoporose e de perturbações relacionamas uso de um componente de hormónio do crescimento uso de uma composição com uma ação de anti-reabsorção sobre os ossos e produtos
EP0923539B1 (en) 1996-07-22 2002-06-05 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU4342097A (en) 1996-09-13 1998-04-02 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
WO1998018815A1 (en) 1996-10-25 1998-05-07 Merck & Co., Inc. Convergent process for the preparation of a growth hormone secretagogue
SE9703929D0 (sv) 1996-11-22 1997-10-28 Pharmacia & Upjohn Ab Therapeutical use and method
WO1998046569A1 (fr) 1997-04-11 1998-10-22 Sumitomo Pharmaceuticals Co., Ltd. Derives de benzene
WO1998051687A1 (en) 1997-05-14 1998-11-19 Fujisawa Pharmaceutical Co., Ltd. Piperidino derivatives which promote growth hormone release
US5861149A (en) 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
AU7906998A (en) 1997-06-20 1999-01-04 Novo Nordisk A/S Compounds with growth hormone releasing properties
DE69837264T2 (de) 1997-06-25 2008-01-31 Pfizer Inc. Dipeptidverbindungen, die Wachstumshormon-Sekretagoga sind
UA64751C2 (uk) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
ZA987383B (en) 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.
EP1021190B1 (en) 1997-08-22 2006-11-08 Kaken Pharmaceutical Co., Ltd. Amid derivatives as growth hormone release promotors
KR20010034198A (ko) 1998-01-16 2001-04-25 한센 핀 베네드 성장 호르몬 방출성을 가지는 화합물
WO1999039730A1 (en) 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Oral preparations containing peptides promoting the secretion of growth hormone
EP1060190B1 (en) 1998-03-03 2003-11-19 Novo Nordisk A/S New salt forms of (2e)- 5-amino-5- methylhex-2- enoic acid n-methyl-n-((1r)-1-(n- methyl-n-((1r)-1-(methylcarbamoyl)-2- phenylethyl)carbamoyl)-2- (2-naphtyl)ethyl)amide
DK1077941T3 (da) 1998-05-11 2009-12-07 Novo Nordisk As Forbindelser med væksthormonfrigörende egenskaber
AU4256799A (en) 1998-06-09 1999-12-30 Novo Nordisk A/S A method for preparing a compound with growth hormone releasing properties
PA8475901A1 (es) 1998-06-16 2000-05-24 Pfizer Prod Inc Terapia de combinacion para la fragilidad musculoesqueletica
HUP0102395A2 (hu) 1998-06-16 2001-11-28 Pfizer Products Inc. Izom- és csontrendszeri gyengeség kezelésére alkalmas szelektív ösztrogén receptor modulátorok és növekedési hormon szekretagógok (GHS) kombinációját tartalmazó gyógyszerkészítmények
WO2000001726A1 (en) 1998-06-30 2000-01-13 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU5301199A (en) 1998-08-20 2000-03-14 Sumitomo Pharmaceuticals Company, Limited Oxindole derivatives as growth hormone releasers
US6358951B1 (en) 1998-08-21 2002-03-19 Pfizer Inc. Growth hormone secretagogues
ATE304373T1 (de) * 1999-12-28 2005-09-15 Kaken Pharma Co Ltd Nervenschutzmittel
CA2411667A1 (en) 2000-05-30 2001-12-06 Merck & Co. Inc. Ghrelin analogs
DE60140285D1 (de) 2000-05-31 2009-12-10 Pfizer Prod Inc Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
CZ305279B6 (cs) 2000-06-13 2015-07-15 Zentaris Ag Deriváty tryptofanu zvyšující sekreci růstového hormonu
EP1297839A4 (en) 2000-06-23 2005-12-07 Kaken Pharma Co Ltd PREVENTIVA OR THERAPEUTIC AGAINST HEART FAILURE
ITMI20011445A1 (it) 2001-07-06 2003-01-06 Europ Geie Analoghi della cortistantina capaci di legarsi selettivamente ai recettori dei secretagoghi dell'ormone della crescita
CU23043A1 (es) 2001-12-20 2005-05-20 Ct Ingenieria Genetica Biotech Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico.
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
WO2005039625A1 (en) 2003-10-28 2005-05-06 Rheoscience A/S Growth hormone secretagogue receptor agonists
EP1682136A4 (en) 2003-11-04 2009-06-03 Elixir Pharmaceuticals Inc THERAPEUTIC COMPOUNDS AND CORRESPONDING USES THEREOF
WO2005048916A2 (en) 2003-11-20 2005-06-02 Biovitrum Ab Tetrahydrospiro-beta-carboline-1,3 '-pyrrolidine derivatives and their use in ghsr-related disorders

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RU2416618C2 (ru) 2011-04-20
CA2637593A1 (en) 2007-09-07
EP1997827B1 (en) 2013-10-09
WO2007098716A8 (es) 2008-12-18
CN101432294A (zh) 2009-05-13
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JP2009528303A (ja) 2009-08-06
AR059646A1 (es) 2008-04-16
AU2007219569A1 (en) 2007-09-07
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