DE69814848T2 - Untersuchung von nukleotiden in loesung mit hilfe von pna-sonden - Google Patents

Untersuchung von nukleotiden in loesung mit hilfe von pna-sonden Download PDF

Info

Publication number
DE69814848T2
DE69814848T2 DE69814848T DE69814848T DE69814848T2 DE 69814848 T2 DE69814848 T2 DE 69814848T2 DE 69814848 T DE69814848 T DE 69814848T DE 69814848 T DE69814848 T DE 69814848T DE 69814848 T2 DE69814848 T2 DE 69814848T2
Authority
DE
Germany
Prior art keywords
nucleotide sequence
intensity
probe
marker
pna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69814848T
Other languages
German (de)
English (en)
Other versions
DE69814848D1 (de
Inventor
Xiao-Feng Eileen NIE
Min Yuan WU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ingeneus Corp
Original Assignee
Ingeneus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/870,370 external-priority patent/US6060242A/en
Application filed by Ingeneus Corp filed Critical Ingeneus Corp
Publication of DE69814848D1 publication Critical patent/DE69814848D1/de
Application granted granted Critical
Publication of DE69814848T2 publication Critical patent/DE69814848T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69814848T 1997-02-27 1998-02-23 Untersuchung von nukleotiden in loesung mit hilfe von pna-sonden Expired - Fee Related DE69814848T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80790197A 1997-02-27 1997-02-27
US807901 1997-02-27
US870370 1997-06-06
US08/870,370 US6060242A (en) 1997-02-27 1997-06-06 PNA diagnostic methods
PCT/IB1998/000521 WO1998038334A1 (en) 1997-02-27 1998-02-23 Assaying nucleotides in solution using pna probes

Publications (2)

Publication Number Publication Date
DE69814848D1 DE69814848D1 (de) 2003-06-26
DE69814848T2 true DE69814848T2 (de) 2004-05-06

Family

ID=27123055

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69814848T Expired - Fee Related DE69814848T2 (de) 1997-02-27 1998-02-23 Untersuchung von nukleotiden in loesung mit hilfe von pna-sonden

Country Status (13)

Country Link
EP (1) EP0975800B1 (2)
JP (1) JP4110223B2 (2)
AT (1) ATE241018T1 (2)
AU (1) AU736701B2 (2)
CA (1) CA2282704C (2)
CY (1) CY2406B1 (2)
DE (1) DE69814848T2 (2)
DK (1) DK0975800T3 (2)
ES (1) ES2202821T3 (2)
IN (1) IN188176B (2)
PT (1) PT975800E (2)
TW (1) TW389791B (2)
WO (1) WO1998038334A1 (2)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4034351B2 (ja) 1996-04-25 2008-01-16 バイオアレイ ソリューションズ エルエルシー 粒子近接表面の光制御した動電学的アッセンブリ
US6251591B1 (en) * 1997-02-27 2001-06-26 Lorne Park Research, Inc. Quantitative method for detecting nucleotide concentration
US6046004A (en) * 1997-02-27 2000-04-04 Lorne Park Research, Inc. Solution hybridization of nucleic acids with antisense probes having modified backbones
WO2000034521A1 (en) * 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
DE69938400T2 (de) * 1998-12-08 2009-04-23 Boston Probes, Inc., Bedford Verfahren, Kits und Zusammensetzungen zur Identifizierung von elektrostatisch an Matrizen gebundenen Nukleinsäuren
US6656692B2 (en) * 1999-12-21 2003-12-02 Ingeneus Corporation Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
US6537755B1 (en) * 1999-03-25 2003-03-25 Radoje T. Drmanac Solution-based methods and materials for sequence analysis by hybridization
US6265170B1 (en) * 2000-01-24 2001-07-24 Ingeneus Corporation Homogenous assay of duplex of triplex hybridization by means of multiple measurements under varied conditions
US7220541B2 (en) * 2000-01-24 2007-05-22 Ingeneus, Inc. Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
EP1392853B1 (en) 2000-08-30 2006-04-26 Avi Biopharma, Inc. Method for analysis of oligonucleotide analogs
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
EP1463825B1 (en) 2001-10-15 2017-12-06 BioArray Solutions Ltd. Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
US7041453B2 (en) 2002-08-22 2006-05-09 Bioarray Solutions Ltd. Molecular constructs and methods of use for detection of biochemical reactions
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1678495A4 (en) * 2003-10-20 2007-06-27 Univ California TRANSDUCTION SYSTEMS IN THE NANOMASSIC STATION FOR DETECTING MOLECULAR INTERACTIONS
CA2899287A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
ES2546743B1 (es) 2014-03-28 2016-07-07 Institut D'investigació Biomèdica De Bellvitge (Idibell) Marcadores mitocondriales de enfermedades neurodegenerativas
CN106716116B (zh) 2014-09-23 2021-04-27 蒂尔实验室研究有限公司 用于微流体泪液收集和感兴趣的分析物的横向流动分析的集成的系统和方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0232967B1 (en) * 1986-01-10 1993-04-28 Amoco Corporation Competitive homogeneous assay
EP0533906A4 (en) * 1991-04-11 1994-09-28 Baxter Diagnostics Inc Detection of dna/rna by fluorescence polarization
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
DE4216949C2 (de) * 1992-05-22 1997-07-24 Christoph Prof Dr Dr Cremer Nichtenzymatisches Verfahren zur In-situ-Hybridisierung bei spezifischen Proben
JPH11512617A (ja) * 1995-10-06 1999-11-02 パーセプテイブ・バイオシステムズ・インコーポレイテツド ペプチド核酸プローブを用いるハイブリダイゼーション分析のための方法、装置及びキット

Also Published As

Publication number Publication date
DE69814848D1 (de) 2003-06-26
PT975800E (pt) 2003-10-31
AU6513598A (en) 1998-09-18
TW389791B (en) 2000-05-11
CA2282704A1 (en) 1998-09-03
CY2406B1 (en) 2004-09-10
ATE241018T1 (de) 2003-06-15
CA2282704C (en) 2007-11-13
AU736701B2 (en) 2001-08-02
ES2202821T3 (es) 2004-04-01
JP4110223B2 (ja) 2008-07-02
EP0975800A1 (en) 2000-02-02
IN188176B (2) 2002-08-31
WO1998038334A1 (en) 1998-09-03
DK0975800T3 (da) 2003-09-22
JP2001514497A (ja) 2001-09-11
EP0975800B1 (en) 2003-05-21

Similar Documents

Publication Publication Date Title
DE69814848T2 (de) Untersuchung von nukleotiden in loesung mit hilfe von pna-sonden
DE69637065T2 (de) Die bestimmung von nukleinsäuren und nukleinsäure-einheiten
US6060242A (en) PNA diagnostic methods
Ferguson-Smith Genetic analysis by chromosome sorting and painting: phylogenetic and diagnostic applications
DE60036307T2 (de) Fluoreszenzintensitätstest für duplex- und triplex-nukleinsäurehybridisierung in lösung unter verwendung von fluoreszenzinterkalatoren
DE69506393T2 (de) Hybridisation-ligitation-verfahren zum nachweis von spezifischen dns sequenzen
CA2295333C (en) Assaying nucleotides in solution using a fluorescent intensity quenching effect
EP0925373B1 (de) Verfahren zum nachweis von nukleinsäuren unter ermittlung der masse
US6046004A (en) Solution hybridization of nucleic acids with antisense probes having modified backbones
DE3854743T2 (de) Verfahren zur schnellen basensequenzierung in dns und rns.
DE69736637T2 (de) Multiplex amplifikation kurzer tandem repeat loci
DE68909514T2 (de) Verfahren zur gleichzeitigen Bestimmung von DNS-Sequenzvariationen von zahlreichen Stellen und ein Satz dafür.
DE68926238T2 (de) Dns-analyse verfahren mit genamplifikation und magnetischen teilchen
DE19935772C2 (de) Verfahren zur relativen Quantifizierung der Methylierung von Cytosin Basen in DNA-Proben
DE69003477T2 (de) Verfahren zum Nachweis von Nucleinsäuren.
DE69936379T2 (de) Verfahren zur genotypisierung und dna-analyse
EP1415003A2 (de) Vorrichtung zur analyse von nukleinsäure
US6251591B1 (en) Quantitative method for detecting nucleotide concentration
DE69605803T2 (de) Nachweis von fehlpaarungen durch spaltung mit resolvase auf einem festträger
WO1999047701A1 (de) Verfahren zum nachweis einer nukleotidsequenz
EP2126134A1 (de) Verfahren und testkit zum schnellen nachweis spezifischer nukleinsäuresequenzen, insbesondere zum nachweis von mutationen oder snp's
DE69724375T2 (de) Verfahren zur Messung der Polynukleotidkonzentration
DE19806962B4 (de) Markierung von Nukleinsäuren mit speziellen Probengemischen
EP1307589A2 (de) Verfahren zum nachweis von mutationen in nucleotidsequenzen
DE60201441T2 (de) Verfahren zur analyse der dna-methylierung unter verwendung von fluoreszenzpolarisation

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee