DE728894C - Verfahren zur Gewinnung von Vitamin-E-Acetat-Konzentraten - Google Patents

Verfahren zur Gewinnung von Vitamin-E-Acetat-Konzentraten

Info

Publication number: DE728894C
Authority: DE; Germany
Prior art keywords: vitamin; acetic anhydride; acetate; concentrates; obtaining vitamin
Prior art date: 1940-08-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

DEK158476D

Other languages

German (de)

English (en)

Inventor

Dr Guenter Hanisch

Dr Kurt Kraft

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott GmbH and Co KG

Original Assignee

Knoll GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1940-08-18

Filing date

1940-08-18

Publication date

1942-12-07

1940-08-18 Application filed by Knoll GmbH filed Critical Knoll GmbH

1940-08-18 Priority to DEK158476D priority Critical patent/DE728894C/de

1941-06-06 Priority to CH224790D priority patent/CH224790A/de

1941-06-13 Priority to DK62771D priority patent/DK62771C/da

1942-12-07 Application granted granted Critical

1942-12-07 Publication of DE728894C publication Critical patent/DE728894C/de

Status Expired legal-status Critical Current

Links

239000012141 concentrate Substances 0.000 title claims description 9
ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 title claims description 7
229940042585 tocopherol acetate Drugs 0.000 title claims description 7
ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 title claims description 6
238000000034 method Methods 0.000 title claims description 3
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 27
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 23
229930003427 Vitamin E Natural products 0.000 claims description 12
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 12
229940046009 vitamin E Drugs 0.000 claims description 12
239000011709 vitamin E Substances 0.000 claims description 12
235000019165 vitamin E Nutrition 0.000 claims description 12
239000003921 oil Substances 0.000 claims description 7
238000001816 cooling Methods 0.000 claims description 2
239000003153 chemical reaction reagent Substances 0.000 claims 1
238000007127 saponification reaction Methods 0.000 description 4
239000010497 wheat germ oil Substances 0.000 description 4
-1 sterol ester Chemical class 0.000 description 3
229940088594 vitamin Drugs 0.000 description 3
229930003231 vitamin Natural products 0.000 description 3
235000013343 vitamin Nutrition 0.000 description 3
239000011782 vitamin Substances 0.000 description 3
150000003722 vitamin derivatives Chemical class 0.000 description 3
229930182558 Sterol Natural products 0.000 description 2
239000013543 active substance Substances 0.000 description 2
235000013339 cereals Nutrition 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
239000000463 material Substances 0.000 description 2
238000000926 separation method Methods 0.000 description 2
239000007858 starting material Substances 0.000 description 2
235000003702 sterols Nutrition 0.000 description 2
239000000126 substance Substances 0.000 description 2
244000098338 Triticum aestivum Species 0.000 description 1
239000012670 alkaline solution Substances 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000004821 distillation Methods 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
150000002168 ethanoic acid esters Chemical class 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
238000010792 warming Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)

DEK158476D 1940-08-18 1940-08-18 Verfahren zur Gewinnung von Vitamin-E-Acetat-Konzentraten Expired DE728894C (de)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
DEK158476D DE728894C (de)	1940-08-18	1940-08-18	Verfahren zur Gewinnung von Vitamin-E-Acetat-Konzentraten
CH224790D CH224790A (de)	1940-08-18	1941-06-06	Verfahren zur Gewinnung von Vitamin-E-ester-Konzentraten.
DK62771D DK62771C (da)	1940-08-18	1941-06-13	Fremgangsmaade til Fremstilling af Koncentrater af Ester med Vitamin-E-Virkning.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DEK158476D DE728894C (de)	1940-08-18	1940-08-18	Verfahren zur Gewinnung von Vitamin-E-Acetat-Konzentraten

Publications (1)

Publication Number	Publication Date
DE728894C true DE728894C (de)	1942-12-07

Family

ID=7253887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DEK158476D Expired DE728894C (de)	1940-08-18	1940-08-18	Verfahren zur Gewinnung von Vitamin-E-Acetat-Konzentraten

Country Status (3)

Country	Link
CH (1)	CH224790A (da)
DE (1)	DE728894C (da)
DK (1)	DK62771C (da)

1940
- 1940-08-18 DE DEK158476D patent/DE728894C/de not_active Expired
1941
- 1941-06-06 CH CH224790D patent/CH224790A/de unknown
- 1941-06-13 DK DK62771D patent/DK62771C/da active

Also Published As

Publication number	Publication date
CH224790A (de)	1942-12-15
DK62771C (da)	1944-10-09

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