DK0400916T3 - 4,5,6,11-Tetrahydrobenzo(6,7)-cycloocta(1,2-b)-thiophen-6,11-iminer og 6,11-dihydrobenzo(6,7)- cycloocta(1,2-b)thiophen-6,11 iminer - Google Patents

4,5,6,11-Tetrahydrobenzo(6,7)-cycloocta(1,2-b)-thiophen-6,11-iminer og 6,11-dihydrobenzo(6,7)- cycloocta(1,2-b)thiophen-6,11 iminer

Info

Publication number: DK0400916T3
Authority: DK; Denmark
Prior art keywords: cycloocta; imines; thiophene; compounds; alkyl
Prior art date: 1989-06-01

Application number

DK90305716.4T

Other languages

English (en)

Inventor

Ralph P Robinson

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-01

Filing date

1990-05-25

Publication date

1994-12-05

1990-05-25 Application filed by Pfizer filed Critical Pfizer

1994-12-05 Application granted granted Critical

1994-12-05 Publication of DK0400916T3 publication Critical patent/DK0400916T3/da

Links

150000002466 imines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
201000006474 Brain Ischemia Diseases 0.000 abstract 1
206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
208000031124 Dementia Alzheimer type Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
206010008118 cerebral infarction Diseases 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000003961 neuronal insult Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Luminescent Compositions (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK90305716.4T 1989-06-01 1990-05-25 4,5,6,11-Tetrahydrobenzo(6,7)-cycloocta(1,2-b)-thiophen-6,11-iminer og 6,11-dihydrobenzo(6,7)- cycloocta(1,2-b)thiophen-6,11 iminer DK0400916T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/002387 WO1990015060A1 (en)	1989-06-01	1989-06-01	4,5,6,11-TETRAHYDROBENZO[6,7]CYCLOOCTA[1,2-b]THIOPHEN-6,11-IMINES AND 6,11-DIHYDROBENZO[6,7]CYCLOOCTA[1,2-b]THIOPHEN-6,11-IMINES

Publications (1)

Publication Number	Publication Date
DK0400916T3 true DK0400916T3 (da)	1994-12-05

Family

ID=22215050

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90305716.4T DK0400916T3 (da)	1989-06-01	1990-05-25	4,5,6,11-Tetrahydrobenzo(6,7)-cycloocta(1,2-b)-thiophen-6,11-iminer og 6,11-dihydrobenzo(6,7)- cycloocta(1,2-b)thiophen-6,11 iminer

Country Status (11)

Country	Link
EP (1)	EP0400916B1 (da)
JP (1)	JPH0662630B2 (da)
AT (1)	ATE113950T1 (da)
CA (1)	CA2017911A1 (da)
DE (1)	DE69013983T2 (da)
DK (1)	DK0400916T3 (da)
ES (1)	ES2063266T3 (da)
FI (1)	FI98462C (da)
IE (1)	IE64909B1 (da)
PT (1)	PT94205B (da)
WO (1)	WO1990015060A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5196415A (en) *	1989-05-09	1993-03-23	The United States Of America As Represented By The Department Of Health And Human Services	5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treatment of epilepsy and cocaine addiction
US5260309A (en) *	1989-06-01	1993-11-09	Pfizer Inc.	4,5,6,11-tetrahydrobenzo [6,7] cycloocta [1,2-b]thiophen-6,11-imines and 6,11-dihydrobenzo [6,7] cycloocta [1,2-b] thiophen-6,11-imines
GB9002834D0 (en) *	1990-02-08	1990-04-04	Ici America Inc	Compounds
US6413410B1 (en)	1996-06-19	2002-07-02	Lifescan, Inc.	Electrochemical cell

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3816455A (en) *	1971-04-23	1974-06-11	Mcneilab Inc	Certain benzothiepino-indoles and indoline-thiochromans
US4112110A (en) *	1974-02-22	1978-09-05	Ciba-Geigy Corporation	Oxygenated azatetracyclic compounds
NL7808848A (nl) *	1977-09-19	1979-03-21	Merck & Co Inc	Dibenzoa.dcyclo-octeen-5.12-(en 6.12)-iminen.
US4414154A (en) *	1977-09-19	1983-11-08	Merck & Co. Inc.	Dibenzo[a,d]cycloocten-5,12-imines
US4252810A (en) *	1978-11-15	1981-02-24	Merck & Co., Inc.	9,10-Dihydro-4H-benzo[4,5]cyclohepta [1,2-b]thiophen-4,9-imines

1989
- 1989-06-01 WO PCT/US1989/002387 patent/WO1990015060A1/en not_active Ceased
1990
- 1990-05-25 DK DK90305716.4T patent/DK0400916T3/da active
- 1990-05-25 DE DE69013983T patent/DE69013983T2/de not_active Expired - Fee Related
- 1990-05-25 EP EP90305716A patent/EP0400916B1/en not_active Expired - Lifetime
- 1990-05-25 ES ES90305716T patent/ES2063266T3/es not_active Expired - Lifetime
- 1990-05-25 AT AT90305716T patent/ATE113950T1/de not_active IP Right Cessation
- 1990-05-30 PT PT94205A patent/PT94205B/pt not_active IP Right Cessation
- 1990-05-30 CA CA002017911A patent/CA2017911A1/en not_active Abandoned
- 1990-05-31 IE IE195190A patent/IE64909B1/en unknown
- 1990-06-01 JP JP2145258A patent/JPH0662630B2/ja not_active Expired - Lifetime
1991
- 1991-11-29 FI FI915646A patent/FI98462C/fi active

Also Published As

Publication number	Publication date
WO1990015060A1 (en)	1990-12-13
ATE113950T1 (de)	1994-11-15
FI98462C (fi)	1997-06-25
PT94205B (pt)	1997-01-31
FI98462B (fi)	1997-03-14
DE69013983T2 (de)	1995-03-16
CA2017911A1 (en)	1990-12-01
DE69013983D1 (de)	1994-12-15
FI915646A0 (fi)	1991-11-29
EP0400916A3 (en)	1991-11-27
JPH0662630B2 (ja)	1994-08-17
ES2063266T3 (es)	1995-01-01
IE901951L (en)	1990-12-01
PT94205A (pt)	1991-02-08
JPH0320278A (ja)	1991-01-29
EP0400916B1 (en)	1994-11-09
IE64909B1 (en)	1995-09-20
EP0400916A2 (en)	1990-12-05

Publication	Publication Date	Title
ES2132284T3 (es)	1999-08-16	Derivados de carbamato de 2-(piperidin-4-il, piridin-4-il y tetrahidropiridin-4-il)-benzofurano-7, su preparacion y su uso como inhibidores de acetilcolinesterasa.
DE69008142D1 (de)	1994-05-19	4-Substituierten Imidazolen zur Senkung des intraokularen Druckes.
MX13270A (es)	1993-06-01	Procedimiento para la preparacion de derivados de 4-aminopiridina
DK213290D0 (da)	1990-09-06	Treatment of cerebrovascular disorders
NO905172D0 (no)	1990-11-29	Aminokarbonylkarbamater beslektet med fysostigmin og fremgangsmaate for fremstilling derav.
DK0400916T3 (da)	1994-12-05	4,5,6,11-Tetrahydrobenzo(6,7)-cycloocta(1,2-b)-thiophen-6,11-iminer og 6,11-dihydrobenzo(6,7)- cycloocta(1,2-b)thiophen-6,11 iminer
FI900365A0 (fi)	1990-01-24	Menetelmä terapeuttisesti käyttökelpoisten 3-fenyyli-5,6-dihydrobents/C/akridiini-7-karboksyylihappojohdannnaisten valmistamiseksi
BR9502079A (pt)	1996-03-05	Composto,formulação farmaceutica e processo para preparar um composto
ZA891769B (en)	1989-12-27	Heterocyclic compounds
PT87005A (pt)	1988-04-01	Process for preparing n-phenethylaminoalkyl-benzamide anti-arrhythmic agents
DK0420224T3 (da)	1993-04-05	Anthihepatopatisk middel
ATE283269T1 (de)	2004-12-15	5-(heteroaryl)alkyl)-3-oxo-pyrido(1,2- a)benzimidazol-4-carboxamid (pbi) derivate zur behandlung von störungen des zentralen nervensystems
BR9902049A (pt)	2000-05-02	Derivados 9a,11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina.
DE68909961D1 (de)	1993-11-25	2-Aminoacetamid Derivate.
IT1274040B (it)	1997-07-14	Composizioni farmaceutiche per la prevenzione e/o il trattamento di disturbi gastrointestinali inclusa l'ulcera