DK0401049T3 - Beta-lactam elastase inhibitorer - Google Patents

Beta-lactam elastase inhibitorer

Info

Publication number: DK0401049T3
Authority: DK; Denmark
Prior art keywords: lower alkyl; compounds; sec; oxycarbonyl; hydrogen
Prior art date: 1989-06-01

Application number

DK90306030.9T

Other languages

English (en)

Inventor

Robert A Volkmann

V John Jasys

Michael S Kellog

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-01

Filing date

1990-06-01

Publication date

1994-09-19

1990-06-01 Application filed by Pfizer filed Critical Pfizer

1994-09-19 Application granted granted Critical

1994-09-19 Publication of DK0401049T3 publication Critical patent/DK0401049T3/da

Links

239000003602 elastase inhibitor Substances 0.000 title 1
150000003952 β-lactams Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 8
150000001875 compounds Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
102000016387 Pancreatic elastase Human genes 0.000 abstract 1
108010067372 Pancreatic elastase Proteins 0.000 abstract 1
208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 1
208000011341 adult acute respiratory distress syndrome Diseases 0.000 abstract 1
201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
-1 beta lactam compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK90306030.9T 1989-06-01 1990-06-01 Beta-lactam elastase inhibitorer DK0401049T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/359,548 US5132300A (en)	1989-06-01	1989-06-01	Beta-lactam elastase inhibitors

Publications (1)

Publication Number	Publication Date
DK0401049T3 true DK0401049T3 (da)	1994-09-19

Family

ID=23414295

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90306030.9T DK0401049T3 (da)	1989-06-01	1990-06-01	Beta-lactam elastase inhibitorer

Country Status (11)

Country	Link
US (1)	US5132300A (da)
EP (1)	EP0401049B1 (da)
JP (1)	JPH0780891B2 (da)
AT (1)	ATE110388T1 (da)
CA (1)	CA2017920C (da)
DE (1)	DE69011747T2 (da)
DK (1)	DK0401049T3 (da)
ES (1)	ES2060042T3 (da)
FI (1)	FI96314C (da)
IE (1)	IE64767B1 (da)
PT (1)	PT94243B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW383308B (en) *	1993-08-24	2000-03-01	Hoffmann La Roche	2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
US5474993A (en) *	1994-06-14	1995-12-12	Sterling Winthrop, Inc.	Lactam inhibitors of cholesterol esterase
US7504228B2 (en) *	2001-06-05	2009-03-17	Qlt Inc.	Integrin linked kinase modulation of monocyte activation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4493839A (en) *	1982-05-24	1985-01-15	Merck & Co., Inc.	1-Carbapenem-3-carboxylic esters as anti-inflammatory agents
US4797396A (en) *	1984-07-02	1989-01-10	Merck & Co., Inc.	β-Lactam derivatives as anti-inflammatory and antidegenerative agents
US4847247A (en) *	1984-07-30	1989-07-11	Merck & Co., Inc.	Penicillin derivatives as anti-inflammatory and antidegenerative agents
DE3779856T2 (de) *	1986-10-16	1993-03-25	Merck & Co Inc	Antibakterielle, 2-substituierte alkyl-carbapeneme.

1989
- 1989-06-01 US US07/359,548 patent/US5132300A/en not_active Expired - Lifetime
1990
- 1990-05-30 CA CA002017920A patent/CA2017920C/en not_active Expired - Fee Related
- 1990-06-01 FI FI902725A patent/FI96314C/fi active IP Right Grant
- 1990-06-01 ES ES90306030T patent/ES2060042T3/es not_active Expired - Lifetime
- 1990-06-01 PT PT94243A patent/PT94243B/pt not_active IP Right Cessation
- 1990-06-01 DK DK90306030.9T patent/DK0401049T3/da active
- 1990-06-01 EP EP90306030A patent/EP0401049B1/en not_active Expired - Lifetime
- 1990-06-01 JP JP2145259A patent/JPH0780891B2/ja not_active Expired - Fee Related
- 1990-06-01 AT AT90306030T patent/ATE110388T1/de not_active IP Right Cessation
- 1990-06-01 IE IE196490A patent/IE64767B1/en not_active IP Right Cessation
- 1990-06-01 DE DE69011747T patent/DE69011747T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0401049A2 (en)	1990-12-05
ES2060042T3 (es)	1994-11-16
DE69011747D1 (de)	1994-09-29
FI96314B (fi)	1996-02-29
DE69011747T2 (de)	1994-12-22
JPH0381279A (ja)	1991-04-05
US5132300A (en)	1992-07-21
ATE110388T1 (de)	1994-09-15
PT94243B (pt)	1997-01-31
CA2017920C (en)	1999-07-06
FI96314C (fi)	1996-06-10
IE64767B1 (en)	1995-09-06
CA2017920A1 (en)	1990-12-01
IE901964L (en)	1990-12-01
PT94243A (pt)	1991-02-08
FI902725A0 (fi)	1990-06-01
EP0401049B1 (en)	1994-08-24
EP0401049A3 (en)	1991-12-27
JPH0780891B2 (ja)	1995-08-30

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