DK0420332T3 - Fremgangsmåde til bestemmelse af det endogene trombinpotentiale af plasma og blod, samt et kit til anvendelse ved fremgangsmåden - Google Patents

Fremgangsmåde til bestemmelse af det endogene trombinpotentiale af plasma og blod, samt et kit til anvendelse ved fremgangsmåden

Info

Publication number
DK0420332T3
DK0420332T3 DK90202509.7T DK90202509T DK0420332T3 DK 0420332 T3 DK0420332 T3 DK 0420332T3 DK 90202509 T DK90202509 T DK 90202509T DK 0420332 T3 DK0420332 T3 DK 0420332T3
Authority
DK
Denmark
Prior art keywords
thrombin
etp
determining
sample
conversion
Prior art date
Application number
DK90202509.7T
Other languages
English (en)
Inventor
Hendrik Coenraad Hemker
Suzette Lucette Beguin
Original Assignee
Hendrik Coenraad Hemker
Suzette Lucette Beguin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hendrik Coenraad Hemker, Suzette Lucette Beguin filed Critical Hendrik Coenraad Hemker
Application granted granted Critical
Publication of DK0420332T3 publication Critical patent/DK0420332T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK90202509.7T 1989-09-27 1990-09-21 Fremgangsmåde til bestemmelse af det endogene trombinpotentiale af plasma og blod, samt et kit til anvendelse ved fremgangsmåden DK0420332T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8902406A NL8902406A (nl) 1989-09-27 1989-09-27 Werkwijze voor het bepalen van de endogene trombinepotentiaal van plasma, en bloed alsmede een bij deze werkwijze te gebruiken kit.

Publications (1)

Publication Number Publication Date
DK0420332T3 true DK0420332T3 (da) 1995-07-03

Family

ID=19855364

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90202509.7T DK0420332T3 (da) 1989-09-27 1990-09-21 Fremgangsmåde til bestemmelse af det endogene trombinpotentiale af plasma og blod, samt et kit til anvendelse ved fremgangsmåden

Country Status (8)

Country Link
US (1) US5192689A (da)
EP (1) EP0420332B1 (da)
JP (1) JP3137261B2 (da)
AT (1) ATE121792T1 (da)
DE (1) DE69018910T2 (da)
DK (1) DK0420332T3 (da)
ES (1) ES2072970T3 (da)
NL (1) NL8902406A (da)

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CA2070813C (en) * 1990-11-05 1996-10-29 Hendrik Coenraad Hemker A method to determine the concentration of anticoagulants
DE4203980A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren
AT397391B (de) * 1992-05-15 1994-03-25 Immuno Ag Verwendung von prothrombinfragmenten
EP0585504A1 (en) * 1992-09-04 1994-03-09 Pentapharm A.G. Phospholipid dependant prothrombin activator and its use in lupus anticoagulant testing
DE69615339T2 (de) * 1995-01-10 2002-07-04 Hemker, Hendrik Coenraad Verfahren zum nachweis des endogenen thrombin-potentials und thrombin substrate zur verwendung in diesen verfahren
DE19533817C2 (de) * 1995-09-13 1999-12-09 Max Planck Gesellschaft Komplex-gebundene Hemmstoffe aktivierbarer Stoffwechselenzyme als molekulare Marker zur Diagnostik und Therapieüberwachung
SE9600216D0 (sv) * 1996-01-18 1996-01-18 Hans Arne Hansson Styrning av läkningsprocesser
DE19904674A1 (de) * 1999-02-04 2000-08-31 Haemosys Gmbh Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren
US6740496B1 (en) 1999-03-04 2004-05-25 Synapse B.V. Determination of biologically active forms of proteolytic enzymes
AUPP971299A0 (en) 1999-04-12 1999-05-06 South Eastern Sydney Area Health Service Procoagulant assay
US6743596B1 (en) 2000-10-27 2004-06-01 Biomerieux, Inc. Method of determining global coagulability hemostatic potential
US6645768B1 (en) * 2000-10-27 2003-11-11 Biomerieux, Inc. Reagent and kit for determining global coagulability and hemostatic potential
EP1367135A1 (en) * 2002-05-29 2003-12-03 Pentapharm AG Improved method for the assessment of thrombin formation in blood or plasma
DE10360628A1 (de) * 2003-12-19 2005-07-21 Dade Behring Marburg Gmbh Kontrollplasma für Thrombinaktivitätstests
GB0402719D0 (en) * 2004-02-07 2004-03-10 Royal College Of Surgeons Ie A method of detecting incomplete inhibition of enzymes in individuals undergoing enzyme inhibitor therapy
CA2566411A1 (en) * 2004-05-11 2005-11-24 Heptest Laboratories, Inc. Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
DE102004059055A1 (de) 2004-12-07 2006-06-08 Dade Behring Marburg Gmbh Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials
ES2357112T3 (es) 2005-01-07 2011-04-18 Stichting Katholieke Universiteit Ensayo de hemostasia.
DE102005003145B4 (de) 2005-01-21 2006-10-19 Dade Behring Marburg Gmbh Stablies, chromogenes Flüssigreagenz und dessen Verwendung in gerinnungsdiagnostischen Tests
US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
DE102005008066A1 (de) 2005-02-22 2006-08-24 Haemosys Gmbh Verfahren zur Bestimmung der Gesamtgerinnungsaktivität einer Blut- oder Plasmaprobe
EP1869082B1 (en) * 2005-03-04 2011-04-13 The Board Of Trustees Of The University Of Illinois Coagulation and fibrinolytic cascades modulator
US8138308B2 (en) 2005-12-27 2012-03-20 Mcmaster University Modified peptide substrate
US9091700B2 (en) 2005-12-27 2015-07-28 Mcmaster University Modified peptide substrate
DE102006035899A1 (de) 2006-07-31 2008-02-07 Dade Behring Marburg Gmbh Polysacharid-Peptid-Konjugate zur Verwendung als Thrombinsubstrate
CN101221188B (zh) * 2007-01-12 2012-04-18 上海太阳生物技术有限公司 临床检验凝血酶时间(tt)测定体外诊断试剂盒
DE102007017906A1 (de) 2007-04-17 2008-10-23 Dade Behring Marburg Gmbh Verfahren zur Bestimmung der Reaktions-Lag-Phase in einer analytabhängigen Reaktion
RU2377246C2 (ru) * 2007-06-08 2009-12-27 Государственное учреждение гематологический научный центр Российской академии медицинских наук (ГУ ГНЦ РАМН) Синтетическое производное пептида, проявляющее антикоагулянтную активность
WO2009046194A2 (en) * 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
US20100297257A1 (en) * 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
DE102007062323A1 (de) 2007-12-21 2009-06-25 Siemens Healthcare Diagnostics Products Gmbh Langzeitstabiles Thromboplastin-Reagenz
US20090298103A1 (en) * 2008-05-20 2009-12-03 The University Of Vermont And State Agriculture College Predicting hemostatic risk; dependence on plasma composition
US8293493B2 (en) * 2010-01-27 2012-10-23 Adventist Health System/Sunbelt, Inc. Thrombin generation determination method
EP2395354A1 (de) 2010-06-10 2011-12-14 Siemens Healthcare Diagnostics Products GmbH Homogener Aktivitätstest zur Bestimmung von enzymatischen Reaktionen
CA2811822C (en) * 2010-09-20 2019-12-03 Q-Sera Pty Ltd Serum preparation
EP3228714B1 (en) 2010-12-14 2019-03-27 Stichting Katholieke Universiteit Chemiluminescence-based haemostasis assay
US9561300B2 (en) 2011-09-26 2017-02-07 Yes, Inc. Hemostatic compositions and dressings for bleeding
WO2013056116A1 (en) * 2011-10-12 2013-04-18 The Trustees Of Columbia University In The City Of New York Hemostatic dressing for arterial bleeding
EP2677037B1 (en) 2012-06-21 2016-04-13 Synapse B.V. Simultaneous measurement of thrombin generation and clot strength in plasma and whole blood
WO2014098056A1 (ja) 2012-12-18 2014-06-26 第一三共株式会社 トロンビン産生の測定方法
US9989532B2 (en) * 2013-07-26 2018-06-05 The University Of North Carolina At Chapel Hill Methods and compositions for detecting coagulation inhibitors
EP3388838B1 (en) 2016-01-29 2022-02-16 Sony Group Corporation Blood coagulation analysis
JP2020524283A (ja) 2017-06-20 2020-08-13 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 急性非代償性心不全（ａｄｈｆ）患者が凝固亢進状態を示すかどうかを同定するための方法
EP3489692A1 (de) 2017-11-28 2019-05-29 Siemens Healthcare Diagnostics Products GmbH Prothrombinzeit-reagenz enthaltend einen eisenchelator
EP4004560A4 (en) 2019-07-31 2022-11-30 Tel Hashomer Medical Research Infrastructure And Services Ltd. METHODS AND KITS FOR IDENTIFYING THE ORIGIN OF A THROMBUS AND OPTIMIZING TREATMENT AFTER AN ISCHEMIC EVENT
WO2022133109A1 (en) * 2020-12-16 2022-06-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating and preventing venom related poisoning
EP4239338A1 (de) 2022-03-03 2023-09-06 Siemens Healthcare Diagnostics Products GmbH Globaltest zur feststellung des status des blutgerinnungssystems
CN117143179B (zh) * 2023-09-18 2024-07-12 安徽峆一药业股份有限公司 一种凝血酶发色底物s-2238的合成方法

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US4247454A (en) * 1975-07-11 1981-01-27 Ab Kabi Novel chromogenic thrombin substrates
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
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US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
WO1982001377A1 (en) * 1980-10-09 1982-04-29 Lill Helmut Method for determining a bm-antithrombin
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
US4594326A (en) * 1983-05-09 1986-06-10 Wade Stephen E Time-integrated measurement for determining substances in biological fluids
DE3407280A1 (de) * 1984-02-28 1985-09-19 Gödecke AG, 1000 Berlin Testsatz zur bestimmung der aktivierten partiellen thromboplastinzeit (ptt) mit erhoehter heparinempfindlichkeit
US4851336A (en) * 1985-09-05 1989-07-25 Yin E Thye Composition, kit, and method for assaying heparinano a method for making the composition

Also Published As

Publication number Publication date
JPH03236798A (ja) 1991-10-22
JP3137261B2 (ja) 2001-02-19
DE69018910T2 (de) 1995-08-24
ES2072970T3 (es) 1995-08-01
EP0420332A3 (en) 1991-05-08
ATE121792T1 (de) 1995-05-15
DE69018910D1 (de) 1995-06-01
EP0420332B1 (en) 1995-04-26
NL8902406A (nl) 1991-04-16
EP0420332A2 (en) 1991-04-03
US5192689A (en) 1993-03-09

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