DK0422566T3 - Fremgangsmåde til fremstilling af 3-(L-pyroglutamyl)-L-thiazolidin-4-carboxylsyre og derivater deraf - Google Patents

Fremgangsmåde til fremstilling af 3-(L-pyroglutamyl)-L-thiazolidin-4-carboxylsyre og derivater deraf

Info

Publication number: DK0422566T3
Authority: DK; Denmark
Prior art keywords: derivatives; thiazolidine; carboxylic acid; pyroglutamyl; preparation
Prior art date: 1989-10-12

Application number

DK90119271.6T

Other languages

English (en)

Inventor

Stefano Poli

Corona Lucio Del

Original Assignee

Poli Ind Chimica Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-12

Filing date

1990-10-08

Publication date

1995-06-26

1990-10-08 Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa

1995-06-26 Application granted granted Critical

1995-06-26 Publication of DK0422566T3 publication Critical patent/DK0422566T3/da

Links

-1 L-pyroglutamyl Chemical group 0.000 title 1
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 2
ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical class OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Thiazole And Isothizaole Compounds (AREA)

DK90119271.6T 1989-10-12 1990-10-08 Fremgangsmåde til fremstilling af 3-(L-pyroglutamyl)-L-thiazolidin-4-carboxylsyre og derivater deraf DK0422566T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT22003A IT1239029B (it)	1989-10-12	1989-10-12	Processo per la preparazione dell'acido 3-(l-piroglutamil)-l- tiazolidin-4-carbossilico e suoi derivati.

Publications (1)

Publication Number	Publication Date
DK0422566T3 true DK0422566T3 (da)	1995-06-26

Family

ID=11190043

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90119271.6T DK0422566T3 (da)	1989-10-12	1990-10-08	Fremgangsmåde til fremstilling af 3-(L-pyroglutamyl)-L-thiazolidin-4-carboxylsyre og derivater deraf

Country Status (18)

Country	Link
US (1)	US5110936A (da)
EP (1)	EP0422566B1 (da)
JP (1)	JP2813450B2 (da)
KR (1)	KR100195895B1 (da)
AT (1)	ATE121420T1 (da)
AU (1)	AU644379B2 (da)
CA (1)	CA2027341C (da)
DE (2)	DE422566T1 (da)
DK (1)	DK0422566T3 (da)
ES (1)	ES2028766T3 (da)
FI (1)	FI95271C (da)
GR (1)	GR910300072T1 (da)
HU (1)	HU210213B (da)
IE (1)	IE67047B1 (da)
IL (1)	IL95949A (da)
IT (1)	IT1239029B (da)
NO (1)	NO178028C (da)
ZA (1)	ZA908097B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1230706B (it) *	1989-02-10	1991-10-29	Poli Ind Chimica Spa	Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
IT1237998B (it) *	1990-01-23	1993-06-21	Poli Ind Chimica Spa	Acido 3-l-(5-tioxo-l-prolil)tiazolidin-4-carbossilico e derivati, loro preparazione e composizioni farmaceutiche che li contengono
IT1270017B (it) *	1994-09-27	1997-04-16	Poli Ind Chimica Spa	"sintesi quantitativa dell'acido 3-(l-piroglutamil)-l-tiazolidin-4- carbossilico e suoi derivati"
EP0929535A4 (en) *	1996-09-06	2001-05-23	Lilly Co Eli	PROCESS AND NEW INTERMEDIATES
US8404804B2 (en) *	2007-08-28	2013-03-26	Ipsen Pharma S.A.S.	Methods and intermediates for chemical synthesis of polypeptides and proteins
CN102167727B (zh) *	2011-01-29	2013-05-15	浙江金立源药业有限公司	一种匹多莫德的合成方法
WO2016112977A1 (en)	2015-01-15	2016-07-21	Polichem S.A.	Di-pidotimod benzathine and solid forms thereof
KR101642445B1 (ko) *	2016-01-11	2016-07-26	(주)남양통신	수상태양광 발전장치용 계류장치
CN107383162A (zh) *	2017-07-06	2017-11-24	成都美域高制药有限公司	一种匹多莫德的制备方法
CN108640912A (zh) *	2018-06-19	2018-10-12	广州大光制药有限公司	一种匹多莫德的工业化规模制备方法
CN111233854A (zh) *	2019-12-30	2020-06-05	常州寅盛药业有限公司	一种匹多莫德杂质的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1202426B (it) *	1987-01-26	1989-02-09	Poli Ind Chimica Spa	Derivato di acido tiazolidin-4-carbossilico,sua preparazione e composizioni farmaceutiche che lo contengono

1989
- 1989-10-12 IT IT22003A patent/IT1239029B/it active IP Right Grant
1990
- 1990-10-08 DE DE199090119271T patent/DE422566T1/de active Pending
- 1990-10-08 AT AT90119271T patent/ATE121420T1/de not_active IP Right Cessation
- 1990-10-08 EP EP90119271A patent/EP0422566B1/en not_active Expired - Lifetime
- 1990-10-08 IE IE359990A patent/IE67047B1/en not_active IP Right Cessation
- 1990-10-08 ES ES90119271T patent/ES2028766T3/es not_active Expired - Lifetime
- 1990-10-08 DK DK90119271.6T patent/DK0422566T3/da active
- 1990-10-08 DE DE69018755T patent/DE69018755T2/de not_active Expired - Fee Related
- 1990-10-09 ZA ZA908097A patent/ZA908097B/xx unknown
- 1990-10-09 US US07/594,313 patent/US5110936A/en not_active Expired - Lifetime
- 1990-10-10 IL IL9594990A patent/IL95949A/en not_active IP Right Cessation
- 1990-10-10 KR KR1019900015999A patent/KR100195895B1/ko not_active Expired - Lifetime
- 1990-10-11 AU AU64521/90A patent/AU644379B2/en not_active Ceased
- 1990-10-11 FI FI905011A patent/FI95271C/fi active IP Right Grant
- 1990-10-11 CA CA002027341A patent/CA2027341C/en not_active Expired - Fee Related
- 1990-10-11 HU HU906417A patent/HU210213B/hu not_active IP Right Cessation
- 1990-10-11 NO NO904404A patent/NO178028C/no unknown
- 1990-10-12 JP JP2275100A patent/JP2813450B2/ja not_active Expired - Fee Related
1991
- 1991-11-15 GR GR91300072T patent/GR910300072T1/el unknown

Also Published As

Publication number	Publication date
CA2027341A1 (en)	1991-04-13
DE422566T1 (de)	1991-09-05
HU906417D0 (en)	1991-04-29
GR910300072T1 (en)	1991-11-15
IT8922003A0 (it)	1989-10-12
AU6452190A (en)	1991-04-18
NO178028B (no)	1995-10-02
DE69018755T2 (de)	1995-08-24
FI95271B (fi)	1995-09-29
AU644379B2 (en)	1993-12-09
KR910007923A (ko)	1991-05-30
HU210213B (en)	1995-02-28
NO178028C (no)	1996-01-10
FI95271C (fi)	1996-01-10
IT1239029B (it)	1993-09-20
IL95949A (en)	1995-10-31
EP0422566A1 (en)	1991-04-17
FI905011A0 (fi)	1990-10-11
US5110936A (en)	1992-05-05
ATE121420T1 (de)	1995-05-15
JP2813450B2 (ja)	1998-10-22
CA2027341C (en)	2007-10-02
NO904404D0 (no)	1990-10-11
IE903599A1 (en)	1991-04-24
DE69018755D1 (de)	1995-05-24
JPH03193799A (ja)	1991-08-23
NO904404L (no)	1991-04-15
HUT59136A (en)	1992-04-28
ZA908097B (en)	1991-08-28
ES2028766T1 (es)	1992-07-16
IL95949A0 (en)	1991-07-18
IE67047B1 (en)	1996-02-21
EP0422566B1 (en)	1995-04-19
KR100195895B1 (ko)	1999-06-15
IT8922003A1 (it)	1991-04-12
ES2028766T3 (es)	1995-07-01

Similar Documents

Publication	Publication Date	Title
NL300181I1 (nl)	2005-05-02	N-(pyrroloÄ2,3-dÜpyrimidine-3-ylacyl)-glutaminezuurderivaten.
IT8720059A0 (it)	1987-04-10	Process per la preparazione di (2,2)-paraciclofano e suoi derivati.
NO903757L (no)	1991-03-01	Kitin.kitosan-oligomer med 2,5-anhydromannitol endegruppeeller 2,5-anhydromannose endegruppe og fremgangsmaate til fremstilling derav.
NO902750D0 (no)	1990-06-20	Fremgangsmaate til fremstilling av 3,5,6-substituerte derivater av 1,2-0-isopropyliden-alfa-glukofuranose og mellomprodukter for fremstilling av derivatene.
NO911432L (no)	1991-10-14	Fremgangsmaate for fremstilling av 3,5-disubstituerte 2-isoksazoliner og isoksazoler.
NO871052D0 (no)	1987-03-13	1,1-disubstituerte cyklopropanderivater, fremgangsmaate til deres fremstilling og deres anvendelse.
NO900309L (no)	1990-07-25	Benzocykloalkenyldihydroksyalkansyrederivater, og fremgangsmaate til fremstilling derav.
IL95949A0 (en)	1991-07-18	Process for the preparation of 3-(l-pyroglutamyl)-l-thiazolidine-4-carboxylic acid and its derivatives
DK0557199T3 (da)	2002-04-29	Polyethylenglycol-hirudin-konjugater, fremgangsmåde til fremstilling deraf og anvendelse deraf til behandling af tromboser
NO953321D0 (no)	1995-08-24	2,3 cyklisk kondenserte 1,4-dihydropyridiner, fremgangsmåte for fremstilling derav og deres anvendelse som legemidler
NO900643L (no)	1990-08-13	Fremgangsmaate for fremstilling og anvendelse av 2,3,23-trihydroksi-urs-12-ener og deres derivater.
IT8919524A0 (it)	1989-02-22	Derivati dal 1 arilsolfonil 2 piperidone, loro procedimento di preparazione e loro impiego come farmaci.
DK0492667T3 (da)	1996-07-08	1,4-Benzothiazin-2-eddikesyrederivater, fremgangsmåder til fremstilling deraf og anvendelse deraf
NO893623D0 (no)	1989-09-08	Mikrobiologisk fremgangsmaate ved fremstilling av agrarkjemisk anvendelige virkestoffer.
NO903338L (no)	1991-01-29	Fremgangsmaate for mikrobiologisk fremstilling av l-carnitin.
DK0538690T3 (da)	1995-03-06	Arylquinolyl-substituerede 1,4-dihydropyridin-dicarboxylsyrederivater, fremgangsmåde til deres fremstilling af deres anvendelse i lægemidler
DK0519512T3 (da)	1996-03-18	Mikrobiologisk fremgangsmåde til fremstilling af 5-hydroxypyrazincarboxylsyre
FI853164A7 (fi)	1986-02-25	Menetelmä optisesti aktiivisten, substituoitujen 1,4-dihydropyridiinien valmistamiseksi ja niiden käyttö lääkeaineina.
DK156436C (da)	1990-01-22	Analogifremgangsmaade til fremstilling af 6,6'methyl-bis-(2,2,4-trimethyl-1,2-dihydroquinolin)-derivater og kondensationsprodukter deraf
DK0393530T3 (da)	1995-05-22	5,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oner og -thioner og deres anvendelse til forebyggelse eller behandling af AIDS
NO872885L (no)	1988-01-18	1,3,5-tritianderivater og fremgangsmte for deres fremstilling.
FI901922A0 (fi)	1990-04-17	Tiazetokinolin-3-karboxylsyraderivat, foerfarande foer deras framstaellning, och en farmaceutisk komposition innehaollande dessa derivat.
NO891987D0 (no)	1989-05-18	Fremgangsmaate for fremstilling av n-substituerte fenyltioaniliner, fenylsulfinylaniliner og fenylsulfonylaniliner.
FI873699A7 (fi)	1988-02-29	Urdamysiini G ja sen johdannaiset, niiden valmistusmenetelmiä ja niiden käyttö.
FI890277A0 (fi)	1989-01-19	Tetrahydropyridinderivat.