DK0424248T3 - 20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf - Google Patents

20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf

Info

Publication number: DK0424248T3
Authority: DK; Denmark
Prior art keywords: optionally substituted; radical; carbon atoms; alkenyl; alkyl
Prior art date: 1989-10-17

Application number

DK90402898.2T

Other languages

English (en)

Inventor

Francois Clemence

Claude Oberlander

Jean-Luc Haesslein

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-17

Filing date

1990-10-16

Publication date

1996-03-04

1990-10-16 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1996-03-04 Application granted granted Critical

1996-03-04 Publication of DK0424248T3 publication Critical patent/DK0424248T3/da

Links

239000003814 drug Substances 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 2
229940079593 drug Drugs 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
238000006467 substitution reaction Methods 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 7
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 5
125000003342 alkenyl group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
ORTFAQDWJHRMNX-UHFFFAOYSA-M oxidooxomethyl Chemical compound [O-][C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-M 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK90402898.2T 1989-10-17 1990-10-16 20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf DK0424248T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8913544A FR2653124B1 (fr)	1989-10-17	1989-10-17	Nouveaux derives substitues en 15 de la 20, 21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant.

Publications (1)

Publication Number	Publication Date
DK0424248T3 true DK0424248T3 (da)	1996-03-04

Family

ID=9386471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90402898.2T DK0424248T3 (da)	1989-10-17	1990-10-16	20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf

Country Status (19)

Country	Link
US (1)	US6534515B2 (da)
EP (1)	EP0424248B1 (da)
JP (1)	JPH03133981A (da)
KR (1)	KR0180706B1 (da)
CN (1)	CN1040000C (da)
AT (1)	ATE132867T1 (da)
AU (1)	AU646817B2 (da)
CA (1)	CA2027724A1 (da)
DE (1)	DE69024745T2 (da)
DK (1)	DK0424248T3 (da)
ES (1)	ES2081957T3 (da)
FR (1)	FR2653124B1 (da)
GR (1)	GR3018736T3 (da)
HU (1)	HU218937B (da)
IE (1)	IE71209B1 (da)
MX (1)	MX22863A (da)
PT (1)	PT95600B (da)
RU (1)	RU2069663C1 (da)
ZA (1)	ZA907832B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2865650B1 (fr) *	2004-01-30	2008-06-13	Biocortech	Utilisation du 14,15 dihydro 20,21-dinoreburnamenin14-ol pour traiter et/ou prevenir les depressions majeures et les desordres du cycle veille-sommeil
FR2865649A1 (fr) *	2004-01-30	2005-08-05	Biocortech	Utilisation du 14,15-dihydro 20,21-dinoreburnamenin14-ol pour traiter et/ou prevenir les depressions majeures

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR22021E (fr) *	1919-12-30	1921-04-21	Dujardin Et Cie	Perfectionnements aux frappeurs pneumatiques
AU532001B2 (en) *	1978-11-20	1983-09-15	Sumitomo Chemical Company, Limited	Polycyclic indole derivatives
FR2514357A1 (fr) *	1981-10-08	1983-04-15	Roussel Uclaf	Nouveaux derives de 20,21-dinoreburnamenine eventuellement substitues sur le cycle e, procede de preparation et application comme medicaments
FR2623503B1 (da) *	1987-11-19	1991-04-05	Roussel Uclaf
FR2623501B1 (fr) *	1987-11-19	1990-03-16	Roussel Uclaf	Nouveaux derives substitues de 20,21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant

1989
- 1989-10-17 FR FR8913544A patent/FR2653124B1/fr not_active Expired - Fee Related
1990
- 1990-10-01 ZA ZA907832A patent/ZA907832B/xx unknown
- 1990-10-16 ES ES90402898T patent/ES2081957T3/es not_active Expired - Lifetime
- 1990-10-16 DE DE69024745T patent/DE69024745T2/de not_active Expired - Fee Related
- 1990-10-16 PT PT95600A patent/PT95600B/pt not_active IP Right Cessation
- 1990-10-16 IE IE370290A patent/IE71209B1/en not_active IP Right Cessation
- 1990-10-16 HU HU462/90A patent/HU218937B/hu not_active IP Right Cessation
- 1990-10-16 CA CA002027724A patent/CA2027724A1/fr not_active Abandoned
- 1990-10-16 AT AT90402898T patent/ATE132867T1/de not_active IP Right Cessation
- 1990-10-16 MX MX2286390A patent/MX22863A/es unknown
- 1990-10-16 DK DK90402898.2T patent/DK0424248T3/da active
- 1990-10-16 EP EP90402898A patent/EP0424248B1/fr not_active Expired - Lifetime
- 1990-10-17 AU AU64668/90A patent/AU646817B2/en not_active Ceased
- 1990-10-17 JP JP2276590A patent/JPH03133981A/ja active Pending
- 1990-10-17 KR KR1019900016818A patent/KR0180706B1/ko not_active Expired - Fee Related
- 1990-10-17 CN CN90108428A patent/CN1040000C/zh not_active Expired - Fee Related
1992
- 1992-01-22 RU SU5010658/04A patent/RU2069663C1/ru not_active IP Right Cessation
1994
- 1994-04-15 US US08/228,300 patent/US6534515B2/en not_active Expired - Fee Related
1996
- 1996-01-19 GR GR950401768T patent/GR3018736T3/el unknown

Also Published As

Publication number	Publication date
RU2069663C1 (ru)	1996-11-27
AU6466890A (en)	1991-04-26
ZA907832B (en)	1991-12-24
MX22863A (es)	1993-11-01
DE69024745T2 (de)	1996-11-14
DE69024745D1 (de)	1996-02-22
KR910007930A (ko)	1991-05-30
HUT55013A (en)	1991-04-29
EP0424248A3 (en)	1992-01-22
CA2027724A1 (fr)	1991-04-18
AU646817B2 (en)	1994-03-10
KR0180706B1 (ko)	1999-03-20
PT95600B (pt)	1997-08-29
FR2653124A1 (fr)	1991-04-19
HU906462D0 (en)	1991-04-29
CN1040000C (zh)	1998-09-30
GR3018736T3 (en)	1996-04-30
CN1051042A (zh)	1991-05-01
IE903702A1 (en)	1991-04-24
HU218937B (hu)	2001-01-29
JPH03133981A (ja)	1991-06-07
ATE132867T1 (de)	1996-01-15
US6534515B2 (en)	2003-03-18
EP0424248A2 (fr)	1991-04-24
PT95600A (pt)	1991-09-13
ES2081957T3 (es)	1996-03-16
EP0424248B1 (fr)	1996-01-10
IE71209B1 (en)	1997-02-12
US20020045637A1 (en)	2002-04-18
FR2653124B1 (fr)	1992-01-17

Publication	Publication Date	Title
DK436081A (da)	1982-04-04	Substituerede acyl-derivater af 1,2,3,4-tetrahydroisoquinolin-3-carboxylsyrer og farmaceutisk acceptable salte deraf fremgangsmaade til deres fremstilling og deres anvendelse
HUP0001192A2 (hu)	2000-11-28	Topiramát és származékainak alkalmazása elhízás kezelésére használható gyógyszerkészítmények előállítására
NO167088C (no)	1991-10-02	Nye 5-alkoxy-2,4 diaminoalkylbenzener saavel som haarfarvemiddel med 5-alkoxy-2,4-diamino-alkylbenzen.
YU89691A (sh)	1994-01-20	Postupak za dobijanje stereoselektivnih derivata fenilizoserina
NZ236605A (en)	1992-08-26	2-aminopyrimidine-4-carboxamide derivatives, preparation and pharmaceutical compositions thereof
ES2054902T3 (es)	1994-08-16	Para-aminofenoles 3-sustituidos, su procedimiento de preparacion, su empleo en la tincion de fibras queratinicas y compuestos intermedios utilizados en el procedimiento de preparacion.
ES2064461T3 (es)	1995-02-01	Derivados de xantina, procedimiento para su preparacion y composicion farmaceutica.
DK0450420T3 (da)	1995-02-20	Heterocyclisk substituerede dihydropyridiner, fremgangsmåde til deres fremstilling og deres anvendelse i lægemidler
ES2008962A6 (es)	1989-08-16	Proceso para la preparacion de nuevos compuestos de 2-guanidinotiazol
DK327286A (da)	1987-01-12	Indolcarboxamidderivater og salte deraf, deres fremstilling og anvendelse som laegemidler samt mellemprodukter til deres fremstilling
DK0424248T3 (da)	1996-03-04	20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf
NZ216125A (en)	1988-10-28	Isoxazoles and pharmaceutical compositions
SE9203824L (sv)	1993-06-28	Bensofuranylimidazol-derivat, foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande desamma
ES2023760A6 (es)	1992-02-01	Procedimiento para la preparacion de derivados benzotiazinicos.
EP0296979A3 (en)	1989-08-16	1-benzoyl-2-oxo-5-alkoxy-pyrrolidine derivatives, their preparation, their use and preparations containing them
ES8602756A1 (es)	1985-12-01	Procedimiento para preparar nuevos derivados de 2-(1-imida- zolil)-etanol
DE3860117D1 (de)	1990-06-07	2,3-dihydro-3-phenyl-benzofuran-2-on-acetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES8800666A1 (es)	1987-11-16	Procedimiento para la obtencion de derivados de 1,4-dihidropiridina
NO922094L (no)	1992-07-08	Heksapeptider med sulfatestergrupper