DK0433897T3 - Fremgangsmåde til fremstilling af optisk aktive cyclobutannukleosider. - Google Patents

Fremgangsmåde til fremstilling af optisk aktive cyclobutannukleosider.

Info

Publication number: DK0433897T3
Authority: DK; Denmark
Prior art keywords: preparation; optically active; nucleosides; cyclobutane; active cyclobutane
Prior art date: 1989-12-18

Application number

DK90124123.2T

Other languages

English (en)

Inventor

Gregory S Bisacchi

Toomas Mitt

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-18

Filing date

1990-12-13

Publication date

1997-10-27

1990-12-13 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1997-10-27 Application granted granted Critical

1997-10-27 Publication of DK0433897T3 publication Critical patent/DK0433897T3/da

Links

239000002777 nucleoside Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/04—N-nitroso compounds
- C07C243/08—N-nitroso-carboxamides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK90124123.2T 1989-12-18 1990-12-13 Fremgangsmåde til fremstilling af optisk aktive cyclobutannukleosider. DK0433897T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/451,664 US5064961A (en)	1989-12-18	1989-12-18	Process for preparing an optically active cyclobutane nucleoside

Publications (1)

Publication Number	Publication Date
DK0433897T3 true DK0433897T3 (da)	1997-10-27

Family

ID=23793189

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90124123.2T DK0433897T3 (da)	1989-12-18	1990-12-13	Fremgangsmåde til fremstilling af optisk aktive cyclobutannukleosider.

Country Status (9)

Country	Link
US (2)	US5064961A (da)
EP (1)	EP0433897B1 (da)
JP (1)	JPH05178857A (da)
AT (1)	ATE158798T1 (da)
CA (1)	CA2031586A1 (da)
DE (1)	DE69031534T2 (da)
DK (1)	DK0433897T3 (da)
ES (1)	ES2106726T3 (da)
GR (1)	GR3025694T3 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5723609A (en) *	1988-03-30	1998-03-03	E. R. Squibb & Sons, Inc.	Bis (hydroxymethyl) cyclobutyl purines
US5130462A (en) *	1988-03-30	1992-07-14	E. R. Squibb & Sons, Inc.	Cyclobutane derivatives
US5126345A (en) *	1988-03-30	1992-06-30	E. R. Squibb & Sons, Inc.	Bis (hydroxymethyl) cyclobutyl triazolopyrimidines
US5185459A (en) *	1988-03-30	1993-02-09	E. R. Squibb & Sons Inc.	Bis protected (hydroxymethyl)cyclobutanols
US5064961A (en) *	1989-12-18	1991-11-12	E. R. Squibb & Sons, Inc.	Process for preparing an optically active cyclobutane nucleoside
GB9004881D0 (en) *	1990-03-05	1990-05-02	Biocompatibles Ltd	Method of improving the ocular of synthetic polymers haemo and biocompatibility
US5235052A (en) *	1990-04-16	1993-08-10	Bristol-Myers Squibb Company	Process for preparing substituted cyclobutane purines
US5233076A (en) *	1990-05-24	1993-08-03	E. R. Squibb & Sons, Inc.	Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside
US5344962A (en) *	1990-05-24	1994-09-06	E. R. Squibb & Sons, Inc.	Intermediates in the synthesis of an optically active cyclobutane nucleoside
US5206244A (en) *	1990-10-18	1993-04-27	E. R. Squibb & Sons, Inc.	Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) *	1990-10-18	1994-08-23	E. R. Squibb & Sons, Inc.	Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
USH1142H (en)	1990-11-05	1993-02-02		Optically active cyclobutyl pyrimidine
DK0502690T3 (da) *	1991-03-05	2000-05-22	Ajinomoto Kk	Cyclopropanderivat
US5218142A (en) *	1991-10-02	1993-06-08	E. R. Squibb & Sons, Inc.	Process for the preparation of an antiviral agent
US5525726A (en) *	1991-10-02	1996-06-11	E. R. Squibb & Sons, Inc.	Process for the preparation of an antiviral agent
US5233086A (en) *	1991-10-02	1993-08-03	E. R. Squibb & Sons, Inc.	Intermediates for the preparation of an antiviral agent
US5237095A (en) *	1991-10-02	1993-08-17	E. R. Squibb & Sons, Inc.	Process for the preparation of an antiviral agent
US5185463A (en) *	1991-10-02	1993-02-09	E. R. Squibb & Sons, Inc.	Process for the preparation of an antiviral agent
US5237096A (en) *	1991-10-02	1993-08-17	E. R. Squibb & Sons, Inc.	Process for the preparation of an antiviral agent
EP0554025A3 (en) *	1992-01-27	1993-11-18	Squibb & Sons Inc	Fluorinated cyclobutyl purines and pyrimidines
US5412134A (en) *	1992-05-26	1995-05-02	E. R. Squibb & Sons, Inc.	Process for preparing diprotected 2,3-hydroxymethyl cyclobutanol
US5821357A (en) *	1992-06-22	1998-10-13	Eli Lilly And Company	Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US5874578A (en) *	1992-07-13	1999-02-23	Bristol-Myers Squibb	Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
US5783593A (en) *	1993-11-04	1998-07-21	Abbott Laboratories	Inhibitors of squalene synthetase and protein farnesyltransferase
IL117574A0 (en) *	1995-04-03	1996-07-23	Bristol Myers Squibb Co	Processes for the preparation of cyclobutanone derivatives
US6353122B1 (en)	1997-02-26	2002-03-05	Bristol-Myers Squibb Company	Method for epoxidation of 3-methylenecyclopropanes
SK285438B6 (sk) *	1998-08-03	2007-01-04	Applied Research Systems Ars Holding N. V.	Spôsob prípravy (1H)-benzo[c]chinolizín-3-ových derivátov
CN111848423B (zh) *	2019-04-30	2022-10-14	尚科生物医药（上海）有限公司	3-氧代环丁基氨基甲酸叔丁酯的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4855466A (en) *	1987-12-28	1989-08-08	E. R. Squibb & Sons, Inc.	Purinyl cyclobutanes
US5723609A (en) *	1988-03-30	1998-03-03	E. R. Squibb & Sons, Inc.	Bis (hydroxymethyl) cyclobutyl purines
AU622926B2 (en) *	1988-09-09	1992-04-30	Nippon Kayaku Kabushiki Kaisha	Pyrimidine or purine cyclobutane derivatives
IL92096A0 (en) *	1988-10-25	1990-07-12	Abbott Lab	Carboxylic nucleoside analogs
US4918075A (en) *	1988-12-20	1990-04-17	E. R. Squibb & Sons, Inc.	Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents
US5241064A (en) *	1989-10-02	1993-08-31	Fujisawa Pharmaceutical Co., Ltd.	Enzymatic process for preparing optically active 3-substituted azetidinones
US5256806A (en) *	1989-12-18	1993-10-26	E. R. Squibb & Sons, Inc.	Intermediates for the preparation of optically active cyclobutane nucleoside
US5198583A (en) *	1989-12-18	1993-03-30	E. R. Squibb & Sons, Inc.	Optically active cyclobutane nucleoside and intermediates, therefor
US5064961A (en) *	1989-12-18	1991-11-12	E. R. Squibb & Sons, Inc.	Process for preparing an optically active cyclobutane nucleoside

1989
- 1989-12-18 US US07/451,664 patent/US5064961A/en not_active Expired - Fee Related
1990
- 1990-12-05 CA CA002031586A patent/CA2031586A1/en not_active Abandoned
- 1990-12-13 DE DE69031534T patent/DE69031534T2/de not_active Expired - Fee Related
- 1990-12-13 EP EP90124123A patent/EP0433897B1/en not_active Expired - Lifetime
- 1990-12-13 ES ES90124123T patent/ES2106726T3/es not_active Expired - Lifetime
- 1990-12-13 DK DK90124123.2T patent/DK0433897T3/da active
- 1990-12-13 AT AT90124123T patent/ATE158798T1/de active
- 1990-12-18 JP JP2412010A patent/JPH05178857A/ja active Pending
1993
- 1993-07-15 US US08/091,389 patent/US5306837A/en not_active Expired - Fee Related
1997
- 1997-12-17 GR GR970403345T patent/GR3025694T3/el unknown

Also Published As

Publication number	Publication date
US5064961A (en)	1991-11-12
EP0433897B1 (en)	1997-10-01
ATE158798T1 (de)	1997-10-15
GR3025694T3 (en)	1998-03-31
DE69031534D1 (de)	1997-11-06
CA2031586A1 (en)	1991-06-19
JPH05178857A (ja)	1993-07-20
US5306837A (en)	1994-04-26
EP0433897A2 (en)	1991-06-26
EP0433897A3 (en)	1992-08-05
DE69031534T2 (de)	1998-04-02
ES2106726T3 (es)	1997-11-16

Publication	Publication Date	Title
DK0433897T3 (da)	1997-10-27	Fremgangsmåde til fremstilling af optisk aktive cyclobutannukleosider.
DK0592435T3 (da)	2000-09-18	Fremgangsmåde til fremstilling af pyrimidinforbindelser
ATE179983T1 (de)	1999-05-15	Antiretrovirale, enantiomere nukleotid-analoge
PT99281A (pt)	1992-08-31	Processo para a preparacao de hidroximetil (metilenociclopentil) purinas e de hidroximetil (metilenociclopentil) pirimidinas
PT96916A (pt)	1991-11-29	Processo para a preparacao de composicoes farmaceuticas contendo um macrolido
ATE21105T1 (de)	1986-08-15	7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
DE3851179D1 (de)	1994-09-29	Oxetanocin.
EP0638575A3 (de)	1995-05-24	Verfahren zur Herstellung von Diorganodialkoxysilanen.
DE69033069D1 (de)	1999-05-27	Prostaglandinanaloge
MX9300875A (es)	1993-08-31	Procedimiento para la preparacion de compuestos azabiciclicos.
SE8501679L (sv)	1985-10-07	Stereokontrollerat acetoxiazetidinon-forfarande
IT8420358A0 (it)	1984-04-02	Procedimento di preparazione di derivati 1-carbamoilmetilici di 4-idrossi-2-osso-pirrolidina nonche' di intermedi per ottenere tali composti.
ATE76399T1 (de)	1992-06-15	Enantiomere glutaramide als harntreibende verbindungen.
DK0452729T3 (da)	1995-08-21	Fremgangsmåde til fremstilling af substituerede cyclobutaner
DK0458643T3 (da)	1995-12-27	Fremgangsmåde til fremstilling af en optisk aktiv cyclobutanon, et mellemprodukt ved syntesen af et optisk aktivt cyclobutannukleosid
DK36689A (da)	1989-07-29	Fremgangsmaade til fremstilling af et 16-methoxy-16-methyl-prostaglandin e1-derivat, samt ved fremgangsmaaden anvendelige mellemprodukter
ATE108767T1 (de)	1994-08-15	Acyclische terpene.
DK0614892T3 (da)	1998-10-26	Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazol-4-carbaldehyder
DK0506235T3 (da)	1999-10-25	Glyceraldehyd-3-pentanid og fremgangsmåde til fremstilling af samme
DK0614890T3 (da)	1997-10-13	Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlorimidazoler.
BR9005746A (pt)	1991-07-30	Forma estereoisomerica de um composto,processo para sua preparacao e composto
DK159432C (da)	1991-03-18	Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater
DK162188A (da)	1988-09-27	Fremgangsmaade til fremstilling af pentandionderivater
IT1198237B (it)	1988-12-21	Intermedi per la sintesi di composti organici
IT8721303A0 (it)	1987-07-15	Processo per la preparazione di intermedi per la sintesi della fosfomicina.