DK0434095T3 - Phenylacetonitrilalkylaminoalkyl-ortho-substituerede arylforbindelser som immunosuppressorer - Google Patents

Phenylacetonitrilalkylaminoalkyl-ortho-substituerede arylforbindelser som immunosuppressorer

Info

Publication number: DK0434095T3
Authority: DK; Denmark
Prior art keywords: ortho; substituted aryl; compounds; alkoxyalkyl; hydroxyalkyl
Prior art date: 1989-12-21

Application number

DK90125245.2T

Other languages

English (en)

Inventor

Chi-Dean Liang

John P Mckearn

John M Farah Jr

Richard A Mueller

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-21

Publication date

1994-03-07

1990-12-21 Application filed by Searle & Co filed Critical Searle & Co

1994-03-07 Application granted granted Critical

1994-03-07 Publication of DK0434095T3 publication Critical patent/DK0434095T3/da

Links

SUSQOBVLVYHIEX-UHFFFAOYSA-N o-phenylene-diaceto-nitrile Natural products N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 3
-1 hydrido, hydroxy Chemical group 0.000 abstract 3
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
230000001363 autoimmune Effects 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001145 hydrido group Chemical group *[H] 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK90125245.2T 1989-12-21 1990-12-21 Phenylacetonitrilalkylaminoalkyl-ortho-substituerede arylforbindelser som immunosuppressorer DK0434095T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US45600489A	1989-12-21	1989-12-21
US60914590A	1990-11-06	1990-11-06
US07/623,596 US5162569A (en)	1989-12-21	1990-12-12	Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives

Publications (1)

Publication Number	Publication Date
DK0434095T3 true DK0434095T3 (da)	1994-03-07

Family

ID=27412651

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90125245.2T DK0434095T3 (da)	1989-12-21	1990-12-21	Phenylacetonitrilalkylaminoalkyl-ortho-substituerede arylforbindelser som immunosuppressorer

Country Status (10)

Country	Link
US (1)	US5162569A (da)
EP (1)	EP0434095B1 (da)
JP (1)	JPH04210667A (da)
AT (1)	ATE101125T1 (da)
CA (1)	CA2032827A1 (da)
DE (1)	DE69006471T2 (da)
DK (1)	DK0434095T3 (da)
ES (1)	ES2062286T3 (da)
IE (1)	IE66056B1 (da)
PT (1)	PT96297A (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5486539A (en) *	1989-12-21	1996-01-23	G. D. Searle & Co.	Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5247119A (en) *	1990-12-12	1993-09-21	G. D. Searle & Co.	Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
WO1996010090A1 (en) *	1994-09-29	1996-04-04	Merck & Co., Inc.	A high capacity screen for immunoregulants
SI2170050T1 (sl)	2007-06-20	2014-12-31	Milestone Pharmaceuticals Inc.	Fenilalkilaminski blokatorji kalcijevih kanalov s kratkotrajnim delovanjem in njihova uporaba

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1154810B (de) *	1961-04-01	1963-09-26	Knoll Ag	Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
JPS5118940B2 (da) *	1971-12-25	1976-06-14
DE2946545A1 (de) *	1979-11-17	1981-05-27	Basf Ag, 6700 Ludwigshafen	Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen
US4593042A (en) *	1985-10-18	1986-06-03	G. D. Searle & Co.	Bicyclo-substituted phenylacetonitrile derivatives
DE3603032A1 (de) *	1986-01-31	1987-08-06	Basf Ag	Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
CS258534B1 (en) *	1986-07-18	1988-08-16	Ludvik Blaha	Derivatives of valeronitrile and method of their preparation
DE3642331A1 (de) *	1986-12-11	1988-06-23	Basf Ag	Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel

1990
- 1990-12-12 US US07/623,596 patent/US5162569A/en not_active Expired - Lifetime
- 1990-12-20 PT PT96297A patent/PT96297A/pt not_active Application Discontinuation
- 1990-12-20 CA CA002032827A patent/CA2032827A1/en not_active Abandoned
- 1990-12-20 IE IE462690A patent/IE66056B1/en not_active IP Right Cessation
- 1990-12-21 DK DK90125245.2T patent/DK0434095T3/da active
- 1990-12-21 ES ES90125245T patent/ES2062286T3/es not_active Expired - Lifetime
- 1990-12-21 JP JP2419049A patent/JPH04210667A/ja active Pending
- 1990-12-21 EP EP90125245A patent/EP0434095B1/en not_active Expired - Lifetime
- 1990-12-21 AT AT90125245T patent/ATE101125T1/de not_active IP Right Cessation
- 1990-12-21 DE DE69006471T patent/DE69006471T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5162569A (en)	1992-11-10
EP0434095B1 (en)	1994-02-02
CA2032827A1 (en)	1991-06-22
DE69006471D1 (de)	1994-03-17
EP0434095A1 (en)	1991-06-26
ATE101125T1 (de)	1994-02-15
DE69006471T2 (de)	1994-06-16
JPH04210667A (ja)	1992-07-31
IE904626A1 (en)	1991-07-17
ES2062286T3 (es)	1994-12-16
IE66056B1 (en)	1995-12-13
PT96297A (pt)	1991-09-30

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ES2166359T3 (es)	2002-04-16	Derivado de depsipeptido, su produccion y uso.
BR9510207A (pt)	1997-11-04	Derivados de benzamidoxima processo para a sua preparação e fungicida para usa agricola e horticola
EA200000834A1 (ru)	2001-06-25	Фунгицидные 7-алкилтриазолопиримидины
BG48205A3 (bg)	1990-12-14	Микробицидно средство
DK0490566T3 (da)	1994-11-14	Fremstilling og anvendelse af N-iodpropargyloxycarbonylaminosyreestere og derivater som antimikrobielle midler
EA200601092A1 (ru)	2006-12-29	Фунгицидные смеси на основе производных карбаматов и инсектицидов
EA200500718A1 (ru)	2005-10-27	Замещённые 6-(2-галогенфенил)триазолопиримидины
DE3776211D1 (de)	1992-03-05	Substituierte pyridine mit herbizider wirkung.
DE69006471D1 (de)	1994-03-17	Phenylacetonitrilalkylaminoalkyl-(ortho-substituierte)-Arylverbindungen als Immunosupressoren.
EA199700446A1 (ru)	1998-08-27	Бис-оксим-производные триазолина и изоксалина и их использование в качестве пестицидов
EA199800896A1 (ru)	1999-04-29	Фунгицидные смеси
EA199800897A1 (ru)	1999-04-29	Фунгицидные смеси
EA199800904A1 (ru)	1999-04-29	Фунгицидные смеси
ES2084120T3 (es)	1996-05-01	Medicamentos para prevenir y tratar enfermedades del aparato circulatorio que contienen compuestos de espiro-3-heteroazolidina.
DE3660171D1 (de)	1988-06-09	Benzaldoxime carbamate derivatives
EA199800898A1 (ru)	1999-04-29	Фунгицидные смеси
EA199901065A1 (ru)	2000-08-28	Фунгицидные смеси
EA199901008A1 (ru)	2000-08-28	Фунгицидная смесь
EA199800903A1 (ru)	1999-06-24	Фунгицидные смеси
DD210597A1 (de)	1984-06-20	Fungizide mittel
HUP0401815A2 (hu)	2005-01-28	Fungicid keverékek
EA199800895A1 (ru)	1999-06-24	Фунгицидные смеси
EA199901069A1 (ru)	2000-06-26	Фунгицидная смесь
WO2002056685A3 (de)	2002-09-12	Fungizide mischungen
EA199800929A1 (ru)	1999-04-29	Фунгицидные смеси