DK0436435T3 - Phenylethanolaminomethyltetraliner og fremstilling deraf samt farmaceutiske midler indeholdende dem - Google Patents

Phenylethanolaminomethyltetraliner og fremstilling deraf samt farmaceutiske midler indeholdende dem

Info

Publication number: DK0436435T3
Authority: DK; Denmark
Prior art keywords: group; alkyl; represents hydrogen; preparation; nitro
Prior art date: 1989-12-29

Application number

DK90403762.9T

Other languages

English (en)

Inventor

Roberto Cecchi

Umberto Guzzi

Original Assignee

Midy Spa

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-29

Filing date

1990-12-26

Publication date

1994-07-25

1989-12-29 Priority claimed from FR8917465A external-priority patent/FR2656607B1/fr

1990-12-26 Application filed by Midy Spa, Sanofi Elf filed Critical Midy Spa

1994-07-25 Application granted granted Critical

1994-07-25 Publication of DK0436435T3 publication Critical patent/DK0436435T3/da

Links

239000003814 drug Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
206010020772 Hypertension Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
-1 chloro, hydroxy Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000008991 intestinal motility Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
- C07C62/12—Saturated compounds containing ether groups, groups, groups, or groups polycyclic
- C07C62/14—Saturated compounds containing ether groups, groups, groups, or groups polycyclic having a carboxyl group on a condensed ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/70—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Ophthalmology & Optometry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK90403762.9T 1989-12-29 1990-12-26 Phenylethanolaminomethyltetraliner og fremstilling deraf samt farmaceutiske midler indeholdende dem DK0436435T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8917465A FR2656607B1 (fr)	1989-12-29	1989-12-29	Phenylethanolaminomethyltetralines.
EP90403342		1990-11-26

Publications (1)

Publication Number	Publication Date
DK0436435T3 true DK0436435T3 (da)	1994-07-25

Family

ID=26127538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90403762.9T DK0436435T3 (da)	1989-12-29	1990-12-26	Phenylethanolaminomethyltetraliner og fremstilling deraf samt farmaceutiske midler indeholdende dem

Country Status (10)

Country	Link
US (1)	US5130339A (da)
EP (1)	EP0436435B1 (da)
JP (1)	JP2521191B2 (da)
AT (1)	ATE103269T1 (da)
CA (3)	CA2033243C (da)
DE (1)	DE69007603T2 (da)
DK (1)	DK0436435T3 (da)
ES (1)	ES2054304T3 (da)
IE (1)	IE65511B1 (da)
PT (1)	PT96391B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0627407A1 (fr) *	1993-05-28	1994-12-07	MIDY S.p.A.	Acide (7S)-7-[(2R)-2(3-chlorophényl)-2-hydroxyéthylamino]-5,6,7,8-tétrahydronaphtalèn-2-yloxy acétique, ses sels pharmaceutiquement acceptables, à action agoniste bêta-3 adrénergique et compositions pharmaceutiques le contenant
WO1995008527A1 (en) *	1993-09-22	1995-03-30	Tokyo Tanabe Company Limited	Novel 2-amino-1-phenylethanol compound, process for producing the same, and medicinal composition containing the same for regulating gastrointestinal tract movement
AU7863394A (en) *	1993-10-20	1995-05-08	Tokyo Tanabe Company Limited	Novel arylethanolamino(aryl)propanol compound
EP0683236B1 (fr) *	1994-04-21	2000-08-09	Sanofi-Synthelabo	Procédé enzymatique pour la préparation de dérivés tétraliniques optiquement actifs
EP0678579A1 (fr) *	1994-04-21	1995-10-25	MIDY S.p.A.	Procédé enzymatique pour la préparation de dérivés tétraliniques optiquement actifs
US6197993B1 (en)	1996-07-02	2001-03-06	Ono Pharmaceutical Co., Ltd.	Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient
JP3909864B2 (ja) *	1995-07-26	2007-04-25	小野薬品工業株式会社	ナフチルオキシ酢酸誘導体およびそれらを有効成分として含有する薬剤
ZA967892B (en) *	1995-09-21	1998-03-18	Lilly Co Eli	Selective β3 adrenergic agonists.
US6075040A (en) *	1996-09-05	2000-06-13	Eli Lilly And Company	Selective β3 adrenergic agonists
DE19604191A1 (de) *	1996-02-06	1997-08-07	Hoechst Schering Agrevo Gmbh	2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
EP0827746B1 (en) *	1996-09-05	2002-04-03	Eli Lilly And Company	Carbazole analogues as selective beta3 adrenergic agonists
FR2758723B1 (fr) *	1997-01-28	1999-04-23	Sanofi Sa	Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
CO5011072A1 (es)	1997-12-05	2001-02-28	Lilly Co Eli	Etanolaminas pirazinil substituidas como agfonistas de los receptores
FR2784582B3 (fr) *	1998-10-14	2000-11-24	Sanofi Sa	Nouvelle utilisation therapeutique de composes a activite beta-3-agoniste
FR2798126B1 (fr) *	1999-09-08	2001-10-19	Sanofi Synthelabo	Heteroaryloxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant
US9784726B2 (en)	2013-01-08	2017-10-10	Atrogi Ab	Screening method, a kit, a method of treatment and a compound for use in a method of treatment
GB201714736D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB201714745D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB201714734D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB201714740D0 (en)	2017-09-13	2017-10-25	Atrogi Ab	New compounds and uses
GB201903832D0 (en)	2019-03-20	2019-05-01	Atrogi Ab	New compounds and methods
CN114230078B (zh) *	2021-12-21	2023-09-22	武汉瑞阳化工有限公司	一种生产1-氟萘产生的酸性废水的综合利用方法
GB202205895D0 (en)	2022-04-22	2022-06-08	Atrogi Ab	New medical uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL79323A (en) *	1985-07-10	1990-03-19	Sanofi Sa	Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them
EP0213080B1 (de) *	1985-08-27	1992-05-20	Ciba-Geigy Ag	Hydropyridin-Derivate
DE3872100T2 (de) *	1987-08-12	1993-01-28	Sanofi Elf	Verfahren zur herstellung von phenylaethanolaminotetralinen.
DE68909253T2 (de) *	1988-01-15	1994-02-24	Abbott Lab	1-Aminomethyl-1,2,3,4-tetrahydronaphthaline und -indane.
DE3901814A1 (de) *	1988-07-28	1990-02-01	Bayer Ag	Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga

1990
- 1990-12-21 IE IE466290A patent/IE65511B1/en not_active IP Right Cessation
- 1990-12-26 DE DE69007603T patent/DE69007603T2/de not_active Expired - Fee Related
- 1990-12-26 AT AT90403762T patent/ATE103269T1/de not_active IP Right Cessation
- 1990-12-26 DK DK90403762.9T patent/DK0436435T3/da active
- 1990-12-26 EP EP90403762A patent/EP0436435B1/fr not_active Expired - Lifetime
- 1990-12-26 ES ES90403762T patent/ES2054304T3/es not_active Expired - Lifetime
- 1990-12-27 JP JP2418873A patent/JP2521191B2/ja not_active Expired - Lifetime
- 1990-12-27 CA CA002033243A patent/CA2033243C/en not_active Expired - Fee Related
- 1990-12-27 CA CA002222657A patent/CA2222657C/en not_active Expired - Fee Related
- 1990-12-27 CA CA002222658A patent/CA2222658A1/en not_active Abandoned
- 1990-12-28 US US02/635,950 patent/US5130339A/en not_active Expired - Fee Related
- 1990-12-28 PT PT96391A patent/PT96391B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE103269T1 (de)	1994-04-15
US5130339A (en)	1992-07-14
PT96391A (pt)	1991-10-15
CA2222657C (en)	2001-10-23
EP0436435A1 (fr)	1991-07-10
EP0436435B1 (fr)	1994-03-23
JPH04210663A (ja)	1992-07-31
ES2054304T3 (es)	1994-08-01
DE69007603D1 (de)	1994-04-28
PT96391B (pt)	1998-06-30
CA2033243C (en)	1998-07-07
CA2222657A1 (en)	1991-06-30
IE65511B1 (en)	1995-11-01
CA2033243A1 (en)	1991-06-30
IE904662A1 (en)	1991-07-17
JP2521191B2 (ja)	1996-07-31
DE69007603T2 (de)	1994-06-30
CA2222658A1 (en)	1991-06-30

Publication	Publication Date	Title
DK0436435T3 (da)	1994-07-25	Phenylethanolaminomethyltetraliner og fremstilling deraf samt farmaceutiske midler indeholdende dem
AU561450B2 (en)	1987-05-07	2-amino-3-acylamino-6-benzylamino pyridine derivatives
DK463983D0 (da)	1983-10-07	Substituered 1-hydroxyethyl-triazolyl-derivater, deres fremstilling og anvendelse som plantebeskyttelsesmidler
ES497426A0 (es)	1982-06-01	Un procedimiento para preparar un compuesto de quinazolina
AU558433B2 (en)	1987-01-29	A fungicidal indanylbenzamide
AU654125B2 (en)	1994-10-27	Novel diphenylthyazole derivative
PT96557A (pt)	1991-10-15	Processo para a preparacao de derivados de ergolina e de composicoes farmaceuticas que os contem
SE8703023L (sv)	1987-07-31	Mellanprodukter for framstellning av fluorprostacykliner
GR79443B (da)	1984-10-30
ES2010089A6 (es)	1989-10-16	Procedimiento para la obtencion de n-oxidos de gamma-carbolina antipsicoticos.
SE8405430L (sv)	1984-10-30	7-acylindolforeningar, lempade som mellanprodukter vid synteser av 7-acylindolin-2-oner
ES2004215A6 (es)	1988-12-16	Procedimiento para preparar quinazolinas tetraciclicas
ES8703404A1 (es)	1987-02-16	Procedimiento para la obtencion de derivados de la feniletilaminoprofiofenona.
BR8204919A (pt)	1983-08-02	Derivado de n-substituido-tetraidroisoftalimida composto processo para a preparacao de um derivado de n-substituido-tetraidroisoftalimida e composicao herbicida
AU579416B2 (en)	1988-11-24	3-Amino-2,3-dihydro-1-benzoxepine-compounds and methods for their preparation and pharmaceutical preparations containing these compounds
ES8106143A1 (es)	1981-08-01	Procedimiento para la preparacion de derivados de cinamoil- piperidinobutirofenona
ES8106144A1 (es)	1981-08-01	Procedimiento para la preparacion de derivados de aroilete- nilpiperidinobutirofenona
DK231787A (da)	1987-11-08	3-amino-dihydropyridiner, fremgangsmaade til deres fremstilling og deres anvendelse i laegemidler
SE8105297L (sv)	1982-03-11	Imidazolderivat
ES2120885A1 (es)	1998-11-01	Nuevas tienopirimidonas con actividad antifungica.