DK0441605T3 - Thiazolidin-derivater med anti-diabetisk virkning samt deres fremstilling og anvendelse - Google Patents

Thiazolidin-derivater med anti-diabetisk virkning samt deres fremstilling og anvendelse

Info

Publication number: DK0441605T3
Authority: DK; Denmark
Prior art keywords: preparation; well; thiazolidine derivatives; hydrogen; diabetic action
Prior art date: 1990-02-07

Application number

DK91300959.3T

Other languages

English (en)

Inventor

Takao Yoshioka

Takashi Fujita

Tsutomu Kanai

Kanichi Nakamura

Hiroyoshi Hirikoshi

Kunihiro Sasahara

Takeshi Kinoshita

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-07

Filing date

1991-02-06

Publication date

1996-07-29

1991-02-06 Application filed by Sankyo Co filed Critical Sankyo Co

1996-07-29 Application granted granted Critical

1996-07-29 Publication of DK0441605T3 publication Critical patent/DK0441605T3/da

Links

230000003178 anti-diabetic effect Effects 0.000 title abstract 2
150000003548 thiazolidines Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
-1 methylene, carbonyl Chemical group 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK91300959.3T 1990-02-07 1991-02-06 Thiazolidin-derivater med anti-diabetisk virkning samt deres fremstilling og anvendelse DK0441605T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2802390		1990-02-07

Publications (1)

Publication Number	Publication Date
DK0441605T3 true DK0441605T3 (da)	1996-07-29

Family

ID=12237153

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91300959.3T DK0441605T3 (da)	1990-02-07	1991-02-06	Thiazolidin-derivater med anti-diabetisk virkning samt deres fremstilling og anvendelse

Country Status (12)

Country	Link
US (1)	US5143930A (da)
EP (1)	EP0441605B1 (da)
KR (1)	KR0184601B1 (da)
AT (1)	ATE136544T1 (da)
AU (1)	AU637456B2 (da)
CA (1)	CA2035832C (da)
DE (1)	DE69118565T2 (da)
DK (1)	DK0441605T3 (da)
ES (1)	ES2088459T3 (da)
FI (1)	FI910583A7 (da)
GR (1)	GR3020196T3 (da)
HK (1)	HK1005451A1 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0514452T4 (da) *	1990-02-09	2000-09-18	Upjohn Co	Anvendelse af insulin-sensibiliserende midler til behandling af hypertension
GB9124513D0 (en) *	1991-11-19	1992-01-08	Smithkline Beecham Plc	Novel process
NO302471B1 (no) *	1991-12-26	1998-03-09	Sankyo Co	Tiazolidinforbindelser og farmasöytisk preparat
NO302519B1 (no) *	1991-12-26	1998-03-16	Sankyo Co	Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat
EP0590793B1 (en) *	1992-08-31	1999-10-13	Sankyo Company Limited	Oxazolidine derivatives having anti-diabetic and anti-obesity properties, their preparation and their therapeutic uses
FR2696743B1 (fr) *	1992-10-12	1994-12-23	Adir	Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.
TW245716B (da) *	1992-12-28	1995-04-21	Takeda Pharm Industry Co
JP3195455B2 (ja) *	1993-01-06	2001-08-06	ウェルファイド株式会社	キノリン−３−酢酸誘導体、その製造法と用途
TW268952B (da) *	1993-02-26	1996-01-21	Takeda Pharm Industry Co Ltd
CZ289317B6 (cs) *	1994-04-11	2002-01-16	Sankyo Company Limited	Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití
US5703096A (en) *	1994-10-07	1997-12-30	Sankyo Company, Limited	Oxime derivatives, their preparation and their therapeutic use
CZ293016B6 (cs) *	1995-06-01	2004-01-14	Sankyo Company Limited	Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
US5801173A (en) *	1996-05-06	1998-09-01	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) *	1996-05-06	1999-07-06	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889025A (en) *	1996-05-06	1999-03-30	Reddy's Research Foundation	Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
BR9711098B1 (pt)	1996-07-01	2011-10-04		compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos e seu uso no tratamento de diabetes e doenças relacionadas.
US6372750B2 (en)	1996-07-01	2002-04-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) *	1996-07-01	1999-03-23	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) *	1996-07-01	2000-09-05	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) *	1996-07-01	2006-09-05	Dr. Reddy's Laboratories, Limited	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
KR100666887B1 (ko)	1997-10-08	2007-01-10	상꾜 가부시키가이샤	치환 축합 복소환 화합물
US6946295B2 (en) *	1998-06-12	2005-09-20	Cellfor, Inc.	Process for ex vitro sowing and germination of plant somatic embryos
US6028088A (en) *	1998-10-30	2000-02-22	The University Of Mississippi	Flavonoid derivatives
TWI284533B (en) *	1999-05-24	2007-08-01	Sankyo Co	Pharmaceutical composition for treating hyperglycemia, impaired glucose tolerance, diabetes complications and for improving insulin resistant
WO2002050024A2 (en) *	2000-12-18	2002-06-27	Smithkline Beecham Corporation	Thiazolidinediones
HUE038042T2 (hu)	2009-12-15	2018-09-28	Cirius Therapeutics Inc	PPAR helyettesítõ tiazolidindion sók metabolikus betegségek kezelésére
EP2560956B1 (en)	2010-04-19	2016-10-26	Octeta Therapeutics, LLC	Novel synthesis for thiazolidinedione compounds
HUE031424T2 (en)	2010-08-10	2017-07-28	Octeta Therapeutics Llc	New synthesis of thiazolidinedione compounds
PL2603507T3 (pl) *	2010-08-10	2016-12-30		Synteza związków tiazolidynodionu

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
JPS6051189A (ja) *	1983-08-30	1985-03-22	Sankyo Co Ltd	チアゾリジン誘導体およびその製造法
US4873255A (en) *	1987-02-04	1989-10-10	Sankyo Company Limited	Thiazolidinone derivatives, their preparation and their use
WO1989008650A1 (en) *	1988-03-08	1989-09-21	Pfizer Inc.	Thiazolidinedione hypoglycemic agents
US4933355A (en) *	1988-04-14	1990-06-12	Sankyo Company Limited	Thiazole derivatives, their preparation and their use in the treatment of diabetes complications
GB8919434D0 (en) *	1989-08-25	1989-10-11	Beecham Group Plc	Novel compounds

1991
- 1991-01-24 US US07/645,108 patent/US5143930A/en not_active Expired - Fee Related
- 1991-02-06 ES ES91300959T patent/ES2088459T3/es not_active Expired - Lifetime
- 1991-02-06 AT AT91300959T patent/ATE136544T1/de not_active IP Right Cessation
- 1991-02-06 DE DE69118565T patent/DE69118565T2/de not_active Expired - Fee Related
- 1991-02-06 CA CA002035832A patent/CA2035832C/en not_active Expired - Fee Related
- 1991-02-06 EP EP91300959A patent/EP0441605B1/en not_active Expired - Lifetime
- 1991-02-06 DK DK91300959.3T patent/DK0441605T3/da active
- 1991-02-07 KR KR1019910002101A patent/KR0184601B1/ko not_active Expired - Fee Related
- 1991-02-07 FI FI910583A patent/FI910583A7/fi unknown
- 1991-02-07 AU AU70906/91A patent/AU637456B2/en not_active Ceased
1996
- 1996-06-12 GR GR960401562T patent/GR3020196T3/el unknown
1998
- 1998-05-27 HK HK98104570A patent/HK1005451A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2035832C (en)	2000-08-29
AU637456B2 (en)	1993-05-27
FI910583A7 (fi)	1991-08-08
GR3020196T3 (en)	1996-09-30
HK1005451A1 (en)	1999-01-08
KR910015552A (ko)	1991-09-30
EP0441605A3 (en)	1992-01-22
ES2088459T3 (es)	1996-08-16
US5143930A (en)	1992-09-01
AU7090691A (en)	1991-08-08
KR0184601B1 (ko)	1999-05-01
FI910583A0 (fi)	1991-02-07
ATE136544T1 (de)	1996-04-15
CA2035832A1 (en)	1991-08-08
DE69118565T2 (de)	1997-01-09
EP0441605A2 (en)	1991-08-14
EP0441605B1 (en)	1996-04-10
DE69118565D1 (de)	1996-05-15

Publication	Publication Date	Title
GR3020196T3 (en)	1996-09-30	Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
DK0412404T3 (da)	1996-02-26	Thiazolderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater omfattende derivaterne
ATE26120T1 (de)	1987-04-15	Substituierte acyl-derivate von 1,2,3,4tetrahydro-6,7-dimethoxy-3-isoquinolincarbons\|ure.
FI906204A0 (fi)	1990-12-17	Menetelmä farmaseuttisesti vaikuttavien peptidiyhdisteiden valmistamiseksi
JPS6479184A (en)	1989-03-24	Pyrazolotriazine derivative
EP0541120A3 (en)	1993-07-21	Xanthine derivatives for the treatment of dementia
ES8704445A1 (es)	1987-04-16	Procedimiento de preparar derivados aminicos
SE8406141L (sv)	1985-12-13	N-acylaminosyradiamidderivat, salter derav, forfarande for deras framstellning och antiulcermedel innehallande dessa
PT83104A (en)	1986-08-01	Novel guanidinomethylbenzoic acid derivatives
MY141488A (en)	2010-04-30	Hydroximic acid derivatives, processes for their preparation, and compositions comprising them
ES510004A0 (es)	1983-07-01	"un procedimiento para preparar derivados de n-naftoilglicina".
FI881104A0 (fi)	1988-03-09	Menetelmä antidiabeettisina aineina käytettävien bentsoksatsiinijohdannaisten valmistamiseksi
ATE168691T1 (de)	1998-08-15	Makrolid-derivate
DE3579189D1 (de)	1990-09-20	Heterocyclische aminoverbindungen.
DK14691D0 (da)	1991-01-28	4-substituerede anthracyclinoner og anthracyclinglycosider samt deres fremstilling
IT1197841B (it)	1988-12-06	Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione
ATE112682T1 (de)	1994-10-15	Isocarbacyclinderivate enthaltende antidiabetika.
ATE129246T1 (de)	1995-11-15	Pyrazolo(1,5-a)pyridine, deren herstellung und verwendung.
LU88449I2 (fr)	1994-09-09	Fleroxacine et ses dérivés pharmaceutiquement acceptables.