DK0443598T3 - Blood clotting inhibitory peptides, methods for their preparation and their use - Google Patents
Blood clotting inhibitory peptides, methods for their preparation and their useInfo
- Publication number
- DK0443598T3 DK0443598T3 DK91102607.8T DK91102607T DK0443598T3 DK 0443598 T3 DK0443598 T3 DK 0443598T3 DK 91102607 T DK91102607 T DK 91102607T DK 0443598 T3 DK0443598 T3 DK 0443598T3
- Authority
- DK
- Denmark
- Prior art keywords
- glu
- asp
- atoms
- phe
- bond
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 230000023555 blood coagulation Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 2
- 229910006069 SO3H Inorganic materials 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 2
- IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical compound C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 abstract 1
- 229960004308 acetylcysteine Drugs 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 150000003857 carboxamides Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Peptides of the formula I A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15 in which A1 is hydrogen, cysteine, acetylcysteine, one or two alkyl groups with 1-4 C atoms, an acyl group with 2-10 C atoms, an acyl group with 2-10 C atoms and another carboxyl group, or a protective group customary in peptide chemistry, A2 is a bond, Asn, Asp, Gln or Glu, A3 is a bond, Gly or Ala, A4 is Glu or Asp, A5 is Phe, Tyr, Trp, Pgl (phenylglycine) or Nal (naphthylalanine), A6 is Glu or Asp, A7 is Glu, Asp, Pro or Ala, A8 is Ile, Leu, Val, Nle or Phe, A9 is Pro or Hyp, A10 is Glu or Asp, A11 is Glu or Asp, A12 is Phe(SO3H) or Phe(PO3H2) (preferably in the p position) or Pgl(SO3H) or Pgl(PO3H2) (preferably in the p position), A13 is a bond, Leu, Ile, Val or Ala, A14 is a bond, Gln, Asn, Glu, Asp or Cys and A15 is Cys, Cys-amide, an OH group of the alpha-carboxyl group, free or esterified with a lower alcohol with up to 4 C atoms, which can also be in the form of the carboxamide functionality whose hydrogens can optionally be replaced by alkyl groups with up to 4 C atoms, and a process for the preparation thereof are described. These peptides inhibit blood coagulation and can be used as anticoagulants.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4005591A DE4005591A1 (en) | 1990-02-22 | 1990-02-22 | THE HERBAL INHIBITING PEPTIDES, METHOD FOR THEIR PRODUCTION AND THEIR USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0443598T3 true DK0443598T3 (en) | 1995-09-25 |
Family
ID=6400736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91102607.8T DK0443598T3 (en) | 1990-02-22 | 1991-02-22 | Blood clotting inhibitory peptides, methods for their preparation and their use |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0443598B1 (en) |
| JP (1) | JPH0770181A (en) |
| KR (1) | KR910021412A (en) |
| AT (1) | ATE122684T1 (en) |
| AU (1) | AU640739B2 (en) |
| CA (1) | CA2036815A1 (en) |
| DE (2) | DE4005591A1 (en) |
| DK (1) | DK0443598T3 (en) |
| ES (1) | ES2073601T3 (en) |
| IE (1) | IE66493B1 (en) |
| PT (1) | PT96836B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4103649A1 (en) * | 1991-02-07 | 1992-08-13 | Basf Ag | NEW ANTICOAGULATORY EFFECTIVE PEPTIDE |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341032C (en) * | 1987-01-23 | 2000-06-20 | John L. Krstenansky | Anticoagulant peptides |
| EP0482069A1 (en) * | 1989-07-20 | 1992-04-29 | Biogen, Inc. | Combinations and methods for treating or preventing thrombotic diseases |
| AU6070490A (en) * | 1989-08-07 | 1991-03-11 | Motorola, Inc. | Speech recognition using spectral line frequencies |
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
-
1990
- 1990-02-22 DE DE4005591A patent/DE4005591A1/en not_active Withdrawn
-
1991
- 1991-02-20 KR KR1019910002692A patent/KR910021412A/en not_active Ceased
- 1991-02-21 PT PT96836A patent/PT96836B/en not_active IP Right Cessation
- 1991-02-21 JP JP3078689A patent/JPH0770181A/en active Pending
- 1991-02-21 AU AU71255/91A patent/AU640739B2/en not_active Ceased
- 1991-02-21 CA CA002036815A patent/CA2036815A1/en not_active Abandoned
- 1991-02-21 IE IE59791A patent/IE66493B1/en not_active IP Right Cessation
- 1991-02-22 DE DE59105479T patent/DE59105479D1/en not_active Expired - Fee Related
- 1991-02-22 DK DK91102607.8T patent/DK0443598T3/en active
- 1991-02-22 ES ES91102607T patent/ES2073601T3/en not_active Expired - Lifetime
- 1991-02-22 EP EP91102607A patent/EP0443598B1/en not_active Expired - Lifetime
- 1991-02-22 AT AT91102607T patent/ATE122684T1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7125591A (en) | 1991-08-29 |
| AU640739B2 (en) | 1993-09-02 |
| ATE122684T1 (en) | 1995-06-15 |
| IE66493B1 (en) | 1996-01-10 |
| ES2073601T3 (en) | 1995-08-16 |
| DE59105479D1 (en) | 1995-06-22 |
| PT96836A (en) | 1991-10-31 |
| DE4005591A1 (en) | 1991-09-05 |
| IE910597A1 (en) | 1991-08-28 |
| EP0443598A2 (en) | 1991-08-28 |
| JPH0770181A (en) | 1995-03-14 |
| EP0443598B1 (en) | 1995-05-17 |
| KR910021412A (en) | 1991-12-20 |
| PT96836B (en) | 1998-07-31 |
| EP0443598A3 (en) | 1992-01-08 |
| CA2036815A1 (en) | 1991-08-23 |
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