DK0452873T3 - 1,8-naphthyridin-2-on-derivater - Google Patents

1,8-naphthyridin-2-on-derivater

Info

Publication number: DK0452873T3
Authority: DK; Denmark
Prior art keywords: substituted; lower alkyl; chem; single bond; unsubstituted
Prior art date: 1990-04-16

Application number

DK91106040.8T

Other languages

English (en)

Inventor

Takeshi Kuroda

Fumio Suzuki

Kenji Ohmori

Tadafumi Tamura

Hisashi Hosoe

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-16

Filing date

1991-04-16

Publication date

1996-07-29

1991-04-16 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

1996-07-29 Application granted granted Critical

1996-07-29 Publication of DK0452873T3 publication Critical patent/DK0452873T3/da

Links

ZFRUGZMCGCYBRC-UHFFFAOYSA-N 1h-1,8-naphthyridin-2-one Chemical class C1=CC=NC2=NC(O)=CC=C21 ZFRUGZMCGCYBRC-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000005054 naphthyridines Chemical class 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002769 thiazolinyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK91106040.8T 1990-04-16 1991-04-16 1,8-naphthyridin-2-on-derivater DK0452873T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP10000690		1990-04-16

Publications (1)

Publication Number	Publication Date
DK0452873T3 true DK0452873T3 (da)	1996-07-29

Family

ID=14262483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91106040.8T DK0452873T3 (da)	1990-04-16	1991-04-16	1,8-naphthyridin-2-on-derivater

Country Status (9)

Country	Link
US (1)	US5126341A (da)
EP (1)	EP0452873B1 (da)
JP (1)	JP2988739B2 (da)
AT (1)	ATE140003T1 (da)
CA (1)	CA2040517C (da)
DE (1)	DE69120581T2 (da)
DK (1)	DK0452873T3 (da)
ES (1)	ES2093041T3 (da)
GR (1)	GR3020848T3 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5219864A (en) *	1991-03-12	1993-06-15	Kyowa Hakko Kogyo Co., Ltd.	Thienopyridine derivatives
GB9127252D0 (en) *	1991-12-23	1992-02-19	Boots Co Plc	Therapeutic agents
DE4227747A1 (de) *	1992-08-21	1994-02-24	Basf Ag	Heteroaromatisch kondensierte Hydroxypyridoncarbonsäureamide, deren Herstellung und Verwendung
GB9312891D0 (en) *	1993-06-22	1993-08-04	Boots Co Plc	Therapeutic agents
GB9318931D0 (en) *	1993-09-14	1993-10-27	Boots Co Plc	Therapeutic agents
GB9409264D0 (en) *	1994-05-10	1994-06-29	Boots Co Ltd	Therapeutic agents
GB9420172D0 (en) *	1994-10-06	1994-11-23	Boots Co Plc	Therapeutic agents
GB9420168D0 (en) *	1994-10-06	1994-11-23	Boots Co Plc	Therapeutic agents
JP4224566B2 (ja) *	2000-12-18	2009-02-18	株式会社医薬分子設計研究所	炎症性サイトカイン産生遊離抑制剤
DE10222895A1 (de) *	2002-05-23	2003-12-11	Bosch Gmbh Robert	Hochdruckspeicher für Kraftstoffeinspritzsysteme mit integriertem Druckregelventil
EP1512396A4 (en) *	2002-06-05	2008-12-31	Inst Med Molecular Design Inc	HEMMER AGAINST ACTIVATION OF AP-1 AND NFAT
CN1658854A (zh) *	2002-06-05	2005-08-24	株式会社医药分子设计研究所	免疫关联蛋白激酶抑制剂
CN101103977A (zh) *	2002-06-05	2008-01-16	株式会社医药分子设计研究所	糖尿病治疗药
CA2488363C (en)	2002-06-06	2011-01-04	Institute Of Medicinal Molecular Design, Inc.	O-substituted hydroxyaryl derivatives
EA009701B1 (ru) *	2002-06-06	2008-02-28	Инститьют Оф Медисинал Молекьюлар Дизайн. Инк.	Противоаллергические средства
EP1535610A4 (en) *	2002-06-10	2008-12-31	Inst Med Molecular Design Inc	THERAPEUTIC CANCER
EA010470B1 (ru) *	2002-06-10	2008-08-29	Инститьют Оф Медисинал Молекьюлар Дизайн. Инк.	ИНГИБИТОРЫ АКТИВАЦИИ NF-kB
US20060035944A1 (en) *	2002-06-11	2006-02-16	Susumu Muto	Remedies for neurodegenerative diseases
AU2003244325A1 (en) *	2002-11-12	2004-06-03	Nok Corporation	Rubber-like elastic part
AU2007334323B2 (en) *	2006-12-18	2011-03-10	Amgen Inc.	Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
ES2393326T3 (es) *	2006-12-18	2012-12-20	Amgen, Inc	Compuestos basados en azaquinolona que presentan actividad inhibidora de prolil hidroxilasas, composiciones y usos de los mismos
US8048894B2 (en) *	2007-04-18	2011-11-01	Amgen Inc.	Quinolones and azaquinolones that inhibit prolyl hydroxylase
ES2446418T3 (es) *	2007-04-18	2014-03-07	Amgen, Inc	Derivados de indanona que inhiben la prolil hidroxilasa
US8030346B2 (en) *	2007-05-04	2011-10-04	Amgen Inc.	Heterocyclic quinolone derivatives that inhibit prolyl hydroxylase activity
EP2155746A2 (en) *	2007-05-04	2010-02-24	Amgen, Inc	Diazaquinolones that inhibit prolyl hydroxylase activity
US9249158B2 (en)	2012-04-05	2016-02-02	Boehringer Ingelheim International Gmbh	Cytomegalovirus inhibitor compounds
KR20230041654A (ko)	2020-05-05	2023-03-24	테온 테라퓨틱스, 인크.	칸나비노이드 수용체 유형 2 (cb2) 조정제 및 그의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3591584A (en) *	1968-08-27	1971-07-06	Pfizer	Benzothiazine dioxides
US4264602A (en) *	1975-08-15	1981-04-28	Sandoz, Inc.	4-Hydroxy-3-nitro-pyrido[2,3-B]pyridine-2(1H)-ones
DE2635216A1 (de) *	1975-08-15	1977-03-03	Sandoz Ag	4-hydorxy-3-nitropyrido eckige klammer auf 2,3-b eckige klammer zu pyridin2-one und ihre herstellung
US4128649A (en) *	1977-06-29	1978-12-05	Sandoz, Inc.	4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters
US4215123A (en) *	1979-05-07	1980-07-29	American Home Products Corporation	Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
EP0092786B1 (en) *	1982-04-26	1987-01-07	Schering Corporation	1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives
EP0267740A1 (en) *	1986-11-06	1988-05-18	Schering Corporation	Naphthyridine and pyridopyrazine compounds and pharmaceutical usage thereof

1991
- 1991-04-11 JP JP3079280A patent/JP2988739B2/ja not_active Expired - Fee Related
- 1991-04-12 US US07/684,214 patent/US5126341A/en not_active Expired - Fee Related
- 1991-04-15 CA CA002040517A patent/CA2040517C/en not_active Expired - Fee Related
- 1991-04-16 DE DE69120581T patent/DE69120581T2/de not_active Expired - Fee Related
- 1991-04-16 AT AT91106040T patent/ATE140003T1/de not_active IP Right Cessation
- 1991-04-16 EP EP91106040A patent/EP0452873B1/en not_active Expired - Lifetime
- 1991-04-16 DK DK91106040.8T patent/DK0452873T3/da active
- 1991-04-16 ES ES91106040T patent/ES2093041T3/es not_active Expired - Lifetime
1996
- 1996-08-22 GR GR960402205T patent/GR3020848T3/el unknown

Also Published As

Publication number	Publication date
DE69120581D1 (de)	1996-08-08
EP0452873A1 (en)	1991-10-23
JP2988739B2 (ja)	1999-12-13
ATE140003T1 (de)	1996-07-15
GR3020848T3 (en)	1996-11-30
ES2093041T3 (es)	1996-12-16
EP0452873B1 (en)	1996-07-03
US5126341A (en)	1992-06-30
DE69120581T2 (de)	1996-10-31
CA2040517C (en)	1997-06-03
JPH04217981A (ja)	1992-08-07
CA2040517A1 (en)	1991-10-17

Publication	Publication Date	Title
DE69120581D1 (de)	1996-08-08	1,8-Naphthyridin-2-on-Derivate
NO174711C (no)	1994-06-22	Analogifremgangsmåte for fremstilling av nye, terapeutisk aktive pyrimidindionderivater
ATE68180T1 (de)	1991-10-15	Morpholinoethylester von mycophenolsaeure und ihre derivate, ihre herstellung und verwendung in pharmazeutische zusammensetzungen.
NO179142C (no)	1996-08-14	3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
CA2124680A1 (en)	1993-06-10	Piperazine derivatives as 5-ht1a antagonists
FI892497A0 (fi)	1989-05-23	Menetelmä terapeuttisesti aktiivisten bentsamidijohdannaisten valmistamiseksi
DK0790987T3 (da)	2001-11-12	Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
DK0916651T3 (da)	2003-12-01	Phenylalkylcarboxylsyrederivater
DE68911773D1 (de)	1994-02-10	Benzimidazol-Derivate mit pharmakologischer Aktivität.
FI900461A0 (fi)	1990-01-30	Imidazopyridaziner, deras framstaellning och anvaendning.
NO940312D0 (no)	1994-01-28	Nytt bisheterocyklisk derivat eller salt derav
IS3828A (is)	1992-09-28	Hliðstæð aðferð til tilreiðslu á nýjum afleiðum thiazolidinone og oxazolidinone sem gagnlegar eru til æðaútvíkkunar
IT1216522B (it)	1990-03-08	Derivati alchiltiobenzimidazolici attivi farmacologicamente eprocedimento per la loro preparazione.
ATE160562T1 (de)	1997-12-15	Piperazinderivate
ATE125807T1 (de)	1995-08-15	Flavonderivate.
ATE73801T1 (de)	1992-04-15	Heterocyclische oxophthalazinylessigsaeure.