DK0453731T3 - Fremgangsmåde til fremstilling af N-[3-(1H-imidazol-1-yl)phenyl]-4-(substitueret)-2-pyrimidinaminer - Google Patents
Fremgangsmåde til fremstilling af N-[3-(1H-imidazol-1-yl)phenyl]-4-(substitueret)-2-pyrimidinaminerInfo
- Publication number
- DK0453731T3 DK0453731T3 DK91102859T DK91102859T DK0453731T3 DK 0453731 T3 DK0453731 T3 DK 0453731T3 DK 91102859 T DK91102859 T DK 91102859T DK 91102859 T DK91102859 T DK 91102859T DK 0453731 T3 DK0453731 T3 DK 0453731T3
- Authority
- DK
- Denmark
- Prior art keywords
- imidazol
- substituted
- phenyl
- dihydrohalide
- pyridinyl
- Prior art date
Links
- -1 N- [3- (1H-imidazol-1-yl) phenyl] -4- (substituted) -2-pyrimidinamines Chemical class 0.000 title abstract 5
- JPPRNSQAQOGYPJ-UHFFFAOYSA-N 2-(3-imidazol-1-ylphenyl)guanidine Chemical compound NC(=N)NC1=CC=CC(N2C=NC=C2)=C1 JPPRNSQAQOGYPJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/514,455 US5064963A (en) | 1990-04-25 | 1990-04-25 | Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0453731T3 true DK0453731T3 (da) | 1999-02-15 |
Family
ID=24047219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91102859T DK0453731T3 (da) | 1990-04-25 | 1991-02-27 | Fremgangsmåde til fremstilling af N-[3-(1H-imidazol-1-yl)phenyl]-4-(substitueret)-2-pyrimidinaminer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5064963A (da) |
| EP (1) | EP0453731B1 (da) |
| JP (1) | JPH04225975A (da) |
| KR (1) | KR0168679B1 (da) |
| AT (1) | ATE170184T1 (da) |
| AU (1) | AU630849B2 (da) |
| CA (1) | CA2041031A1 (da) |
| DE (1) | DE69130029T2 (da) |
| DK (1) | DK0453731T3 (da) |
| ES (1) | ES2121757T3 (da) |
| FI (1) | FI100533B (da) |
| GR (1) | GR3027762T3 (da) |
| HU (1) | HU211774B (da) |
| IE (1) | IE911366A1 (da) |
| NO (1) | NO177567C (da) |
| NZ (1) | NZ237870A (da) |
| SG (1) | SG47565A1 (da) |
| TW (1) | TW215087B (da) |
| ZA (1) | ZA913092B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521184A (en) * | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| US5516775A (en) * | 1992-08-31 | 1996-05-14 | Ciba-Geigy Corporation | Further use of pyrimidine derivatives |
| KR100643419B1 (ko) * | 1998-03-27 | 2006-11-10 | 얀센 파마슈티카 엔.브이. | Ｈｉｖ를 억제하는 피리미딘 유도체 |
| TR200200763T2 (tr) | 1999-09-24 | 2003-09-22 | Janssen Pharmaceutica N.V. | Antiviral bileşimler |
| US7803806B2 (en) | 2005-11-03 | 2010-09-28 | Sgx Pharmaceuticals, Inc. | Pyrimidinyl-thiophene kinase modulators |
| KR20090130345A (ko) * | 2007-05-04 | 2009-12-22 | 아이알엠 엘엘씨 | Ｃ-ｋｉｔ 및 ｐｄｇｆｒ 키나제 억제제로서의 화합물 및 조성물 |
| EP2863913B1 (en) | 2012-06-20 | 2018-09-12 | Merck Sharp & Dohme Corp. | Imidazolyl analogs as syk inhibitors |
| EP2863914B1 (en) * | 2012-06-20 | 2018-10-03 | Merck Sharp & Dohme Corp. | Pyrazolyl derivatives as syk inhibitors |
| CN110330447B (zh) * | 2019-07-16 | 2022-04-15 | 北京赛升药业股份有限公司 | 一种甲磺酸萘莫司他中间体的制备方法及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5319479A (en) * | 1978-12-22 | 1980-06-26 | Ici Australia Limited | Pyrimidinyl amino phenoxy carboxylate derivatives |
| EP0164204A1 (en) * | 1984-05-12 | 1985-12-11 | FISONS plc | Novel pharmaceutically useful pyrimidines |
| US4788195A (en) * | 1986-01-13 | 1988-11-29 | American Cyanamid Company | 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines |
-
1990
- 1990-04-25 US US07/514,455 patent/US5064963A/en not_active Expired - Fee Related
-
1991
- 1991-02-27 DK DK91102859T patent/DK0453731T3/da active
- 1991-02-27 SG SG1996002850A patent/SG47565A1/en unknown
- 1991-02-27 AT AT91102859T patent/ATE170184T1/de active
- 1991-02-27 ES ES91102859T patent/ES2121757T3/es not_active Expired - Lifetime
- 1991-02-27 EP EP91102859A patent/EP0453731B1/en not_active Expired - Lifetime
- 1991-02-27 DE DE69130029T patent/DE69130029T2/de not_active Expired - Fee Related
- 1991-03-22 TW TW080102248A patent/TW215087B/zh active
- 1991-04-18 NZ NZ237870A patent/NZ237870A/xx unknown
- 1991-04-23 CA CA002041031A patent/CA2041031A1/en not_active Abandoned
- 1991-04-23 JP JP3117918A patent/JPH04225975A/ja active Pending
- 1991-04-24 AU AU75905/91A patent/AU630849B2/en not_active Ceased
- 1991-04-24 NO NO911632A patent/NO177567C/no unknown
- 1991-04-24 HU HU911373A patent/HU211774B/hu not_active IP Right Cessation
- 1991-04-24 IE IE136691A patent/IE911366A1/en unknown
- 1991-04-24 FI FI911983A patent/FI100533B/fi active
- 1991-04-24 KR KR1019910006612A patent/KR0168679B1/ko not_active Expired - Fee Related
- 1991-04-24 ZA ZA913092A patent/ZA913092B/xx unknown
-
1998
- 1998-08-27 GR GR980401941T patent/GR3027762T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI911983L (fi) | 1991-10-26 |
| DE69130029D1 (de) | 1998-10-01 |
| US5064963A (en) | 1991-11-12 |
| NZ237870A (en) | 1993-05-26 |
| AU7590591A (en) | 1991-11-07 |
| GR3027762T3 (en) | 1998-11-30 |
| EP0453731A3 (en) | 1992-09-02 |
| SG47565A1 (en) | 1998-04-17 |
| NO911632D0 (no) | 1991-04-24 |
| AU630849B2 (en) | 1992-11-05 |
| EP0453731A2 (en) | 1991-10-30 |
| ATE170184T1 (de) | 1998-09-15 |
| FI911983A0 (fi) | 1991-04-24 |
| NO911632L (no) | 1991-10-28 |
| DE69130029T2 (de) | 1999-02-18 |
| NO177567B (no) | 1995-07-03 |
| ZA913092B (en) | 1992-02-26 |
| HU911373D0 (en) | 1991-10-28 |
| IE911366A1 (en) | 1991-11-06 |
| HUT57719A (en) | 1991-12-30 |
| CA2041031A1 (en) | 1991-10-26 |
| JPH04225975A (ja) | 1992-08-14 |
| NO177567C (no) | 1995-10-11 |
| HU211774B (en) | 1995-12-28 |
| KR910018375A (ko) | 1991-11-30 |
| TW215087B (da) | 1993-10-21 |
| EP0453731B1 (en) | 1998-08-26 |
| KR0168679B1 (ko) | 1999-01-15 |
| ES2121757T3 (es) | 1998-12-16 |
| FI100533B (fi) | 1997-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5675006A (en) | Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor | |
| JPH0262547B2 (da) | ||
| DK0453731T3 (da) | Fremgangsmåde til fremstilling af N-[3-(1H-imidazol-1-yl)phenyl]-4-(substitueret)-2-pyrimidinaminer | |
| JPH0339061B2 (da) | ||
| US5552557A (en) | Process for preparing 2-cyanoimidazole compounds by reaction of an amino ketone compound | |
| WO1998029394A1 (en) | Process for the preparation of carbamoyllated imidazole derivatives | |
| HU212611B (en) | Process for the preparation of 2-substituted 4,6-dialkoxy-pyrimidine derivatives | |
| US5030738A (en) | Synthesis of antiulcer compounds | |
| US20020004600A1 (en) | Process for the preparation of substituted pyrimidines | |
| WO2013120852A1 (en) | Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors | |
| US4855439A (en) | Process for the preparation of cimetidine | |
| US7067671B2 (en) | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | |
| JPH0113469B2 (da) | ||
| JP2668168B2 (ja) | フェノキシ誘導体 | |
| JPS636063B2 (da) | ||
| EP1508569A2 (en) | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof | |
| JPH0710843B2 (ja) | ピリドン−３−カルボキサミド化合物の製造法 | |
| JPH07309843A (ja) | ２−シアノイミダゾール系化合物の製造方法 |