DK0456833T3 - Immunosuppressivt middel og fremgangsmåde til fremstilling deraf - Google Patents

Immunosuppressivt middel og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0456833T3
DK0456833T3 DK90917694.3T DK90917694T DK0456833T3 DK 0456833 T3 DK0456833 T3 DK 0456833T3 DK 90917694 T DK90917694 T DK 90917694T DK 0456833 T3 DK0456833 T3 DK 0456833T3
Authority
DK
Denmark
Prior art keywords
alkyl
immunosuppressant
preparation
day
antagonist
Prior art date
Application number
DK90917694.3T
Other languages
Danish (da)
English (en)
Inventor
Shu Matsumoto
Hiroshi Nagase
Koji Kawai
Takashi Endoh
Yoshiaki Katsura
Kohei Arakawa
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of DK0456833T3 publication Critical patent/DK0456833T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Light Receiving Elements (AREA)
  • Amplifiers (AREA)
DK90917694.3T 1989-11-28 1990-11-28 Immunosuppressivt middel og fremgangsmåde til fremstilling deraf DK0456833T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30849189 1989-11-28
JP32216089 1989-12-11
JP32694189 1989-12-15

Publications (1)

Publication Number Publication Date
DK0456833T3 true DK0456833T3 (da) 1995-05-01

Family

ID=27338974

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90917694.3T DK0456833T3 (da) 1989-11-28 1990-11-28 Immunosuppressivt middel og fremgangsmåde til fremstilling deraf

Country Status (14)

Country Link
US (1) US5332818A (fr)
EP (1) EP0456833B1 (fr)
JP (1) JP2906654B2 (fr)
KR (1) KR940008032B1 (fr)
AT (1) ATE119039T1 (fr)
AU (1) AU639053B2 (fr)
CA (1) CA2045481C (fr)
DE (1) DE69017434T2 (fr)
DK (1) DK0456833T3 (fr)
ES (1) ES2069100T3 (fr)
FI (1) FI913583A0 (fr)
GR (1) GR3015266T3 (fr)
NO (1) NO912940D0 (fr)
WO (1) WO1991007966A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852030A (en) * 1992-09-29 1998-12-22 Toray Industries, Inc. Indole derivatives, process for producing the same and medicinal uses of the same
KR100301093B1 (ko) * 1992-09-29 2001-10-22 히라이 가쯔히꼬 인돌유도체,그제조방법및그의약용도
AU674379B2 (en) * 1992-12-22 1996-12-19 Toray Industries, Inc. Antitussive
US5464841A (en) * 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
SE9304236D0 (sv) * 1993-12-22 1993-12-22 Astra Ab New use
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
US5578725A (en) * 1995-01-30 1996-11-26 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
BR9707136A (pt) * 1996-01-10 1999-08-31 Smithkline Beecham Spa Derivados morfinóides condesados em heterociclo (ii)
AU739367B2 (en) * 1997-01-16 2001-10-11 Toray Industries, Inc. Indolomorphinan derivative and agent for curing and preventing cerebral disorder
WO1998043977A1 (fr) * 1997-03-31 1998-10-08 Toray Industries, Inc. Derives de quinolinomorphinane et leur usage medical
US6359111B1 (en) 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
US7232829B2 (en) 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
US6858619B2 (en) 2001-05-04 2005-02-22 Amgen Inc. Fused heterocyclic compounds
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
EP1517689A2 (fr) * 2002-01-25 2005-03-30 Regents Of The University Of Minnesota Agents analgesiques selectifs
CN1288158C (zh) * 2002-07-11 2006-12-06 东丽株式会社 用于预防恶心和呕吐的治疗剂或预防剂
CN101134757A (zh) 2002-11-06 2008-03-05 安姆根有限公司 稠合杂环化合物
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
JP2008514612A (ja) * 2004-09-23 2008-05-08 ミシャロウ、アレクサンダー 対抗適応を誘発することにより神経伝達物質系を調節する方法
CN1298718C (zh) * 2005-03-18 2007-02-07 中国科学院上海有机化学研究所 C环连接有吡嗪环的青藤碱衍生物、合成方法及其用途
US20070185145A1 (en) * 2006-02-03 2007-08-09 Royds Robert B Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443605A (en) * 1982-07-30 1984-04-17 Miles Laboratories, Inc. 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
HU196376B (en) * 1985-05-23 1988-11-28 Sandoz Ag Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
US4816586A (en) 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US4857533A (en) * 1988-12-15 1989-08-15 Baker Cummins Pharmaceuticals, Inc. Method of treatment for autoimmune diseases

Also Published As

Publication number Publication date
CA2045481C (fr) 1995-11-14
DE69017434D1 (de) 1995-04-06
JP2906654B2 (ja) 1999-06-21
KR920700643A (ko) 1992-08-10
DE69017434T2 (de) 1995-06-29
NO912940L (no) 1991-07-29
FI913583A7 (fi) 1991-07-26
JPH03223288A (ja) 1991-10-02
ES2069100T3 (es) 1995-05-01
CA2045481A1 (fr) 1991-05-29
NO912940D0 (no) 1991-07-29
GR3015266T3 (en) 1995-06-30
KR940008032B1 (ko) 1994-09-01
EP0456833B1 (fr) 1995-03-01
AU639053B2 (en) 1993-07-15
EP0456833A4 (en) 1992-03-18
FI913583A0 (fi) 1991-07-26
EP0456833A1 (fr) 1991-11-21
US5332818A (en) 1994-07-26
WO1991007966A1 (fr) 1991-06-13
ATE119039T1 (de) 1995-03-15
AU6876891A (en) 1991-06-26

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