DK0457514T3 - Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer - Google Patents

Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer

Info

Publication number: DK0457514T3
Authority: DK; Denmark
Prior art keywords: atherosclerosis; combination; cholesterol; ace inhibitor; recurrence
Prior art date: 1990-05-15

Application number

DK91304232.1T

Other languages

English (en)

Inventor

Werner Tschollar

James L Bergey

James C Kawano

Cary S Yonce

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-15

Filing date

1991-05-10

Publication date

1996-09-16

1991-05-10 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1996-09-16 Application granted granted Critical

1996-09-16 Publication of DK0457514T3 publication Critical patent/DK0457514T3/da

Links

239000005541 ACE inhibitor Substances 0.000 title abstract 2
201000001320 Atherosclerosis Diseases 0.000 title abstract 2
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title abstract 2
239000003529 anticholesteremic agent Substances 0.000 title abstract 2
230000001939 inductive effect Effects 0.000 title 1
230000003405 preventing effect Effects 0.000 title 1
230000000087 stabilizing effect Effects 0.000 title 1
206010020772 Hypertension Diseases 0.000 abstract 1
TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 abstract 1
230000003143 atherosclerotic effect Effects 0.000 abstract 1
229960000830 captopril Drugs 0.000 abstract 1
FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 abstract 1
230000001631 hypertensive effect Effects 0.000 abstract 1
230000003902 lesion Effects 0.000 abstract 1
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 abstract 1
229960002965 pravastatin Drugs 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
229960002769 zofenopril Drugs 0.000 abstract 1
IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK91304232.1T 1990-05-15 1991-05-10 Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer DK0457514T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US52426690A	1990-05-15	1990-05-15

Publications (1)

Publication Number	Publication Date
DK0457514T3 true DK0457514T3 (da)	1996-09-16

Family

ID=24088484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91304232.1T DK0457514T3 (da)	1990-05-15	1991-05-10	Fremgangsmåde til forebyggelse, stabilisering eller fremkaldelse af tilbagegang af atherosklerose ved anvendelse af en kombination af et cholesterolsænkende medikament og en ACE-hæmmer

Country Status (15)

Country	Link
EP (1)	EP0457514B1 (da)
JP (1)	JPH04226921A (da)
KR (1)	KR100200467B1 (da)
AT (1)	ATE141514T1 (da)
AU (1)	AU651579B2 (da)
CA (1)	CA2040865C (da)
DE (1)	DE69121464T2 (da)
DK (1)	DK0457514T3 (da)
ES (1)	ES2090244T3 (da)
GR (1)	GR3021703T3 (da)
HU (1)	HU212102B (da)
IE (1)	IE77637B1 (da)
NZ (1)	NZ237929A (da)
PT (1)	PT97660B (da)
ZA (1)	ZA913509B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5157025A (en) *	1991-04-01	1992-10-20	E. R. Squibb & Sons, Inc.	Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
WO1993013801A1 (en) *	1992-01-17	1993-07-22	The Procter & Gamble Company	Treatment for atherosclerosis
WO1995013063A1 (en) *	1993-11-09	1995-05-18	Merck & Co., Inc.	HMG-CoA REDUCTASE INHIBITORS IN THE NORMALIZATION OF VASCULAR ENDOTHELIAL DYSFUNCTION
DE4402379C2 (de) *	1994-01-27	1997-09-25	Lohmann Therapie Syst Lts	Orale Arzneiform mit sauren Wirkstoffen und Verfahren zu ihrer Herstellung
JP3883205B2 (ja) *	1994-03-29	2007-02-21	メルクエンドカンパニーインコーポレーテッド	アンギオテンシン▲ｉｉ▼レセプタ遮断イミダゾールによるアテローム性動脈硬化症の治療
US6107323A (en) *	1996-04-05	2000-08-22	Takeda Chemical Industries, Ltd.	Pharmaceutical composition
EP1514543A1 (en)	1997-08-29	2005-03-16	Pfizer Inc.	Combination therapy comprising atorvastatin and an antihypertensive agent
SI20305A (sl)	1999-08-06	2001-02-28	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Kristali natrijeve soli pravastatina
AU2007200367B2 (en) *	1999-02-06	2010-04-08	Astrazeneca Ab	Use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy
GB0001662D0 (en)	1999-02-06	2000-03-15	Zeneca Ltd	Pharmaceutical compositions
US6172441B1 (en)	1999-06-28	2001-01-09	Visteon Global Technologies, Inc.	Rotor assembly
HUP0203326A3 (en)	1999-08-30	2003-04-28	Sanofi Aventis Deutschland	Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
RS20100015A (sr)	2001-01-26	2010-12-31	Schering Corporation	Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
PT1355644E (pt)	2001-01-26	2006-11-30	Schering Corp	Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
US6669955B2 (en) *	2001-08-28	2003-12-30	Longwood Pharmaceutical Research, Inc.	Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US6576256B2 (en)	2001-08-28	2003-06-10	The Brigham And Women's Hospital, Inc.	Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
EP1429756B1 (en)	2001-09-21	2006-11-22	Schering Corporation	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
EP1501546B1 (de) *	2002-05-03	2012-10-10	Hexal AG	Stabile pharmazeutische formulierung für eine kombination aus einem statin mit einem ace-hemmer
AR040588A1 (es)	2002-07-26	2005-04-13	Schering Corp	Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
JP2006508188A (ja)	2002-11-06	2006-03-09	シェーリング　コーポレイション	脱髄の処置のためのコレステロール吸収インヒビター
CN1756756A (zh)	2003-03-07	2006-04-05	先灵公司	取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756755A (zh)	2003-03-07	2006-04-05	先灵公司	取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
DE602004016123D1 (de)	2003-03-07	2008-10-09	Schering Corp	Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004085448A2 (en) *	2003-03-19	2004-10-07	Genzyme Corporation	Unsaturated phosphinyl-phosphonate phosphate transport inhibitors
GB0322552D0 (en)	2003-09-26	2003-10-29	Astrazeneca Uk Ltd	Therapeutic treatment
CA2745383A1 (en) *	2008-12-01	2010-06-10	In Vasc Therapeutics, Inc.	Compositions comprising renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, and the use thereof for the treatment of renin-angiotensin aldosterone system related disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3536687A1 (de) *	1985-10-15	1987-04-16	Hoechst Ag	Verfahren zur behandlung von atherosklerose, thrombose und der peripheren gefaesskrankheit

1991
- 1991-04-19 CA CA002040865A patent/CA2040865C/en not_active Expired - Lifetime
- 1991-04-24 NZ NZ237929A patent/NZ237929A/en unknown
- 1991-04-26 AU AU76270/91A patent/AU651579B2/en not_active Expired
- 1991-04-29 IE IE143191A patent/IE77637B1/en not_active IP Right Cessation
- 1991-05-08 ZA ZA913509A patent/ZA913509B/xx unknown
- 1991-05-10 ES ES91304232T patent/ES2090244T3/es not_active Expired - Lifetime
- 1991-05-10 EP EP91304232A patent/EP0457514B1/en not_active Expired - Lifetime
- 1991-05-10 AT AT91304232T patent/ATE141514T1/de not_active IP Right Cessation
- 1991-05-10 DK DK91304232.1T patent/DK0457514T3/da active
- 1991-05-10 DE DE69121464T patent/DE69121464T2/de not_active Expired - Lifetime
- 1991-05-14 KR KR1019910007749A patent/KR100200467B1/ko not_active Expired - Lifetime
- 1991-05-14 PT PT97660A patent/PT97660B/pt not_active IP Right Cessation
- 1991-05-14 HU HU911620A patent/HU212102B/hu unknown
- 1991-05-15 JP JP3110268A patent/JPH04226921A/ja not_active Withdrawn
1996
- 1996-11-19 GR GR960403096T patent/GR3021703T3/el unknown

Also Published As

Publication number	Publication date
HUT57993A (en)	1992-01-28
ZA913509B (en)	1992-02-26
GR3021703T3 (en)	1997-02-28
IE77637B1 (en)	1997-12-31
PT97660B (pt)	1998-09-30
JPH04226921A (ja)	1992-08-17
EP0457514A1 (en)	1991-11-21
PT97660A (pt)	1992-02-28
NZ237929A (en)	1997-06-24
AU7627091A (en)	1991-11-21
HU212102B (en)	1996-02-28
CA2040865C (en)	2002-07-23
KR100200467B1 (ko)	1999-06-15
DE69121464T2 (de)	1997-03-27
HU911620D0 (en)	1991-11-28
ES2090244T3 (es)	1996-10-16
IE911431A1 (en)	1991-11-20
EP0457514B1 (en)	1996-08-21
KR910019614A (ko)	1991-12-19
AU651579B2 (en)	1994-07-28
DE69121464D1 (de)	1996-09-26
ATE141514T1 (de)	1996-09-15
CA2040865A1 (en)	1991-11-16

Publication	Publication Date	Title
GR3021703T3 (en)	1997-02-28	Method for preventing, stabilizing or causing regression of atherosclerosis employing a combination of a cholesterol lowering drug and an ace inhibitor
DK0738512T3 (da)	2003-10-06	Fremgangsmåde til forebyggelse af et andet hjerteanfald ved anvendelse af en HMG coenzsym A reduktasehæmmer
MX9702175A (es)	1997-06-28	Combinacion de un inhibidor de absorcion de colesterol y un inhibidor de sintesis de colesterol.
DK0641325T3 (da)	2001-04-17	Inhibitorer af retroviral protease
TW256839B (en)	1995-09-11	Process of preventing (methyl) acrylic acid and its ester from polymerization
DK1140184T3 (da)	2003-09-29	Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer
FI932249A0 (fi)	1993-05-18	Dubbelverkande inhibitorer
DK370486A (da)	1987-02-06	Hmg-coa-reduktaseinhibitor og fremgangsmaade til fremstilling deraf
DK162488A (da)	1988-09-25	Middel til behandling af hyperchlolesterolaemi
DE69306808D1 (de)	1997-01-30	Hilfs- oder ergänzungsorthese des knies
DK0428302T3 (da)	1997-10-13	Enzymatisk spaltning af endo-bicyclo(2.2.1)heptan-2-o1 og afledte farmaceutiske midler
NO972426L (no)	1997-07-29	Metode for anvendelse av triarylethylenderivater ved behandling og forhindring av osteoporose
EP0425909A3 (en)	1992-06-17	Method for rehabilitating the vasorelaxant action of the coronary arteries impaired through atherosclerosis or hypercholesterolemia employing an ace inhibitor
DK571289D0 (da)	1989-11-15	Fremgangsmaade til behandling af spildgas
DK485888D0 (da)	1988-09-01	Hmg-coa reduktaseinhibitor og fremgangsmaade til fremstilling deraf
DE69218196D1 (de)	1997-04-17	Cholesterinsenkende tocopherolanaloga
DE59107262D1 (de)	1996-02-29	Oxetanone
NO920546D0 (no)	1992-02-12	Fremgangsmaate ved fluksing og fluksholdige komponenter
DK0458892T3 (da)	1994-08-15	Anvendelse af chlormethiazol ved fremstillingen af et medikament til forebyggelsen og/eller behandlingen af neurodegeneration
FI934550A0 (fi)	1993-10-14	Foerfarande och ugnkonstruktion foer anvaendning i processer i vilka laettflyktiga metaller produceras
DK486088D0 (da)	1988-09-01	Hmg-coa reduktaseinhibitor og fremgangsmaade til fremstilling deraf
ES1034672Y (es)	1997-06-16	Guia telescopica para deslizamiento de paneles expositores verticales de piezas ceramicas o similares.
KR970006087U (ko)	1997-02-21	보조서랍이 부설된 탁상금고
DK0457659T3 (da)	1994-03-07	Fremgangsmåde til spaltnng af kløvede kævler eller klov til træ til fremstilling af tøndestave og maskine beregnet hertil
KR950015818U (ko)	1995-06-19	고조파 제거용 안정화 증폭회로