DK0459449T3 - Furano(2,3-F)isoindoler som aldose-reduktase-inhibitorer - Google Patents

Furano(2,3-F)isoindoler som aldose-reduktase-inhibitorer

Info

Publication number: DK0459449T3
Authority: DK; Denmark
Prior art keywords: aldose reductase; isoindoles; furano; reductase inhibitors; inhibitor
Prior art date: 1990-05-30

Application number

DK91108805.2T

Other languages

English (en)

Inventor

Tadashi Yoshida

Koichi Matsumoto

Toshiyuki Kato

Yoshimi Kawamura

Hiroshi Itazaki

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-30

Filing date

1991-05-29

Publication date

1995-02-20

1991-05-29 Application filed by Shionogi & Co filed Critical Shionogi & Co

1995-02-20 Application granted granted Critical

1995-02-20 Publication of DK0459449T3 publication Critical patent/DK0459449T3/da

Links

239000003288 aldose reductase inhibitor Substances 0.000 title abstract 2
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title 1
150000002518 isoindoles Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 2
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
229940118148 Aldose reductase inhibitor Drugs 0.000 abstract 1
241001550554 Crucibulum <gastropod> Species 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Ophthalmology & Optometry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK91108805.2T 1990-05-30 1991-05-29 Furano(2,3-F)isoindoler som aldose-reduktase-inhibitorer DK0459449T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP14246390		1990-05-30

Publications (1)

Publication Number	Publication Date
DK0459449T3 true DK0459449T3 (da)	1995-02-20

Family

ID=15315903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91108805.2T DK0459449T3 (da)	1990-05-30	1991-05-29	Furano(2,3-F)isoindoler som aldose-reduktase-inhibitorer

Country Status (9)

Country	Link
US (1)	US5324742A (da)
EP (1)	EP0459449B1 (da)
JP (1)	JPH04217684A (da)
KR (1)	KR910020176A (da)
AT (1)	ATE115956T1 (da)
DE (1)	DE69106047T2 (da)
DK (1)	DK0459449T3 (da)
ES (1)	ES2069118T3 (da)
GR (1)	GR3014909T3 (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5624148B2 (ja)	2009-10-13	2014-11-12	エランコ・アニマル・ヘルス・アイルランド・リミテッド	大環状インテグラーゼ阻害剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU163443B (da) *	1970-08-26	1973-08-28
US4337265A (en) *	1981-08-21	1982-06-29	Ayerst, Mckenna & Harrison Inc.	Cyclohepta[b]pyrrole derivatives
US4503236A (en) *	1982-04-19	1985-03-05	Warner-Lambert Company	Antiallergic 4Hfuro[3,2-b]indoles
FR2533563A1 (fr) *	1982-09-23	1984-03-30	Adir	Nouveaux derives de la sulfonyluree, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
HU203350B (en) *	1984-08-24	1991-07-29	Pfizer	Process for producing antiinflammatory tricyclic oxindole derivatives
ES2032749T3 (es) *	1985-11-07	1993-03-01	Pfizer Inc.	Acidos oxoftalazinil-aceticos heterociclicos.
WO1993012786A1 (en) *	1986-07-10	1993-07-08	Howard Harry R Jr	Indolinone derivatives

1991
- 1991-03-07 JP JP3068730A patent/JPH04217684A/ja active Pending
- 1991-05-08 US US07/697,009 patent/US5324742A/en not_active Expired - Fee Related
- 1991-05-29 ES ES91108805T patent/ES2069118T3/es not_active Expired - Lifetime
- 1991-05-29 AT AT91108805T patent/ATE115956T1/de not_active IP Right Cessation
- 1991-05-29 EP EP91108805A patent/EP0459449B1/en not_active Expired - Lifetime
- 1991-05-29 DE DE69106047T patent/DE69106047T2/de not_active Expired - Fee Related
- 1991-05-29 DK DK91108805.2T patent/DK0459449T3/da active
- 1991-05-30 KR KR1019910008967A patent/KR910020176A/ko not_active Withdrawn
1995
- 1995-02-01 GR GR940404067T patent/GR3014909T3/el unknown

Also Published As

Publication number	Publication date
JPH04217684A (ja)	1992-08-07
DE69106047T2 (de)	1995-06-22
US5324742A (en)	1994-06-28
DE69106047D1 (de)	1995-02-02
ATE115956T1 (de)	1995-01-15
EP0459449B1 (en)	1994-12-21
KR910020176A (ko)	1991-12-19
EP0459449A1 (en)	1991-12-04
ES2069118T3 (es)	1995-05-01
GR3014909T3 (en)	1995-05-31

Publication	Publication Date	Title
NO308599B1 (no)	2000-10-02	Piperidinderivater og fremgangsmate for fremstilling derav
ATE138935T1 (de)	1996-06-15	Als süsstoffe brauchbare verbindungen und hir herstellungsverfahren
DK0594291T3 (da)	2003-01-27	Fremgangsmåder til fremstilling af 13-etherderivater af milbemyciner og mellemprodukter dertil
DK0405864T3 (da)	1995-07-03	Phospholipase A2-inhibitor, mikroorganismer der producerer inhibitoren og fremgangsmåder til den fremstilling
AU3274997A (en)	1998-04-14	Intermediates for the preparation of duocarmycin sa and derivatives thereof, and process for the production of the intermediates
DK0559533T3 (da)	1998-12-14	Fremgangsmåde til fremstilling af beta-lactamderivat og syntetisk mellemprodukt deraf
DK0597423T3 (da)	2002-05-21	Azetidinonforbindelse og fremgangsmåde til fremstilling deraf
AU8230891A (en)	1992-03-02	Novel benzopyran derivative
ATE239701T1 (de)	2003-05-15	Polyethoxylierte retinamid-derivate und verfahren zu ihrer herstellung
DK0668279T3 (da)	2001-08-27	6-azaindol thromboxansytaseinhibitor
EP0335979A4 (en)	1992-02-26	Thienopyrimidine derivatives
CA2221946A1 (en)	1996-11-28	Production process of cyclic compound
ATE115956T1 (de)	1995-01-15	Furano(2,3-f>isoindole als aldose-reduktase- inhibitoren.
ES2120498T3 (es)	1998-11-01	Nuevo compuesto tetraciclico.
EP0516860A4 (en)	1993-12-01	Chromone derivative and aldose reductase inhibitor containing the same as active ingredient
DK0478173T3 (da)	1995-06-12	4,5-polymethylen-4-isothiazolin-3-onderivater og anvendelse heraf som biocider
DE602005010369D1 (de)	2008-11-27	2-thiaquinolizidines als Glycosidase- und Glycosyltransferase-Inhibitoren
DK0874807T3 (da)	2002-05-13	Fremgangsmåde til fremstilling af methoximinophenylglyoxylsyrederivater
ES2074770T3 (es)	1995-09-16	Procedimiento de preparacion de derivados de 1,3-dioxano-4,6-diona.
DE69323894D1 (de)	1999-04-15	Verfahren zur herstellung von provitamin-d-verbindungen
NO20013037L (no)	2001-06-19	Fremgangsmåte for fremstilling av optisk aktive 1-amino-4- (hydroksymetyl)-cyklopenten-2-en-derivater
ES8700693A1 (es)	1986-10-16	Un procedimiento para producir un nuevo inhibidor de (-d-ma-nosidasa,la manostatina,o su s-oxido
MXPA03005556A (es)	2004-05-31	Derivados de 1,1-dioxo-1,2-benzotiacina-3-carboxamidas, metodo para prepararlos y composiciones farmaceuticas que los contienen.