DK0461039T3 - Nye benzimidazolafledte forbindelser, fremgangsmåde til deres fremstilling, de opnåede mellemprodukter, deres anvendelse so - Google Patents

Nye benzimidazolafledte forbindelser, fremgangsmåde til deres fremstilling, de opnåede mellemprodukter, deres anvendelse so

Info

Publication number: DK0461039T3
Authority: DK; Denmark
Prior art keywords: alkenyl; alkyl; preparation; image; processes
Prior art date: 1990-06-08

Application number

DK91401480T

Other languages

Danish (da)

English (en)

Inventor

Michel Fortin

Daniel Frechet

Gilles Hamon

Simone Jouquey

Jean-Paul Vevert

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-08

Filing date

1991-06-06

Publication date

1999-06-14

1990-06-08 Priority claimed from FR909007135A external-priority patent/FR2663028B1/fr

1990-12-18 Priority claimed from FR909015811A external-priority patent/FR2670489B1/fr

1991-03-28 Priority claimed from FR9103778A external-priority patent/FR2674523A1/fr

1991-06-06 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1999-06-14 Application granted granted Critical

1999-06-14 Publication of DK0461039T3 publication Critical patent/DK0461039T3/da

Links

HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK91401480T 1990-06-08 1991-06-06 Nye benzimidazolafledte forbindelser, fremgangsmåde til deres fremstilling, de opnåede mellemprodukter, deres anvendelse so DK0461039T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR909007135A FR2663028B1 (fr)	1990-06-08	1990-06-08	Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR909015811A FR2670489B1 (fr)	1990-12-18	1990-12-18	Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR9103778A FR2674523A1 (fr)	1991-03-28	1991-03-28	Nouveaux derives de benzimidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number	Publication Date
DK0461039T3 true DK0461039T3 (da)	1999-06-14

Family

ID=27252235

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91401480T DK0461039T3 (da)	1990-06-08	1991-06-06	Nye benzimidazolafledte forbindelser, fremgangsmåde til deres fremstilling, de opnåede mellemprodukter, deres anvendelse so

Country Status (11)

Country	Link
EP (1)	EP0461039B1 (de)
JP (1)	JP3084302B2 (de)
KR (1)	KR100204633B1 (de)
AT (1)	ATE171177T1 (de)
AU (2)	AU7820091A (de)
CA (1)	CA2044124A1 (de)
DE (1)	DE69130192T2 (de)
DK (1)	DK0461039T3 (de)
ES (1)	ES2121773T3 (de)
HU (1)	HUT58061A (de)
IE (1)	IE911950A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE70593B1 (en) *	1989-09-29	1996-12-11	Eisai Co Ltd	Biphenylmethane derivative the use of it and pharmacological compositions containing same
EP0461040A1 (de) *	1990-06-08	1991-12-11	Roussel Uclaf	Imidazolderivate, Verfahren zu deren Herstellung, Zwischenprodukte, deren Anwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen
US5616599A (en) *	1991-02-21	1997-04-01	Sankyo Company, Limited	Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
TW274551B (de) *	1991-04-16	1996-04-21	Takeda Pharm Industry Co Ltd
EP0531874A1 (de) *	1991-09-10	1993-03-17	Tanabe Seiyaku Co., Ltd.	Imidazopyridin-Derivate und Verfahren für ihre Herstellung
TW300219B (de) *	1991-09-14	1997-03-11	Hoechst Ag
DE4315349A1 (de) *	1992-10-06	1994-11-10	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
HU219598B (hu) *	1992-12-17	2001-05-28	Sankyo Co. Ltd.	Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
DE4304455A1 (de) *	1993-02-15	1994-08-18	Bayer Ag	Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
CA2115985A1 (en) *	1993-02-25	1994-08-26	Kohei Nishikawa	Vascular hypertrophy suppressor
JP3810020B2 (ja) *	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤
CA2125251C (en) *	1993-06-07	2005-04-26	Yoshiyuki Inada	A pharmaceutical composition for angiotensin ii-mediated diseases
US5753672A (en) *	1994-04-19	1998-05-19	Tanabe Seiyaku Co., Ltd.	Imidazopyridine derivatives and process for preparing the same
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61151176A (ja) *	1984-12-24	1986-07-09	Sumitomo Chem Co Ltd	ベンズイミダゾール誘導体およびそれを有効成分とする殺虫、殺ダニ剤
CA1334092C (en) *	1986-07-11	1995-01-24	David John Carini	Angiotensin ii receptor blocking imidazoles
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
DE3928177A1 (de) *	1989-04-08	1991-02-28	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (de) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Substituierte Benzimidazole als Angiotensin II-Hemmer
GB8911854D0 (en) *	1989-05-23	1989-07-12	Ici Plc	Heterocyclic compounds
IE70593B1 (en) *	1989-09-29	1996-12-11	Eisai Co Ltd	Biphenylmethane derivative the use of it and pharmacological compositions containing same
IL95975A (en) *	1989-10-24	1997-06-10	Takeda Chemical Industries Ltd	N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them

1991
- 1991-06-06 DE DE69130192T patent/DE69130192T2/de not_active Expired - Fee Related
- 1991-06-06 AT AT91401480T patent/ATE171177T1/de not_active IP Right Cessation
- 1991-06-06 DK DK91401480T patent/DK0461039T3/da active
- 1991-06-06 ES ES91401480T patent/ES2121773T3/es not_active Expired - Lifetime
- 1991-06-06 EP EP91401480A patent/EP0461039B1/de not_active Expired - Lifetime
- 1991-06-06 AU AU78200/91A patent/AU7820091A/en not_active Abandoned
- 1991-06-07 KR KR1019910009418A patent/KR100204633B1/ko not_active Expired - Fee Related
- 1991-06-07 JP JP03162300A patent/JP3084302B2/ja not_active Expired - Fee Related
- 1991-06-07 CA CA002044124A patent/CA2044124A1/fr not_active Abandoned
- 1991-06-07 AU AU78246/91A patent/AU657478B2/en not_active Ceased
- 1991-06-07 IE IE195091A patent/IE911950A1/en not_active IP Right Cessation
- 1991-06-07 HU HU911914A patent/HUT58061A/hu unknown

Also Published As

Publication number	Publication date
KR100204633B1 (ko)	1999-06-15
EP0461039B1 (de)	1998-09-16
ES2121773T3 (es)	1998-12-16
HU911914D0 (en)	1991-12-30
IE911950A1 (en)	1991-12-18
EP0461039A1 (de)	1991-12-11
KR920000730A (ko)	1992-01-29
AU7824691A (en)	1991-12-12
AU657478B2 (en)	1995-03-16
CA2044124A1 (fr)	1991-12-09
DE69130192T2 (de)	1999-03-25
ATE171177T1 (de)	1998-10-15
JPH04235973A (ja)	1992-08-25
AU7820091A (en)	1991-12-12
HUT58061A (en)	1992-01-28
JP3084302B2 (ja)	2000-09-04
DE69130192D1 (de)	1998-10-22

Publication	Publication Date	Title
AU7820091A (en)	1991-12-12	New benzimidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
ATE3712T1 (de)	1983-06-15	Verfahren zur herstellung von acylcyaniden.
DK1005841T3 (da)	2005-05-17	Fremgangsmåde til formning af dentale genopbygninger samt apparat hertil
DE69609993D1 (de)	2000-09-28	Calixarene und ihre verwendung für das abtrennen von metallen
ZA891408B (en)	1989-11-29	Substituted 1,2,4-triazinediones,processes for their preparation and their use
DK0408371T3 (da)	1996-12-16	Hæmoregulatoriske peptider
AU635239B2 (en)	1993-03-18	N-acyl-2-amino acid amides containing phosphinic esters, process for their preparation, and n-acyl-2-amino acid nitriles as precursors
DE69518165D1 (de)	2000-08-31	Bicyclische nonan-und decanverbindungen mit dopamine-rezeptor-affinitaet
DK0648763T3 (da)	2001-08-13	Ny fremgangsmåde til fremstilling af afledede svovlforbindelser af imidazol og de opnåede nye mellemstoffer
DE69334164D1 (de)	2007-10-11	Verfahren zur epigenetischen regelung der protein-biosynthese durch wellen-resonanz
DE59401372D1 (de)	1997-02-06	Verfahren zur Herstellung von Halogenmethylbenzoylcyaniden und neue Halogenmethyl-benzoylcyanide
DK0399748T3 (da)	1996-02-12	Fremgangsmåde til fremstilling af 2-oxindol-1-carboxamider
ATE214921T1 (de)	2002-04-15	Neuer kalium-kanal-agonist, der von trichoderma virens gewonnen wird
ES494257A0 (es)	1981-03-16	Procedimiento para la preparacion de una peptidamida
IL86943A0 (en)	1988-12-30	Process for the preparation of bicyclic amino carboxylic acids and novel compounds obtained by such process
ES508652A0 (es)	1982-11-01	"procedimiento para la preparacion de compuestos que contienen grupos amida de acido carboxilico".
DE69232406D1 (de)	2002-03-21	Verfahren zur Herstellung von Fluoro-Chinolin-3-Carbonsäurederivate
DE59602077D1 (de)	1999-07-08	Verfahren zur Herstellung von (4,5)-trans-Oxazolidin-derivaten
HUT75196A (en)	1997-04-28	Method of preparing 5-chloro-4-hydroxypyrimidines, 2-chlorenamines as intermediates in the method
FR2358404A1 (fr)	1978-02-10	Composes a structure du type de l'adamantane et leur preparation
DK293889D0 (da)	1989-06-14	2-amino-7-hydroxytetralinethere
SE9102571D0 (sv)	1991-09-06	A novel method of generating clones for the expression of unfused proteins
DK0547124T3 (da)	1996-07-22	Fremgangsmåde til fremstilling af E/Z-blandinger af 2-(6-alkyl-bicyklo-(3.3.0)-octan-3-yliden)- eddikesyreestere med en overvejende andel af E-isomeren
ES456161A1 (es)	1978-07-01	Un procedimiento para la preparacion de nuevas triazindionasherbicidas.
RO79565A2 (ro)	1982-08-17	Substante din clasa amidelor acizilor-3-aril-piridazonil-1-acetici