DK0463162T3 - Fremgangsmåde til fremstilling af 5,6,7-trinor-4,8-inter-m-phenylen-PGI2-derivater - Google Patents

Fremgangsmåde til fremstilling af 5,6,7-trinor-4,8-inter-m-phenylen-PGI2-derivater

Info

Publication number: DK0463162T3
Authority: DK; Denmark
Prior art keywords: trinor; inter; preparation; reaction; cyclopenta
Prior art date: 1989-02-27

Application number

DK90903426.6T

Other languages

Danish (da)

English (en)

Inventor

Kiyotaka Ohno

Hiroshi Nagase

Yutaka Hosono

Hisanori Wakita

Koji Kawai

Hideo Yoshiwara

Original Assignee

Toray Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-27

Filing date

1990-02-27

Publication date

1994-06-20

1990-02-27 Application filed by Toray Industries filed Critical Toray Industries

1994-06-20 Application granted granted Critical

1994-06-20 Publication of DK0463162T3 publication Critical patent/DK0463162T3/da

Links

QZOYBAYFYVVGBT-UHFFFAOYSA-N 1,1-dibromo-2,3-dihydrocyclopenta[b][1]benzofuran Chemical compound BrC1(CCC=2OC3=C(C21)C=CC=C3)Br QZOYBAYFYVVGBT-UHFFFAOYSA-N 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
238000003747 Grignard reaction Methods 0.000 abstract 1
238000010478 Prins reaction Methods 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
229960001123 epoprostenol Drugs 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/235—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/247—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Luminescent Compositions (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK90903426.6T 1989-02-27 1990-02-27 Fremgangsmåde til fremstilling af 5,6,7-trinor-4,8-inter-m-phenylen-PGI2-derivater DK0463162T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP4687489		1989-02-27
JP4687389		1989-02-27

Publications (1)

Publication Number	Publication Date
DK0463162T3 true DK0463162T3 (da)	1994-06-20

Family

ID=26387021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90903426.6T DK0463162T3 (da)	1989-02-27	1990-02-27	Fremgangsmåde til fremstilling af 5,6,7-trinor-4,8-inter-m-phenylen-PGI2-derivater

Country Status (12)

Country	Link
US (2)	US5202447A (fr)
EP (1)	EP0463162B1 (fr)
JP (2)	JP2527277B2 (fr)
AT (1)	ATE105555T1 (fr)
AU (1)	AU634213B2 (fr)
CA (1)	CA2028626C (fr)
DE (1)	DE69008851T2 (fr)
DK (1)	DK0463162T3 (fr)
ES (1)	ES2053180T3 (fr)
FI (1)	FI106715B (fr)
NO (1)	NO176962C (fr)
WO (1)	WO1990010003A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69005006T2 (de) *	1989-03-14	1994-05-11	Toray Industries	2,5,6,7-Tetranor-4,8-inter-m-phenylen-PGI2-Derivate.
US5169959A (en) *	1991-09-23	1992-12-08	Iowa State University Research Foundation, Inc.	Free radical-catalyzed synthesis of benzoprostacyclins
EP0915073B1 (fr) *	1997-02-21	2003-08-13	Toray Industries, Inc.	Procede de production d'isomeres de composes tricycliques a activite optique
WO1999051609A1 (fr) *	1998-04-06	1999-10-14	Basf Aktiengesellschaft	Procede de production de composes de grignard
JP3340732B1 (ja)	2001-10-05	2002-11-05	日本医薬品工業株式会社	シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物
GB0215757D0 (en) *	2002-07-08	2002-08-14	Cascade Biochem Ltd	Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
KR100903311B1 (ko) *	2002-09-18	2009-06-17	연성정밀화학(주)	프로스타글란딘 유도체의 제조방법 및 그를 위한 출발물질
CN103717585B (zh)	2011-06-16	2015-11-25	琅歌生物技术股份有限公司	贝前列素的生产方法
CN103509044A (zh) *	2012-06-21	2014-01-15	上海天伟生物制药有限公司	贝前列素钠中间体及其制备方法
EP2978313B1 (fr)	2013-03-25	2018-02-21	United Therapeutics Corporation	Procédé de fabrication de composés de prostacycline ayant un lieur thiol et des formes pégylées
KR20170012314A (ko) *	2014-05-20	2017-02-02	렁 바이오테크놀로지 인크.	베라프로스트 및 그의 유도체의 제조 방법
KR101986966B1 (ko)	2015-08-12	2019-06-07	유나이티드 쎄러퓨틱스 코포레이션	베라프로스트의 제조 방법
RU2020106540A (ru)	2017-07-27	2021-08-27	Аллерган, Инк.	Агонисты простациклинового рецептора для уменьшения жировых отложений в организме
ES3036901T3 (en)	2018-10-22	2025-09-25	United Therapeutics Corp	Synthesis of esuberaprost prodrugs
CN113493430B (zh) *	2020-03-19	2024-09-10	江西科睿药业有限公司	一种贝前列素及其盐的中间体及其制备方法
US11884640B2 (en)	2021-06-02	2024-01-30	Chirogate International Inc.	Processes and intermediates for the preparations of benzoprostacyclin analogues and benzoprostacyclin analogues prepared therefrom
TW202317527A (zh) *	2021-06-28	2023-05-01	日商大內新興化學工業股份有限公司	貝前列素或光學活性物之合成中間物及其製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57144277A (en) *	1981-03-02	1982-09-06	Toray Ind Inc	Cyclopentabenzofuran derivative
JPS57144233A (en) *	1981-03-02	1982-09-06	Toray Ind Inc	Cyclopentene derivative
JPS57144276A (en) *	1981-03-03	1982-09-06	Toray Ind Inc	5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
JPS58124778A (ja) *	1982-01-20	1983-07-25	Toray Ind Inc	５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
US4880939A (en) *	1986-12-11	1989-11-14	Toray Industries	2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives
DE69005006T2 (de) *	1989-03-14	1994-05-11	Toray Industries	2,5,6,7-Tetranor-4,8-inter-m-phenylen-PGI2-Derivate.

1990
- 1990-02-27 DE DE69008851T patent/DE69008851T2/de not_active Expired - Lifetime
- 1990-02-27 WO PCT/JP1990/000237 patent/WO1990010003A1/fr not_active Ceased
- 1990-02-27 JP JP2503652A patent/JP2527277B2/ja not_active Expired - Lifetime
- 1990-02-27 DK DK90903426.6T patent/DK0463162T3/da active
- 1990-02-27 AU AU51077/90A patent/AU634213B2/en not_active Expired
- 1990-02-27 AT AT9090903426T patent/ATE105555T1/de not_active IP Right Cessation
- 1990-02-27 ES ES90903426T patent/ES2053180T3/es not_active Expired - Lifetime
- 1990-02-27 CA CA002028626A patent/CA2028626C/fr not_active Expired - Lifetime
- 1990-02-27 US US07/601,783 patent/US5202447A/en not_active Expired - Lifetime
- 1990-02-27 EP EP90903426A patent/EP0463162B1/fr not_active Expired - Lifetime
- 1990-10-26 FI FI905315A patent/FI106715B/fi active IP Right Grant
- 1990-10-26 NO NO904668A patent/NO176962C/no not_active IP Right Cessation
1992
- 1992-11-20 US US07/957,357 patent/US5420310A/en not_active Expired - Lifetime
1995
- 1995-11-27 JP JP7331130A patent/JP2836556B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0463162A4 (en)	1992-05-20
CA2028626C (fr)	1997-12-09
CA2028626A1 (fr)	1990-08-28
JP2527277B2 (ja)	1996-08-21
DE69008851D1 (de)	1994-06-16
WO1990010003A1 (fr)	1990-09-07
ES2053180T3 (es)	1994-07-16
ATE105555T1 (de)	1994-05-15
NO176962C (no)	1995-06-28
FI905315A0 (fi)	1990-10-26
AU634213B2 (en)	1993-02-18
EP0463162A1 (fr)	1992-01-02
FI106715B (fi)	2001-03-30
NO176962B (no)	1995-03-20
JPH08225561A (ja)	1996-09-03
US5202447A (en)	1993-04-13
US5420310A (en)	1995-05-30
JP2836556B2 (ja)	1998-12-14
DE69008851T2 (de)	1994-08-18
NO904668L (no)	1990-12-27
NO904668D0 (no)	1990-10-26
AU5107790A (en)	1990-09-26
EP0463162B1 (fr)	1994-05-11

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