DK0464009T3 - Oligopeptidderivater af ipoxantin udstyret med immunomodulerende aktivitet, og farmaceutiske præparater indeholdende samme - Google Patents

Oligopeptidderivater af ipoxantin udstyret med immunomodulerende aktivitet, og farmaceutiske præparater indeholdende samme

Info

Publication number: DK0464009T3
Authority: DK; Denmark
Prior art keywords: arginine; lysyl; prolyl; aspartyl; arginyl
Prior art date: 1990-06-28

Application number

DK91830284T

Other languages

English (en)

Inventor

Mauro Marzi

Piero Foresta

Patrizia Minetti

Maria Ornella Tinti

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-28

Filing date

1991-06-26

Publication date

1999-03-08

1991-06-26 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1999-03-08 Application granted granted Critical

1999-03-08 Publication of DK0464009T3 publication Critical patent/DK0464009T3/da

Links

230000002519 immonomodulatory effect Effects 0.000 title abstract 2
102000015636 Oligopeptides Human genes 0.000 title 1
108010038807 Oligopeptides Proteins 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 abstract 2
SHAVAUDERMUSPN-DVRYWGNFSA-N (2s)-2,6-diamino-n-[(2s)-1-[(2-amino-2-oxoethyl)amino]-3-(4h-imidazol-4-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(=O)NCC(N)=O)CC1C=NC=N1 SHAVAUDERMUSPN-DVRYWGNFSA-N 0.000 abstract 1
AFLBTVGQCQLOFJ-UHFFFAOYSA-N 2-[[1-(2,6-diaminohexanoyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NCCCCC(N)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(O)=O AFLBTVGQCQLOFJ-UHFFFAOYSA-N 0.000 abstract 1
NTUPOKHATNSWCY-UHFFFAOYSA-N 2-[[1-(2-amino-3-phenylpropanoyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C1CCC(C(=O)NC(CCCN=C(N)N)C(O)=O)N1C(=O)C(N)CC1=CC=CC=C1 NTUPOKHATNSWCY-UHFFFAOYSA-N 0.000 abstract 1
UZFHNLYQWMGUHU-UHFFFAOYSA-N 2-[[6-amino-2-[(2-amino-3-carboxypropanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound OC(=O)CC(N)C(=O)NC(CCCCN)C(=O)NC(CCCN=C(N)N)C(O)=O UZFHNLYQWMGUHU-UHFFFAOYSA-N 0.000 abstract 1
JLMZKEQFMVORMA-UHFFFAOYSA-N 5-(diaminomethylideneamino)-2-[[1-(pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl]amino]pentanoic acid Chemical compound NC(N)=NCCCC(C(O)=O)NC(=O)C1CCCN1C(=O)C1NCCC1 JLMZKEQFMVORMA-UHFFFAOYSA-N 0.000 abstract 1
239000004475 Arginine Substances 0.000 abstract 1
PSZNHSNIGMJYOZ-UHFFFAOYSA-N Aspartyl-Arginine Chemical compound OC(=O)CC(N)C(=O)NC(C(O)=O)CCCNC(N)=N PSZNHSNIGMJYOZ-UHFFFAOYSA-N 0.000 abstract 1
108010016626 Dipeptides Proteins 0.000 abstract 1
SCCPDJAQCXWPTF-UHFFFAOYSA-N Glycyl-Aspartate Chemical compound NCC(=O)NC(C(O)=O)CC(O)=O SCCPDJAQCXWPTF-UHFFFAOYSA-N 0.000 abstract 1
108010008488 Glycylglycine Proteins 0.000 abstract 1
SENJXOPIZNYLHU-IUCAKERBSA-N Leu-Arg Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-IUCAKERBSA-N 0.000 abstract 1
CXISPYVYMQWFLE-UHFFFAOYSA-N alanylglycine Chemical compound CC(N)C(=O)NCC(O)=O CXISPYVYMQWFLE-UHFFFAOYSA-N 0.000 abstract 1
108010047495 alanylglycine Proteins 0.000 abstract 1
108010026970 bursopoietin Proteins 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
229940043257 glycylglycine Drugs 0.000 abstract 1
108010000761 leucylarginine Proteins 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108010089198 phenylalanyl-prolyl-arginine Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
108010001055 thymocartin Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK91830284T 1990-06-28 1991-06-26 Oligopeptidderivater af ipoxantin udstyret med immunomodulerende aktivitet, og farmaceutiske præparater indeholdende samme DK0464009T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT48102A IT1241452B (it)	1990-06-28	1990-06-28	Derivati oligopeptidici dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono

Publications (1)

Publication Number	Publication Date
DK0464009T3 true DK0464009T3 (da)	1999-03-08

Family

ID=11264531

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91830284T DK0464009T3 (da)	1990-06-28	1991-06-26	Oligopeptidderivater af ipoxantin udstyret med immunomodulerende aktivitet, og farmaceutiske præparater indeholdende samme

Country Status (8)

Country	Link
US (1)	US5298621A (da)
EP (1)	EP0464009B1 (da)
JP (1)	JPH04230298A (da)
AT (1)	ATE166063T1 (da)
DE (1)	DE69129387T2 (da)
DK (1)	DK0464009T3 (da)
ES (1)	ES2117003T3 (da)
IT (1)	IT1241452B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU717160B2 (en) *	1994-06-22	2000-03-16	Shire Canada Inc.	Novel substituted purinyl derivatives with immunomodulating activity
US5994361A (en) *	1994-06-22	1999-11-30	Biochem Pharma	Substituted purinyl derivatives with immunomodulating activity
US5969135A (en) *	1995-11-02	1999-10-19	Icn Pharmaceuticals, Inc.	Oligonucleotide analogs with an amino acid or a modified amino alcohol residue
DE19541264A1 (de) *	1995-11-06	1997-05-07	Bayer Ag	Purin-6-on-derivate
RU2210382C1 (ru) *	2002-07-09	2003-08-20	Терентьев Александр Александрович	Пептид, обладающий иммунорегуляторным свойством, и его композиция
KR100721144B1 (ko) *	2006-03-22	2007-05-25	(주)아르떼르화장품	펩타이드 혼합물을 포함하는 주름개선용 화장료 조성물
FR3021319B1 (fr)	2014-05-22	2018-08-31	Sederma	Peptides, compositions les comprenant et utilisations notamment cosmetiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU564576B2 (en) *	1981-09-24	1987-08-20	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Purine derivatives
IT1213495B (it) *	1986-09-17	1989-12-20	Sigma Tau Ind Farmaceuti	Processo per la preparazione dell'alfa-n-[(ipoxatin-9-il)pentilossicarbonil-]arginina
IT1223604B (it) *	1987-12-24	1990-09-29	Co Pharma Corp Srl	Derivati purinici ad azione farmacologica

1990
- 1990-06-28 IT IT48102A patent/IT1241452B/it active IP Right Grant
1991
- 1991-06-26 AT AT91830284T patent/ATE166063T1/de not_active IP Right Cessation
- 1991-06-26 EP EP91830284A patent/EP0464009B1/en not_active Expired - Lifetime
- 1991-06-26 DK DK91830284T patent/DK0464009T3/da active
- 1991-06-26 ES ES91830284T patent/ES2117003T3/es not_active Expired - Lifetime
- 1991-06-26 DE DE69129387T patent/DE69129387T2/de not_active Expired - Fee Related
- 1991-06-28 JP JP3158342A patent/JPH04230298A/ja active Pending
- 1991-06-28 US US07/723,418 patent/US5298621A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2117003T3 (es)	1998-08-01
DE69129387T2 (de)	1998-09-17
IT9048102A1 (it)	1991-12-28
EP0464009A2 (en)	1992-01-02
ATE166063T1 (de)	1998-05-15
IT1241452B (it)	1994-01-17
US5298621A (en)	1994-03-29
EP0464009B1 (en)	1998-05-13
DE69129387D1 (de)	1998-06-18
IT9048102A0 (it)	1990-06-28
EP0464009A3 (en)	1992-06-17
JPH04230298A (ja)	1992-08-19

Publication	Publication Date	Title
AU5571190A (en)	1990-11-29	Retroviral protease inhibiting compounds
DE3365772D1 (en)	1986-10-09	1,4-dihydropyridines, process for their preparation and their application as pharmaceutical preparations
CA2263983A1 (en)	1998-03-05	Cyclic amine derivatives for inhibiting blood platelet aggregation
TR200100438T2 (tr)	2001-06-21	Hepatit C inhibitörü peptitler
IE801342L (en)	1980-12-29	Peptides
IL110151A0 (en)	1994-10-07	Amide and urea derivatives and pharmaceutical compositions containing the same
DK0571253T3 (da)	1999-07-19	Benzimidazolderivater med antidiabetisk og antiblodpladekoagulerende virkning
DK0437563T3 (da)	1995-05-29	Bioligiske aktive lægemiddelpolymerderivater
IT1244501B (it)	1994-07-15	Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono
DE69129387D1 (de)	1998-06-18	Mit Ipoxantin ausgestattete Oligopeptidderivate mit immunomodulatorischer Wirksamkeit und diese enthaltende pharmazeutische Zusammensetzungen
UA8028A1 (uk)	1995-12-26	Спосіб отримання похідних птерідіна
NZ229450A (en)	1990-08-28	Condensed pyrazole 3-oxo-propanenitrile derivatives and pharmaceutical compositions
BR9610876A (pt)	1999-07-13	Inibidores de protease de guanidino
EP0533951A4 (en)	1993-09-01	Novel oxazinone derivative
DE68917211D1 (de)	1994-09-08	N-(5,6,7,8-Tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)-glutaminsäure-Derivate.
NZ219012A (en)	1988-11-29	Glu-asp-ala tripeptide derivatives and pharmaceutical compositions
AU3624089A (en)	1989-12-21	Analgesic phenothiazine derivatives
GR3025164T3 (en)	1998-02-27	Analogs of 15-déoxyspergualine, process for their preparation and their use as immunosuppressive agents.
ATE104315T1 (de)	1994-04-15	Peptid-derivate und wirkstoffe gegen dementia.
DK540589A (da)	1990-05-01	Pyrrolidinderivater
IL84195A0 (en)	1988-03-31	The synthesis of peptide amino-alkylamides and peptide hydrazides by the solid-phase method and novel compounds thus produced
ATE46347T1 (de)	1989-09-15	Immunostimulierende peptide.
DE3471938D1 (en)	1988-07-14	Antibiotics, method for their preparation, their use as medicines and intermediates for their preparation
LV10289A (lv)	1994-10-20	Jauns pentapeptids ta iegusanas panemiens kompozicija sunu augsanas inhibesanai inhibesanas panemiens
EP0493346A3 (en)	1992-08-26	Derivatives of 1,2,3,4-tetrahydronaphtylamine endowed with nootropic activity and pharmaceutical compositions containing same