DK0465368T3 - Nye svovlforbindelser afledt af imidazol, fremgangsmåde til deres fremstilling, nye opnåede mellemforbindelser, deres anven - Google Patents

Nye svovlforbindelser afledt af imidazol, fremgangsmåde til deres fremstilling, nye opnåede mellemforbindelser, deres anven

Info

Publication number
DK0465368T3
DK0465368T3 DK91401857T DK91401857T DK0465368T3 DK 0465368 T3 DK0465368 T3 DK 0465368T3 DK 91401857 T DK91401857 T DK 91401857T DK 91401857 T DK91401857 T DK 91401857T DK 0465368 T3 DK0465368 T3 DK 0465368T3
Authority
DK
Denmark
Prior art keywords
imidazole
preparation
aryl
alkyl
amino
Prior art date
Application number
DK91401857T
Other languages
Danish (da)
English (en)
Inventor
Jean-Claude Caille
Alain Corbier
Michel Fortin
Gilles Hamon
Simone Jouquey
Jean-Paul Vevert
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9008538A external-priority patent/FR2664271B1/fr
Priority claimed from FR9104882A external-priority patent/FR2675503B1/fr
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DK0465368T3 publication Critical patent/DK0465368T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK91401857T 1990-07-05 1991-07-04 Nye svovlforbindelser afledt af imidazol, fremgangsmåde til deres fremstilling, nye opnåede mellemforbindelser, deres anven DK0465368T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9008538A FR2664271B1 (fr) 1990-07-05 1990-07-05 Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR9104882A FR2675503B1 (fr) 1991-04-19 1991-04-19 Nouveaux derives soufres de l'imidazole, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number Publication Date
DK0465368T3 true DK0465368T3 (da) 1999-03-08

Family

ID=26228128

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91401857T DK0465368T3 (da) 1990-07-05 1991-07-04 Nye svovlforbindelser afledt af imidazol, fremgangsmåde til deres fremstilling, nye opnåede mellemforbindelser, deres anven

Country Status (21)

Country Link
US (3) US5412101A (de)
EP (1) EP0465368B1 (de)
JP (2) JP3192171B2 (de)
KR (1) KR100216006B1 (de)
CN (1) CN1045769C (de)
AT (1) ATE166344T1 (de)
AU (1) AU653160B2 (de)
CA (1) CA2046265C (de)
DE (1) DE69129428T2 (de)
DK (1) DK0465368T3 (de)
ES (1) ES2117001T3 (de)
FI (1) FI111542B (de)
HU (1) HU217444B (de)
IE (1) IE912335A1 (de)
IL (1) IL98319A (de)
MA (1) MA22203A1 (de)
MX (1) MX9100092A (de)
OA (1) OA09506A (de)
RU (1) RU2086542C1 (de)
UA (1) UA26130A (de)
WO (1) WO2004074258A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
FR2687674B1 (fr) * 1992-02-07 1995-05-19 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
EP0573218B1 (de) * 1992-06-02 2001-03-07 Sankyo Company Limited 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung
GB9213934D0 (en) * 1992-06-30 1992-08-12 Smithkline Beecham Corp Chemical compounds
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
IT1255461B (it) * 1992-07-28 1995-11-02 Luso Farmaco Inst Eteri di imidazoli ad attivita' a ii antagonista
US5376666A (en) * 1992-11-30 1994-12-27 The Du Pont Merck Pharmaceutical Company Angiotension-II receptor blocking, azacycloalkyl or azacycloalkenyl
JP3501484B2 (ja) * 1992-12-17 2004-03-02 三共株式会社 ビフェニル誘導体
FR2711367B1 (fr) * 1993-10-19 1995-12-01 Roussel Uclaf Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus.
US5395844A (en) * 1993-06-10 1995-03-07 The Du Pont Merck Pharmaceutical Company Imidazole 5-position substituted angiotensin II antagonists
US5409926A (en) * 1993-07-19 1995-04-25 Merck & Co., Inc. AT-2 antagonist inhibition of vascular restenosis
FR2711368B1 (fr) * 1993-09-16 1996-01-05 Roussel Uclaf Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus.
FR2716882B1 (fr) * 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
DE69532245T2 (de) * 1994-09-26 2004-09-16 Shionogi & Co., Ltd. Imidazolderivat
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19739113A1 (de) * 1997-09-06 1999-03-11 Gefinex Polymerschaeume Gmbh Vorexpandierte polyolefinische Schaumpartikel
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
KR20010048940A (ko) * 1999-11-30 2001-06-15 서평원 프로세서의 디바이스 제어 시스템
NZ531153A (en) * 2001-08-09 2005-10-28 Ono Pharmaceutical Co Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
EP1752450A1 (de) 2005-08-01 2007-02-14 Merck Sante Imidazolderivate als Fruktose-1,6-biphosphataseinhibitoren und pharmazeutische Zusammensetzungen diese enthaltend
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en) 2007-11-15 2010-11-09 Med Institute, Inc. Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
EP2810951B1 (de) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP5395905B2 (ja) * 2008-09-02 2014-01-22 エルダー・ファーマシューティカルズ・リミテッド 抗炎症化合物
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179512A (en) * 1977-03-01 1979-12-18 Merck & Co., Inc. 4-Substituted-2-arylimidazoles
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4882348A (en) * 1987-12-29 1989-11-21 Smithkline Beckman Corporation 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids

Also Published As

Publication number Publication date
RU2086542C1 (ru) 1997-08-10
DE69129428D1 (de) 1998-06-25
DE69129428T2 (de) 1998-11-05
KR920002552A (ko) 1992-02-28
FI913250A7 (fi) 1992-01-06
ATE166344T1 (de) 1998-06-15
HU912265D0 (en) 1991-12-30
JP3261403B2 (ja) 2002-03-04
US5412101A (en) 1995-05-02
MA22203A1 (fr) 1992-04-01
OA09506A (fr) 1992-11-15
IL98319A0 (en) 1992-06-21
JP2001151759A (ja) 2001-06-05
CA2046265A1 (fr) 1992-01-06
AU653160B2 (en) 1994-09-22
US5684028A (en) 1997-11-04
US5599830A (en) 1997-02-04
EP0465368A1 (de) 1992-01-08
FI913250A0 (fi) 1991-07-04
HU217444B (hu) 2000-01-28
UA26130A (uk) 1999-06-07
MX9100092A (es) 1992-02-28
IE912335A1 (en) 1992-01-15
JP3192171B2 (ja) 2001-07-23
IL98319A (en) 1997-04-15
KR100216006B1 (ko) 1999-08-16
EP0465368B1 (de) 1998-05-20
AU8016391A (en) 1992-01-09
CN1058775A (zh) 1992-02-19
WO2004074258A1 (fr) 2004-09-02
HUT58297A (en) 1992-02-28
ES2117001T3 (es) 1998-08-01
JPH04230369A (ja) 1992-08-19
FI111542B (fi) 2003-08-15
CN1045769C (zh) 1999-10-20
CA2046265C (fr) 2005-10-18

Similar Documents

Publication Publication Date Title
FI913250A0 (fi) Nya svavelderivat av imidazol, foerfarande foer framstaellning av dessa, nya mellanprodukter, anvaendning av dessa som laekemedel och farmaceutiska kompositioner innehaollande dessa.
DK370682A (da) Fremgangsmaade til fremstilling af carbapenemderivater
ES8500911A1 (es) Procedimiento para la obtencion de derivados de guanidina
HUP9802859A2 (hu) Acil-amino-szalicilsav-amid-származékok és alkalmazásuk peszticidként
DK0997459T3 (da) Mellemprodukter til fremstilling af retrovirale protease-hæmmere
DK138283A (da) Spiro(4.(3+n))-2-aza-3-carboxylsyre-derivater, fremgangsmaade til fremstilling deraf samt midler indeholdende disse forbindelser og deres anvendelse
BR8403562A (pt) Herbicidas derivados de ciclo-hexano-1,3-diona
BG101538A (bg) Фунгицидна смес
ATE78461T1 (de) Schaedlingsbekaempfungsverbindungen.
DE3668171D1 (de) 1-aryl-5-alkoximinoalkylamino-pyrazole.
MX9101986A (es) Inhibidores acat de urea de oxisulfonilo
DK333185A (da) Stabilisering af monoclonale antistoffer
ES8604897A1 (es) Procedimiento para la obtencion de 1-(2-oxiaminocarbonilfe- nilsulfonil)-3-heteroaril-ureas
DE3876314D1 (de) Substituierte imidazolone mit herbizider wirkung.
FI940030A0 (fi) Uusi menetelmä imidatsolin rikkijohdannaisten valmistamiseksi ja uusiavälituotteita
NO964801L (no) Eksplosivblandinger
HUT44264A (en) Herbicides comprising phosphorous 5-amino-1-arylpyrazole derivative as active substance and process for preparing the active substances
DK350387D0 (da) Substituerede furazaner, deres fremstilling og anvendelse til bekaempelse af skadelige organismer samt ved fremstillingen anvendelige mellemprodukter og disses fremstilling
ES8604941A1 (es) Procedimiento para la obtencion de benzodisultamas
MX9700821A (es) Nueva utilizacion y derivados novedosos del imidazol, su procedimiento de preparacion, los nuevos intermediarios obtenidos, su aplicacion a manera de medicamentos y las composiciones farmaceuticas que los incluyen.
BR9811679A (pt) Antifúngicos de 1,3-dioxolanos 2,4,4-trissubstituìdos.
HUT38501A (en) Herbicidal compositions comprising substituted tetrahydrothiopyrane-2,4-dion-derivatives as active substance and process for preparing substituted tetrahydrothiopyrane-2,4-dion-derivatives
ES2004804A6 (es) Un procedimiento para preparar derivados de carboxialquildipeptidos
PT77541A (en) Process for preparing substituted 9h-8-oxo-pyrimido<2,1-f>puri-ne-2,4-diones and pharmaceutical compositions containing them
ES8505516A1 (es) Procedimiento para la obtencion de alcoximinoalquilamino-1, 3, 5-triazinas