DK0466730T3 - Geminale biphosphonsyrer og derivater deraf som anti-arthritismidler - Google Patents

Geminale biphosphonsyrer og derivater deraf som anti-arthritismidler

Info

Publication number
DK0466730T3
DK0466730T3 DK90905160.9T DK90905160T DK0466730T3 DK 0466730 T3 DK0466730 T3 DK 0466730T3 DK 90905160 T DK90905160 T DK 90905160T DK 0466730 T3 DK0466730 T3 DK 0466730T3
Authority
DK
Denmark
Prior art keywords
geminal
derivatives
arthritic agents
biphosphonic acids
acids
Prior art date
Application number
DK90905160.9T
Other languages
English (en)
Inventor
Colin John Dunn
Richard Allen Nugent
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DK0466730T3 publication Critical patent/DK0466730T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503Five-membered rings
    • C07F9/65031Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK90905160.9T 1989-04-03 1990-03-08 Geminale biphosphonsyrer og derivater deraf som anti-arthritismidler DK0466730T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33261889A 1989-04-03 1989-04-03

Publications (1)

Publication Number Publication Date
DK0466730T3 true DK0466730T3 (da) 1993-10-18

Family

ID=23299047

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90905160.9T DK0466730T3 (da) 1989-04-03 1990-03-08 Geminale biphosphonsyrer og derivater deraf som anti-arthritismidler

Country Status (10)

Country Link
EP (1) EP0466730B1 (da)
JP (1) JPH04505011A (da)
KR (1) KR920701216A (da)
AT (1) ATE91689T1 (da)
AU (1) AU628158B2 (da)
CA (1) CA2046905A1 (da)
DE (1) DE69002328T2 (da)
DK (1) DK0466730T3 (da)
HU (1) HU207095B (da)
WO (1) WO1990012017A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69108733T2 (de) * 1990-08-21 1995-09-14 Upjohn Co Bisphosphonsäurederivate als antiarthritische mittel.
US5391743A (en) * 1992-05-29 1995-02-21 Procter & Gamble Pharmaceuticals, Inc. Quaternary nitrogen-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism and methods of treating and preventing dental calculus and plaque
DK0642519T3 (da) * 1992-05-29 2000-09-18 Procter & Gamble Pharma Svovlholdige phosphonatforbindelser til behandling af unormal calcium- og phosphatmetabolisme
US5753634A (en) * 1992-05-29 1998-05-19 The Procter & Gamble Company Quaternary nitrogen containing phosphonate compounds, pharmaceutical compostions, and methods for treating abnormal calcium and phosphate metabolism
US5763611A (en) * 1992-05-29 1998-06-09 The Procter & Gamble Company Thio-substituted cyclic phosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
FI945595A7 (fi) * 1992-05-29 1994-11-28 Procter & Gamble Pharmaceuticals Inc Tiosubstituoituja typpipitoisia heterosyklisiä fosfonaattiyhdisteitä e pänormaalin kalsium- ja fosfaattiaineenvaihdunnan hoitamiseksi
EP0646119B1 (en) * 1992-05-29 1998-07-15 PROCTER & GAMBLE PHARMACEUTICALS, INC. Quaternary nitrogen-containing phosphonate compounds for treating abnormal calcium and phosphate metabolism as well as dental calculus and plaque
WO1994002152A2 (en) * 1992-07-16 1994-02-03 The Upjohn Company Phosphono derivatives as antiinflammatory and antiarthritic agents
WO1994007501A1 (en) * 1992-09-23 1994-04-14 The Upjohn Company Arylmethylphosphonates and phosphonic acids useful as anti-inflammatory agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687768A (en) * 1984-12-21 1987-08-18 The Procter & Gamble Company Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism
HU199151B (en) * 1987-03-10 1990-01-29 Yamanouchi Pharma Co Ltd Process for producing bis-phosphonic acid derivatives
DE3719513A1 (de) * 1987-06-11 1988-12-22 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
HUT58751A (en) 1992-03-30
EP0466730A1 (en) 1992-01-22
HU902754D0 (en) 1991-12-30
KR920701216A (ko) 1992-08-11
EP0466730B1 (en) 1993-07-21
HU207095B (en) 1993-03-01
AU5330690A (en) 1990-11-05
CA2046905A1 (en) 1990-10-04
WO1990012017A1 (en) 1990-10-18
JPH04505011A (ja) 1992-09-03
DE69002328D1 (de) 1993-08-26
DE69002328T2 (de) 1993-12-09
AU628158B2 (en) 1992-09-10
ATE91689T1 (de) 1993-08-15

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