DK0469352T3 - Fremgangsmåde til isolering og oprensning af monosialgangliosid fra en udgangslipidblanding ved kompleksering med alfa-cyclodextrin og beslægtet mellemforbindelse - Google Patents

Fremgangsmåde til isolering og oprensning af monosialgangliosid fra en udgangslipidblanding ved kompleksering med alfa-cyclodextrin og beslægtet mellemforbindelse

Info

Publication number: DK0469352T3
Authority: DK; Denmark
Prior art keywords: cyclodextrin; monosialganglioside; complexation; purifying; isolating
Prior art date: 1990-07-13

Application number

DK91111469.2T

Other languages

English (en)

Inventor

Benito Casu

Ennio Lanzarotti

Giangiacomo Torri

Annamaria Naggi

Armando Cedro

Original Assignee

Crinos Industria Farmaco

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-13

Filing date

1991-07-10

Publication date

1994-01-03

1991-07-10 Application filed by Crinos Industria Farmaco filed Critical Crinos Industria Farmaco

1994-01-03 Application granted granted Critical

1994-01-03 Publication of DK0469352T3 publication Critical patent/DK0469352T3/da

Links

238000000034 method Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2
229920001450 Alpha-Cyclodextrin Polymers 0.000 title 1
HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 title 1
229940043377 alpha-cyclodextrin Drugs 0.000 title 1
238000010668 complexation reaction Methods 0.000 title 1
150000002632 lipids Chemical class 0.000 title 1
229920000858 Cyclodextrin Polymers 0.000 abstract 3
150000002270 gangliosides Chemical class 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
238000000108 ultra-filtration Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Crystallography & Structural Chemistry (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Saccharide Compounds (AREA)
Separation Using Semi-Permeable Membranes (AREA)

DK91111469.2T 1990-07-13 1991-07-10 Fremgangsmåde til isolering og oprensning af monosialgangliosid fra en udgangslipidblanding ved kompleksering med alfa-cyclodextrin og beslægtet mellemforbindelse DK0469352T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT02094290A IT1243340B (it)	1990-07-13	1990-07-13	Metodo per isolare e purificare il monosialoganglioside ad elevato grado di purezza da una miscela lipidica che lo contiene e relativo composto intermedio

Publications (1)

Publication Number	Publication Date
DK0469352T3 true DK0469352T3 (da)	1994-01-03

Family

ID=11174397

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91111469.2T DK0469352T3 (da)	1990-07-13	1991-07-10	Fremgangsmåde til isolering og oprensning af monosialgangliosid fra en udgangslipidblanding ved kompleksering med alfa-cyclodextrin og beslægtet mellemforbindelse

Country Status (9)

Country	Link
US (1)	US5108613A (da)
EP (1)	EP0469352B1 (da)
JP (1)	JPH04230398A (da)
AT (1)	ATE96804T1 (da)
DE (1)	DE69100588T2 (da)
DK (1)	DK0469352T3 (da)
ES (1)	ES2060257T3 (da)
IT (1)	IT1243340B (da)
PT (1)	PT98270A (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1747785A1 (en) *	2005-07-28	2007-01-31	Istituto Clinico Humanitas	Cyclodextrins for blood detoxification
US7943750B2 (en) *	2007-06-18	2011-05-17	Laboratoire Medidom S.A.	Process for obtaining pure monosialoganglioside GM1 for medical use
CN103087120B (zh) *	2013-02-26	2015-12-02	北京四环制药有限公司	单唾液酸四己糖神经节苷脂的制备方法及其应用
CN121712580A (zh)	2023-08-07	2026-03-20	碳码股份公司	糖鞘脂的分离方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS615024A (ja) *	1984-06-18	1986-01-10	Takeda Chem Ind Ltd	生薬製剤の製造法
US4868291A (en) *	1987-08-20	1989-09-19	Bristol-Myers Company	4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
IT1223408B (it) *	1987-12-09	1990-09-19	Crinos Industria Farmaco	Procedimento per la preparazione di monosialoganglioside
CH677494A5 (da) *	1988-10-28	1991-05-31	Nestle Sa

1990
- 1990-07-13 IT IT02094290A patent/IT1243340B/it active IP Right Grant
1991
- 1991-07-10 PT PT98270A patent/PT98270A/pt not_active Application Discontinuation
- 1991-07-10 DK DK91111469.2T patent/DK0469352T3/da active
- 1991-07-10 AT AT91111469T patent/ATE96804T1/de not_active IP Right Cessation
- 1991-07-10 DE DE91111469T patent/DE69100588T2/de not_active Expired - Fee Related
- 1991-07-10 ES ES91111469T patent/ES2060257T3/es not_active Expired - Lifetime
- 1991-07-10 EP EP91111469A patent/EP0469352B1/en not_active Expired - Lifetime
- 1991-07-15 JP JP3174194A patent/JPH04230398A/ja active Pending
- 1991-07-15 US US07/729,728 patent/US5108613A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69100588T2 (de)	1994-03-31
PT98270A (pt)	1992-05-29
JPH04230398A (ja)	1992-08-19
IT9020942A0 (it)	1990-07-13
IT9020942A1 (it)	1992-01-13
EP0469352B1 (en)	1993-11-03
DE69100588D1 (de)	1993-12-09
IT1243340B (it)	1994-06-10
EP0469352A1 (en)	1992-02-05
ATE96804T1 (de)	1993-11-15
ES2060257T3 (es)	1994-11-16
US5108613A (en)	1992-04-28

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