DK0469548T3 - 4-Amino-delta4-steroider og deres anvendelse som inhibitorer af 5alfa-reduktase - Google Patents

4-Amino-delta4-steroider og deres anvendelse som inhibitorer af 5alfa-reduktase

Info

Publication number: DK0469548T3
Authority: DK; Denmark
Prior art keywords: steroids; reductase; inhibitors; amino; delta4
Prior art date: 1990-08-01

Application number

DK91112796.7T

Other languages

English (en)

Inventor

Joseph P Burkhart

Philip M Weintraub

Thomas R Blohm

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-01

Filing date

1991-07-30

Publication date

1996-06-24

1991-03-19 Priority claimed from US07/671,555 external-priority patent/US5143909A/en

1991-07-02 Priority claimed from US07/720,900 external-priority patent/US5120840A/en

1991-07-30 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-06-24 Application granted granted Critical

1996-06-24 Publication of DK0469548T3 publication Critical patent/DK0469548T3/da

Links

108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
150000003431 steroids Chemical class 0.000 title 1
RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0027—Azides

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK91112796.7T 1990-08-01 1991-07-30 4-Amino-delta4-steroider og deres anvendelse som inhibitorer af 5alfa-reduktase DK0469548T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US56104190A	1990-08-01	1990-08-01
US07/671,555 US5143909A (en)	1991-03-19	1991-03-19	Aminosteroids in a method for inhibiting c17-20 lyase
US07/720,900 US5120840A (en)	1990-08-01	1991-07-02	4-amino-4-ene-steroids and their use as 5α-reductase inhibitors

Publications (1)

Publication Number	Publication Date
DK0469548T3 true DK0469548T3 (da)	1996-06-24

Family

ID=27415841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91112796.7T DK0469548T3 (da)	1990-08-01	1991-07-30	4-Amino-delta4-steroider og deres anvendelse som inhibitorer af 5alfa-reduktase

Country Status (17)

Country	Link
EP (1)	EP0469548B1 (da)
JP (1)	JP3021819B2 (da)
KR (1)	KR100186812B1 (da)
AT (1)	ATE138931T1 (da)
AU (1)	AU637247B2 (da)
CA (1)	CA2048242C (da)
DE (1)	DE69119992T2 (da)
DK (1)	DK0469548T3 (da)
ES (1)	ES2090184T3 (da)
FI (1)	FI102377B (da)
GR (1)	GR3020672T3 (da)
HU (1)	HU210046B (da)
IE (1)	IE75198B1 (da)
IL (1)	IL98999A (da)
NO (1)	NO180339C (da)
NZ (1)	NZ239142A (da)
PT (1)	PT98518B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5143909A (en) *	1991-03-19	1992-09-01	Merrell Dow Pharmaceuticals Inc.	Aminosteroids in a method for inhibiting c17-20 lyase
EP0641356B1 (en) *	1991-12-20	1998-04-22	Glaxo Wellcome Inc.	Inhibitors of 5-alpha-testosterone reductase
US5302589A (en) *	1992-08-07	1994-04-12	Glaxo, Inc.	Heterocyclic inhibitors of 5-α-testosterone reductase
US5486511A (en) *	1993-05-25	1996-01-23	Merrell Dow Pharmaceuticals Inc.	4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5356935A (en) *	1993-12-13	1994-10-18	Eli Lilly And Company	Reduced phenanthrenes
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US20100048524A1 (en)	2008-03-14	2010-02-25	Angela Brodie	Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2010091306A1 (en)	2009-02-05	2010-08-12	Tokai Pharmaceuticals	Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
EP2968370A4 (en)	2013-03-14	2016-09-21	Univ Maryland	AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF
EP3033088A4 (en)	2013-08-12	2017-03-08	Tokai Pharmaceuticals, Inc.	Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3780070A (en) *	1972-09-21	1973-12-18	Schering Corp	4-azido-17alpha-alkinyl-4-gonen-17beta-ol-3-ones and method for their preparation
CA1154008A (en) *	1979-05-02	1983-09-20	Thomas R. Blohm	STEROID 5.alpha.-REDUCTASE INHIBITORS
GB8503940D0 (en) *	1985-02-15	1985-03-20	Erba Farmitalia	4-substituted androstendione derivatives
GB8622330D0 (en) *	1986-09-17	1986-10-22	Erba Farmitalia	4-substituted 6-alkylidenandrostene-3,17-dione derivatives
GB8711579D0 (en) *	1987-05-15	1987-06-17	Erba Farmitalia	4-amino-androstenedione derivatives

1991
- 1991-07-26 NZ NZ239142A patent/NZ239142A/en unknown
- 1991-07-26 AU AU81362/91A patent/AU637247B2/en not_active Ceased
- 1991-07-29 IL IL9899991A patent/IL98999A/en active IP Right Grant
- 1991-07-30 DK DK91112796.7T patent/DK0469548T3/da active
- 1991-07-30 ES ES91112796T patent/ES2090184T3/es not_active Expired - Lifetime
- 1991-07-30 EP EP91112796A patent/EP0469548B1/en not_active Expired - Lifetime
- 1991-07-30 AT AT91112796T patent/ATE138931T1/de not_active IP Right Cessation
- 1991-07-30 DE DE69119992T patent/DE69119992T2/de not_active Expired - Fee Related
- 1991-07-31 IE IE270591A patent/IE75198B1/en not_active IP Right Cessation
- 1991-07-31 HU HU912558A patent/HU210046B/hu not_active IP Right Cessation
- 1991-07-31 FI FI913657A patent/FI102377B/fi active
- 1991-07-31 NO NO912981A patent/NO180339C/no not_active IP Right Cessation
- 1991-07-31 KR KR1019910013238A patent/KR100186812B1/ko not_active Expired - Fee Related
- 1991-07-31 CA CA002048242A patent/CA2048242C/en not_active Expired - Fee Related
- 1991-07-31 PT PT98518A patent/PT98518B/pt not_active IP Right Cessation
- 1991-08-01 JP JP3214163A patent/JP3021819B2/ja not_active Expired - Lifetime
1996
- 1996-07-31 GR GR960402030T patent/GR3020672T3/el unknown

Also Published As

Publication number	Publication date
FI913657A0 (fi)	1991-07-31
HUT59156A (en)	1992-04-28
PT98518A (pt)	1992-06-30
NZ239142A (en)	1994-05-26
ATE138931T1 (de)	1996-06-15
FI102377B1 (fi)	1998-11-30
JPH06172379A (ja)	1994-06-21
NO180339B (no)	1996-12-23
HU210046B (en)	1995-01-30
CA2048242C (en)	2003-04-15
NO180339C (no)	1997-04-02
EP0469548B1 (en)	1996-06-05
IL98999A (en)	1995-10-31
GR3020672T3 (en)	1996-10-31
ES2090184T3 (es)	1996-10-16
JP3021819B2 (ja)	2000-03-15
AU8136291A (en)	1992-02-06
AU637247B2 (en)	1993-05-20
EP0469548A2 (en)	1992-02-05
DE69119992D1 (de)	1996-07-11
FI102377B (fi)	1998-11-30
DE69119992T2 (de)	1997-02-06
IE75198B1 (en)	1997-08-27
CA2048242A1 (en)	1992-02-02
FI913657A7 (fi)	1992-02-02
IE912705A1 (en)	1992-02-12
NO912981L (no)	1992-02-03
IL98999A0 (en)	1992-07-15
EP0469548A3 (en)	1992-06-03
HU912558D0 (en)	1992-01-28
KR100186812B1 (ko)	1999-04-01
PT98518B (pt)	1999-01-29
NO912981D0 (no)	1991-07-31
KR920004409A (ko)	1992-03-27

Publication	Publication Date	Title
DK0590428T3 (da)	2000-05-22	Azaquinoxaliner, fremgangsmåde til deres fremstilling og deres anvendelse
DK0640069T3 (da)	1999-07-19	Fluoralkenylforbindelser og deres anvendelse som midler til bekæmpelse af skadelige organismer
DK396284D0 (da)	1984-08-17	17beta-methoxycarbonylderivater af androstan-raekken samt deres fremstiling og anvendelse
GR1000118B (el)	1991-06-28	Συνθεσις 1,2-διοξετανων & ενδιαμεσαι ουσιαι δι αυτην.
DK0532515T3 (da)	1997-04-21	Fremstilling af substituerede piperidiner
NO912981L (no)	1992-02-03	Fremgangsmaate for fremstilling av 4-amino-delta4-steroider og deres anvendelse som 5alfa-reduktaseinhibitorer
ATE154607T1 (de)	1997-07-15	Neue steroide
DK0469547T3 (da)	1996-06-10	4-Amino-delta4,6-steroider og deres anvendelse som inhibitorer af 5alfa-reduktase
BR9713176A (pt)	2000-02-08	Benzotiofenos amorfos,métodos de preparação e métodos de uso
ATE145213T1 (de)	1996-11-15	Kardioaktive steroide
DK0643070T3 (da)	2000-02-28	Steroidmellemproduker og fremgangsmåde til deres fremstilling
FI946189A0 (fi)	1994-12-30	5-alfa-reduktaasi-inhibiittoreina käyttökelpoiset 17-alkyyliketonisteroidit
EP1196428A4 (en)	2002-10-16	STEROIDS SUBSTITUTED BY 11-BETA-ARYL-17.17-SPIROTHIOLANE
ZA844402B (en)	1986-01-29	Hexahydropyrrolo(2,1-a)isoquinoline derivatives
DE69716598D1 (de)	2002-11-28	Stabilisierung von anstrichen durch spiroindanderivaten
GR1000098B (el)	1991-03-15	Παραγωγα διοξαζοκινης, παρασκευη των και συνθεσεις που τα περιεχουν.
DK484988D0 (da)	1988-08-31	Thionophosphonsyreestere, deres fremstilling og anvendelse til bekaempelse af skadelige organismer
GR900100394A (el)	1991-10-10	Νεοι μέ?οδοι λήψεως 6-με?υλ 19-ΝΟΡ στεροειδών και η μετατροπή αυτών εις 17α-υποκατεστημένα 19-ΝΟΡ πρεγναδιένια.
ATE144779T1 (de)	1996-11-15	17-phenyl-substituierte steroide mit cardiotonischer wirksamkeit
DK300183D0 (da)	1983-06-29	Fremgangsmade til fremstilling af antiallergiske pyrazin-bis-(2-oxoglycin) forbindelser
JPS51118019A (en)	1976-10-16	Voltage regulator of generator