DK0476045T3 - Bionedbrydelige polymerer til lægemiddel-afgivelse i knogler - Google Patents

Bionedbrydelige polymerer til lægemiddel-afgivelse i knogler

Info

Publication number: DK0476045T3
Authority: DK; Denmark
Prior art keywords: bones; drug delivery; biodegradable polymers; bone; delivery
Prior art date: 1989-06-05

Application number

DK90909880.8T

Other languages

English (en)

Inventor

Robert S Langer

Tobin N Gerhart

Cato T Laurencin

Abraham J Domb

Wilson C Hayes

Original Assignee

Massachusetts Inst Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-05

Filing date

1990-06-01

Publication date

1996-09-16

1990-06-01 Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology

1996-09-16 Application granted granted Critical

1996-09-16 Publication of DK0476045T3 publication Critical patent/DK0476045T3/da

Links

210000000988 bone and bone Anatomy 0.000 title abstract 2
229920002988 biodegradable polymer Polymers 0.000 title 1
239000004621 biodegradable polymer Substances 0.000 title 1
238000012377 drug delivery Methods 0.000 title 1
229920002732 Polyanhydride Polymers 0.000 abstract 1
229920000954 Polyglycolide Polymers 0.000 abstract 1
229920001710 Polyorthoester Polymers 0.000 abstract 1
230000033115 angiogenesis Effects 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000012867 bioactive agent Substances 0.000 abstract 1
229920013641 bioerodible polymer Polymers 0.000 abstract 1
230000008468 bone growth Effects 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
229940127089 cytotoxic agent Drugs 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
229920000747 poly(lactic acid) Polymers 0.000 abstract 1
239000004633 polyglycolic acid Substances 0.000 abstract 1
239000004626 polylactic acid Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Materials Engineering (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

DK90909880.8T 1989-06-05 1990-06-01 Bionedbrydelige polymerer til lægemiddel-afgivelse i knogler DK0476045T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US36122289A	1989-06-05	1989-06-05

Publications (1)

Publication Number	Publication Date
DK0476045T3 true DK0476045T3 (da)	1996-09-16

Family

ID=23421153

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90909880.8T DK0476045T3 (da)	1989-06-05	1990-06-01	Bionedbrydelige polymerer til lægemiddel-afgivelse i knogler

Country Status (8)

Country	Link
EP (1)	EP0476045B1 (da)
JP (1)	JPH05503286A (da)
AT (1)	ATE141804T1 (da)
CA (1)	CA2056384C (da)
DE (1)	DE69028303T2 (da)
DK (1)	DK0476045T3 (da)
ES (1)	ES2093647T3 (da)
WO (1)	WO1990015586A2 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5328695A (en) *	1983-03-22	1994-07-12	Massachusetts Institute Of Technology	Muscle morphogenic protein and use thereof
US5206023A (en) *	1991-01-31	1993-04-27	Robert F. Shaw	Method and compositions for the treatment and repair of defects or lesions in cartilage
DE69232555T2 (de) *	1991-02-01	2002-10-31	Massachusetts Institute Of Technology, Cambridge	Biologisch abbaubare Polymermischungen zur Arzneistoffabgabe
FR2673843B1 (fr) *	1991-03-14	1995-01-13	Centre Nat Rech Scient	Composition pharmaceutique implantable, bioresorbable a base de poly(acide lactique), destinee a mettre en óoeuvre une antibiotherapie interne locale.
DK0591392T3 (da) *	1991-06-21	1996-09-30	Genetics Inst	Farmaceutiske formuleringer af osteogene proteiner
US5171579A (en) *	1991-10-11	1992-12-15	Genetics Institute, Inc.	Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
CA2119090A1 (en) *	1993-03-26	1994-09-27	Wayne R. Gombotz	Compositions for controlled release of biologically active tgf-.beta.
WO1995011707A1 (en) *	1993-10-28	1995-05-04	Thm Biomedical, Inc.	Improved process and device for treating and healing a bone void
US5981825A (en) *	1994-05-13	1999-11-09	Thm Biomedical, Inc.	Device and methods for in vivo culturing of diverse tissue cells
DE19521642C2 (de) *	1995-06-14	2000-11-09	Aesculap Ag & Co Kg	Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung
US6391336B1 (en) *	1997-09-22	2002-05-21	Royer Biomedical, Inc.	Inorganic-polymer complexes for the controlled release of compounds including medicinals
WO2000063268A1 (en) *	1999-04-16	2000-10-26	Wm. Marsh Rice University	Poly(propylene fumarate) cross linked with poly(ethylene glycol)
IL140017A (en) *	2000-11-30	2009-09-22	Abraham J Domb	Polyhedra
EP1228772A1 (en) *	2001-02-01	2002-08-07	AM-Pharma B.V.	Novel bone cement containing bioactive agents
WO2006071813A2 (en)	2004-12-23	2006-07-06	Massachusetts Institute Of Technology	Disposable medical supplies from hydrolytically biodegradable plastics
US20170360947A1 (en) *	2014-12-18	2017-12-21	Universite de Bordeaux	Polymer particles and biomaterials comprising the same
WO2016097848A1 (en)	2014-12-18	2016-06-23	Dexcel Pharma Technologies Ltd.	Alternating and semi-alternating poly(ester-anhydride) copolymers
CA3057766A1 (en)	2017-03-29	2018-10-04	Dexcel Pharma Technologies Ltd.	Compositions comprising biodegradable copolymers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4186448A (en) *	1976-04-16	1980-02-05	Brekke John H	Device and method for treating and healing a newly created bone void
DK154260C (da) *	1981-02-20	1989-05-22	Mundipharma Gmbh	Fremgangsmaade til fremstilling af et knogleimplantat af braendt tricalciumphosphat, specielt til udfyldning af hulrum eller til sammensaetning af knogledele efter fraktur.
US4761289A (en) *	1986-10-10	1988-08-02	International Minerals & Chemical Corp.	Sustained release implant and method for preparing same
US4952403A (en) *	1987-06-19	1990-08-28	President And Fellows Of Harvard College	Implants for the promotion of healing of meniscal tissue
DE3734223A1 (de) *	1987-10-09	1989-04-20	Boehringer Ingelheim Kg	Implantierbares, biologisch abbaubares wirkstofffreigabesystem
FI83729C (fi) *	1987-11-26	1991-08-26	Biocon Oy	Kirurgisk implantat.
WO1990009783A1 (en) *	1989-02-22	1990-09-07	Massachusetts Institute Of Technology	Delivery system for controlled release of bioactive factors

1990
- 1990-06-01 WO PCT/US1990/003136 patent/WO1990015586A2/en not_active Ceased
- 1990-06-01 DE DE69028303T patent/DE69028303T2/de not_active Expired - Fee Related
- 1990-06-01 EP EP90909880A patent/EP0476045B1/en not_active Expired - Lifetime
- 1990-06-01 ES ES90909880T patent/ES2093647T3/es not_active Expired - Lifetime
- 1990-06-01 CA CA002056384A patent/CA2056384C/en not_active Expired - Fee Related
- 1990-06-01 DK DK90909880.8T patent/DK0476045T3/da active
- 1990-06-01 JP JP2509835A patent/JPH05503286A/ja active Pending
- 1990-06-01 AT AT90909880T patent/ATE141804T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1990015586A2 (en)	1990-12-27
WO1990015586A3 (en)	1991-03-21
DE69028303D1 (de)	1996-10-02
EP0476045B1 (en)	1996-08-28
ATE141804T1 (de)	1996-09-15
JPH05503286A (ja)	1993-06-03
DE69028303T2 (de)	1997-01-30
ES2093647T3 (es)	1997-01-01
CA2056384C (en)	1998-06-23
CA2056384A1 (en)	1990-12-06
EP0476045A1 (en)	1992-03-25

Publication	Publication Date	Title
ATE141804T1 (de)	1996-09-15	Biodegradierbare polymere zur arzneimittelverabreichung in knochen
BR9402861A (pt)	1995-04-04	Composição adesiva, biocompatível, biodegradável e não tóxica, biomaterial e material adesivo
FI883594A0 (fi)	1988-08-01	Hedelmöitystä ehkäisevä implantti
EP0626404A3 (en)	1995-04-12	Absorbable block copolymers and surgical articles fabricated therefrom.
EP1018978A4 (en)	2004-06-23	BIODEGRADABLE IMPLANT MATERIAL WITH BIOACTIVE CERAMICS
SE8902288D0 (sv)	1989-06-22	Farmaceutisk komposition
WO2004071356A3 (en)	2004-12-23	Resorbable devices
BR0107942A (pt)	2004-01-06	Polìmeros de proteìna de liberação lenta
DE69010764D1 (de)	1994-08-25	Verfahren für chirurgische Implantate.
FR2663836B1 (fr)	1994-09-23	Implant orthopedique ou dentaire multibloc.
FI970522A0 (fi)	1997-02-07	Koostumukset ja menetelmät pidennetyn paikallisanestesian aikaansaamiseksi
DE60126498D1 (de)	2007-03-22	Biodegradierbare chirurgische Implantate
CA2111193A1 (en)	1992-12-23	Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
ATE40519T1 (de)	1989-02-15	Implantat mit resorbierbarem schaft.
DE69426740D1 (de)	2001-04-05	Antibakterielle Gefässprothese und chirurgisches Nahtmaterial
DE69026100D1 (de)	1996-04-25	Biologisch abbaubarer und resorbierbarer Formkörper für chirurgischen Gebrauch
FR2693108B3 (fr)	1994-08-12	Matériau chirurgical résorbable en particulier fil de suture résorbable.
BR9404567A (pt)	1995-08-08	Peça de implante dentário ósseo individual
CA2004166A1 (en)	1990-05-31	Implant for use in bone surgery
PT1071483E (pt)	2002-08-30	Implantacao de ossos
ES2053833T3 (es)	1994-08-01	Recubrimiento bioabsorbible para un articulo quirurgico.
GB2366738A (en)	2002-03-20	Including a body of non-resorbable bioactive material implant
FR2659224B1 (fr)	1992-06-19	Repere chirurgical, et mesureur, notamment pour prothese de hanche, mettant en óoeuvre un tel repere.
DK0782865T3 (da)	2001-12-10	Resorberbare, fysiologisk acceptable copolymerer og anvendelse deraf
DE60022776D1 (de)	2005-10-27	Verfahren und material zur hämostase bei knochen