DK0479066T3 - Fremgangsmåde til fremstilling af stabile, injicerbare beta-caroten-solubilisater - Google Patents

Fremgangsmåde til fremstilling af stabile, injicerbare beta-caroten-solubilisater

Info

Publication number
DK0479066T3
DK0479066T3 DK91116027.3T DK91116027T DK0479066T3 DK 0479066 T3 DK0479066 T3 DK 0479066T3 DK 91116027 T DK91116027 T DK 91116027T DK 0479066 T3 DK0479066 T3 DK 0479066T3
Authority
DK
Denmark
Prior art keywords
solubilisates
carotene
preparation
stable injectable
beta
Prior art date
Application number
DK91116027.3T
Other languages
Danish (da)
English (en)
Inventor
Dieter Dr Horn
Lutz Dr End
Erik Dr Lueddecke
Joachim U Dr Schneider
Peter Paul Dr Hoppe
Friedrich-Wilhelm Dr Rensmann
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0479066T3 publication Critical patent/DK0479066T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07Retinol compounds, e.g. vitamin A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Colloid Chemistry (AREA)
  • Cosmetics (AREA)
DK91116027.3T 1990-10-02 1991-09-20 Fremgangsmåde til fremstilling af stabile, injicerbare beta-caroten-solubilisater DK0479066T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4031094A DE4031094A1 (de) 1990-10-02 1990-10-02 Verfahren zur herstellung von stabilen injizierbaren (beta)-carotin-solubilisaten

Publications (1)

Publication Number Publication Date
DK0479066T3 true DK0479066T3 (da) 1995-02-13

Family

ID=6415401

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91116027.3T DK0479066T3 (da) 1990-10-02 1991-09-20 Fremgangsmåde til fremstilling af stabile, injicerbare beta-caroten-solubilisater

Country Status (7)

Country Link
US (1) US5453447A (fr)
EP (1) EP0479066B1 (fr)
JP (1) JP3105307B2 (fr)
CA (1) CA2051978A1 (fr)
DE (2) DE4031094A1 (fr)
DK (1) DK0479066T3 (fr)
ES (1) ES2066306T3 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024454A1 (fr) * 1992-06-04 1993-12-09 Betatene Limited Composition a haute teneur en cis beta-carotene
DK19393D0 (da) * 1993-02-19 1993-02-19 Danochemo As Fremgangsmaade til fremstilling af et i vand dispergerbart pulverformigt carotenoidpraeparat
DE19609538A1 (de) * 1996-03-11 1997-09-18 Basf Ag Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung
ES2178651T3 (es) * 1993-03-22 2003-01-01 Cognis Australia Pty Ltd Compuestos carotenoides terapeuticos deispersables en agua.
ES2149264T3 (es) * 1993-03-22 2000-11-01 Cognis Australia Pty Ltd Agente terapeutico para el tratamiento de melanomas.
US5843334A (en) * 1994-06-20 1998-12-01 Nippon Shinyaku Co., Ltd. Method of producing emulsions and an emulsification apparatus
JPH10513444A (ja) * 1995-02-03 1998-12-22 ビーエーエスエフ アクチェンゲゼルシャフト 皮膚疾患の治療のための医薬品の製造のためのカロチノイドの使用
DE19609477A1 (de) * 1996-03-11 1997-09-18 Basf Ag Stabile wäßrige Solubilisate von Carotinoiden und Vitamine
DE19609476A1 (de) * 1996-03-11 1997-09-18 Basf Ag Stabile zur parenteralen Verabreichung geeignete Carotinoid-Emulsionen
DE19653410A1 (de) * 1996-12-20 1998-06-25 Basf Ag Verwendung von Carotinoid-Solubilisaten zum Färben von Lebensmitteln und pharmazeutischen Zubereitungen
DE19838636A1 (de) 1998-08-26 2000-03-02 Basf Ag Carotinoid-Formulierungen, enthaltend ein Gemisch aus beta-Carotin, Lycopin und Lutein
WO2000029103A1 (fr) * 1998-11-13 2000-05-25 Optime Therapeutics, Inc. Procede et dispositif de production de liposomes
US6855296B1 (en) 1998-11-13 2005-02-15 Optime Therapeutics, Inc. Method and apparatus for liposome production
AT408186B (de) * 1998-12-15 2001-09-25 Sanochemia Pharmazeutika Ag Wässerige zubereitung von beta-carotin
ATE269301T1 (de) * 2001-01-24 2004-07-15 Kuraray Co Verfahren zur herstellung von carotinoid emulsionen
DE10221212A1 (de) * 2002-05-13 2003-11-27 Andreas Maack Sporopollenin enthaltende lösliche Zusammensetzung und Verwendung
CN1768033A (zh) * 2003-03-28 2006-05-03 株式会社可乐丽 制备类胡萝卜素乳液的方法
US20110137243A1 (en) * 2007-09-06 2011-06-09 Abbott Cardiovascular Systems Inc. Coating On A Balloon Device
JP5680275B2 (ja) 2009-01-20 2015-03-04 富士フイルム株式会社 エマルション組成物、該エマルション組成物を含む食品及び化粧品
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
US20140023712A1 (en) * 2012-07-20 2014-01-23 Basf Se Aqueous Transparent Oil-In-Water Emulsion Comprising an Emulsified Carotenoid
AU2013363208B2 (en) 2012-12-19 2016-04-14 ew nutrition Carotenoid Technologies S.A.U. Xanthophyll compositions and methods of use
WO2017027528A1 (fr) * 2015-08-10 2017-02-16 Purdue Research Foundation Procédés et systèmes pour déposer des principes actifs sur des substrats
CN112841645A (zh) * 2021-01-14 2021-05-28 江南大学 一种β-胡萝卜素微胶囊的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976024A (en) * 1954-10-06 1961-03-21 Pure Oil Co Apparatus for preparing colloidal dispersions
US3932634A (en) * 1973-06-28 1976-01-13 Pfizer Inc. High potency vitamin water dispersible formulations
DE2526938C2 (de) * 1975-02-14 1982-04-22 F. Hoffmann-La Roche & Co. AG, 4002 Basel Vitaminpräparate
DE3048000A1 (de) * 1980-12-19 1982-07-15 Basf Ag Stabile injizierbare (beta)-carotin-solubilisate und verfahren zu ihrer herstellung
US4895452A (en) * 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles

Also Published As

Publication number Publication date
JPH04247028A (ja) 1992-09-03
EP0479066A2 (fr) 1992-04-08
JP3105307B2 (ja) 2000-10-30
US5453447A (en) 1995-09-26
CA2051978A1 (fr) 1992-04-03
DE59103790D1 (de) 1995-01-19
EP0479066B1 (fr) 1994-12-07
DE4031094A1 (de) 1992-04-09
EP0479066A3 (en) 1993-03-10
ES2066306T3 (es) 1995-03-01

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