DK0482013T3 - Ikke-glycolyserede humant interleukin-3 analoge proteiner - Google Patents

Ikke-glycolyserede humant interleukin-3 analoge proteiner

Info

Publication number
DK0482013T3
DK0482013T3 DK90909318.9T DK90909318T DK0482013T3 DK 0482013 T3 DK0482013 T3 DK 0482013T3 DK 90909318 T DK90909318 T DK 90909318T DK 0482013 T3 DK0482013 T3 DK 0482013T3
Authority
DK
Denmark
Prior art keywords
glycolysed
human interleukin
analog proteins
analog
proteins
Prior art date
Application number
DK90909318.9T
Other languages
Danish (da)
English (en)
Inventor
David L Urdal
Helmut Sassenfeld
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of DK0482013T3 publication Critical patent/DK0482013T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/823—Lower fungi, e.g. mold
    • Y10S530/824—Yeasts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK90909318.9T 1989-06-30 1990-06-13 Ikke-glycolyserede humant interleukin-3 analoge proteiner DK0482013T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/374,667 US5128450A (en) 1989-06-30 1989-06-30 Nonglycosylated human interleukin-3 analog proteins

Publications (1)

Publication Number Publication Date
DK0482013T3 true DK0482013T3 (da) 1996-06-03

Family

ID=23477728

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90909318.9T DK0482013T3 (da) 1989-06-30 1990-06-13 Ikke-glycolyserede humant interleukin-3 analoge proteiner

Country Status (12)

Country Link
US (1) US5128450A (de)
EP (1) EP0482013B1 (de)
JP (1) JPH04506342A (de)
AT (1) ATE138099T1 (de)
AU (1) AU630207B2 (de)
CA (1) CA2033182A1 (de)
DE (1) DE69027031T2 (de)
DK (1) DK0482013T3 (de)
ES (1) ES2090135T3 (de)
FI (1) FI916077A7 (de)
NO (1) NO301482B1 (de)
WO (1) WO1991000350A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714585A (en) * 1987-10-26 1998-02-03 Sterling Winthrop, Inc. Antibodies that are immunoreactive with interleukin-7
US5328988A (en) * 1987-10-26 1994-07-12 Immunex Corporation Interleukin-7
US5705362A (en) * 1992-05-25 1998-01-06 Gist-Brocades, N.V. Modified signal sequences
US5463029A (en) * 1992-11-23 1995-10-31 Immunex Corporation Purification of fusion proteins comprising GM-CSF and IL-3
DK0672145T3 (da) * 1992-11-24 2003-08-11 Searle & Co Interleukin-3-(IL-3)-polypeptider med flere mutationer
US6361976B1 (en) 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6403076B1 (en) 1992-11-24 2002-06-11 S. Christopher Bauer Compositions for increasing hematopoiesis with interleukin-3 mutants
US6153183A (en) * 1992-11-24 2000-11-28 G. D. Searle & Company Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
WO1995013089A1 (en) * 1993-11-10 1995-05-18 Henry M. Jackson Foundation For The Advancement Of Military Medicine Compositions and method for stimulating antibody release by b lymphocytes
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
EP1140198B1 (de) 1999-01-13 2007-10-31 Alchemia Oncology Pty Limited Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
JP2004537506A (ja) 2001-03-01 2004-12-16 ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド 血液細胞欠乏症を治療するためのある種のステロイドの使用
MXPA04001828A (es) * 2001-08-27 2005-03-07 Meditech Res Ltd Protocolos terapeuticos mejorados.
JP4212827B2 (ja) * 2002-05-16 2009-01-21 シスメックス株式会社 骨髄液有核細胞自動分析方法
WO2004019953A1 (en) 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
WO2006079169A1 (en) * 2005-01-25 2006-08-03 Apollo Life Sciences Limited Parameter selected gm-csf, il-3, il-4, il-5 and chimeras thereof for therapeutic and diagnostic purposes
CA2616607C (en) * 2005-07-27 2015-06-02 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
EP1922077A4 (de) * 2005-09-07 2013-03-06 Alchemia Oncology Pty Ltd Therapeutische zusammensetzungen mit hyaluron und therapeutische antikörper sowie behandlungsverfahren
JP5628544B2 (ja) * 2010-04-07 2014-11-19 株式会社豊田中央研究所 クロストリジウム・サーモセラム由来のタンパク質複合体を構築するためのタンパク質及びその利用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695542A (en) * 1983-10-04 1987-09-22 Dnax Research Institute Of Molecular And Cellular Biology, Inc. cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
US4877729A (en) * 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
WO1988004691A1 (en) * 1986-12-16 1988-06-30 Gist-Brocades N.V. Molecular cloning and expression of human il-3
EP0275598B1 (de) * 1986-12-16 1998-01-07 Gist-Brocades N.V. Molekulare Klonierung und Expression von menschlichem IL-3
WO1988005469A1 (en) * 1987-01-20 1988-07-28 Immunex Corporation Human interleukin-3 proteins
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
EP0425536A4 (en) * 1988-07-20 1992-01-02 Immunex Corporation Nonglycosylated human interleukin-3 compositions

Also Published As

Publication number Publication date
FI916077A0 (fi) 1991-12-20
US5128450A (en) 1992-07-07
NO301482B1 (no) 1997-11-03
DE69027031T2 (de) 1996-12-19
EP0482013A1 (de) 1992-04-29
NO915116D0 (no) 1991-12-27
ES2090135T3 (es) 1996-10-16
NO915116L (no) 1992-02-28
WO1991000350A1 (en) 1991-01-10
FI916077A7 (fi) 1991-12-20
AU630207B2 (en) 1992-10-22
ATE138099T1 (de) 1996-06-15
CA2033182A1 (en) 1990-12-31
DE69027031D1 (de) 1996-06-20
AU5821690A (en) 1991-01-17
JPH04506342A (ja) 1992-11-05
EP0482013B1 (de) 1996-05-15

Similar Documents

Publication Publication Date Title
DE69027031D1 (de) Nicht glycosierte proteine, analoge des menschlichen interleukin-3
MXPA02007932A (es) Analogos de nucleosidos con base biciclica modificada con carboxamidina.
AU6701890A (en) Process for the production of biologically active protein
IL85523A (en) Stable alpha interferon complex,its preparation and pharmaceutical compositions comprising it
SE7705432L (sv) Polypeptid och sett for dess framstellning
DE69129248D1 (de) Peptide mit Endothelin antagonistischer Aktivität, deren Herstellung und pharmazeutische Zusammensetzungen
YU174490A (sh) Novi estri tienil-karboksilne kiseline sa aminoalkoholima, njihova kvaterna jedinjenja kao i pripremanje i primena tih jedinjenja
DK395689A (da) Pharmaceutisk tilberedning til behandling af diabetes mellitus
ATE204178T1 (de) Methode zur behandlung und vorbeugung von typ-1 diabetis durch orale verabreichung von insulin
AU6020099A (en) Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
HUP9602498A2 (hu) Antimikrobiális hatású gyógyászati készítmények
PT89534A (pt) Processo para a preparacao de composicoes farmaceuticas anticoagulantes contendo como ingrediente activo proteina c ou proteina c activada combinada com heparina
DE69521693D1 (de) Taxanderivate enthaltende arzneizubereitungen
ES2173858T3 (es) Analogos de huperzina a.
HUP9700826A1 (hu) Peptikus fekély elleni gyógyászati készítmények
ATE183775T1 (de) Cysteinfreie il-6 mutanten
AU4363199A (en) Use of hmg proteins for the preparation of medicaments having cytotoxic activity
ES2003856T3 (es) Derivado del acido tiazolidin-4-carboxilico, su preparacion y composiciones farmaceuticas que lo contienen.
DE69636052D1 (de) Mpl-liganden analoga
DK0427124T3 (da) Antacidatabletter
WO2004028457A3 (en) PHARMACEUTICAL COMPOSITION FOR IMPROVED ADMINISTRATION OF HIV gp41-DERIVED PEPTIDES, AND ITS USE IN THERAPY
EP0820771A3 (de) Arzneimittel zur Behandlung von Neuropathien, das ein lipidlösliches Thiamin und eine Magnesiumverbindung enthält
YU64192A (sh) Analozi insulina
AU7618391A (en) Aqueous pharmaceutical formulations of erythropoietin and the use thereof
GB8908457D0 (en) Pharmaceutical compositions and uses therefor