DK0486565T3 - Discodermolid-forbindelser, præparater indeholdende disse samt metoder til fremstilling og anvendelse deraf - Google Patents

Discodermolid-forbindelser, præparater indeholdende disse samt metoder til fremstilling og anvendelse deraf

Info

Publication number
DK0486565T3
DK0486565T3 DK90912243.4T DK90912243T DK0486565T3 DK 0486565 T3 DK0486565 T3 DK 0486565T3 DK 90912243 T DK90912243 T DK 90912243T DK 0486565 T3 DK0486565 T3 DK 0486565T3
Authority
DK
Denmark
Prior art keywords
methods
compounds
preparation
compositions containing
coz
Prior art date
Application number
DK90912243.4T
Other languages
Danish (da)
English (en)
Inventor
Malika Gunasekera
Sarath P Gunasekera
Ross E Longley
Neal Burres
Original Assignee
Harbor Branch Oceanographic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Branch Oceanographic filed Critical Harbor Branch Oceanographic
Application granted granted Critical
Publication of DK0486565T3 publication Critical patent/DK0486565T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Liquid Crystal Substances (AREA)
DK90912243.4T 1989-08-11 1990-08-09 Discodermolid-forbindelser, præparater indeholdende disse samt metoder til fremstilling og anvendelse deraf DK0486565T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/392,468 US4939168A (en) 1989-08-11 1989-08-11 Discodermolide compounds, compositions containing same and methods of preparation and use

Publications (1)

Publication Number Publication Date
DK0486565T3 true DK0486565T3 (da) 1995-10-02

Family

ID=23550726

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90912243.4T DK0486565T3 (da) 1989-08-11 1990-08-09 Discodermolid-forbindelser, præparater indeholdende disse samt metoder til fremstilling og anvendelse deraf

Country Status (9)

Country Link
US (1) US4939168A (fr)
EP (1) EP0486565B1 (fr)
JP (1) JP3008985B2 (fr)
AT (1) ATE121739T1 (fr)
CA (1) CA2056412C (fr)
DE (1) DE69018991T2 (fr)
DK (1) DK0486565T3 (fr)
ES (1) ES2071826T3 (fr)
WO (1) WO1991001982A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0711158T4 (da) 1993-07-29 2008-11-03 Us Gov Health & Human Serv Metode til behandling af atherosclerose eller restenose ved anvendelse af mikrotubulus-stabiliserende middel
GB9315802D0 (en) * 1993-07-30 1993-09-15 Roussel Lab Ltd Chemical compounds
US5478861A (en) * 1994-02-18 1995-12-26 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
US5684036A (en) * 1994-02-18 1997-11-04 Harbor Branch Oceanographic Institution, Inc. Cytotoxic macrolides and methods of use
US5681847A (en) * 1995-12-05 1997-10-28 Harbor Branch Oceanographic Institution, Inc. Methods of using discodermolide compounds
US20050065353A1 (en) * 1996-12-03 2005-03-24 Smith Amos B. Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US5789605A (en) * 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6127406A (en) * 1998-10-09 2000-10-03 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds and methods of use
US6384187B1 (en) 1999-05-15 2002-05-07 Harbor Branch Oceanographic Institution, Inc. Antiproliferative activity of microsclerodermins
US6495594B2 (en) 2000-03-01 2002-12-17 Harbor Branch Oceanographic Institution, Inc. Biologically active analogs of discodermolide
MY127609A (en) * 2000-08-07 2006-12-29 Novartis Ag Process for preparing discodermolide and analogues thereof
US6541509B2 (en) 2000-09-15 2003-04-01 Albert Einstein College Of Medicine Of Yeshiva University Method for treating neoplasia using combination chemotherapy
US6734177B2 (en) * 2001-04-17 2004-05-11 Novartis Ag Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors
CN100522956C (zh) * 2001-08-06 2009-08-05 诺瓦提斯公司 取代的聚酮化合物,包含它们的药物组合物及其在治疗肿瘤中的用途
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
AU2003226717A1 (en) * 2002-03-27 2003-10-08 Novartis Ag Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation
US7348436B2 (en) * 2004-03-02 2008-03-25 Kosan Biosciences Incorporated Compounds useful for the synthesis of (+)-discodermolide and methods thereof
EP1768662A2 (fr) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
US7772177B2 (en) 2005-05-18 2010-08-10 Aegera Therapeutics, Inc. BIR domain binding compounds
RU2469721C2 (ru) 2006-05-09 2012-12-20 Новартис Аг Комбинация, включающая комплексон железа и противоопухолевый агент, и ее применение
SG171682A1 (en) 2006-05-16 2011-06-29 Aegera Therapeutics Inc Iap bir domain binding compounds
WO2009049378A1 (fr) * 2007-10-17 2009-04-23 Qbiotics Limited Dérivés de lactone
MX358013B (es) 2009-11-13 2018-08-01 Amgen Inc Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3.
EP3263583A1 (fr) 2010-02-12 2018-01-03 Pharmascience Inc. Composés de liaison du domaine iap bir
CA2815154A1 (fr) 2010-08-06 2012-02-09 U3 Pharma Gmbh Utilisation d'agents de liaison her3 dans le traitement de la prostate

Also Published As

Publication number Publication date
EP0486565A1 (fr) 1992-05-27
ES2071826T3 (es) 1995-07-01
ATE121739T1 (de) 1995-05-15
DE69018991D1 (de) 1995-06-01
EP0486565B1 (fr) 1995-04-26
CA2056412A1 (fr) 1991-02-12
WO1991001982A1 (fr) 1991-02-21
DE69018991T2 (de) 1995-08-24
JP3008985B2 (ja) 2000-02-14
JPH04507245A (ja) 1992-12-17
CA2056412C (fr) 2001-04-10
US4939168A (en) 1990-07-03

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