DK0495982T3 - Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel - Google Patents

Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel

Info

Publication number
DK0495982T3
DK0495982T3 DK90914955.1T DK90914955T DK0495982T3 DK 0495982 T3 DK0495982 T3 DK 0495982T3 DK 90914955 T DK90914955 T DK 90914955T DK 0495982 T3 DK0495982 T3 DK 0495982T3
Authority
DK
Denmark
Prior art keywords
preparation
pharmaceutical composition
active ingredient
pyrimidine derivative
bicyclic pyrimidine
Prior art date
Application number
DK90914955.1T
Other languages
Danish (da)
English (en)
Inventor
Yasuji Sakuma
Masaichi Hasegawa
Kenichiro Kataoka
Kenji Hoshina
Noboru Yamazaki
Takashi Kadota
Hisao Yamaguchi
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DK0495982T3 publication Critical patent/DK0495982T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK90914955.1T 1989-10-11 1990-10-11 Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel DK0495982T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26476389 1989-10-11

Publications (1)

Publication Number Publication Date
DK0495982T3 true DK0495982T3 (da) 1996-07-01

Family

ID=17407851

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90914955.1T DK0495982T3 (da) 1989-10-11 1990-10-11 Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel

Country Status (11)

Country Link
US (1) US5378700A (de)
EP (1) EP0495982B1 (de)
JP (1) JP2541702B2 (de)
KR (1) KR0155955B1 (de)
AT (1) ATE139232T1 (de)
AU (1) AU645504B2 (de)
CA (1) CA2067221C (de)
DE (1) DE69027440T2 (de)
DK (1) DK0495982T3 (de)
ES (1) ES2087916T3 (de)
WO (1) WO1991005784A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970009225B1 (ko) * 1989-09-19 1997-06-09 데이진 가부시끼가이샤 피롤로[2,3-디] 피리미딘 유도체, 그의 제조방법 및 그것을 유효성분으로 하는 의약제제
US5254716A (en) * 1992-10-15 1993-10-19 Eli Lilly And Company Intermediates, and processes thereto, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines
FR2699176B1 (fr) * 1992-12-11 1995-03-03 Adir Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
EP0766684A4 (de) * 1994-06-09 1997-07-16 Smithkline Beecham Corp Endothelin-rezeptor antagonisten
JPH10506126A (ja) 1995-05-12 1998-06-16 ニューロゲン コーポレイション 新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス
EP0831829B1 (de) * 1995-06-07 2003-08-20 Pfizer Inc. Heterocyclische kondensierte pyrimidin-derivate
US6395733B1 (en) 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
AU6344396A (en) * 1996-06-28 1998-01-21 James E. Dowling 5,6,7,8-tetrahydropyrimido{4,5-b}azepine derivatives
US6339089B2 (en) 1997-08-13 2002-01-15 Fujirebio Inc. Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
WO1999011643A1 (en) * 1997-09-02 1999-03-11 Du Pont Pharmaceuticals Company Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders
US6472402B1 (en) 1998-04-02 2002-10-29 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives
EP1068205A1 (de) 1998-04-02 2001-01-17 Neurogen Corporation Aminoalkylsubstituierte 5,6,7,8-tetrahydro-9h-pyrido[2,3-b]indol- und 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indolderivate: crf1-spezifische liganden
US6194574B1 (en) 1998-06-09 2001-02-27 Neurogen Corporation Pyrido[2,3-b]indolizine derivatives and aza analogues thereof: CRF1 specific ligands
GB0117396D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
US20070021429A1 (en) * 2003-04-09 2007-01-25 Yves St-Denis Condensed n-heterocyclic compounds and their use as crf receptor antagonists
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
CN103214484B (zh) 2005-12-13 2016-07-06 因塞特控股公司 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶
US8022205B2 (en) * 2006-08-08 2011-09-20 Chugai Seiyaku Kabushiki Kaisha Pyrimidine derivatives as PI3K inhibitor and use thereof
HUE029236T2 (en) 2007-06-13 2017-02-28 Incyte Holdings Corp (R) -3- (4- (7H-Pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile Crystalline salts of Janus kinase inhibitor
EP2231282A1 (de) * 2008-01-22 2010-09-29 Merck Patent GmbH Proteinkinasehemmer und ihre verwendung
TW200938201A (en) 2008-02-07 2009-09-16 Chugai Pharmaceutical Co Ltd Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof
WO2009107767A1 (ja) * 2008-02-29 2009-09-03 大日本住友製薬株式会社 Ｈ４受容体アンタゴニスト作用を有する新規２環性ピリミジン誘導体
EP2432472B1 (de) 2009-05-22 2019-10-02 Incyte Holdings Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octan- oder heptannitril als jak-inhibitoren
TW201113285A (en) * 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
EP3354652B1 (de) 2010-03-10 2020-05-06 Incyte Holdings Corporation Piperidin-4-yl azetidin-derivate als jak1-inhibitoren
AR084691A1 (es) 2010-05-21 2013-06-05 Incyte Corp Formulacion de uso topico para un inhibidor de jak y metodo para tratar trastorno de la piel
CA2818542A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
WO2012068440A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
US20120295911A1 (en) 2010-11-29 2012-11-22 Galleon Pharmaceuticals, Inc. Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases
EP2646423A4 (de) 2010-11-29 2014-04-30 Galleon Pharmaceuticals Inc Neue verbindungen als atemstimulantien zur behandlung von atmungsteuerungsstörungen oder erkrankungen
MY165963A (en) 2011-06-20 2018-05-18 Incyte Holdings Corp Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
TWI761825B (zh) 2012-11-15 2022-04-21 美商英塞特控股公司 盧梭利替尼之緩釋性劑型
MX384910B (es) 2013-03-06 2025-03-14 Incyte Holdings Corp Procesos e intermedios para hacer un inhibidor de jak.
SG11201600815WA (en) 2013-08-07 2016-03-30 Incyte Corp Sustained release dosage forms for a jak1 inhibitor
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
EP3496717A4 (de) * 2016-08-15 2020-01-15 Purdue Research Foundation 4-substituierte aminoisochinolinderivate
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
JP7393348B2 (ja) 2018-01-30 2023-12-06 インサイト・コーポレイション （１－（３－フルオロ－２（トリフルオロメチル）イソニコチニル）ピぺリジン―４－オン）を作製するためのプロセス及び中間体
CN113768934A (zh) 2018-03-30 2021-12-10 因赛特公司 使用jak抑制剂治疗化脓性汗腺炎
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631045A (en) * 1969-11-04 1971-12-28 American Home Prod 4 5-diamino-7h-pyrrolo(2 3-d)pyrimidine derivatives
KR970009225B1 (ko) * 1989-09-19 1997-06-09 데이진 가부시끼가이샤 피롤로[2,3-디] 피리미딘 유도체, 그의 제조방법 및 그것을 유효성분으로 하는 의약제제

Also Published As

Publication number Publication date
JP2541702B2 (ja) 1996-10-09
ES2087916T3 (es) 1996-08-01
CA2067221A1 (en) 1991-04-12
DE69027440D1 (de) 1996-07-18
WO1991005784A1 (en) 1991-05-02
EP0495982B1 (de) 1996-06-12
AU645504B2 (en) 1994-01-20
KR0155955B1 (ko) 1998-11-16
DE69027440T2 (de) 1997-02-06
EP0495982A4 (en) 1994-07-20
CA2067221C (en) 1997-04-15
EP0495982A1 (de) 1992-07-29
US5378700A (en) 1995-01-03
AU6522090A (en) 1991-05-16
ATE139232T1 (de) 1996-06-15

Similar Documents

Publication Publication Date Title
EP0495982A4 (en) Bicyclic pyrimidine derivative, method of producing the same, and pharmaceutical preparation containing the same as active ingredient
DK551989A (da) 3-piperidinyl-1,2-benzisoxazoler, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
TNSN90032A1 (fr) Derives de n-(3-hydroxy-4-piperidinyl) (dihydro-benzofuranne, dihydro-2h-benzopyranne ou dihydro-benzodioxin) carboxamide, et leur procede de preparation
AU2724292A (en) Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-d-neuraminic acid
PT97689A (pt) Processo para a preparacao de composicoes farmaceuticas incorporando como ingrediente activo isoxazol-4-carboxilamida e hidroxialquilideno-cianoacetamida
DK0648778T3 (da) Nye 11-benzaldoximestradien-derivater, fremgangsmåde til deres fremstilling og lægemidler indeholdende disse forbindelser
FI872864A0 (fi) Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
HUT70426A (en) Pyrazolo-pyrimidine derivatives, process for preparing them and pharmaceutical compositions containing them as active agents
BR9303235A (pt) Compostos e processo para sua preparacao,formulacao farmaceutica,metodo para o combate de bacterias e metodo para o tratamento de infecoes bacterianas
FI95773B (fi) Menetelmä vesipitoisen, N-(3,4-dimetoksikinnamoyyli)antraniilihappoa sisältävän farmaseuttisen koostumuksen valmistamiseksi
FI102177B1 (fi) Menetelmä uusien terapeuttisesti aktiivisten kromaani- ja tiokromaanijohdannaisten valmistamiseksi ja välituotteet
FI884375A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten N-(1-alkyyli-3-hydroksi-4-piperidinyyli)bentsamidien valmistamiseksi
FI894899A0 (fi) Menetelmä dispergoituvan kiinteän lääkeainekoostumuksen valmistamiseksi
DK0648779T3 (da) 11-benzaldoxim-17beta-methoxy-17alfa-methoxymethyl-estradien-derivater, fremgangsmåder til deres fremstilling og lægemidler indeholdende disse forbindelser
ZA936658B (en) Benzopyran compounds process for their preparation and the pharmaceutical compositions which contain them
PT97395A (pt) Processo para a preparacao de 2,9-di-substituidas-4h-pirido{1,2-a}-pirimidin-4-onas e de composicoes farmaceuticas que os contem
DE69834500D1 (de) Xanthinderivative zur behandlung von hirnischämie
FI893701A0 (fi) Menetelmä antipsykoottisten 3-piperatsinyylibentsatsolijohdannaisten valmistamiseksi
ES2147749T3 (es) Procedimiento para la preparacion de derivados de ciano-metoxiiminometilo.
BR9611276A (pt) Composto formulação farmacêutica processo para tratamento ou profilaxia de doenças ou condições de seres humanos e uso de um composto
HUT64318A (en) Process for production benzodpyrane derivativs and pharmaceutical preparations containing these compounds as effective substance
HUT45081A (en) Process for producing amino acid derivatives and pharmaceuticals comprising these compounds as active ingredient
BR9502079A (pt) Composto,formulação farmaceutica e processo para preparar um composto
ITMI911853A1 (it) Sale del diclofenac, metodo di preparazione e composizioni farmaceutiche che lo contengono.
ES2196174T3 (es) `derivados de sesquiterpeno de actividad antiviral.