DK0498144T3 - Anvendelse af acetyl-L-carnitin ved terapeutisk behandling af coma - Google Patents
Anvendelse af acetyl-L-carnitin ved terapeutisk behandling af comaInfo
- Publication number
- DK0498144T3 DK0498144T3 DK91830583.0T DK91830583T DK0498144T3 DK 0498144 T3 DK0498144 T3 DK 0498144T3 DK 91830583 T DK91830583 T DK 91830583T DK 0498144 T3 DK0498144 T3 DK 0498144T3
- Authority
- DK
- Denmark
- Prior art keywords
- carnitine
- acetyl
- coma
- therapeutic treatment
- acceptable salts
- Prior art date
Links
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 title abstract 3
- 206010010071 Coma Diseases 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910002A IT1244636B (it) | 1991-01-04 | 1991-01-04 | Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0498144T3 true DK0498144T3 (da) | 1995-07-24 |
Family
ID=11399703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91830583.0T DK0498144T3 (da) | 1991-01-04 | 1992-01-01 | Anvendelse af acetyl-L-carnitin ved terapeutisk behandling af coma |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5192805A (da) |
| EP (1) | EP0498144B1 (da) |
| JP (1) | JP3145451B2 (da) |
| AT (1) | ATE119770T1 (da) |
| DE (1) | DE69201660T2 (da) |
| DK (1) | DK0498144T3 (da) |
| ES (1) | ES2070478T3 (da) |
| GR (1) | GR3015431T3 (da) |
| HK (1) | HK1005847A1 (da) |
| IE (1) | IE66025B1 (da) |
| IT (1) | IT1244636B (da) |
| ZA (1) | ZA9110037B (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1254314B (it) * | 1992-03-27 | 1995-09-14 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari. |
| IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
| IT1277898B1 (it) * | 1995-08-03 | 1997-11-12 | Mendes Srl | Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie |
| IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
| IT1276253B1 (it) | 1995-12-15 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi |
| US5872008A (en) * | 1996-02-09 | 1999-02-16 | Bair; Glenn O. | Methods for diagnosing pre-menstrual syndrome |
| IT1283951B1 (it) * | 1996-03-15 | 1998-05-07 | Mendes Srl | Uso della acetil l-carnitina o dei suoi sali farmacologicamente accettabili per il trattamento terapeutico o la profilassi di |
| IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
| US6090848A (en) * | 1997-12-01 | 2000-07-18 | Sigma-Tau Healthscience S.P.A. | Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans |
| US5863940A (en) | 1997-12-01 | 1999-01-26 | Sigma-Tau Healthscience S.P.A. | Medicament and therapeutical method for treating idiopathic asthenozoospermia |
| DK0951909T4 (da) | 1998-03-19 | 2011-01-24 | Sigma Tau Ind Farmaceuti | Kombinationspræparat omfattende en L-carnitin eller en alkanoyl-L-carnitin, en glycosaminoglycan og/eller bestanddel deraf |
| US8173618B2 (en) * | 2003-07-25 | 2012-05-08 | University Of Massachusetts | Formulations for reducing neuronal degeneration |
| US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
| US8597640B2 (en) * | 2007-10-31 | 2013-12-03 | University Of Massachusetts Lowell | Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging |
| PT2582368T (pt) * | 2010-06-16 | 2018-06-04 | Alfasigma Spa | Acetil-carnitina, para utilização num método para o aumento da neurogénese em tecido neuronal |
| EP2586438A1 (en) | 2011-10-28 | 2013-05-01 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Compound useful for preventing cognitive deficit disorders in a new born from HIV-seropositive pregnant female who is in treatment with azidothymidine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
| IT1150396B (it) * | 1982-12-09 | 1986-12-10 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari |
| IT1184655B (it) * | 1985-10-14 | 1987-10-28 | Sigma Tau Ind Farmaceuti | Imiego di acetil l-carnitina nel trattamento terapeutico degli stati di shock |
| IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
| IT1240760B (it) * | 1990-02-12 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. |
-
1991
- 1991-01-04 IT ITRM910002A patent/IT1244636B/it active IP Right Grant
- 1991-12-20 ZA ZA9110037A patent/ZA9110037B/xx unknown
- 1991-12-27 JP JP34691591A patent/JP3145451B2/ja not_active Expired - Fee Related
- 1991-12-30 IE IE456891A patent/IE66025B1/en not_active IP Right Cessation
-
1992
- 1992-01-01 DK DK91830583.0T patent/DK0498144T3/da active
- 1992-01-01 EP EP91830583A patent/EP0498144B1/en not_active Expired - Lifetime
- 1992-01-01 DE DE69201660T patent/DE69201660T2/de not_active Expired - Fee Related
- 1992-01-01 ES ES91830583T patent/ES2070478T3/es not_active Expired - Lifetime
- 1992-01-01 AT AT91830583T patent/ATE119770T1/de not_active IP Right Cessation
- 1992-01-03 US US07/816,224 patent/US5192805A/en not_active Expired - Lifetime
-
1995
- 1995-03-16 GR GR940403979T patent/GR3015431T3/el unknown
-
1998
- 1998-06-05 HK HK98104930A patent/HK1005847A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM910002A1 (it) | 1992-07-04 |
| ATE119770T1 (de) | 1995-04-15 |
| DE69201660D1 (de) | 1995-04-20 |
| ES2070478T3 (es) | 1995-06-01 |
| EP0498144A1 (en) | 1992-08-12 |
| HK1005847A1 (en) | 1999-01-29 |
| IE66025B1 (en) | 1996-01-10 |
| ITRM910002A0 (it) | 1991-01-04 |
| ZA9110037B (en) | 1992-09-30 |
| JPH04295424A (ja) | 1992-10-20 |
| IT1244636B (it) | 1994-08-08 |
| EP0498144B1 (en) | 1995-03-15 |
| JP3145451B2 (ja) | 2001-03-12 |
| GR3015431T3 (en) | 1995-06-30 |
| IE914568A1 (en) | 1992-07-15 |
| US5192805A (en) | 1993-03-09 |
| DE69201660T2 (de) | 1995-07-20 |
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