DK0520320T3 - Tetrahydropyrrolo 1,2-a pyrazin-4-spiro-3-pyrrolidinderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater indeholdende samme - Google Patents

Tetrahydropyrrolo 1,2-a pyrazin-4-spiro-3-pyrrolidinderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater indeholdende samme

Info

Publication number: DK0520320T3
Authority: DK; Denmark
Prior art keywords: tetrahydropyrrolo; pyrazine; spiro; processes; preparation
Prior art date: 1991-06-26

Application number

DK92110270.3T

Other languages

Danish (da)

English (en)

Inventor

Toshiyuki Negoro

Makoto Murata

Shozo Ueda

Buichi Fujitani

Yoshiyuki Ono

Original Assignee

Dainippon Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-26

Filing date

1992-06-17

Publication date

1997-10-13

1992-06-17 Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co

1997-10-13 Application granted granted Critical

1997-10-13 Publication of DK0520320T3 publication Critical patent/DK0520320T3/da

Links

238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
USIPCBPGIIPILV-UHFFFAOYSA-N spiro[2,3-dihydro-1h-pyrrolo[1,2-a]pyrazine-4,3'-pyrrolidine] Chemical class C1NCCC21N1C=CC=C1CNC2 USIPCBPGIIPILV-UHFFFAOYSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

DK92110270.3T 1991-06-26 1992-06-17 Tetrahydropyrrolo 1,2-a pyrazin-4-spiro-3-pyrrolidinderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater indeholdende samme DK0520320T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP03183185		1991-06-26

Publications (1)

Publication Number	Publication Date
DK0520320T3 true DK0520320T3 (da)	1997-10-13

Family

ID=16131263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92110270.3T DK0520320T3 (da)	1991-06-26	1992-06-17	Tetrahydropyrrolo 1,2-a pyrazin-4-spiro-3-pyrrolidinderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater indeholdende samme

Country Status (20)

Country	Link
US (1)	US5258382A (2)
EP (1)	EP0520320B1 (2)
JP (1)	JP2516147B2 (2)
KR (1)	KR100241196B1 (2)
CN (1)	CN1034176C (2)
AT (1)	ATE157980T1 (2)
AU (1)	AU648901B2 (2)
CA (1)	CA2071273C (2)
DE (1)	DE69222096T2 (2)
DK (1)	DK0520320T3 (2)
ES (1)	ES2108717T3 (2)
FI (1)	FI98066C (2)
GR (1)	GR3024870T3 (2)
HU (1)	HU218214B (2)
IE (1)	IE921891A1 (2)
MX (1)	MX9203231A (2)
NO (1)	NO300637B1 (2)
NZ (1)	NZ243255A (2)
TW (1)	TW202450B (2)
ZA (1)	ZA924425B (2)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3195455B2 (ja) *	1993-01-06	2001-08-06	ウェルファイド株式会社	キノリン−３−酢酸誘導体、その製造法と用途
JP3681082B2 (ja) *	1996-06-27	2005-08-10	住友ベークライト株式会社	イミド環含有エポキシ樹脂及びエポキシ樹脂組成物
CZ299018B6 (cs)	1997-10-20	2008-04-02	Dainippon Sumitomo Pharma Co., Ltd.	Rychlerozpustný farmaceutický prípravek
EP1038525B1 (en) *	1997-10-20	2004-07-07	Dainippon Pharmaceutical Co., Ltd.	Stabilized composition of tetrahydropyrrolo [1,2-a] pyrazine-4-spiro-3'-pyrrolidine
JP2007246539A (ja) *	1997-10-20	2007-09-27	Dainippon Sumitomo Pharma Co Ltd	速溶性医薬組成物
TWI271192B (en) *	1999-11-11	2007-01-21	Kyorin Pharmaceutical Co Ltd	Solid formulation for oral administration
WO2001046195A1 (en)	1999-12-21	2001-06-28	Gpi Nil Holdings, Inc.	Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
JP4552189B2 (ja) *	2002-11-14	2010-09-29	小野薬品工業株式会社	脊柱管狭窄症治療剤
WO2008004416A1 (fr) *	2006-07-07	2008-01-10	Dainippon Sumitomo Pharma Co., Ltd.	3-amino-2,5-dioxopyrrolidine-3-carboxylate optiquement actif, procédé de production du composé, et utilisation du composé
EP2058300B1 (en) *	2006-08-31	2013-01-09	Dainippon Sumitomo Pharma Co., Ltd.	Succinic acid diester derivative, process for production thereof, and use of the derivative in the production of pharmaceutical preparation
CN101517092A (zh)	2006-09-20	2009-08-26	日产化学工业株式会社	光学活性琥珀酰亚胺化合物的制造方法
US7807846B2 (en)	2006-09-27	2010-10-05	Nissan Chemical Industries, Ltd.	Method for producing succinimide compound
US20110190497A1 (en) *	2006-09-29	2011-08-04	Daisuke Tanaka	Process for production of 2,5 dioxopyrrolidine 3 carboxylate
CN101541311B (zh)	2006-10-25	2013-01-23	大日本住友制药株式会社	不易结块的颗粒制剂
WO2008081860A1 (ja) *	2006-12-28	2008-07-10	Dainippon Sumitomo Pharma Co., Ltd.	光学活性コハク酸イミド誘導体およびその製造方法ならびにその使用
WO2008136527A1 (ja) *	2007-05-08	2008-11-13	Dainippon Sumitomo Pharma Co., Ltd.	光学活性ジオキソピロリジン誘導体の精製方法
WO2009011410A1 (en) *	2007-07-13	2009-01-22	Eisai R & D Management Co., Ltd.	Ampa receptor antagonists and aldose reductase inhibitors for neuropathic pain
JP2011026201A (ja) *	2007-10-17	2011-02-10	Mitsubishi Tanabe Pharma Corp	光学活性ピロリル−コハク酸イミド誘導体の立体選択的な製造方法
JP5697998B2 (ja)	2009-02-06	2015-04-08	大日本住友製薬株式会社	光学活性スクシンイミド誘導体の製造方法及びその中間体
JP5844257B2 (ja)	2010-07-29	2016-01-13	大日本住友製薬株式会社	光学活性スクシンイミド誘導体の製造方法
WO2012105610A1 (ja)	2011-02-02	2012-08-09	公立大学法人名古屋市立大学	眼内血管新生及び／又は眼内血管透過性亢進を伴う疾患の予防又は治療のための医薬
WO2016039422A1 (ja) *	2014-09-11	2016-03-17	大日本住友製薬株式会社	点眼用懸濁製剤
CN106928234A (zh) *	2017-02-07	2017-07-07	上海合全药业股份有限公司	（2‑苄基‑1,2,3,4‑四氢吡咯并[1,2‑a]吡嗪）‑4‑甲醇的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60142984A (ja) *	1983-12-28	1985-07-29	Kyorin Pharmaceut Co Ltd	新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法
US4656169A (en) *	1984-08-14	1987-04-07	Pfizer Inc.	Tetracyclic spiro-hydantoin aldose reductase inhibitors and compositions
JPS63132889A (ja) *	1986-11-21	1988-06-04	Tanabe Seiyaku Co Ltd	キナゾリノン誘導体
AU617541B2 (en) *	1988-10-20	1991-11-28	Wyeth	Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors

1992
- 1992-06-13 TW TW081104635A patent/TW202450B/zh active
- 1992-06-15 CA CA002071273A patent/CA2071273C/en not_active Expired - Lifetime
- 1992-06-17 ZA ZA924425A patent/ZA924425B/xx unknown
- 1992-06-17 ES ES92110270T patent/ES2108717T3/es not_active Expired - Lifetime
- 1992-06-17 DK DK92110270.3T patent/DK0520320T3/da active
- 1992-06-17 DE DE69222096T patent/DE69222096T2/de not_active Expired - Lifetime
- 1992-06-17 AT AT92110270T patent/ATE157980T1/de active
- 1992-06-17 EP EP92110270A patent/EP0520320B1/en not_active Expired - Lifetime
- 1992-06-18 FI FI922848A patent/FI98066C/fi not_active IP Right Cessation
- 1992-06-19 KR KR1019920010679A patent/KR100241196B1/ko not_active Expired - Lifetime
- 1992-06-19 US US07/901,029 patent/US5258382A/en not_active Expired - Lifetime
- 1992-06-22 NZ NZ243255A patent/NZ243255A/en not_active IP Right Cessation
- 1992-06-24 MX MX9203231A patent/MX9203231A/es unknown
- 1992-06-24 HU HU9202105A patent/HU218214B/hu unknown
- 1992-06-24 AU AU18483/92A patent/AU648901B2/en not_active Expired
- 1992-06-25 JP JP4193074A patent/JP2516147B2/ja not_active Expired - Lifetime
- 1992-06-25 NO NO922512A patent/NO300637B1/no not_active IP Right Cessation
- 1992-06-26 CN CN92108832A patent/CN1034176C/zh not_active Expired - Lifetime
- 1992-07-01 IE IE189192A patent/IE921891A1/en not_active IP Right Cessation
1997
- 1997-09-26 GR GR970402515T patent/GR3024870T3/el unknown

Also Published As

Publication number	Publication date
CA2071273C (en)	2002-08-20
NO300637B1 (no)	1997-06-30
HK1001728A1 (en)	1998-07-03
DE69222096T2 (de)	1998-01-22
CA2071273A1 (en)	1992-12-27
ATE157980T1 (de)	1997-09-15
IE921891A1 (en)	1992-12-30
US5258382A (en)	1993-11-02
EP0520320B1 (en)	1997-09-10
EP0520320A3 (en)	1993-03-24
NO922512D0 (no)	1992-06-25
AU1848392A (en)	1993-01-14
TW202450B (2)	1993-03-21
HU218214B (hu)	2000-06-28
KR930000519A (ko)	1993-01-15
AU648901B2 (en)	1994-05-05
CN1034176C (zh)	1997-03-05
FI922848A0 (fi)	1992-06-18
DE69222096D1 (de)	1997-10-16
HU9202105D0 (en)	1992-10-28
KR100241196B1 (ko)	2000-03-02
GR3024870T3 (en)	1998-01-30
NZ243255A (en)	1994-03-25
FI922848L (fi)	1992-12-27
JPH05186472A (ja)	1993-07-27
ZA924425B (en)	1993-03-31
HUT63424A (en)	1993-08-30
FI98066B (fi)	1996-12-31
JP2516147B2 (ja)	1996-07-10
FI98066C (fi)	1997-04-10
CN1068825A (zh)	1993-02-10
NO922512L (no)	1992-12-28
MX9203231A (es)	1993-08-01
ES2108717T3 (es)	1998-01-01
EP0520320A2 (en)	1992-12-30

Publication	Publication Date	Title
NO922512D0 (no)	1992-06-25	Tetrahydropyrrolo(1,2-a)pyrazin-4-spiro-3'-pyrrolidinderivater, fremgangsmaate for fremstilling derav, samt farmasoeytiske preparater inneholdende slike
AU3761185A (en)	1985-07-18	5-Methyl-4,5 dihydro-3(2H) Pyridazinone derivatives
ATE247654T1 (de)	2003-09-15	Neue heterozyklische verbindungen
CA2029420A1 (en)	1991-05-22	Pharmaceutical compositions and methods for inhibition of maillard's reaction
TW377352B (en)	1999-12-21	Pyrido[2,3-d]pyrimidine derivatives and pharmaceutical compositions thereof
NZ330973A (en)	2000-03-27	Azolobenzazepine derivatives as neurologically active agents
DE69030616D1 (de)	1997-06-05	Pharmazeutische Zusammensetzungen zur Hemmung der Maillardreaktion
AU626740B2 (en)	1992-08-06	Aminocarbonylcarbamates related to physostigmine, a process for their preparation and their use as medicaments
CA2042113A1 (en)	1991-11-22	Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
CA2119662A1 (fr)	1994-09-25	Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IE960774L (en)	1990-02-12	Arylalkylamides having neuroprotective properties
AU560429B2 (en)	1987-04-09	Spiro-imidazolidines as aldose reductase inhibitors
ES552782A0 (es)	1987-11-01	Un procedimiento para preparar un compuesto de n-fenil-trans-4-guanidincometilciclohexanocarboxamida.
DE69320911D1 (de)	1998-10-15	Chinuclidine derivate als squalen synthase inhibitore
AU586089B2 (en)	1989-06-29	Phosphodiesterace type 111 inhibitors having a thiadiazinone ring as part of a tricyclic structure
IL83216A (en)	1991-07-18	1((5-(10->9)abeo-6-methylergolin-8beta-yl)methyl)-imidazolidine-(and hexahydropyrimidine)-2,4-dione derivatives,their preparation and pharmaceutical compositions containing them
NZ216741A (en)	1988-10-28	6-oxo-1,6-dihydropyridazines and pharmaceutical compositions
EP0919233B8 (en)	2003-08-13	Therapeutic agent for kidney diseases
SG47554A1 (en)	1998-04-17	1'-amino-2-[(benzothiazolyl)methyl)]spiro [isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
WO1995013280A3 (en)	1995-06-15	1,3,8,10 tetrasubstituted derivatives of 4,5,6,7-tetrathiocino-(1,2-b:3,4-b')-diimidazolyl-2,9-dithione, their preparation and their use as antitumor agent