DK0520882T3 - Derivater af 2-aminopyrimidin-4-carboxamid, deres fremstilling og deres terapeutiske anvendelse - Google Patents

Derivater af 2-aminopyrimidin-4-carboxamid, deres fremstilling og deres terapeutiske anvendelse

Info

Publication number: DK0520882T3
Authority: DK; Denmark
Prior art keywords: aminopyrimidine; carboxamide; derivatives; preparation; therapeutic use
Prior art date: 1991-06-27

Application number

DK92401771.8T

Other languages

Danish (da)

English (en)

Inventor

Christian Maloizel

Pascal George

Jean-Pierre Merly

Benoit Marabout

Original Assignee

Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-27

Filing date

1992-06-24

Publication date

1995-12-11

1991-06-27 Priority claimed from FR9107938A external-priority patent/FR2678268B1/fr

1992-05-18 Priority claimed from FR9206005A external-priority patent/FR2691148B1/fr

1992-06-24 Application filed by Synthelabo filed Critical Synthelabo

1995-12-11 Application granted granted Critical

1995-12-11 Publication of DK0520882T3 publication Critical patent/DK0520882T3/da

Links

ASFQWXQESJPZFG-UHFFFAOYSA-N 2-aminopyrimidine-4-carboxamide Chemical class NC(=O)C1=CC=NC(N)=N1 ASFQWXQESJPZFG-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)
Hydrogenated Pyridines (AREA)

DK92401771.8T 1991-06-27 1992-06-24 Derivater af 2-aminopyrimidin-4-carboxamid, deres fremstilling og deres terapeutiske anvendelse DK0520882T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9107938A FR2678268B1 (fr)	1991-06-27	1991-06-27	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR9206005A FR2691148B1 (fr)	1992-05-18	1992-05-18	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number	Publication Date
DK0520882T3 true DK0520882T3 (da)	1995-12-11

Family

ID=26228783

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92401771.8T DK0520882T3 (da)	1991-06-27	1992-06-24	Derivater af 2-aminopyrimidin-4-carboxamid, deres fremstilling og deres terapeutiske anvendelse

Country Status (20)

Country	Link
US (1)	US5246939A (de)
EP (1)	EP0520882B1 (de)
JP (1)	JP3159525B2 (de)
KR (1)	KR930000507A (de)
CN (1)	CN1067887A (de)
AT (1)	ATE124942T1 (de)
AU (1)	AU645429B2 (de)
CA (1)	CA2072434A1 (de)
CZ (1)	CZ9202001A3 (de)
DE (1)	DE69203401T2 (de)
DK (1)	DK0520882T3 (de)
ES (1)	ES2077376T3 (de)
FI (1)	FI922981L (de)
GR (1)	GR3017612T3 (de)
HU (1)	HUT61745A (de)
IE (1)	IE922092A1 (de)
IL (1)	IL102329A0 (de)
MX (1)	MX9203332A (de)
NO (1)	NO922523L (de)
PL (1)	PL295046A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9319534D0 (en) *	1993-09-22	1993-11-10	Boots Co Plc	Therapeutic agents
JP2002513799A (ja) *	1998-05-06	2002-05-14	デューク・ユニバーシティー	膀胱および下部尿路症候群の治療方法
KR20190015748A (ko)	2016-06-08	2019-02-14	글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드	Atf4 경로 억제제로서의 화학적 화합물
KR102177766B1 (ko) *	2019-03-15	2020-11-11	주식회사 엠에스바이오	양막링 및 이의 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2618436B1 (fr) *	1987-07-23	1989-10-27	Synthelabo	Derives de piperidine, leur preparation et leur application en therapeutique
HU206337B (en) *	1988-12-29	1992-10-28	Mitsui Petrochemical Ind	Process for producing pyrimidine derivatives and pharmaceutical compositions
FR2667317B1 (fr) *	1990-10-02	1992-12-04	Synthelabo	Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

1992
- 1992-06-24 DK DK92401771.8T patent/DK0520882T3/da active
- 1992-06-24 AT AT92401771T patent/ATE124942T1/de not_active IP Right Cessation
- 1992-06-24 EP EP92401771A patent/EP0520882B1/de not_active Expired - Lifetime
- 1992-06-24 ES ES92401771T patent/ES2077376T3/es not_active Expired - Lifetime
- 1992-06-24 DE DE69203401T patent/DE69203401T2/de not_active Expired - Fee Related
- 1992-06-25 MX MX9203332A patent/MX9203332A/es unknown
- 1992-06-26 FI FI922981A patent/FI922981L/fi unknown
- 1992-06-26 HU HU9202142A patent/HUT61745A/hu unknown
- 1992-06-26 AU AU18587/92A patent/AU645429B2/en not_active Ceased
- 1992-06-26 KR KR1019920011215A patent/KR930000507A/ko not_active Withdrawn
- 1992-06-26 CN CN92105077A patent/CN1067887A/zh active Pending
- 1992-06-26 CZ CS922001A patent/CZ9202001A3/cs unknown
- 1992-06-26 NO NO92922523A patent/NO922523L/no unknown
- 1992-06-26 US US07/903,977 patent/US5246939A/en not_active Expired - Fee Related
- 1992-06-26 IL IL102329A patent/IL102329A0/xx unknown
- 1992-06-26 CA CA002072434A patent/CA2072434A1/en not_active Abandoned
- 1992-06-26 JP JP16899192A patent/JP3159525B2/ja not_active Expired - Fee Related
- 1992-06-26 PL PL29504692A patent/PL295046A1/xx unknown
- 1992-07-01 IE IE209292A patent/IE922092A1/en not_active Application Discontinuation
1995
- 1995-10-04 GR GR950402725T patent/GR3017612T3/el unknown

Also Published As

Publication number	Publication date
CZ9202001A3 (en)	1993-01-13
IL102329A0 (en)	1993-01-14
US5246939A (en)	1993-09-21
MX9203332A (es)	1992-12-01
CN1067887A (zh)	1993-01-13
EP0520882B1 (de)	1995-07-12
HU9202142D0 (en)	1992-10-28
NO922523D0 (no)	1992-06-26
AU645429B2 (en)	1994-01-13
HUT61745A (en)	1993-03-01
FI922981A7 (fi)	1992-12-28
ES2077376T3 (es)	1995-11-16
AU1858792A (en)	1993-01-07
NO922523L (no)	1992-12-28
IE922092A1 (en)	1992-12-30
EP0520882A1 (de)	1992-12-30
GR3017612T3 (en)	1996-01-31
CA2072434A1 (en)	1993-01-28
FI922981L (fi)	1992-12-28
DE69203401D1 (de)	1995-08-17
DE69203401T2 (de)	1996-03-07
FI922981A0 (fi)	1992-06-26
ATE124942T1 (de)	1995-07-15
JPH05194419A (ja)	1993-08-03
JP3159525B2 (ja)	2001-04-23
KR930000507A (ko)	1993-01-15
PL295046A1 (en)	1993-03-22

Publication	Publication Date	Title
FI922983A0 (fi)	1992-06-26	Pyrimidin-4-karboxamidderivat, framstaellning av dessa och terapeutisk anvaendning av dessa.
DK0534859T3 (da)	1995-05-08	3-Benzazepin-2-oner, som er substituerede med en benzocyklobutyl- eller indanylalkylaminoalkylgruppe, og som er anvendelige til behandling af cardiovaskulære sygdomme
ES2188280T3 (es)	2003-06-16	Acetales heteroaril-ciclicos.
DK0532515T3 (da)	1997-04-21	Fremstilling af substituerede piperidiner
ZA9010412B (en)	1991-10-30	2-aminopyrimidine-4-carboxamide derivatives,their preparation and their application in therapeutics
DK0619806T3 (da)	1996-02-05	Fremstilling af substituerede piperidiner
NO940788D0 (no)	1994-03-07	Benzoxazin-derivater, deres fremstilling og deres terapeutiske anvendelse
FI892344A0 (fi)	1989-05-16	6-fenyl-3-piperazinylalkyl-1h,3h -pyrimidin-2-4-dionderivat, deras framstaellning och deras terapeutiska anvaendning.
AU643290B2 (en)	1993-11-11	Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their preparation and their therapeutic application
DK0533827T3 (da)	1994-09-26	Oxazolderivater, deres fremstilling og farmaceutiske præparater deraf
MX9203332A (es)	1992-12-01	Derivados de 2-amino pirimidina -4- carboxamida, su preparacion y su aplicacion en terapeutica.
TW336929B (en)	1998-07-21	Benzenesulphonamide derivatives, their preparation and their application in therapy
FI871316A0 (fi)	1987-03-25	Foerfarande foer framstaellning av acymmetriska esterderivat av 1,4-dihydropyridin-3,5-dikarboxylsyra.
HUP9802938A2 (hu)	1999-10-28	4-Cikloalkil-piperidin és 4-cikloalkil-alkil-piperidin-származékok, eljárás a vegyületek előállítására és a vegyületek alkalmazása a gyógyászatban