DK0521963T3 - CRF-analoger - Google Patents

CRF-analoger

Info

Publication number: DK0521963T3
Authority: DK; Denmark
Prior art keywords: leu; analogs; glu; ala; gln
Prior art date: 1990-03-23

Application number

DK91906643T

Other languages

English (en)

Inventor

Jean Edouard Frederic Rivier

Wylie Walker Vale Jr

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-23

Filing date

1991-03-21

Publication date

1999-05-10

1991-03-21 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1999-05-10 Application granted granted Critical

1999-05-10 Publication of DK0521963T3 publication Critical patent/DK0521963T3/da

Links

102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 3
239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
241000272517 Anseriformes Species 0.000 abstract 1
101800005049 Beta-endorphin Proteins 0.000 abstract 1
OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 abstract 1
101800000414 Corticotropin Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
108010069820 Pro-Opiomelanocortin Proteins 0.000 abstract 1
108010042362 beta-Lipotropin Proteins 0.000 abstract 1
WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 abstract 1
230000036772 blood pressure Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
KFUIXDNQSMKKJQ-ZLFMSJRASA-N chembl439883 Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)CNC(=O)[C@H]2NC(=O)CC2)CCC1 KFUIXDNQSMKKJQ-ZLFMSJRASA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 abstract 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
229960000258 corticotropin Drugs 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
230000036651 mood Effects 0.000 abstract 1
AOCUKGFDRUSDQH-PIKKTMSISA-N ocrf Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)CC)[C@@H](C)O)C(C)C)C(C)O)C1=CNC=N1 AOCUKGFDRUSDQH-PIKKTMSISA-N 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
108010086511 sauvagine Proteins 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
239000000021 stimulant Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
LJGOZJHDEQHJRI-SITYYSIOSA-N α-helical crf Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(C)C)C1=CNC=N1 LJGOZJHDEQHJRI-SITYYSIOSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Control Of Eletrric Generators (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Vehicle Body Suspensions (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Superconductors And Manufacturing Methods Therefor (AREA)
Amplifiers (AREA)
Details Of Television Scanning (AREA)
Polymerisation Methods In General (AREA)
Compositions Of Macromolecular Compounds (AREA)

DK91906643T 1990-03-23 1991-03-21 CRF-analoger DK0521963T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49823090A	1990-03-23	1990-03-23
PCT/US1991/001896 WO1991014446A1 (en)	1990-03-23	1991-03-21	Crf analogs

Publications (1)

Publication Number	Publication Date
DK0521963T3 true DK0521963T3 (da)	1999-05-10

Family

ID=23980142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91906643T DK0521963T3 (da)	1990-03-23	1991-03-21	CRF-analoger

Country Status (14)

Country	Link
EP (1)	EP0521963B1 (da)
JP (1)	JP3243250B2 (da)
KR (1)	KR0174564B1 (da)
AT (1)	ATE169639T1 (da)
AU (1)	AU638823B2 (da)
CA (1)	CA2075718C (da)
DE (1)	DE69129985T2 (da)
DK (1)	DK0521963T3 (da)
ES (1)	ES2121778T3 (da)
FI (1)	FI105013B (da)
IE (1)	IE62607B1 (da)
IL (1)	IL97644A (da)
NO (1)	NO923672L (da)
WO (1)	WO1991014446A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6354364B1 (en)	1994-03-30	2002-03-12	Nichols Aluminum-Golden, Inc.	Apparatus for cooling and coating a mold in a continuous caster
US6039956A (en) *	1994-09-12	2000-03-21	Pennsylvania, Trustees Of The University Of, The	Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder
WO1996008265A1 (en) *	1994-09-12	1996-03-21	The Trustees Of The University Of Pennsylvania	Corticotropin release inhibiting factor and methods of using same
CN1361180A (zh) *	2000-12-26	2002-07-31	上海博德基因开发有限公司	一种新的多肽——促肾上腺皮质激素释放因子8.8和编码这种多肽的多核苷酸
GB0119920D0 (en) *	2001-08-15	2001-10-10	Pfizer Ltd	New use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH467246A (de) *	1965-08-24	1969-01-15	Sandoz Ag	Verfahren zur Herstellung eines neuen Polypeptids
EP0518391A1 (en) *	1984-02-23	1992-12-16	The Salk Institute For Biological Studies	CRF analogs
CA1335227C (en) *	1987-06-22	1995-04-11	Wylie W. Vale, Jr.	Crf analog conjugates
IE64788B1 (en) *	1988-06-21	1995-09-06	Salk Inst For Biological Studi	CRF analogs
CA1341051C (en) *	1988-09-23	2000-07-11	Jean Edouard Frederic Rivier	Crf antagonists
CA1340964C (en) *	1988-09-30	2000-04-18	Jean E. F. Rivier	Crf analogs

1991
- 1991-03-21 AU AU75517/91A patent/AU638823B2/en not_active Expired
- 1991-03-21 ES ES91906643T patent/ES2121778T3/es not_active Expired - Lifetime
- 1991-03-21 WO PCT/US1991/001896 patent/WO1991014446A1/en not_active Ceased
- 1991-03-21 JP JP50730291A patent/JP3243250B2/ja not_active Expired - Lifetime
- 1991-03-21 KR KR1019920702299A patent/KR0174564B1/ko not_active Expired - Lifetime
- 1991-03-21 DK DK91906643T patent/DK0521963T3/da active
- 1991-03-21 CA CA002075718A patent/CA2075718C/en not_active Expired - Lifetime
- 1991-03-21 DE DE69129985T patent/DE69129985T2/de not_active Expired - Lifetime
- 1991-03-21 EP EP91906643A patent/EP0521963B1/en not_active Expired - Lifetime
- 1991-03-21 IE IE94491A patent/IE62607B1/en not_active IP Right Cessation
- 1991-03-21 AT AT91906643T patent/ATE169639T1/de not_active IP Right Cessation
- 1991-03-22 IL IL9764491A patent/IL97644A/en not_active IP Right Cessation
1992
- 1992-08-28 FI FI923863A patent/FI105013B/fi active
- 1992-09-22 NO NO92923672A patent/NO923672L/no unknown

Also Published As

Publication number	Publication date
IE62607B1 (en)	1995-02-22
CA2075718A1 (en)	1991-09-24
FI105013B (fi)	2000-05-31
DE69129985D1 (de)	1998-09-17
CA2075718C (en)	2001-08-07
FI923863L (fi)	1992-08-28
EP0521963A1 (en)	1993-01-13
KR930700137A (ko)	1993-03-13
AU7551791A (en)	1991-10-21
KR0174564B1 (ko)	1999-02-01
ES2121778T3 (es)	1998-12-16
AU638823B2 (en)	1993-07-08
IE910944A1 (en)	1991-09-25
JPH05505821A (ja)	1993-08-26
ATE169639T1 (de)	1998-08-15
EP0521963A4 (en)	1993-06-02
DE69129985T2 (de)	1999-03-25
EP0521963B1 (en)	1998-08-12
NO923672D0 (no)	1992-09-22
FI923863A0 (fi)	1992-08-28
WO1991014446A1 (en)	1991-10-03
NO923672L (no)	1992-11-12
IL97644A0 (en)	1992-06-21
IL97644A (en)	1995-03-30
JP3243250B2 (ja)	2002-01-07

Publication	Publication Date	Title
PH23123A (en)	1989-05-05	Crf analogs
DE69129985D1 (de)	1998-09-17	Crf-analoge
EP0361954A3 (en)	1991-12-04	Crf analogs
DE68918271D1 (de)	1994-10-20	Crf-analoge.
DE3587276D1 (de)	1993-05-27	Crf-analoga.
ES2057147T3 (es)	1994-10-16	Crf de pescado.