DK0524742T3 - Benzo(a)fluorenforbindelser - Google Patents

Benzo(a)fluorenforbindelser

Info

Publication number: DK0524742T3
Authority: DK; Denmark
Prior art keywords: benzo; fluoro compounds; estrogenic; fluoro; compounds
Prior art date: 1991-07-22

Application number

DK92306221.0T

Other languages

English (en)

Inventor

Charles David Jones

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-22

Filing date

1992-07-07

Publication date

1996-03-18

1992-07-07 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1996-03-18 Application granted granted Critical

1996-03-18 Publication of DK0524742T3 publication Critical patent/DK0524742T3/da

Links

125000005605 benzo group Chemical group 0.000 title 1
125000001153 fluoro group Chemical group F* 0.000 title 1
HKMTVMBEALTRRR-UHFFFAOYSA-N Benzo[a]fluorene Chemical class C1=CC=CC2=C3CC4=CC=CC=C4C3=CC=C21 HKMTVMBEALTRRR-UHFFFAOYSA-N 0.000 abstract 1
125000002431 aminoalkoxy group Chemical group 0.000 abstract 1
230000001833 anti-estrogenic effect Effects 0.000 abstract 1
230000001076 estrogenic effect Effects 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/16—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

DK92306221.0T 1991-07-22 1992-07-07 Benzo(a)fluorenforbindelser DK0524742T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/733,529 US5147880A (en)	1991-07-22	1991-07-22	Benzo[a]fluorene compounds

Publications (1)

Publication Number	Publication Date
DK0524742T3 true DK0524742T3 (da)	1996-03-18

Family

ID=24948005

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92306221.0T DK0524742T3 (da)	1991-07-22	1992-07-07	Benzo(a)fluorenforbindelser

Country Status (9)

Country	Link
US (1)	US5147880A (da)
EP (1)	EP0524742B1 (da)
JP (1)	JPH05238974A (da)
AT (1)	ATE134645T1 (da)
CA (1)	CA2073488A1 (da)
DE (1)	DE69208551T2 (da)
DK (1)	DK0524742T3 (da)
ES (1)	ES2084943T3 (da)
GR (1)	GR3019500T3 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7501441B1 (en) *	1994-09-20	2009-03-10	Eli Lilly And Company	Naphthyl compounds, intermediates, processes, compositions, and methods
US5554628A (en) *	1994-09-20	1996-09-10	Eli Lilly And Company	Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs
US5589482A (en) *	1994-12-14	1996-12-31	Pfizer Inc.	Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
US5998401A (en) *	1995-02-28	1999-12-07	Eli Lilly And Company	Naphthyl compounds, intermediates, compositions, and methods
US6451817B1 (en) *	1995-03-10	2002-09-17	Eli Lilly And Company	Alpha-substituted-1-benzyl-napthyls
US5726186A (en) *	1995-09-08	1998-03-10	Eli Lilly And Company	Pentacyclic compounds, intermediates, processes, compositions, and methods
CA2214929A1 (en) *	1996-09-26	1998-03-26	Charles Willis Lugar, Iii	Naphthofluorene compounds, intermediates, compositions and methods
CA2214176A1 (en) *	1996-09-26	1998-03-26	Eli Lilly And Company	Dihydrobenzo[b]indeno[2,1-d]thiophene compounds, intermediates, processes, compositions and methods
CA2215856A1 (en) *	1996-09-26	1998-03-26	Eli Lilly And Company	Dihydrobenzofluorene compounds, intermediates, compositions, and methods
CA2214935A1 (en) *	1996-09-26	1998-03-26	Henry Uhlman Bryant	Benzofluorene compounds, intermediates, compositions, and methods
CA2214196A1 (en) *	1996-09-26	1998-03-26	Eli Lilly And Company	Benzo[b]indeno[2,1-d]thiophene compounds, intermediates, processes, compositions and methods
CA2214931A1 (en) *	1996-09-26	1998-03-26	Henry Uhlman Bryant	Tetrahydrobenzo-a-fluorene compounds and method of use
CA2214872C (en) *	1996-10-24	2002-01-22	Eli Lilly And Company	Benzothiophene compounds, compositions and methods
CA2215647A1 (en) *	1996-10-24	1998-04-24	Eli Lilly And Company	Naphthyl compounds, compositions, and methods
AU7467398A (en) *	1997-04-25	1998-11-24	Eli Lilly And Company	Indene compounds having activity as serms
US5834488A (en) *	1997-09-19	1998-11-10	Eli Lilly And Company	Dihydrobenzo B! indeno 2, 1-D! thiophene compounds, intermediates, processes, compositions and methods
ES2293986T3 (es)	2000-03-27	2008-04-01	N.V. Organon	Compuestos no esteroides tetraciclicos para tratamientos relacionados con el estrogeno.
TW200408385A (en) *	2001-12-21	2004-06-01	Akzo Nobel Nv	Tetrahydrobenzfluorene derivatives
TW200304371A (en) *	2002-02-22	2003-10-01	Akzo Nobel Nv	Substituted 10-ary1-11H-benzo [b] fluorenes and 7-ary1-5, 6-dihydro-benz [a] anthracenes for selective effects on estrogen receptors
JP2008505095A (ja) *	2004-07-01	2008-02-21	ワイス	エストロゲンリガンドとしての四環式化合物
KR101166809B1 (ko) *	2006-04-13	2012-07-26	토소가부시키가이샤	벤조플루오렌 화합물 및 그 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4230862A (en) *	1975-10-28	1980-10-28	Eli Lilly And Company	Antifertility compounds
US4418068A (en) *	1981-04-03	1983-11-29	Eli Lilly And Company	Antiestrogenic and antiandrugenic benzothiophenes
US4677193A (en) *	1985-02-22	1987-06-30	The Salk Institute For Biological Studies	Peptides containing an aliphatic-aromatic ketone side chain

1991
- 1991-07-22 US US07/733,529 patent/US5147880A/en not_active Expired - Lifetime
1992
- 1992-07-07 DE DE69208551T patent/DE69208551T2/de not_active Expired - Fee Related
- 1992-07-07 DK DK92306221.0T patent/DK0524742T3/da active
- 1992-07-07 AT AT92306221T patent/ATE134645T1/de not_active IP Right Cessation
- 1992-07-07 EP EP92306221A patent/EP0524742B1/en not_active Expired - Lifetime
- 1992-07-07 ES ES92306221T patent/ES2084943T3/es not_active Expired - Lifetime
- 1992-07-08 JP JP4180966A patent/JPH05238974A/ja not_active Withdrawn
- 1992-07-08 CA CA002073488A patent/CA2073488A1/en not_active Abandoned
1996
- 1996-04-02 GR GR960400888T patent/GR3019500T3/el unknown

Also Published As

Publication number	Publication date
ES2084943T3 (es)	1996-05-16
ATE134645T1 (de)	1996-03-15
CA2073488A1 (en)	1993-01-23
US5147880A (en)	1992-09-15
DE69208551T2 (de)	1996-08-08
JPH05238974A (ja)	1993-09-17
DE69208551D1 (de)	1996-04-04
EP0524742B1 (en)	1996-02-28
EP0524742A2 (en)	1993-01-27
EP0524742A3 (en)	1994-06-15
GR3019500T3 (en)	1996-07-31

Publication	Publication Date	Title
ES2084943T3 (es)	1996-05-16	Compuestos de benzo(a)fluoreno.
DE59203362D1 (de)	1995-09-28	Flanschring.
DE58905877D1 (de)	1993-11-18	Ringventil.
DE69104892D1 (de)	1994-12-08	Zwischendrehverbindung für Perforator.
GB9603325D0 (en)	1996-04-17	A compound
DE68915148D1 (de)	1994-06-09	Fotoresist-zusammensetzung.
DE59009431D1 (de)	1995-08-31	Photoresist.
DE3870218D1 (de)	1992-05-21	Ringfoermige flanschverbindung.
DE69021945D1 (de)	1995-10-05	Schaltsteuervorrichtung für Ringnetz.
DE69001901D1 (de)	1993-07-15	Gegossener halbmaskenklappenaufbau.
DE68911402D1 (de)	1994-01-27	Flacher Kombinationsschnappring.
DE58901096D1 (de)	1992-05-07	Ventillamelle.
DE68910902D1 (de)	1994-01-05	Drehverbindung.
DE69032077D1 (de)	1998-04-09	Fotoresist für nahes U.V.
DE68912569D1 (de)	1994-03-03	Schlüsselring.
KR920701688A (ko)	1992-08-12	축선방향 흐름 링 팬
DE69011265D1 (de)	1994-09-08	Ausgleichsventil.
DE58901004D1 (de)	1992-04-30	Ringspinnmaschine.
FI861820A7 (fi)	1986-11-07	Antipsykotiska, en kondenserad ring innehaollande pyridinylpiperazinderivat.
DE69015386D1 (de)	1995-02-09	E-förmiger Haltering.
DE69130691D1 (de)	1999-02-11	Lichtempfindliche, elektroabscheidbare Photoresistzusammensetzung
FR2679792B1 (fr)	1995-08-25	Perfectionnements aux broyeurs a anneaux.
DE68922901D1 (de)	1995-07-06	Photoresistzusammensetzung.
FI944655A7 (fi)	1994-10-05	Uudet 2,3-dihydro-2,2,4,6,7-penta-alkyyli-5-bentsofuranolit
DE69002190D1 (de)	1993-08-19	Radialluftreifen.