DK0556332T3 - Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet - Google Patents

Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet

Info

Publication number: DK0556332T3
Authority: DK; Denmark
Prior art keywords: nervous system; central nervous; agents; hydroxypiperidines; treatment
Prior art date: 1990-11-05

Application number

DK92901652.5T

Other languages

Danish (da)

English (en)

Inventor

Shelly Glase

Juan Carlos Jaen

Sarah Jane Smith

Lawrence David Wise

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-05

Filing date

1991-10-29

Publication date

1996-06-03

1991-10-29 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1996-06-03 Application granted granted Critical

1996-06-03 Publication of DK0556332T3 publication Critical patent/DK0556332T3/da

Links

LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical class ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 title abstract 2
125000004853 tetrahydropyridinyl group Chemical class N1(CCCC=C1)* 0.000 title abstract 2
210000003169 central nervous system Anatomy 0.000 title 1
230000000561 anti-psychotic effect Effects 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
239000003576 central nervous system agent Substances 0.000 abstract 1
229940125693 central nervous system agent Drugs 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
230000003291 dopaminomimetic effect Effects 0.000 abstract 1
208000031424 hyperprolactinemia Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK92901652.5T 1990-11-05 1991-10-29 Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet DK0556332T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60927490A	1990-11-05	1990-11-05
US07/778,248 US5273977A (en)	1990-11-05	1991-10-24	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents

Publications (1)

Publication Number	Publication Date
DK0556332T3 true DK0556332T3 (da)	1996-06-03

Family

ID=27085995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92901652.5T DK0556332T3 (da)	1990-11-05	1991-10-29	Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet

Country Status (11)

Country	Link
US (3)	US5273977A (de)
EP (1)	EP0556332B1 (de)
JP (1)	JP3047470B2 (de)
AT (1)	ATE135690T1 (de)
AU (1)	AU670532B2 (de)
CA (1)	CA2094702C (de)
DE (1)	DE69118198T2 (de)
DK (1)	DK0556332T3 (de)
ES (1)	ES2084339T3 (de)
GR (1)	GR3019782T3 (de)
WO (1)	WO1992007831A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5273977A (en) *	1990-11-05	1993-12-28	Warner-Lambert Company	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
DE4425145A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Verwendung von Thiazol- und Thiadiazolverbindungen
GB9523462D0 (en) *	1995-11-16	1996-01-17	Merck Sharp & Dohme	Therapeutic agents
ZA9610738B (en)	1995-12-22	1997-06-24	Warner Lambert Co	Subtype selective nmda receptor ligands and the use thereof
ZA9610741B (en)	1995-12-22	1997-06-24	Warner Lambert Co	4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) *	1995-12-22	1997-06-27	Warner Lambert Co	2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610745B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
WO1998037070A1 (en) *	1997-02-21	1998-08-27	Takeda Chemical Industries, Ltd.	Fused ring compounds, process for producing the same and use thereof
DE19728996A1 (de)	1997-07-07	1999-01-14	Basf Ag	Triazolverbindungen und deren Verwendung
EP1200086A4 (de) *	1999-08-04	2009-05-27	Icagen Inc	Methoden zur behandlung oder vorbeugung von schmerzen und angstzuständen
ATE380176T1 (de) *	1999-08-04	2007-12-15	Icagen Inc	Benzanilide als öffner des kaliumkanals
US6495550B2 (en)	1999-08-04	2002-12-17	Icagen, Inc.	Pyridine-substituted benzanilides as potassium ion channel openers
US6509351B1 (en) *	1999-10-22	2003-01-21	Sanofi-Syntelabo	Phenyl- and pyridyl-tetrahydro-pyridines having TNF inhibiting activity
FR2803593B1 (fr)	2000-01-06	2002-02-15	Sanofi Synthelabo	Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
GB0413605D0 (en) *	2004-06-17	2004-07-21	Addex Pharmaceuticals Sa	Novel compounds
CL2009000725A1 (es)	2008-03-24	2009-05-29	Medivation Technologies Inc	Compuestos derivados de heterociclos con uniones puente sustituidos, moduladores de receptores adrenergicos, de serotonina, de dopamina y de histaminas; composicion farmaceutica; kit farmaceutico; y su uso en el tratamiento del trastorno cognitivo y trastorno psicotico.
WO2011038164A1 (en) *	2009-09-23	2011-03-31	Medivation Technologies, Inc.	Bridged heterocyclic compounds and methods of use
CA2775328A1 (en)	2009-09-23	2011-03-31	Medivation Technologies, Inc.	Pyrido[4,3-b]indoles and methods of use
PT2636668T (pt) *	2010-11-05	2018-10-09	Oat Agrio Co Ltd	Composto de etinilfenilamidina ou um seu sal, processo para a sua produção e fungicida para ser utilizado na agricultura e na horticultura
US8791132B2 (en)	2011-02-18	2014-07-29	Medivation Technologies, Inc.	Compounds and methods for treatment of hypertension
US10316025B2 (en)	2015-06-03	2019-06-11	Sunshine Lake Pharma Co., Ltd.	Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE633474A (de) *
GB1055548A (en) *	1965-08-23	1967-01-18	Acraf	New substituted 1-aryl-3-aminopropynes and process for their preparation
FR1490501A (fr) *	1966-02-23	1967-08-04	Docteur Jacques Auciair Lab Du	Nouveaux dérivés du butyne-2 et leur procédé de préparation
US4208415A (en) *	1978-02-06	1980-06-17	E. R. Squibb & Sons, Inc.	4-[2-(2-Substituted phenyl)ethenyl]-N-alkenyl or alkinyl substituted 1,2,3,6-tetrahydropyridines
JP2660407B2 (ja) *	1986-09-26	1997-10-08	住友製薬株式会社	新規なイミド誘導体
CA2071897A1 (en) *	1989-12-28	1991-06-29	Richard A. Glennon	Sigma receptor ligands and the use thereof
US5034392A (en) *	1990-04-16	1991-07-23	Hoechst-Roussel Pharmaceuticals Incorporated	4-(3-(4-oxothiazolidinyl)butynylamines
US5273977A (en) *	1990-11-05	1993-12-28	Warner-Lambert Company	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents

1991
- 1991-10-24 US US07/778,248 patent/US5273977A/en not_active Expired - Lifetime
- 1991-10-29 CA CA002094702A patent/CA2094702C/en not_active Expired - Fee Related
- 1991-10-29 WO PCT/US1991/008017 patent/WO1992007831A1/en not_active Ceased
- 1991-10-29 AT AT92901652T patent/ATE135690T1/de not_active IP Right Cessation
- 1991-10-29 AU AU91231/91A patent/AU670532B2/en not_active Ceased
- 1991-10-29 ES ES92901652T patent/ES2084339T3/es not_active Expired - Lifetime
- 1991-10-29 DE DE69118198T patent/DE69118198T2/de not_active Expired - Fee Related
- 1991-10-29 JP JP4502236A patent/JP3047470B2/ja not_active Expired - Fee Related
- 1991-10-29 DK DK92901652.5T patent/DK0556332T3/da active
- 1991-10-29 EP EP92901652A patent/EP0556332B1/de not_active Expired - Lifetime
1993
- 1993-09-29 US US08/128,923 patent/US5466698A/en not_active Expired - Fee Related
1995
- 1995-06-06 US US08/469,127 patent/US5620988A/en not_active Expired - Fee Related
1996
- 1996-04-29 GR GR960401162T patent/GR3019782T3/el unknown

Also Published As

Publication number	Publication date
WO1992007831A1 (en)	1992-05-14
AU9123191A (en)	1992-05-26
DE69118198T2 (de)	1996-11-14
GR3019782T3 (en)	1996-07-31
AU670532B2 (en)	1996-07-25
DE69118198D1 (de)	1996-04-25
US5466698A (en)	1995-11-14
US5620988A (en)	1997-04-15
US5273977A (en)	1993-12-28
ES2084339T3 (es)	1996-05-01
EP0556332A1 (de)	1993-08-25
JPH06501952A (ja)	1994-03-03
EP0556332B1 (de)	1996-03-20
CA2094702C (en)	2002-02-12
CA2094702A1 (en)	1992-05-06
ATE135690T1 (de)	1996-04-15
JP3047470B2 (ja)	2000-05-29

Publication	Publication Date	Title
DK0556332T3 (da)	1996-06-03	Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet
NO905253D0 (no)	1990-12-05	Fremgangsmaate for fremstilling av substituerte cykloheksanoler.
EE03253B1 (et)	2000-02-15	(R)-5-karbamoüül-8-fluoro-3-N,N-diasendatud-amino-3,4-dihüdro-2H-1-bensopüraani d, nende valmistamise protsess ja neid sisaldavad ravimkoostised
DK0556329T3 (da)	1996-05-06	Substituerede piperaziner som midler til behandling af centralnervesystemet
BG100830A (en)	1997-10-31	Naphthylamides as central nervous system agents
NO180632C (no)	1997-05-21	1,3-substituerte cykloalkener og cykloalkaner som sentralnervesystem-midler
MY107354A (en)	1995-11-30	Substituted cyclohexenes as central nervous system agents
DK0996435T3 (da)	2003-01-27	Aminosyrederivater anvendelige til behandling af slagtilfælde
MX9101928A (es)	1994-01-31	Piperazinas substituidas como agentes del sistema nervioso central.
MX9101926A (es)	1994-01-31	Tetrahidropiridinas e hidroxipiperidinas substituidas como agentes del sistema nervioso central.
MX9206635A (es)	1994-07-29	Cicloalquenos y cicloalcanos 1,3-substituidos como agentes del sistema nervioso central.
MX9302225A (es)	1994-04-29	Cicloalquenos y cicloalcanos 1,3-substituidos como agentes del sistema nervioso central.