DK0556332T3 - Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet - Google Patents

Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet

Info

Publication number: DK0556332T3
Authority: DK; Denmark
Prior art keywords: nervous system; central nervous; agents; hydroxypiperidines; treatment
Prior art date: 1990-11-05

Application number

DK92901652.5T

Other languages

Danish (da)

English (en)

Inventor

Shelly Glase

Juan Carlos Jaen

Sarah Jane Smith

Lawrence David Wise

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-05

Filing date

1991-10-29

Publication date

1996-06-03

1991-10-29 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1996-06-03 Application granted granted Critical

1996-06-03 Publication of DK0556332T3 publication Critical patent/DK0556332T3/da

Links

LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical class ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 title abstract 2
125000004853 tetrahydropyridinyl group Chemical class N1(CCCC=C1)* 0.000 title abstract 2
210000003169 central nervous system Anatomy 0.000 title 1
230000000561 anti-psychotic effect Effects 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
239000000164 antipsychotic agent Substances 0.000 abstract 1
239000003576 central nervous system agent Substances 0.000 abstract 1
229940125693 central nervous system agent Drugs 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
239000003136 dopamine receptor stimulating agent Substances 0.000 abstract 1
230000003291 dopaminomimetic effect Effects 0.000 abstract 1
208000031424 hyperprolactinemia Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK92901652.5T 1990-11-05 1991-10-29 Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet DK0556332T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US60927490A	1990-11-05	1990-11-05
US07/778,248 US5273977A (en)	1990-11-05	1991-10-24	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents

Publications (1)

Publication Number	Publication Date
DK0556332T3 true DK0556332T3 (da)	1996-06-03

Family

ID=27085995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92901652.5T DK0556332T3 (da)	1990-11-05	1991-10-29	Substituerede tetrahydropyridiner og hydroxypiperidiner som midler til behandling af centralnervesystemet

Country Status (11)

Country	Link
US (3)	US5273977A (de)
EP (1)	EP0556332B1 (de)
JP (1)	JP3047470B2 (de)
AT (1)	ATE135690T1 (de)
AU (1)	AU670532B2 (de)
CA (1)	CA2094702C (de)
DE (1)	DE69118198T2 (de)
DK (1)	DK0556332T3 (de)
ES (1)	ES2084339T3 (de)
GR (1)	GR3019782T3 (de)
WO (1)	WO1992007831A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5273977A (en) *	1990-11-05	1993-12-28	Warner-Lambert Company	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
DE4425145A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Verwendung von Thiazol- und Thiadiazolverbindungen
GB9523462D0 (en) *	1995-11-16	1996-01-17	Merck Sharp & Dohme	Therapeutic agents
ZA9610741B (en)	1995-12-22	1997-06-24	Warner Lambert Co	4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en)	1995-12-22	1997-06-24	Warner Lambert Co	Subtype selective nmda receptor ligands and the use thereof
ZA9610736B (en)	1995-12-22	1997-06-27	Warner Lambert Co	2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610745B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
EP0974584B1 (de) *	1997-02-21	2003-01-15	Takeda Chemical Industries, Ltd.	Verbindungen mit kondensierten ringen, verfahren zu ihrer herstellung und ihre anwendung
DE19728996A1 (de)	1997-07-07	1999-01-14	Basf Ag	Triazolverbindungen und deren Verwendung
US6495550B2 (en)	1999-08-04	2002-12-17	Icagen, Inc.	Pyridine-substituted benzanilides as potassium ion channel openers
JP2003506387A (ja) *	1999-08-04	2003-02-18	アイカゲンインコーポレイテッド	カリウムチャンネルオープナーとしてのベンズアニリド
NZ527771A (en) *	1999-08-04	2005-04-29	Icagen Inc	Methods for treating or preventing anxiety
IL149250A0 (en) *	1999-10-22	2002-11-10	Sanofi Synthelabo	Phenyl-and pyridyl-tetrahydro-pyridines having tnf inhibiting activity
FR2803593B1 (fr) *	2000-01-06	2002-02-15	Sanofi Synthelabo	Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
GB0413605D0 (en)	2004-06-17	2004-07-21	Addex Pharmaceuticals Sa	Novel compounds
WO2009120720A1 (en) *	2008-03-24	2009-10-01	Medivation Technologies,Inc.	Bridged heterocyclic compounds and methods of use
JP5869484B2 (ja) *	2009-09-23	2016-02-24	メディベイションテクノロジーズ，インコーポレイテッド	架橋複素環化合物およびその使用
US8859561B2 (en)	2009-09-23	2014-10-14	Medivation Technologies, Inc.	Pyrido[4,3-b]indoles and methods of use
ES2689956T3 (es) *	2010-11-05	2018-11-16	Oat Agrio Co., Ltd.	Compuesto de etinilfenilamidina o sal del mismo, procedimiento para producir el mismo y fungicida para una utilización agrícola y hortícola
BR112013021126A2 (pt)	2011-02-18	2019-09-24	Medivation Technologies Inc	método para reduzir a pressão sanguínea, método para aumentar o fluxo sanguíneo renal ou diminuir a reabsorção de sódio, método para tratar uma doença, kit, composto e composição farmacêutica
WO2016192657A1 (en)	2015-06-03	2016-12-08	Sunshine Lake Pharma Co., Ltd.	Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE633474A (de) *
GB1055548A (en) *	1965-08-23	1967-01-18	Acraf	New substituted 1-aryl-3-aminopropynes and process for their preparation
FR1490501A (fr) *	1966-02-23	1967-08-04	Docteur Jacques Auciair Lab Du	Nouveaux dérivés du butyne-2 et leur procédé de préparation
US4208415A (en) *	1978-02-06	1980-06-17	E. R. Squibb & Sons, Inc.	4-[2-(2-Substituted phenyl)ethenyl]-N-alkenyl or alkinyl substituted 1,2,3,6-tetrahydropyridines
AU593194B2 (en) *	1986-09-26	1990-02-01	Sumitomo Pharmaceuticals Company, Limited	Imide derivatives ,and their production and use
AU658134B2 (en) *	1989-12-28	1995-04-06	Virginia Commonwealth University	Sigma receptor ligands and the use thereof
US5034392A (en) *	1990-04-16	1991-07-23	Hoechst-Roussel Pharmaceuticals Incorporated	4-(3-(4-oxothiazolidinyl)butynylamines
US5273977A (en) *	1990-11-05	1993-12-28	Warner-Lambert Company	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents

1991
- 1991-10-24 US US07/778,248 patent/US5273977A/en not_active Expired - Lifetime
- 1991-10-29 AU AU91231/91A patent/AU670532B2/en not_active Ceased
- 1991-10-29 ES ES92901652T patent/ES2084339T3/es not_active Expired - Lifetime
- 1991-10-29 EP EP92901652A patent/EP0556332B1/de not_active Expired - Lifetime
- 1991-10-29 DE DE69118198T patent/DE69118198T2/de not_active Expired - Fee Related
- 1991-10-29 AT AT92901652T patent/ATE135690T1/de not_active IP Right Cessation
- 1991-10-29 WO PCT/US1991/008017 patent/WO1992007831A1/en not_active Ceased
- 1991-10-29 CA CA002094702A patent/CA2094702C/en not_active Expired - Fee Related
- 1991-10-29 DK DK92901652.5T patent/DK0556332T3/da active
- 1991-10-29 JP JP4502236A patent/JP3047470B2/ja not_active Expired - Fee Related
1993
- 1993-09-29 US US08/128,923 patent/US5466698A/en not_active Expired - Fee Related
1995
- 1995-06-06 US US08/469,127 patent/US5620988A/en not_active Expired - Fee Related
1996
- 1996-04-29 GR GR960401162T patent/GR3019782T3/el unknown

Also Published As

Publication number	Publication date
EP0556332A1 (de)	1993-08-25
DE69118198T2 (de)	1996-11-14
DE69118198D1 (de)	1996-04-25
WO1992007831A1 (en)	1992-05-14
AU9123191A (en)	1992-05-26
CA2094702A1 (en)	1992-05-06
US5620988A (en)	1997-04-15
JPH06501952A (ja)	1994-03-03
CA2094702C (en)	2002-02-12
ATE135690T1 (de)	1996-04-15
GR3019782T3 (en)	1996-07-31
JP3047470B2 (ja)	2000-05-29
US5273977A (en)	1993-12-28
EP0556332B1 (de)	1996-03-20
US5466698A (en)	1995-11-14
ES2084339T3 (es)	1996-05-01
AU670532B2 (en)	1996-07-25

Publication	Publication Date	Title
GR3019782T3 (en)	1996-07-31	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
NO905253L (no)	1991-06-07	Fremgangsmaate for fremstilling av substituerte cykloheksanoler.
IS4226A (is)	1995-04-29	Hliðstæðar aðferðir við framleiðslu á nýjum (R)-5-karbamóýl-8-flúor-3-N,N-tvíútskiptum-amínó-3,4-díhýdró-2H-1-bensópýrönum
DK0556329T3 (da)	1996-05-06	Substituerede piperaziner som midler til behandling af centralnervesystemet
DK0751939T5 (da)	2004-11-08	Naphthylamider som centralnervesystemmidler
NO180632C (no)	1997-05-21	1,3-substituerte cykloalkener og cykloalkaner som sentralnervesystem-midler
MY107354A (en)	1995-11-30	Substituted cyclohexenes as central nervous system agents
DK0996435T3 (da)	2003-01-27	Aminosyrederivater anvendelige til behandling af slagtilfælde
MX9101928A (es)	1994-01-31	Piperazinas substituidas como agentes del sistema nervioso central.
MX9101926A (es)	1994-01-31	Tetrahidropiridinas e hidroxipiperidinas substituidas como agentes del sistema nervioso central.
MX9206635A (es)	1994-07-29	Cicloalquenos y cicloalcanos 1,3-substituidos como agentes del sistema nervioso central.
MX9302225A (es)	1994-04-29	Cicloalquenos y cicloalcanos 1,3-substituidos como agentes del sistema nervioso central.