DK0593348T3 - Thiazolidine-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

Thiazolidine-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
DK0593348T3
DK0593348T3 DK93402497T DK93402497T DK0593348T3 DK 0593348 T3 DK0593348 T3 DK 0593348T3 DK 93402497 T DK93402497 T DK 93402497T DK 93402497 T DK93402497 T DK 93402497T DK 0593348 T3 DK0593348 T3 DK 0593348T3
Authority
DK
Denmark
Prior art keywords
thiazolidine
preparation
pharmaceutical compositions
compositions containing
dione derivatives
Prior art date
Application number
DK93402497T
Other languages
Danish (da)
Inventor
Jacques Duhault
Joseph Espinal
Gilbert Regnier
Yves Charton
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0593348T3 publication Critical patent/DK0593348T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

New thiazolidinedione compounds of formula: <IMAGE> in which Ar, A, X and B are as defined in the description, their enantiomers, diastereoisomers and pharmaceutically acceptable acid addition salts. They can be used in therapeutics, especially in the treatment of insulin-resistant states and/or of non-insulinopenic diabetes, possibly in association with hypertension (high blood pressure).
DK93402497T 1992-10-12 1993-10-11 Thiazolidine-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them DK0593348T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9212123A FR2696743B1 (en) 1992-10-12 1992-10-12 New thiazolidine dione compounds, process for their preparation and pharmaceutical compositions containing them.

Publications (1)

Publication Number Publication Date
DK0593348T3 true DK0593348T3 (en) 1999-01-11

Family

ID=9434401

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93402497T DK0593348T3 (en) 1992-10-12 1993-10-11 Thiazolidine-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (12)

Country Link
EP (1) EP0593348B1 (en)
JP (1) JP2948076B2 (en)
AT (1) ATE164374T1 (en)
AU (1) AU662658B2 (en)
CA (1) CA2108064C (en)
DE (1) DE69317621T2 (en)
DK (1) DK0593348T3 (en)
ES (1) ES2117114T3 (en)
FR (1) FR2696743B1 (en)
GR (1) GR3026633T3 (en)
NZ (1) NZ248905A (en)
ZA (1) ZA937552B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU712802B2 (en) * 1994-10-20 1999-11-18 Nippon Chemiphar Co. Ltd. Quinoline derivatives
JP3906935B2 (en) * 1995-12-18 2007-04-18 杏林製薬株式会社 N-substituted dioxothiazolidylbenzamide derivative and process for producing the same
WO1998020871A1 (en) * 1996-11-08 1998-05-22 Nippon Chemiphar Co., Ltd. Visceral fat lowering agent
WO1998052946A1 (en) * 1997-12-02 1998-11-26 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension
IN187716B (en) * 1998-09-14 2002-06-15 Reddy Research Foundation
EP3018122B1 (en) * 2007-11-06 2018-10-10 BioElectron Technology Corporation 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
DK173350B1 (en) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidine derivatives, their preparation and pharmaceutical composition containing them
WO1989008652A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
MX15171A (en) * 1988-03-08 1993-05-01 Pfizer DERIVATIVES OF TIAZOLIDINODIONA HIPOGLICEMICOS
WO1989008650A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents
GB8919434D0 (en) * 1989-08-25 1989-10-11 Beecham Group Plc Novel compounds
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
GB9023584D0 (en) * 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
JPH07309852A (en) 1995-11-28
FR2696743A1 (en) 1994-04-15
ATE164374T1 (en) 1998-04-15
GR3026633T3 (en) 1998-07-31
CA2108064C (en) 2001-10-23
AU662658B2 (en) 1995-09-07
DE69317621T2 (en) 1998-10-15
NZ248905A (en) 1994-12-22
DE69317621D1 (en) 1998-04-30
ZA937552B (en) 1994-05-02
JP2948076B2 (en) 1999-09-13
EP0593348A1 (en) 1994-04-20
CA2108064A1 (en) 1994-04-13
FR2696743B1 (en) 1994-12-23
EP0593348B1 (en) 1998-03-25
AU4890593A (en) 1994-04-28
ES2117114T3 (en) 1998-08-01

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