DK0593901T3 - Oligoribonucleotid- og ribozym-analoge med terminale 3-3- og 5-5-bindinger. - Google Patents

Oligoribonucleotid- og ribozym-analoge med terminale 3-3- og 5-5-bindinger.

Info

Publication number
DK0593901T3
DK0593901T3 DK93114773.0T DK93114773T DK0593901T3 DK 0593901 T3 DK0593901 T3 DK 0593901T3 DK 93114773 T DK93114773 T DK 93114773T DK 0593901 T3 DK0593901 T3 DK 0593901T3
Authority
DK
Denmark
Prior art keywords
terminal
oligoribonucleotide
bonds
ribozyme analogs
ribozyme
Prior art date
Application number
DK93114773.0T
Other languages
English (en)
Inventor
H Prof Dr Seliger
Flavio Ramalho Dr Ortigao
Hannelore Roesch
Rudi Roesch
Bernd Krist
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6468696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0593901(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0593901T3 publication Critical patent/DK0593901T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Shaping Of Tube Ends By Bending Or Straightening (AREA)
DK93114773.0T 1992-09-24 1993-09-14 Oligoribonucleotid- og ribozym-analoge med terminale 3-3- og 5-5-bindinger. DK0593901T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4231949 1992-09-24

Publications (1)

Publication Number Publication Date
DK0593901T3 true DK0593901T3 (da) 1997-10-27

Family

ID=6468696

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93114773.0T DK0593901T3 (da) 1992-09-24 1993-09-14 Oligoribonucleotid- og ribozym-analoge med terminale 3-3- og 5-5-bindinger.

Country Status (14)

Country Link
US (1) US6420546B1 (da)
EP (1) EP0593901B2 (da)
JP (1) JP3653102B2 (da)
AT (1) ATE151773T1 (da)
AU (1) AU665113B2 (da)
CA (1) CA2106819C (da)
DE (1) DE59306170D1 (da)
DK (1) DK0593901T3 (da)
ES (1) ES2103408T3 (da)
FI (1) FI115400B (da)
GR (1) GR3023858T3 (da)
HU (1) HU219638B (da)
NO (1) NO307656B1 (da)
NZ (1) NZ248739A (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646042A (en) * 1992-08-26 1997-07-08 Ribozyme Pharmaceuticals, Inc. C-myb targeted ribozymes
US5998203A (en) * 1996-04-16 1999-12-07 Ribozyme Pharmaceuticals, Inc. Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
ES2221942T3 (es) * 1996-05-24 2005-01-16 Aventis Pharma Deutschland Gmbh Reactivo y metodo para inhibir la expresion de n-ras.
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
EP1071753A2 (en) * 1998-04-20 2001-01-31 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
DE19935303A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
US7312325B2 (en) 2000-09-26 2007-12-25 Duke University RNA aptamers and methods for identifying the same
DK2070939T3 (da) 2001-05-25 2014-06-23 Univ Duke Modulatorer af farmakologiske midler
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
EP2460811A1 (en) 2004-04-22 2012-06-06 Regado Biosciences, Inc. Improved modulators of coagulation factors
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
US7935811B2 (en) 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
US20060166234A1 (en) 2004-11-22 2006-07-27 Barbara Robertson Apparatus and system having dry control gene silencing compositions
EP1820804A1 (en) * 2006-02-20 2007-08-22 Humboldt-Universität zu Berlin Lipidated oligonucleotides
AU2007299705B2 (en) 2006-09-22 2012-09-06 Dharmacon, Inc. Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
US7845686B2 (en) * 2007-12-17 2010-12-07 S & B Technical Products, Inc. Restrained pipe joining system for plastic pipe
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
EP2781523A1 (en) 2013-03-18 2014-09-24 Miltenyi Biotec GmbH Lipophilic oligonucleotide analogs
CA3033867A1 (en) 2016-08-17 2018-02-22 Solstice Biologics, Ltd. Polynucleotide constructs
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use
US11104941B2 (en) * 2018-09-28 2021-08-31 Bioo Scientific Corporation 5′ adapter comprising an internal 5′-5′ linkage
CN118373865B (zh) * 2024-06-25 2024-11-08 苏州诺维康生物科技有限公司 一种4-乙酰氨基-1-(2-脱氧-2-氟-beta-D-阿拉伯呋喃基)-2(1H)-嘧啶酮的新合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3916871A1 (de) 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
US5399676A (en) * 1989-10-23 1995-03-21 Gilead Sciences Oligonucleotides with inverted polarity
DE59108644D1 (de) * 1990-07-02 1997-05-07 Hoechst Ag Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
KR930016437A (ko) * 1992-01-22 1993-08-26 귀틀라인, 슈미트 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도

Also Published As

Publication number Publication date
NZ248739A (en) 1995-08-28
DE59306170D1 (de) 1997-05-22
NO307656B1 (no) 2000-05-08
NO933397D0 (no) 1993-09-23
ES2103408T3 (es) 1997-09-16
GR3023858T3 (en) 1997-09-30
EP0593901A2 (de) 1994-04-27
EP0593901B1 (de) 1997-04-16
FI934154A7 (fi) 1994-03-25
EP0593901A3 (en) 1994-09-28
CA2106819A1 (en) 1994-03-25
JP3653102B2 (ja) 2005-05-25
JPH06189753A (ja) 1994-07-12
NO933397L (no) 1994-03-25
US6420546B1 (en) 2002-07-16
HU219638B (hu) 2001-06-28
ATE151773T1 (de) 1997-05-15
FI115400B (fi) 2005-04-29
EP0593901B2 (de) 2008-04-09
HUT66458A (en) 1994-11-28
AU4755193A (en) 1994-03-31
HU9302697D0 (en) 1993-12-28
CA2106819C (en) 2007-04-17
FI934154A0 (fi) 1993-09-22
AU665113B2 (en) 1995-12-14

Similar Documents

Publication Publication Date Title
DK0593901T3 (da) Oligoribonucleotid- og ribozym-analoge med terminale 3-3- og 5-5-bindinger.
ATE151076T1 (de) Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-internucleotidverknüpfungen
ATE328896T1 (de) Faktor viii vom schwein und hybriden
MX9203137A (es) Moleculas de adhesion de leucocitos de celulas endoteliales (elams) y moleculas involucradas en adhesion de leucocitos (milas).
DE3575296D1 (de) Pyrazolkarboxamidabkoemmlinge, deren herstellung und diese enthaltende bakterientoetende mittel.
TR28384A (tr) Flüoroalifatik -ve karboksil- iceren terminal gruplarina sahip polisilokzanlar, bunlarin hazirlanmasi, ve lifli malzemelerin muamelesinde kullanimlari.
DE69325970D1 (de) Walzdraht, Feinstdraht und verdrillter Draht aus Stahl, Verfahren zur Herstellung von Feinstdraht
DE3884453D1 (de) Homogene additionscopolymere von ethylen und cycloolefinmonomeren und deren herstellung.
ATE267841T1 (de) Hochmolekulare und niedermolekulare fraktionen des von willebrand-faktors
GR3006073T3 (da)
ATE312174T1 (de) Antisense-oligonucleotide gegen hsv-1 sowie deren herstellung
DE3851584D1 (de) Gegen Allergie wirkende Benzothiophene und neue und andere ausgewählte Benzothiophene, beide mit Wirkung zur Behandlung von akuten Atmungsangstanzeichen.
EP0273800A3 (en) Hirudine variants, their use and preparation
DE69832216D1 (de) Rantes Mutanten und deren therapeutischen Anwendungen
ATE119783T1 (de) Neue, nicht-ionische carboxamid-kontrastmittel.
DE69512674D1 (de) Konversion von nylon und/oder nylon 6,6 zur adipinsäure
DE69205535D1 (de) Verfahren zur Herstellung von Phenylbutyronitrilen und Verwendung in der Parfümerie des 2,2-Dimethyl-4-Phenyl-Valeriannitrile.
DE69435058D1 (de) Vektor zur vielfachklonierung, expressionsvektor und herstellung von fremdprotein mit expressionsvektor
RU93054766A (ru) Олигорибонуклеотиды и их рибозимные аналоги с концевыми 3'-3'-соответственно, 5'-5'-связями
ATE230267T1 (de) Zusammensetzungen enthaltend vx478, zidovudine und 159u89 für die verwendung in der behandlung von hiv
DE69326050D1 (de) Verfahren zur Herstellung von 0,0'-Diacylweinsäureanhydrid und Verfahren zur Herstellung von 0,0'-Diacylweinsäure
DE69729780D1 (de) Protein mit Ethylendiamine-N,N'-Dibarnsteinsäure: Ethylendiamin Lyase Aktivität und dafür kodierendes Gen
石晓波 et al. The Preparation and Crystal Structure of Ammonium Oxalatooxodiperoxotungstate (NH_4) _2 [WO (O_2) _2 (C_2O_2)]
GB9116373D0 (en) Affinity purified,filter sterilized,targeted nanoparticles for delivery by intraneural,vascular and lymphatic routes
GB9117851D0 (en) Affinity purified, filter sterilized, targeted nanoparticles for delivery by intraneural, vascular, and lymphatic routes