DK0595888T3 - Fremgangsmåde til fremstilling af demethylepipodophyllotoxin - Google Patents

Fremgangsmåde til fremstilling af demethylepipodophyllotoxin

Info

Publication number: DK0595888T3
Authority: DK; Denmark
Prior art keywords: demethylepipodophyllotoxin; beta; alkylidene; react; ester
Prior art date: 1991-07-23

Application number

DK92915482.1T

Other languages

English (en)

Inventor

Pietro Allevi

Mario Anastasia

Ettore Bigatti

Peter Macdonald

Original Assignee

Sicor Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-23

Filing date

1992-07-15

Publication date

1998-05-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11360401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0595888(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1992-07-15 Application filed by Sicor Spa filed Critical Sicor Spa

1998-05-18 Application granted granted Critical

1998-05-18 Publication of DK0595888T3 publication Critical patent/DK0595888T3/da

Links

KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 abstract 2
239000002841 Lewis acid Substances 0.000 abstract 1
125000001118 alkylidene group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
229960005420 etoposide Drugs 0.000 abstract 1
125000005179 haloacetyl group Chemical group 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK92915482.1T 1991-07-23 1992-07-15 Fremgangsmåde til fremstilling af demethylepipodophyllotoxin DK0595888T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI912025A IT1250692B (it)	1991-07-23	1991-07-23	Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.

Publications (1)

Publication Number	Publication Date
DK0595888T3 true DK0595888T3 (da)	1998-05-18

Family

ID=11360401

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92915482.1T DK0595888T3 (da)	1991-07-23	1992-07-15	Fremgangsmåde til fremstilling af demethylepipodophyllotoxin

Country Status (16)

Country	Link
US (1)	US5688925A (da)
EP (1)	EP0595888B1 (da)
JP (1)	JP3231765B2 (da)
AT (1)	ATE159026T1 (da)
AU (1)	AU666322B2 (da)
CA (1)	CA2113894C (da)
DE (1)	DE69222643T2 (da)
DK (1)	DK0595888T3 (da)
ES (1)	ES2107546T3 (da)
FI (1)	FI110782B (da)
GR (1)	GR3025729T3 (da)
IL (1)	IL102610A (da)
IT (1)	IT1250692B (da)
MX (1)	MX9204334A (da)
WO (1)	WO1993002094A1 (da)
ZA (1)	ZA925515B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69627277T2 (de) *	1995-12-04	2004-03-04	Nippon Kayaku K.K.	Verfahren zur Herstellung von Etoposide
WO1998055491A1 (en) *	1997-06-02	1998-12-10	Bristol-Myers Squibb Company	Process for preparing etoposide
AU5612399A (en)	1998-09-10	2000-04-03	Phytogen Life Sciences Inc.	Synthetic method for the preparation of the antineoplastic agent etoposide
FR2791681B1 (fr) *	1999-03-29	2001-06-22	Pf Medicament	Nouveau procede de preparation de l'etoposide
GB0019124D0 (en) *	2000-08-03	2000-09-27	Pfizer	Novel process
EP1845974A1 (en)	2005-01-21	2007-10-24	Astex Therapeutics Limited	Pharmaceutical compounds
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
DK2750683T4 (da)	2011-10-03	2021-04-12	Croda Int Plc	Nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf som bærer for amfipatiske eller hydrofobe molekyler inden for medicin, herunder cancerbehandling, og i fødevarerelaterede forbindelser
WO2014163558A1 (en)	2013-04-01	2014-10-09	Moreinx Ab	Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds
EP3616688A1 (en)	2018-08-27	2020-03-04	Centre National de la Recherche Scientifique - CNRS	Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents
EP3669890A1 (en)	2018-12-18	2020-06-24	Croda International PLC	Filamentous nanoparticles having vaccine adjuvant effect
CN113121618A (zh) *	2021-04-07	2021-07-16	梯尔希（南京）药物研发有限公司	两种依托泊苷杂质的制备方法
CN115197281B (zh) *	2021-04-09	2024-06-14	四川汇宇制药股份有限公司	依托泊苷中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0111058B1 (en) *	1982-11-26	1987-11-04	Nippon Kayaku Kabushiki Kaisha	Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS60246393A (ja) *	1984-05-22	1985-12-06	Nippon Kayaku Co Ltd	エトポシドの新規製造法
IL77334A (en) *	1985-12-16	1991-04-15	Univ Bar Ilan	Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
DK39886D0 (da) *	1986-01-27	1986-01-27	Hans Goeran Magnusson	Hydroxybeskyttelsesgrupper
US4904768A (en) *	1987-08-04	1990-02-27	Bristol-Myers Company	Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4965348A (en) *	1989-05-19	1990-10-23	Bristol-Myers Company	Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) *	1989-06-07	1991-07-30	Bristol-Myers Company	Acylated derivatives of etoposide
DE3935016A1 (de) *	1989-10-20	1991-04-25	Behringwerke Ag	Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
FR2658824B1 (fr) *	1990-02-27	1992-07-03	Pf Medicament	Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
US5081234A (en) *	1990-04-30	1992-01-14	Bristol-Myers Squibb Co.	4'-demethylepipodophyllotoxin glycosides
CN1025918C (zh) *	1990-06-07	1994-09-14	国家医药管理局上海医药工业研究院	抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺

1991
- 1991-07-23 IT ITMI912025A patent/IT1250692B/it active IP Right Grant
1992
- 1992-07-15 DE DE69222643T patent/DE69222643T2/de not_active Expired - Fee Related
- 1992-07-15 AU AU23265/92A patent/AU666322B2/en not_active Ceased
- 1992-07-15 WO PCT/EP1992/001605 patent/WO1993002094A1/en not_active Ceased
- 1992-07-15 JP JP50258193A patent/JP3231765B2/ja not_active Expired - Fee Related
- 1992-07-15 AT AT92915482T patent/ATE159026T1/de not_active IP Right Cessation
- 1992-07-15 ES ES92915482T patent/ES2107546T3/es not_active Expired - Lifetime
- 1992-07-15 EP EP92915482A patent/EP0595888B1/en not_active Expired - Lifetime
- 1992-07-15 CA CA002113894A patent/CA2113894C/en not_active Expired - Fee Related
- 1992-07-15 DK DK92915482.1T patent/DK0595888T3/da active
- 1992-07-22 IL IL102610A patent/IL102610A/xx not_active IP Right Cessation
- 1992-07-22 ZA ZA925515A patent/ZA925515B/xx unknown
- 1992-07-23 MX MX9204334A patent/MX9204334A/es unknown
1994
- 1994-01-20 FI FI940280A patent/FI110782B/fi not_active IP Right Cessation
1995
- 1995-05-15 US US08/441,210 patent/US5688925A/en not_active Expired - Fee Related
1997
- 1997-12-22 GR GR970403378T patent/GR3025729T3/el unknown

Also Published As

Publication number	Publication date
ES2107546T3 (es)	1997-12-01
JP3231765B2 (ja)	2001-11-26
ITMI912025A1 (it)	1993-01-23
IL102610A (en)	1997-03-18
CA2113894C (en)	2003-12-16
FI110782B (fi)	2003-03-31
EP0595888B1 (en)	1997-10-08
MX9204334A (es)	1993-02-01
GR3025729T3 (en)	1998-03-31
JPH06509334A (ja)	1994-10-20
AU2326592A (en)	1993-02-23
FI940280L (fi)	1994-01-20
DE69222643T2 (de)	1998-02-05
ITMI912025A0 (it)	1991-07-23
AU666322B2 (en)	1996-02-08
WO1993002094A1 (en)	1993-02-04
US5688925A (en)	1997-11-18
IT1250692B (it)	1995-04-21
CA2113894A1 (en)	1993-02-04
EP0595888A1 (en)	1994-05-11
ATE159026T1 (de)	1997-10-15
ZA925515B (en)	1993-04-28
DE69222643D1 (de)	1997-11-13
FI940280A0 (fi)	1994-01-20

Publication	Publication Date	Title
FI940280A0 (fi)	1994-01-20	Menetelmä demetyyliepypodofyylilotoksiinin valmistamiseksi
ZA905996B (en)	1991-05-29	Avermectin derivatives
CA2006222A1 (en)	1990-06-27	Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
CA2044619A1 (en)	1991-05-18	Preparation method for .alpha.,.beta.-unsaturated ketones
DK0799058T3 (da)	2003-11-24	Forbedringer af eller med hensyn til endometriefunktion
DK386789A (da)	1991-02-08	Fermentor
AU4404185A (en)	1985-12-31	Tubular trash net for pre-treating sewage
IE821260L (en)	1982-11-28	Anthracycline derivatives
GB2245140B (en)	1993-07-07	Nutrient fluid composition
WO1990010948A3 (en)	1990-10-18	Magnetic bottle employing meissner effect
PT82530A (en)	1986-06-01	<1,4> benzodioxin and <1,4> benzoxazine derivatives
FR2574184B1 (fr)	1988-04-22	Composes fluorescents, derives d'(amino-4 disulfonato-3,6) naphtalimide, leur application aux dosages immunologiques en polarisation de fluorescence
IE883358L (en)	1989-05-09	Ethylated avermectins
JPS5714590A (en)	1982-01-25	2-benzyl-5-alkyl-tetrahydro-benzo(b)-1,6-naphthyridin-10-one derivative and its preparation
EA199800918A1 (ru)	1999-04-29	Происходящие от хозяина сигналы для индуцирования экспрессии гена изопреноида и их применение
KR890000156B1 (en)	1989-03-08	Hydantoin derivatives
GB2234520B (en)	1993-04-28	Fuel thermal stability enhancement by chemical deoxygenation
TR199901956T2 (xx)	1999-10-21	4H-4-Okso-kinolizin-3-karboksilik asit t�revlerinin haz�rlanmas� i�in bir i�lem.
岩元睦夫	1989	Non-destructive analysis
JPS53111385A (en)	1978-09-28	Preparation of 4-methyl-1-pentene polymer composition
Madero et al.	1980	Altitudinal distribution of the vespids in the Sierra Nevada(Granada, Spain)(Hymenoptera, Vespidae).).
Koehler-Samouilidis	1984	Investigations on sensitivity of the microbiological flora of ram semen against antibiotics.
ES287391U (es)	1988-06-16	Colector solar fluorescente integrado en la construccion
IT8718703A0 (it)	1987-04-02	Processo per l'utilizzazione di materiali vegetali di scarto mediante fermentazioni aerobiche controllate precedute da pretrattamenti chimici
JPS53125455A (en)	1978-11-01	Poly-(dialkylaminoalkylene)-methacrylate solution