DK0607400T3 - Fluorerede 17beta-substituerede 4-aza-5-alfa-androstan-3-on-derivater - Google Patents

Fluorerede 17beta-substituerede 4-aza-5-alfa-androstan-3-on-derivater

Info

Publication number: DK0607400T3
Authority: DK; Denmark
Prior art keywords: hydrogen; fluorine; alkyl; 17beta; androstan
Prior art date: 1992-07-31

Application number

DK93917705.1T

Other languages

English (en)

Inventor

Achille Panzeri

Marcella Nesi

Salle Enrico Di

Original Assignee

Pharmacia & Upjohn Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-31

Filing date

1993-07-29

Publication date

1998-01-26

1993-07-29 Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa

1998-01-26 Application granted granted Critical

1998-01-26 Publication of DK0607400T3 publication Critical patent/DK0607400T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Glass Compositions (AREA)
Percussion Or Vibration Massage (AREA)
Lubricants (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK93917705.1T 1992-07-31 1993-07-29 Fluorerede 17beta-substituerede 4-aza-5-alfa-androstan-3-on-derivater DK0607400T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929216284A GB9216284D0 (en)	1992-07-31	1992-07-31	Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Publications (1)

Publication Number	Publication Date
DK0607400T3 true DK0607400T3 (da)	1998-01-26

Family

ID=10719598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK93917705.1T DK0607400T3 (da)	1992-07-31	1993-07-29	Fluorerede 17beta-substituerede 4-aza-5-alfa-androstan-3-on-derivater

Country Status (28)

Country	Link
US (1)	US5407939A (da)
EP (1)	EP0607400B1 (da)
JP (1)	JP3325025B2 (da)
KR (1)	KR100311547B1 (da)
CN (1)	CN1041096C (da)
AT (1)	ATE159951T1 (da)
AU (1)	AU660562B2 (da)
CA (1)	CA2120343A1 (da)
CZ (1)	CZ286240B6 (da)
DE (1)	DE69315050T2 (da)
DK (1)	DK0607400T3 (da)
ES (1)	ES2110620T3 (da)
FI (1)	FI113778B (da)
GB (1)	GB9216284D0 (da)
GR (1)	GR3025546T3 (da)
HU (2)	HUT67043A (da)
IL (1)	IL106520A (da)
MX (1)	MX9304579A (da)
MY (1)	MY109633A (da)
NO (1)	NO305401B1 (da)
NZ (1)	NZ254787A (da)
PH (1)	PH29938A (da)
PL (1)	PL178591B1 (da)
RU (1)	RU2125061C1 (da)
TW (1)	TW286319B (da)
UA (1)	UA41291C2 (da)
WO (1)	WO1994003475A1 (da)
ZA (1)	ZA935481B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2158887T3 (es) *	1992-12-18	2001-09-16	Merck & Co Inc	Procedimiento para tratar la prostatitis cronica con 17 beta-n-terc-butilcarbamoil-4-aza-5 alfa-androst-1-en-ona.
AU681585B2 (en) *	1993-06-24	1997-09-04	Richter Gedeon Vegyeszeti Gyar Rt.	Novel process for preparing 17beta -substituted 4-azaandrostane derivatives
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
UA44257C2 (uk) *	1993-10-21	2002-02-15	Мерк Енд Ко, Інк	16-ЗАМІЩЕНІ ПОХІДНІ 4-АЗААНДРОСТАНУ, ЯК ІНГІБІТОРИ ІЗОФЕРМЕНТУ 5-<font face="Symbol">a</font>-РЕДУКТАЗИ, СПОСІБ ІНГІБУВАННЯ 5-<font face="Symbol">a</font>-РЕДУКТАЗИ ТА ЇЇ ІЗОФЕРМЕНТУ, СПОСІБ ЛІКУВАННЯ, СПОСІБ ПРИПИНЕННЯ ТА ОБЕРНЕННЯ АНДРОГЕННОЇ АЛОПЕЦІЇ ТА СТИМУЛЮВАННЯ РОСТУ ВОЛОССЯ У ССАВЦІВ, СПОСІБ ІНГІБУВАННЯ БІОСИНТЕТИЧНОЇ КОНВЕРСІЇ ТЕСТОСТЕРОНУ В ДИГІДРОТЕСТОСТЕРОН У ССАВЦІВ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ
GB9415178D0 (en) *	1994-07-28	1994-09-21	Erba Carlo Spa	4-azasteroids with side-chain fluoroketones
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5543417A (en) *	1994-10-21	1996-08-06	Merck & Co., Inc.	Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) *	1994-10-25	1997-01-21	Merck & Co., Inc.	7-substituted 4-aza cholanic acid derivatives and their use
IT1275594B1 (it) *	1995-07-21	1997-08-06	Pharmacia S P A Ora Pharmacia	Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide
GB9518858D0 (en) *	1995-09-14	1995-11-15	Pharmacia Spa	Phenylsubstituted 4-azasteroid fluoroderivatives
GB9727522D0 (en)	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Process for preparing carboxamido-4-azasteroids
US6645974B2 (en) *	2001-07-31	2003-11-11	Merck & Co., Inc.	Androgen receptor modulators and methods for use thereof
NZ534946A (en) *	2002-03-13	2007-05-31	Merck & Co Inc	Fluorinated 4-azasteroid derivatives as androgen receptor modulators
WO2005009949A2 (en) *	2003-06-30	2005-02-03	Merck & Co., Inc.	17-acetamido-4-azasteroid derivatives as androgen receptor modulators
AU2004255749B2 (en)	2003-06-30	2008-12-18	Merck Sharp & Dohme Corp.	17-acetamido-4-azasteroid derivatives as androgen receptor modulators
EP1641535A4 (en) *	2003-06-30	2008-05-14	Merck & Co Inc	17-ACETAMIDO-4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS
EP1641761A4 (en) *	2003-06-30	2008-05-14	Merck & Co Inc	17-ACETAMIDO-4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS
EP1670483A4 (en)	2003-09-10	2010-02-17	Merck & Co Inc	17-heterocyclic 4-azasteroid derivatives as androgen receptor modules
EP1663228A4 (en) *	2003-09-10	2010-10-06	Merck Sharp & Dohme	17-heterocyclic 4-azasteroid derivatives as androgen receptor modules
CA2562132A1 (en) *	2004-04-08	2005-10-27	Merck & Co., Inc.	17 beta-acetamide-4-azasteroids as androgen receptor modulators
BRPI0920681A2 (pt) *	2008-10-28	2015-12-29	Biomarin Pharm Inc	inibidores de decahidro-1h-indenoquinolinona e decahidro-3h-ciclopentafenantridinona de cyp17
KR102541494B1 (ko)	2019-09-11	2023-06-08	주식회사 엘지화학	고흡수성 수지의 제조 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ211145A (en) *	1984-02-27	1988-10-28	Merck & Co Inc	4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
GB8505862D0 (en) *	1985-03-07	1985-04-11	Erba Farmitalia	Steroidic 5alpha-reductase inhibitors
GB9002922D0 (en) *	1990-02-09	1990-04-04	Erba Carlo Spa	17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
IE76452B1 (en) *	1990-10-29	1997-10-22	Sankyo Co	Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) *	1991-10-09	1994-04-19	Ciba-Geigy Corporation	17β-substituted Aza-androstane derivatives
AUPP930799A0 (en) *	1999-03-18	1999-04-15	University Of Sydney, The	Optical planar waveguide device and method of its fabrication

1992
- 1992-07-31 GB GB929216284A patent/GB9216284D0/en active Pending
1993
- 1993-07-28 CZ CZ19931538A patent/CZ286240B6/cs not_active IP Right Cessation
- 1993-07-29 KR KR1019940701034A patent/KR100311547B1/ko not_active Expired - Fee Related
- 1993-07-29 RU RU94021145A patent/RU2125061C1/ru not_active IP Right Cessation
- 1993-07-29 US US08/098,729 patent/US5407939A/en not_active Expired - Fee Related
- 1993-07-29 NZ NZ254787A patent/NZ254787A/en unknown
- 1993-07-29 PH PH46606A patent/PH29938A/en unknown
- 1993-07-29 AU AU47048/93A patent/AU660562B2/en not_active Ceased
- 1993-07-29 MX MX9304579A patent/MX9304579A/es not_active IP Right Cessation
- 1993-07-29 DK DK93917705.1T patent/DK0607400T3/da active
- 1993-07-29 MY MYPI93001489A patent/MY109633A/en unknown
- 1993-07-29 IL IL106520A patent/IL106520A/xx not_active IP Right Cessation
- 1993-07-29 ZA ZA935481A patent/ZA935481B/xx unknown
- 1993-07-29 DE DE69315050T patent/DE69315050T2/de not_active Expired - Fee Related
- 1993-07-29 CA CA002120343A patent/CA2120343A1/en not_active Abandoned
- 1993-07-29 ES ES93917705T patent/ES2110620T3/es not_active Expired - Lifetime
- 1993-07-29 HU HU9400914A patent/HUT67043A/hu unknown
- 1993-07-29 AT AT93917705T patent/ATE159951T1/de not_active IP Right Cessation
- 1993-07-29 PL PL93303048A patent/PL178591B1/pl not_active IP Right Cessation
- 1993-07-29 CN CN93109305A patent/CN1041096C/zh not_active Expired - Fee Related
- 1993-07-29 TW TW082106069A patent/TW286319B/zh active
- 1993-07-29 UA UA94005429A patent/UA41291C2/uk unknown
- 1993-07-29 WO PCT/EP1993/002037 patent/WO1994003475A1/en not_active Ceased
- 1993-07-29 JP JP50499494A patent/JP3325025B2/ja not_active Expired - Fee Related
- 1993-07-29 EP EP93917705A patent/EP0607400B1/en not_active Expired - Lifetime
1994
- 1994-03-24 NO NO941080A patent/NO305401B1/no unknown
- 1994-03-28 FI FI941424A patent/FI113778B/fi not_active IP Right Cessation
1995
- 1995-06-30 HU HU95P/P00706P patent/HU211238A9/hu unknown
1997
- 1997-12-02 GR GR970403195T patent/GR3025546T3/el unknown

Also Published As

Publication number	Publication date
US5407939A (en)	1995-04-18
ATE159951T1 (de)	1997-11-15
CZ286240B6 (cs)	2000-02-16
HUT67043A (en)	1995-01-30
GR3025546T3 (en)	1998-03-31
AU4704893A (en)	1994-03-03
MX9304579A (es)	1994-02-28
CN1041096C (zh)	1998-12-09
ZA935481B (en)	1994-05-16
EP0607400B1 (en)	1997-11-05
DE69315050T2 (de)	1998-03-05
FI941424A0 (fi)	1994-03-28
NZ254787A (en)	1995-11-27
PH29938A (en)	1996-09-16
IL106520A (en)	1997-11-20
HU211238A9 (en)	1995-11-28
CA2120343A1 (en)	1994-02-17
JPH06511497A (ja)	1994-12-22
KR100311547B1 (ko)	2002-06-20
ES2110620T3 (es)	1998-02-16
NO305401B1 (no)	1999-05-25
CZ153893A3 (en)	1994-02-16
RU2125061C1 (ru)	1999-01-20
FI941424A7 (fi)	1994-05-27
MY109633A (en)	1997-03-31
NO941080D0 (no)	1994-03-24
GB9216284D0 (en)	1992-09-16
HU9400914D0 (en)	1994-06-28
UA41291C2 (uk)	2001-09-17
PL178591B1 (pl)	2000-05-31
CN1085224A (zh)	1994-04-13
NO941080L (no)	1994-05-18
TW286319B (da)	1996-09-21
DE69315050D1 (de)	1997-12-11
EP0607400A1 (en)	1994-07-27
FI113778B (fi)	2004-06-15
AU660562B2 (en)	1995-06-29
HK1011693A1 (en)	1999-07-16
WO1994003475A1 (en)	1994-02-17
IL106520A0 (en)	1993-11-15
JP3325025B2 (ja)	2002-09-17

Publication	Publication Date	Title
FI941424A0 (fi)	1994-03-28	Fluoratut 17beta-substituoidut 4-atsa-5alfa-androstan-3-onijohdannaiset
AU591238B2 (en)	1989-11-30	1-arylpyrazoles
AU596389B2 (en)	1990-05-03	1-arylpyrazoles
AU5898580A (en)	1981-01-08	Pyroglutamic acid derivatives
DE3876813D1 (de)	1993-02-04	3(2h)pyridazinon, verfahren zu dessen herstellung und dieses enthaltendes mittel gegen srs-a.
DK0490566T3 (da)	1994-11-14	Fremstilling og anvendelse af N-iodpropargyloxycarbonylaminosyreestere og derivater som antimikrobielle midler
KR900701717A (ko)	1990-12-04	2--1,3-시클로헥산디온제초제 화합물과 이를 이용한 조성물 및 식물억제방법
ATE386724T1 (de)	2008-03-15	Substituierte hexahydrobenzo(a) phenanthridine
AU572109B2 (en)	1988-05-05	Pyridyl-thiadiazole derivatives
DK0696585T3 (da)	1999-08-23	Nyt bisoxadiazolidinderivat
AU572668B2 (en)	1988-05-12	5-acylamino-1-phenylpyrazoles
ES2140524T3 (es)	2000-03-01	Derivados de metotrexato.
ES2001102A6 (es)	1988-04-16	Un procedimiento para la preparacion de un derivado de indeno.
GB2003866A (en)	1979-03-21	Thiourea derivatives
ATE148462T1 (de)	1997-02-15	Isoxazole derivate als lichtschutzmittel
EP0443474A3 (en)	1992-04-22	1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents
FI920403A0 (fi)	1992-01-29	Uppteckningsmaterial.