DK0611157T3 - Fremgangsmåde til fremstilling af nukleinsyrer fra en biologisk prøve ved anvendelse af lavt pH og sur protease - Google Patents
Fremgangsmåde til fremstilling af nukleinsyrer fra en biologisk prøve ved anvendelse af lavt pH og sur proteaseInfo
- Publication number
- DK0611157T3 DK0611157T3 DK94300971T DK94300971T DK0611157T3 DK 0611157 T3 DK0611157 T3 DK 0611157T3 DK 94300971 T DK94300971 T DK 94300971T DK 94300971 T DK94300971 T DK 94300971T DK 0611157 T3 DK0611157 T3 DK 0611157T3
- Authority
- DK
- Denmark
- Prior art keywords
- biological sample
- preparation
- low
- nucleic acids
- acid protease
- Prior art date
Links
- 239000012472 biological sample Substances 0.000 title abstract 5
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 108091005508 Acid proteases Proteins 0.000 title abstract 2
- 101710163270 Nuclease Proteins 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/015,729 US5386024A (en) | 1993-02-10 | 1993-02-10 | Method to prepare nucleic acids from a biological sample using low pH and acid protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0611157T3 true DK0611157T3 (da) | 2003-05-19 |
Family
ID=21773244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94300971T DK0611157T3 (da) | 1993-02-10 | 1994-02-10 | Fremgangsmåde til fremstilling af nukleinsyrer fra en biologisk prøve ved anvendelse af lavt pH og sur protease |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5386024A (da) |
| EP (1) | EP0611157B1 (da) |
| JP (1) | JP3477205B2 (da) |
| KR (1) | KR960701081A (da) |
| AT (1) | ATE238430T1 (da) |
| AU (2) | AU690895B2 (da) |
| CA (1) | CA2155744C (da) |
| DE (1) | DE69432540T2 (da) |
| DK (1) | DK0611157T3 (da) |
| ES (1) | ES2198411T3 (da) |
| WO (1) | WO1994018238A1 (da) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5545539A (en) * | 1994-10-18 | 1996-08-13 | Genzyme Corporation | Method for nucleotide sequence amplification |
| US6329139B1 (en) | 1995-04-25 | 2001-12-11 | Discovery Partners International | Automated sorting system for matrices with memory |
| US6416714B1 (en) * | 1995-04-25 | 2002-07-09 | Discovery Partners International, Inc. | Remotely programmable matrices with memories |
| US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
| US5874214A (en) | 1995-04-25 | 1999-02-23 | Irori | Remotely programmable matrices with memories |
| US6017496A (en) | 1995-06-07 | 2000-01-25 | Irori | Matrices with memories and uses thereof |
| US6331273B1 (en) | 1995-04-25 | 2001-12-18 | Discovery Partners International | Remotely programmable matrices with memories |
| US5981235A (en) * | 1996-07-29 | 1999-11-09 | Promega Corporation | Methods for isolating nucleic acids using alkaline protease |
| US7569342B2 (en) | 1997-12-10 | 2009-08-04 | Sierra Molecular Corp. | Removal of molecular assay interferences |
| US6699986B2 (en) | 1998-08-04 | 2004-03-02 | Ortho-Clinical Diagnostics, Inc. | Electrophoretic separation of nucleic acids from proteins at low ph |
| EP2290098A1 (en) | 2002-01-28 | 2011-03-02 | Ambion, Inc. | Preparing crude biological extracts using protease, suitable for preparing cDNA |
| DE10237317B4 (de) * | 2002-08-15 | 2010-04-08 | 3M Espe Ag | Enzymhaltige Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung |
| US20040157219A1 (en) * | 2003-02-06 | 2004-08-12 | Jianrong Lou | Chemical treatment of biological samples for nucleic acid extraction and kits therefor |
| US7601491B2 (en) | 2003-02-06 | 2009-10-13 | Becton, Dickinson And Company | Pretreatment method for extraction of nucleic acid from biological samples and kits therefor |
| CN100395257C (zh) * | 2003-05-08 | 2008-06-18 | 慈溪市中鼎生物技术有限公司 | 钾离子酸性水溶液和利用这种溶液的dna提取方法和试剂盒 |
| US20050164204A1 (en) * | 2004-01-27 | 2005-07-28 | Reed Thomas D. | Single use lyophilized rnase reagents, and kits and methods for using same |
| EP2251441B1 (en) * | 2004-02-10 | 2013-05-08 | F. Hoffmann-La Roche AG | Detection of parvovirus B19 |
| US7794932B2 (en) | 2004-04-16 | 2010-09-14 | Piotr Chomczynski | Reagents and methods for isolation of purified RNA |
| EP1600141B1 (en) * | 2004-05-24 | 2013-04-17 | 3M Deutschland GmbH | Collagenolytic active enzyme containing compositions for the treatment of dental caries |
| US20050277121A1 (en) * | 2004-06-11 | 2005-12-15 | Ambion, Inc. | Crude biological derivatives competent for nucleic acid detection |
| EP1774334B1 (en) * | 2004-08-03 | 2017-10-04 | Becton, Dickinson and Company | Use of magnetic material to direct isolation of compounds and fractionation of multipart samples |
| EP1773865A1 (en) * | 2004-08-03 | 2007-04-18 | Becton, Dickinson and Company | Use of magnetic material to fractionate samples |
| US7786086B2 (en) * | 2004-09-08 | 2010-08-31 | Ramot At Tel-Aviv University Ltd. | Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same |
| ATE493494T1 (de) | 2005-02-18 | 2011-01-15 | Gen Probe Inc | Probenherstellungsverfahren mit einem alkali- stoss |
| US20060188892A1 (en) * | 2005-02-18 | 2006-08-24 | Ambion, Inc. | Enzymatic digestion of tissue |
| US8628918B2 (en) * | 2005-05-09 | 2014-01-14 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
| US8632970B2 (en) | 2005-05-09 | 2014-01-21 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
| WO2006124771A2 (en) * | 2005-05-12 | 2006-11-23 | Panomics, Inc. | Multiplex branched-chain dna assays |
| ES2511218T5 (es) * | 2005-06-20 | 2017-12-07 | Advanced Cell Diagnostics, Inc. | Kits y productos para detección de ácidos nucleicos en células individuales y para identificación de células raras en grandes poblaciones de células heterogéneas |
| EP1749892B1 (en) | 2005-08-02 | 2008-03-19 | Roche Diagnostics GmbH | Nucleotide sequence for assessing TSE |
| US20070042408A1 (en) * | 2005-08-02 | 2007-02-22 | Michael Knoll | Nucleotide sequence for assessing transmissible spongiform encephalopathies |
| EP1754464A1 (en) * | 2005-08-17 | 2007-02-21 | 3M Innovative Properties Company | Enzyme comprising dental composition |
| US7569367B2 (en) * | 2005-09-07 | 2009-08-04 | Roche Diagnostics Operations, Inc. | Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy |
| WO2007044427A2 (en) * | 2005-10-05 | 2007-04-19 | Panomics, Inc. | Detection of nucleic acids from whole blood |
| EP1932913B1 (en) | 2006-12-11 | 2013-01-16 | Roche Diagnostics GmbH | Nucleic acid isolation using polidocanol and derivatives |
| CN102776173B (zh) | 2006-12-11 | 2014-10-29 | 霍夫曼-拉罗奇有限公司 | 使用聚多卡醇和衍生物的核酸分离 |
| US8535888B2 (en) * | 2006-12-29 | 2013-09-17 | Mayo Foundation For Medical Education And Research | Compositions and methods for detecting methicillin-resistant S. aureus |
| US7964350B1 (en) | 2007-05-18 | 2011-06-21 | Applied Biosystems, Llc | Sample preparation for in situ nucleic acid analysis |
| EP2171098B1 (en) * | 2007-06-29 | 2018-03-28 | Becton, Dickinson and Company | Methods for extraction and purification of components of biological samples |
| ES2439951T3 (es) | 2008-06-06 | 2014-01-27 | F. Hoffmann-La Roche Ag | Detección y cuantificación multiplex de ácidos nucleicos microbianos controlada de forma interna |
| CN103025891A (zh) | 2010-07-29 | 2013-04-03 | 霍夫曼-拉罗奇有限公司 | 通用样品制备 |
| CN103154269A (zh) | 2010-07-29 | 2013-06-12 | 霍夫曼-拉罗奇有限公司 | 用于多种参数的对照核酸 |
| ES2605303T3 (es) | 2010-07-29 | 2017-03-13 | F. Hoffmann-La Roche Ag | Detección cualitativa y cuantitativa de ácidos nucleicos microbianos |
| EP2598653B1 (en) | 2010-07-29 | 2017-08-23 | F. Hoffmann-La Roche AG | Generic pcr |
| EP2426222A1 (en) | 2010-09-07 | 2012-03-07 | F. Hoffmann-La Roche AG | Generic buffer for amplification |
| CA2811333C (en) | 2010-09-16 | 2020-05-12 | Gen-Probe Incorporated | Capture probes immobilizable via l-nucleotide tail |
| CN104849472A (zh) | 2010-10-21 | 2015-08-19 | 领先细胞医疗诊断有限公司 | 用于原位检测核酸的超灵敏方法 |
| AU2011323478B2 (en) | 2010-11-01 | 2015-09-10 | Gen-Probe Incorporated | Integrated capture and amplification of target nucleic acid for sequencing |
| EP2465945A1 (en) | 2010-12-17 | 2012-06-20 | F. Hoffmann-La Roche AG | Generic matrix for control nucleic acids |
| WO2013067069A2 (en) * | 2011-10-31 | 2013-05-10 | Leinweber Barbara | Dual digestion method for high yield nucleic acid recovery |
| CA2863084C (en) | 2012-02-01 | 2020-07-07 | Gen-Probe Incorporated | Asymmetric hairpin target capture oligomers |
| US10017759B2 (en) | 2014-06-26 | 2018-07-10 | Illumina, Inc. | Library preparation of tagged nucleic acid |
| JP6822974B2 (ja) | 2015-05-29 | 2021-01-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | シトラコン酸無水物によって微生物を不活性化する方法 |
| DK3362462T3 (da) | 2015-10-12 | 2021-10-11 | Advanced Cell Diagnostics Inc | In situ-detektion af nukleotidvarianter i prøver med højt støjniveau, og sammensætninger og fremgangsmåder relateret dertil |
| KR102313431B1 (ko) | 2016-11-21 | 2021-10-18 | 나노스트링 테크놀로지스, 인크. | 화학적 조성물 및 이것을 사용하는 방법 |
| AU2019271028B2 (en) | 2018-05-14 | 2025-09-18 | Bruker Spatial Biology, Inc. | Chemical compositions and methods of using same |
| JP2024510996A (ja) * | 2021-03-15 | 2024-03-12 | ジェン－プローブ・インコーポレーテッド | 生物学的サンプル処理のための組成物および方法 |
| EP4317454A4 (en) | 2021-03-29 | 2025-02-19 | Toray Industries, Inc. | Method for detecting microrna in biological sample, composition of hydrochloride of neutral amino acid, and container |
| CA3254118A1 (en) | 2022-03-15 | 2023-09-21 | Diagenode S.A. | DETECTION OF THE METHYLATION STATE OF A DNA SAMPLE |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900677A (en) * | 1986-09-26 | 1990-02-13 | E. I. Du Pont De Nemours And Company | Process for rapid isolation of high molecular weight DNA |
| AU646635B2 (en) | 1989-03-07 | 1994-03-03 | Syngene, Inc. | In-situ hybridization in suspension for detection or separation of cells |
| US5128247A (en) * | 1989-08-14 | 1992-07-07 | Board Of Regents, The University Of Texas System | Methods for isolation of nucleic acids from eukaryotic and prokaryotic sources |
| US5284940A (en) | 1990-11-14 | 1994-02-08 | Hri Research, Inc. | Preparation for nucleic acid samples |
-
1993
- 1993-02-10 US US08/015,729 patent/US5386024A/en not_active Expired - Lifetime
-
1994
- 1994-02-07 JP JP51831894A patent/JP3477205B2/ja not_active Expired - Fee Related
- 1994-02-07 KR KR1019950703298A patent/KR960701081A/ko not_active Withdrawn
- 1994-02-07 WO PCT/US1994/001421 patent/WO1994018238A1/en not_active Ceased
- 1994-02-07 CA CA002155744A patent/CA2155744C/en not_active Expired - Fee Related
- 1994-02-07 AU AU61359/94A patent/AU690895B2/en not_active Ceased
- 1994-02-10 DK DK94300971T patent/DK0611157T3/da active
- 1994-02-10 AT AT94300971T patent/ATE238430T1/de not_active IP Right Cessation
- 1994-02-10 EP EP94300971A patent/EP0611157B1/en not_active Expired - Lifetime
- 1994-02-10 ES ES94300971T patent/ES2198411T3/es not_active Expired - Lifetime
- 1994-02-10 DE DE69432540T patent/DE69432540T2/de not_active Expired - Fee Related
- 1994-11-30 US US08/347,272 patent/US6610475B1/en not_active Expired - Lifetime
-
1998
- 1998-06-04 AU AU69936/98A patent/AU6993698A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU690895B2 (en) | 1998-05-07 |
| WO1994018238A1 (en) | 1994-08-18 |
| JPH08508637A (ja) | 1996-09-17 |
| EP0611157A2 (en) | 1994-08-17 |
| JP3477205B2 (ja) | 2003-12-10 |
| US6610475B1 (en) | 2003-08-26 |
| US5386024A (en) | 1995-01-31 |
| ATE238430T1 (de) | 2003-05-15 |
| AU6993698A (en) | 1998-07-30 |
| DE69432540D1 (de) | 2003-05-28 |
| KR960701081A (ko) | 1996-02-24 |
| CA2155744A1 (en) | 1994-08-18 |
| CA2155744C (en) | 2007-05-15 |
| ES2198411T3 (es) | 2004-02-01 |
| DE69432540T2 (de) | 2003-11-06 |
| AU6135994A (en) | 1994-08-29 |
| EP0611157A3 (en) | 1994-12-28 |
| EP0611157B1 (en) | 2003-04-23 |
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