DK0615978T3 - Peptidderivater af borsyre med proteaseinhiberende virkning, fremgangsmåde til fremstilling heraf samt farmaceutiske sammen - Google Patents

Peptidderivater af borsyre med proteaseinhiberende virkning, fremgangsmåde til fremstilling heraf samt farmaceutiske sammen

Info

Publication number: DK0615978T3
Authority: DK; Denmark
Prior art keywords: hydrogen atom; group; methyl; preparation; pharmaceutical compositions
Prior art date: 1993-02-24

Application number

DK94400393T

Other languages

English (en)

Inventor

Nanteuil Guillaume De

Christine Lila

Michel Laubie

Tony Verbeuren

Serge Simonet

Alain Rupin

Bernard Portevin

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-24

Filing date

1994-02-24

Publication date

1999-11-15

1994-02-24 Application filed by Adir filed Critical Adir

1999-11-15 Application granted granted Critical

1999-11-15 Publication of DK0615978T3 publication Critical patent/DK0615978T3/da

Links

108091005804 Peptidases Proteins 0.000 title 1
239000004365 Protease Substances 0.000 title 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical class OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
-1 5-[(dimethyl)amino]naphthylsulphonyl Chemical group 0.000 abstract 11
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
MOILFCKRQFQVFS-BDNRQGISSA-N (1r,3s,4r,5r)-4,6,6-trimethylbicyclo[3.1.1]heptane-3,4-diol Chemical compound C1[C@@H]2C(C)(C)[C@H]1C[C@H](O)[C@@]2(O)C MOILFCKRQFQVFS-BDNRQGISSA-N 0.000 abstract 1
108090000190 Thrombin Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000005079 alkoxycarbonylmethyl group Chemical group 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 abstract 1
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
125000006678 phenoxycarbonyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Chemical group O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1
108010036927 trypsin-like serine protease Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK94400393T 1993-02-24 1994-02-24 Peptidderivater af borsyre med proteaseinhiberende virkning, fremgangsmåde til fremstilling heraf samt farmaceutiske sammen DK0615978T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9302082A FR2701951B1 (fr)	1993-02-24	1993-02-24	Nouveaux derives peptidiques de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
DK0615978T3 true DK0615978T3 (da)	1999-11-15

Family

ID=9444358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94400393T DK0615978T3 (da)	1993-02-24	1994-02-24	Peptidderivater af borsyre med proteaseinhiberende virkning, fremgangsmåde til fremstilling heraf samt farmaceutiske sammen

Country Status (13)

Country	Link
US (1)	US5444049A (da)
EP (1)	EP0615978B1 (da)
JP (1)	JP2533290B2 (da)
AT (1)	ATE179988T1 (da)
AU (1)	AU666801B2 (da)
CA (1)	CA2116181A1 (da)
DE (1)	DE69418368T2 (da)
DK (1)	DK0615978T3 (da)
ES (1)	ES2133504T3 (da)
FR (1)	FR2701951B1 (da)
GR (1)	GR3030311T3 (da)
NZ (1)	NZ250957A (da)
ZA (1)	ZA941273B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6825169B1 (en)	1991-10-22	2004-11-30	Trustees Of Tufts College	Inhibitors of dipeptidyl-aminopeptidase type IV
FR2721611B1 (fr) *	1994-06-22	1996-09-27	Adir	Nouveaux dérivés peptidiques de l'acide boronique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent .
US5639739A (en) *	1995-03-24	1997-06-17	The Dupont Merck Pharmaceutical Company	Imidazole containing aminoboronic acids
DE69624365T2 (de)	1995-07-26	2003-06-26	Mitsubishi Chemical Corp., Tokio/Tokyo	Penizillaminamid-derivate
FR2739858B1 (fr) *	1995-10-11	1997-11-14	Synthelabo	Derives de n-sulfonyl- et n-sulfamoylpeptidylprolinamide, leur preparation et leur application en therapeutique
US5965532A (en)	1996-06-28	1999-10-12	Trustees Of Tufts College	Multivalent compounds for crosslinking receptors and uses thereof
FR2758329B1 (fr) *	1997-01-16	1999-02-12	Synthelabo	Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
US6100234A (en)	1997-05-07	2000-08-08	Tufts University	Treatment of HIV
US6040145A (en)	1997-05-07	2000-03-21	Tufts University	Potentiation of the immune response
CA2304206A1 (en)	1997-09-29	1999-04-08	Point Therapeutics, Inc.	Stimulation of hematopoietic cells in vitro
MY132924A (en)	1998-05-04	2007-10-31	Point Therapeutics Inc	Hematopoietic stimulation
WO1999062914A1 (en)	1998-06-05	1999-12-09	Point Therapeutics, Inc.	Cyclic boroproline compounds
US6979697B1 (en) *	1998-08-21	2005-12-27	Point Therapeutics, Inc.	Regulation of substrate activity
FR2793248B1 (fr) *	1999-05-03	2001-06-29	Adir	Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6890904B1 (en)	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
EP1371663B1 (en) *	2001-03-19	2010-09-22	Fujimori Kogyo Co., Ltd.	Anhydrothrombin derivatives and process for producing the same, platelet agglutination-inducing compositions, method of inducing platelet agglutination, clinical test reagents, clinical test method, thrombosis inhibitors, adsorbent and process
AU2003248921A1 (en) *	2002-07-09	2004-01-23	Point Therapeutics, Inc.	Boroproline compound combination therapy
US20060084592A1 (en) *	2002-09-09	2006-04-20	Trigen Limited	Peptide boronic acid inhibitors
US7112572B2 (en) *	2002-09-09	2006-09-26	Trigen Limited	Multivalent metal salts of boronic acids
US20050119226A1 (en) *	2003-09-09	2005-06-02	Trigen Limited	Methods for synthesizing organoboronic compounds and products thereof
AU2003263343A1 (en) *	2002-09-09	2004-03-29	Trigen Limited	Boronic acid salts ant their use in the treatment of thromobis
US20050176651A1 (en) *	2002-09-09	2005-08-11	Trigen Limited	Peptide boronic acids useful in making salts thereof
US20050282757A1 (en) *	2002-09-09	2005-12-22	Trigen Limited	Peptide boronic acid compounds useful in anticoagulation
GB0405272D0 (en) *	2004-03-09	2004-04-21	Trigen Ltd	Compounds
FR2867780B1 (fr) *	2004-03-19	2006-05-19	Servier Lab	Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20060063719A1 (en) *	2004-09-21	2006-03-23	Point Therapeutics, Inc.	Methods for treating diabetes
GB0507577D0 (en)	2005-04-14	2005-05-18	Novartis Ag	Organic compounds
WO2022198196A1 (en)	2021-03-15	2022-09-22	Maze Therapeutics, Inc.	Inhibitors of glycogen synthase 1 (gys1) and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5187157A (en) *	1987-06-05	1993-02-16	Du Pont Merck Pharmaceutical Company	Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (de) *	1987-11-05	1990-08-22	Hoechst Aktiengesellschaft	Renin-Inhibitoren
GB9017694D0 (en) *	1990-08-13	1990-09-26	Sandoz Ltd	Improvements in or relating to organic chemistry
GB9024129D0 (en) *	1990-11-06	1990-12-19	Thrombosis Research Trust	Inhibitors and substrates of thrombin
FR2694295B1 (fr) *	1992-07-28	1994-09-02	Adir	Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.

1993
- 1993-02-24 FR FR9302082A patent/FR2701951B1/fr not_active Expired - Fee Related
1994
- 1994-02-22 US US08/199,473 patent/US5444049A/en not_active Expired - Fee Related
- 1994-02-22 CA CA002116181A patent/CA2116181A1/fr not_active Abandoned
- 1994-02-22 AU AU56302/94A patent/AU666801B2/en not_active Ceased
- 1994-02-23 JP JP6025245A patent/JP2533290B2/ja not_active Expired - Lifetime
- 1994-02-23 NZ NZ250957A patent/NZ250957A/en unknown
- 1994-02-24 AT AT94400393T patent/ATE179988T1/de not_active IP Right Cessation
- 1994-02-24 DK DK94400393T patent/DK0615978T3/da active
- 1994-02-24 EP EP94400393A patent/EP0615978B1/fr not_active Expired - Lifetime
- 1994-02-24 ZA ZA941273A patent/ZA941273B/xx unknown
- 1994-02-24 DE DE69418368T patent/DE69418368T2/de not_active Expired - Fee Related
- 1994-02-24 ES ES94400393T patent/ES2133504T3/es not_active Expired - Lifetime
1999
- 1999-05-27 GR GR990401397T patent/GR3030311T3/el unknown

Also Published As

Publication number	Publication date
HK1010378A1 (en)	1999-06-17
US5444049A (en)	1995-08-22
ES2133504T3 (es)	1999-09-16
ATE179988T1 (de)	1999-05-15
AU666801B2 (en)	1996-02-22
CA2116181A1 (fr)	1994-08-25
AU5630294A (en)	1994-09-01
DE69418368T2 (de)	1999-12-16
FR2701951B1 (fr)	1995-06-09
JP2533290B2 (ja)	1996-09-11
EP0615978B1 (fr)	1999-05-12
EP0615978A1 (fr)	1994-09-21
DE69418368D1 (de)	1999-06-17
NZ250957A (en)	1995-09-26
FR2701951A1 (fr)	1994-09-02
ZA941273B (en)	1994-10-19
GR3030311T3 (en)	1999-09-30
JPH06298795A (ja)	1994-10-25

Publication	Publication Date	Title
ATE179988T1 (de)	1999-05-15	Peptidderivate aus boronsäure mit protease- inhibierender aktivität, ihr herstellungsverfahren und sie enthaltende pharmazeutische zusammensetzungen
AU617875B2 (en)	1991-12-05	Novel peptidase inhibitors
NO930517L (no)	1993-08-16	Benzimidazolylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
MY130830A (en)	2007-07-31	Inhibitors
DK0705254T3 (da)	1999-01-25	Phenylheterocykliske forbindelser som cyclooxygenase-2-inhibitorer
DE69420564D1 (de)	1999-10-14	Immunsuppressive und antiallergische verbindungen; z.b. n-(3-oxohexanoyl)-homoserinlacton
EP0670309A4 (en)	1995-07-24	RELATED TO PROLYE-ENDOPEPTIDASE INHIBITING ACTIVITY AND THEIR PHARMACEUTICAL USE.
WO1996030395A3 (en)	1996-12-27	Cysteine protease inhibitor
CZ284872B6 (cs)	1999-03-17	Cyklické močoviny a jejich analogy a farmaceutické přípravky na jejich bázi
BR9713126B1 (pt)	2009-01-13	compostos derivados da piridin-2-il-metilamina, processo para sua preparaÇço, compostos intermediÁrios de sÍntese, uso de um composto, e, composiÇço farmacÊutica.
HUP0301249A2 (hu)	2004-01-28	APO B termelődés gátló benzamid-vegyületek ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
MY103233A (en)	1993-05-29	Novel thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions
DK0578083T3 (da)	1999-10-18	Cykliske adhæsionsinhibitorer
WO2003047512A3 (en)	2003-10-16	Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
HUP0001383A1 (hu)	2001-05-28	N-(Aril/heteroaril)-aminosav-származékok, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
EP1184373A4 (en)	2004-10-20	TRICYCLIC CONNECTIONS
CA2127067A1 (fr)	1994-12-31	Derives d'acide phosphonique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2003015706A3 (en)	2004-06-03	Borinic acid protease inhibitors
EA200400409A1 (ru)	2004-10-28	Новые соединения изохинолина, способ их получения и фармацевтические композиции, содержащие их
HUP9802291A2 (hu)	1999-01-28	Penicillamin-amid-származékok, és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
WO2002024711A1 (en)	2002-03-28	Novel thiazole bicyclic compounds
MXPA04011363A (es)	2005-02-14	Nuevos derivados acil hidrazino del tiofeno, su procedimiento de preparacion, su aplicacion como medicamentos, composiciones farmaceuticas y nueva utilizacion.
AR044258A1 (es)	2005-09-07	Intermedios utiles en la sintesis de los inhibidores de las proteasas de vih y procedimientos para preparar los mismos
HUP0204144A2 (en)	2003-05-28	N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses